Aim：The visceral fat area (VFA) and subcutaneous fat area (SFA) evaluated by the conventional CT are gold standards, but due to problems such as radiation exposure, it is not necessarily suitable for routine practice. VFA and SFA measurements by the dual impedance method do not need radiation exposure and are suitable for repeated measurements, but their clinical significance is not well established. In this circumstance, we investigated the correlations of VFA and SFA measured by the dual impedance method to liver enzymes as well as other metabolic parameters. Methods：Ninety-nine subjects with lifestyle diseases (M/F = 54/45 ；age 59 ± 11；BMI 25 ± 3.1) were involved in this study and underwent VFA and SFA measurements with DUALSCAN Omron HDS-2000. Univariate analysis was conducted for the correlations of VFA, SFA, waist circumference (WC) and body mass index (BMI) to each of these parameters or to liver enzymes, lipids, and glucose. Multiple regression analysis was performed with alanine aminotransferase (ALT), serum triglycerides (TG), HbA1c as dependent variables and VFA, SFA, sex, and age as independent variables. Results：By univariate analysis, VFA had positive correlations with aspartate aminotransferase (AST), ALT, plasma glucose (PG), HbA1c, and TG and had inverse correlations with HDL-C. On the other hand, SFA had a positive correlation with only PG. WC had positive correlations with AST, PG, and HbA1c. BMI had positive correlations with AST, ALT, and PG. Multiple regression analysis showed that VFA was associated with ALT (p<0.001), HbA1c (p=0.007) and TG (p=0.015) independently of confounding factors. On the other hand, SFA, correlated only with ALT (p=0.011), in consideration of these confounding factors. Conclusion：VFA by dual impedance method is superior to SFA in estimating liver dysfunction and cardiovascular risk factors.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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