Japanese Journal of Developmental and Therapeutics

Japanese Journal of Developmental and Therapeutics

Online ISSN : 2759-9256
Print ISSN : 1342-6753

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Overdoses of OTC drug: Who's going to stop them?

Yuko Isizaki

2026Volume 38Issue 1 Pages 3-6
Published: March 31, 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_3

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Clinical research using diagnosis procedure combination database and medical records: From conception to publication

Hiroki Kitaoka

2026Volume 38Issue 1 Pages 7-11
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_7

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From clinical question to research

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2026Volume 38Issue 1 Pages 12-15
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_12

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What can be done for pediatric healthcare: A clinical perspective on challenges in pediatric drug formulations

Akimasa Yamatani

2026Volume 38Issue 1 Pages 16-23
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_16

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Efficacy and safety of melatonin（Melatobel®）for sleep disorders associated with neurodevelopmental disorders

Kazutoshi Murakoso, Erina Ozawa, Arisa Imabayashi, Saki Takahashi, Tak ...

2026Volume 38Issue 1 Pages 24-29
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_24

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Neonatal seizures in which multiple antiepileptic drugs were used: A case report

Naoko Akiyama, Madoka Ishihara, Takaharu Ichiki, Tetsuya Ueki

2026Volume 38Issue 1 Pages 30-35
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_30

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Pharmacist support for Valganciclovir administration in a very low birth weight infant with symptomatic congenital cytomegalovirus disease

Sayaka Azuma, Noriko Matsuoka, Shusaku Noguchi, Keishi Yoshida, Yoshio ...

2026Volume 38Issue 1 Pages 36-41
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_36

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A survey on drug passability through feeding tube in a neonatal ward

Yurie Hamamachi, Makiko Kayaba, Kei Ishiga, Masae Nishino, Yukako Hozu ...

2026Volume 38Issue 1 Pages 42-47
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_42

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Actual use of Japanese herbal medicines in very low birth weight infants

Yuki Tanaka, Meguru Goma, Makoto Kishigami, Yoshinori Katayama, Saori ...

2026Volume 38Issue 1 Pages 48-54
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_48

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The actual use of oral omega-3 fat preparations for cholestasis in preterm infants; Single-center retrospective observational study

Daiki Yamada, Saori Miyake, Makoto Kishigami, Meguru Goma, Yoshinori K ...

2026Volume 38Issue 1 Pages 55-61
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_55

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Survey on off-label use in neonatal pharmacotherapy in Japan

Tomoko Iwashita, Michiyo Okudaira, Naoki Ito, Shiori Furukawa, Kinuko ...

2026Volume 38Issue 1 Pages 62-69
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_62

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Relationship between thiopurines and hypoglycemia in the Japanese Adverse Drug Event Report database

Shunichi Okumura, Shogo Akahoshi, Junko Hiroi

2026Volume 38Issue 1 Pages 70-75
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_70

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In October 2023, Japanese health services issued a warning about the risk of hypoglycemia associated with the use of 6-mercaptopurine（6-MP）in pediatric patients in Japan after several such cases were reported overseas. However, because there are, as of yet, few reports of pediatric hypoglycemia associated with 6-MP therapy in Japan, the veracity of the overseas reports has been called into question. Moreover, no warnings have been issued in Japan about the risks associated with the use of azathioprine, another thiopurine, and it is unclear whether pediatric hypoglycemia is a common adverse effect of this drug class. Based on the Japanese Adverse Drug Event Report database（JADER）, the present study analyzed the relationship between thiopurines and pediatric hypoglycemia using the reporting odds ratio（ROR）and found that the ROR for hypoglycemia caused by thiopurines in all age groups was 0.22（95% confidence interval［CI］: 0.18-0.27）, indicating no significant increase in the hypoglycemia signal. However, when patients receiving thiopurines were stratified into pediatric and adult groups, the ROR for hypoglycemia in the pediatric group was 3.22（95% CI: 2.09–4.97）compared to the adult group, indicating a significantly increased signal. In addition, when the same analysis was conducted separately for 6-MP and azathioprine, the ROR was 15.72（95% CI: 2.07-119.36） and 3.00（95% CI: 1.78-5.05）, respectively, suggesting a significantly increased signal of hypoglycemia. Therefore, 6-MP and other allied drugs, such as azathioprine, should be administered to pediatric patients with due consideration of the possibility of hypoglycemia.

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Effects of community pharmacy AMR awareness activities on the public: Evaluation of a distribution campaign by the Japan study group for pediatric pharmacotherapy

Michiyo Kawana, Misato Tomita, Ayaka Ohno, Kousei Nakamura, Jun Ohnita ...

2026Volume 38Issue 1 Pages 76-82
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_76

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Survey of broad-spectrum antimicrobials for early-onset neonatal bacterial sepsis （Single-site, retrospective study）

Michiyo Tatsumi, Yusuke Niinuma, Mitsuru Sugawara, Yoh Takekuma

2026Volume 38Issue 1 Pages 83-87
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_83

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An exploratory study on the palatability of levocetirizine hydrochloride dry syrup mixed with flavored vehicles in pediatric patients

Tomona Sogo, Hiroshi Shinonaga, Toui Tsuchiya, Hisatoshi Mori, Ikuko O ...

2026Volume 38Issue 1 Pages 88-95
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_88

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The requisite quantity of water necessary for the preparation of a paste comprising herbal medicine

Satoshi Yoshikawa, Erena Sato, Tomofumi Watanabe, Yukie Suzuki, Ryoko ...

2026Volume 38Issue 1 Pages 96-100
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_96

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Impact of the discontinuation of distribution of Norditropin® FlexPro® 10 mg on the therapeutic burden of self-Injection: A case series of four patients

Yumika Koike, Ikkou Hirata, Saki Tsuchiya, Yasue Ishikawa, Ryohkan Fun ...

2026Volume 38Issue 1 Pages 101-104
Published: 2026
Released on J-STAGE: May 11, 2026

DOIhttps://doi.org/10.69325/jdpt.38.1_101

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