It has been noted by some investigators that Pb is present in human saliva, but there are no data on lead concentration in normal saliva in the Japanese.
This report describes the levels of lead concentrations in 272 saliva samples obtained from residents of five different geographical areas in Japan, namely, Tokyo, Kumagaya City in Saitama Prefecture, Chiba City, and Nagoya City and Tahara in Aichi Prefecture.
Lead concentrations were determined by the simplified method, in which lead in saliva was chelated by 1% APDC, extracted with MIBK, and detected by flameless atomic absorption spectrophotometry.
The results were as follows:
1) The distribution of lead concentration in mixed saliva from inhabitants of the five different geographical areas was approximately logarithmic-normal.
2) The geometric mean of lead concentrations in mixed saliva from Tokyo (2.23 μg/d
l), the capital of Japan, was significantly higher than that for Kumagaya, Chiba, Nagoya, and Tahara.
3) The geometric mean of lead concentrations in mixed saliva from Tahara (0.32 μg/d
l), a rural area, was significantly lower than that for the four other locations.
4) Significant correlation was observed between the geometric mean of lead concentrations in air and in mixed saliva from 5 locations in Japan (r=0.95).
5) The mean values of lead concentrations in parotid and mixed saliva from 71 normal subjects were 0.306 μg/d
l and 0.687 μg/d
l, respectively.
6) Significant correlation was observed between the lead in urine and in parotid saliva and the lead in plasma and parotid saliva. The mean ratio of the lead concentrations in simultaneously obtained parotid saliva to plasma was 0.96.
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