We report two cases of patients with metastatic anal fistula cancer who underwent local resection of the anal fistula and tumor, and achieved long-term survival.
Case 1: A 58-year-old man who had developed an anal fistula 8 years previously underwent high anterior resection and lymph node dissection for ileus caused by rectosigmoid cancer. The final diagnosis was pSE, pN1, cM0, fStage IIIa. Eight months after surgery, a perianal tumor developed.
Case 2: A 65-year-old man underwent low anterior resection and lymph node dissection for lower rectal cancer, and the final diagnosis was pMP, pN0, cM0, fStage II. Nine months after surgery, a perianal tumor enlarged gradually.
In both cases, the perianal tumor was diagnosed as metastatic anal fistula cancer from rectal cancer by biopsy. Local resection of the anal fistula and tumor was performed. The histological findings of the primary rectal cancer and the resected anal fistula tumor were nearly identical, and immunohistochemical staining patterns were similar as well. These findings suggest that the metastatic lesion resulted from implantation of rectal cancer cells via the anal fistula. Case 1 achieved recurrence-free survival for 8 years and 3 months and Case 2 for 5 years and 10 months.
View full abstract