Purpose: The purpose of this study is to predict the mechanism of cardiac sudden death (CSD) by analyzing the fatal events associated with acute myocardial infarction (AMI). Methods and Results: To predict the mechanism of CSD, clinical characteristics were analyzed in 5 AMI cases which presented early ventricular tachyarrhythmia over the 7 months from January, 2011. Case 1; 30-year-old (y/o) male underwent primary percutaneous coronary intervention (PCI) for acute inferior MI. He was wearing an ambulatory electrocardiography 2 days before the onset of AMI. ST segment depression with prolonged QTc interval followed by ventricular tachycardia (VT) was shown in the recording at night. Intracoronary injection of acetylcholine revealed multivessel spasm with subsequent prolonged QTc and ventricular ectopy. Case 2 and 3; two 67 y/o males were treated with primary PCI after direct current (DC) shock for ventricular fibrillation (VF). Case 4; 62 y/o male whose VF was treated with DC shocks in the emergency room (ER), and died of pulseless electrical activity (PEA) with heart rupture after successful PCI for acute anterior MI. Case 5; 71 y/o female with acute inferior MI due to stent thrombosis presented cardiogenic shock and VF which was treated in the ER. Conclusions: The fatal events associated with AMI were VF, VT induced by prolonged QTc via multivessel spasm, and PEA due to heart rupture. Coronary spasm is also suspected to be an important factor to induce VT, resulting in CSD.
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