A sequential injection chromatography (SIC) constructed from a short monolithic column and a microfluidic polymer chip with an embedded Cl- ion-selective electrode (Cl--ISE) as a detector was developed for simultaneous determination of common inorganic anions. Under the optimal flow conditions of the SIC system, the determination range for Cl
-, NO
2-, Br
-, NO
3- ions was as follows: For Cl
- ion in a concentration range from 1.0 x 10
-3 to 5.0 x 10
-2 mol dm
-3, for NO
2- ion in the concentration range from 1.0 x 10
-3 to 5.0 x 10
-2 mol dm
-3, for Br
- ion in the concentration range from 1.0 x 10
-3 to 5.0 x 10
-2 mol dm
-3, and for NO
3- ion in the concentration range from 3.0 x 10
-4 to 1.0 x 10
-2 mol dm
-3, respectively. Limit of detection, defined as S/N=3, was ca. 3.0 x 10
-4 mol dm
-3 for Cl
-, NO
2-, Br
-, NO
3- ions.
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