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Volume 54, Issue 5
Displaying 1-8 of 8 articles from this issue
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T. Yamaguchi, M. Inomata, S. Orii2001 Volume 54 Issue 5 Pages 317-322
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSThe suppressive effect and mechanism of Nimesulide (NIM), a COX-2 selective inhibitor, for azoxymethane-induced mice colorectal carcinogenesis in dextran sodium sulfate-induced chronic colitis, were studied. Mice were divided into 3 groups: no NIM (control), 200ppin NIM, and 400ppm NIM. In the NIM groups, the mean numbers of tumors per tumor-bearing mouse, and mean numbers of aberrant crypt foci, were significantly lower than in the control. Furthermore, the positive rates of COX-2 expression in the tumor epithelial cells of the NIM groups were significantly lower than that of the control, and the degrees of COX-2 expression tended to decrease with the higher dose of NIM. The apoptosis indices in the NIM groups were significantly higher than in the control. NIM, a COX-2 selective inhibitor, reduces tumorigenesis of the colorectum by an increase of apoptosis.View full abstractDownload PDF (5142K) -
Y. Nakajima, K. Takahashi, M. Yasuno, T. Mori2001 Volume 54 Issue 5 Pages 323-327
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSWe define early postoperative intestinal obstruction as that occurring within 30 days following the pri-mary surgery for colorectal cancer. From 1975 to 1998, 2193 patients received surgery for colorectal cancer in our hospital. The incidence of early postoperative intestinal obstruction was 4.5% (99 cases). A total of 99 patients was divided into three groups as follows : the early re-exploration group (n=12) received re-operation before beginning oral intake, the late re-exploration group (n=18) received re-operation after beginning oral intake, and the conservative treatment group (n=69) received no surgical treatment. Their factors of age, sex, primary operation, location of tumor, and lymph node dissection had no statistical significant difference. Operation time and loss of blood were statistically greater in the early re-exploration group than in the conservative treatment group (p=0.0079 and 0.0017). Early postoperative intestinal obstruction occurred within the sixth postoperative day in 31.4%of them, and after the seventh postoperative day in 68.6%. By conservative treatment, 40 cases (40.0%) were improved within 6 days, and 63 cases (63.6%) within 9 days. In contrast, all in the early re-exploration group was not improved by only conservative treatment, and was undergone reoperation within eighth postoperative day. The late re-exploration group finally underwent re-operation after an average of 20 days' conservative treatment. Surgical treatment should be chosen for early postoperative intestinal obstruction if it dose not improve by conservative treatment for 6 to 9 days.View full abstractDownload PDF (365K) -
Y. Takagi, S. Thurui, K. Tamura, T. Aoki, [in Japanese], Y. Wakana, K. ...2001 Volume 54 Issue 5 Pages 329-333
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSCase 1 : A 52-year-old man was admitted with perianal pain as the chief complaint. Redness and marked swelling were noted, extending from the scrotum to the perianal region. CT scans showed an abscess with gas in the painful region. Incision and debridement of the abscess were performed. Postoperatively, hyperbaric oxygen therapy and endotoxin absorption therapy were perfomed concomitantly.
Case 2 : A 57-year-old man who was admitted with perianal pain as the chief complaint. He also had severe redness and swelling extending from the scrotum to the perianal region. CT scans revealed an abscess with gas in this region. Incision and debridement of the abscess were performed, and hyperbaric oxygen therapy and endotoxin absorption therapy were provided concomitantly after the operation. However, he died from rupture of an aortic aneurysm on hospital day 11. In treatment of this disease, early diagnosis and extensive debridement of the necrotic tissue are important to cure the patient. It is also necessary to perform frequent drug sensitivity testing and to change antibiotics, in addition to providing concomitant treatments, such as hyperbaric oxygen therapy and endotoxin absorption therapy.View full abstractDownload PDF (7158K) -
M. Man-i, T. Tsujinaka, I. Nishisho, H. Mishima, [in Japanese]2001 Volume 54 Issue 5 Pages 335-341
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 58-year-old man was admitted to our hospital because of lower abdominal pain and diarrhea ; he had received curative total gastrectomy for gastric cancer 7 years previously. Barium enema showed marginal serration of the bowel wall, narrowing of the bowel canal, and a coarse granular pattern of the mucosal surface at the transverse, descending, and sigmoid colon, as well as the rectum. Colonoscopy showed stenosis of the lumen with multiple nodular elevations and ulcers. Histological examination of a biopsy specimen demonstrated poorly differentiated adenocarcinoma. Under a diagnosis of primary or metastatic diffuse infiltrative carcinoma, laparotomy was scheduled. Since peritoneal dissemination was not found, a left hemicolectomy and Mile's operation was performed. Macroscopically, the resected specimen contained multiple annular narrowings with thickening of the wall and ulceration. Histologically, diffuse infiltration of signet cell carcinoma was found involving the entire layer of intestinal wall, especially the submucosal layer. These features were compatible with the histology of the previously resected stomach. Metastatic colorectal carcinomas are mostly asymptomatic and are often diagnosed more than 5 years after primary surgery. The barium enema is considered most useful for surveillance. Differential diagnosis for primary diffuse infiltrative colorectal carcinoma is necessary, and curative operation should be intended in the absence of peritoneal dissemination or multiple liver metastases.View full abstractDownload PDF (4844K) -
Koutarou Maeda, Morito Maruta, Toshiaki Utsumi, Harunobu Sato, Kohji M ...2001 Volume 54 Issue 5 Pages 343-344
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (3660K) -
Hidejiro Kawahara, Haruhisa Kuroda, Hideharu Mukai, Keiichi Sato, Masa ...2001 Volume 54 Issue 5 Pages 345-346
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (6033K) -
2001 Volume 54 Issue 5 Pages 347-372
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (3636K) -
2001 Volume 54 Issue 5 Pages 373-382
Published: 2001
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (931K)
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