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Volume 12 (1971)
- Issue 6 Pages 507-
- Issue 5 Pages 415-
- Issue 4 Pages 325-
- Issue 3 Pages 205-
- Issue 2 Pages 111-
- Issue 1 Pages 1-
Volume 12, Issue 4
Displaying 1-10 of 10 articles from this issue
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Toshiaki MORISHITA, Rikuro SASAKI, Shizuka ICHIKAWA, Hirotsugu YAMAGIW ...1971 Volume 12 Issue 4 Pages 325-334
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSChemical determination of DNA content and histometric estimation of the cell count and the thickness of muscle fibers in the human left ventricle were performed on 24 autopsy cases, in order to know relationships between heart weight, DNA content, cell count and thickness of muscle fibers with increasing heart weight. The following conclusions were obtained.
It is considered that DNA synthesis and the increase in cell count are attributable for the increase in heart weight. The mean thickness of muscle fibers in cardiovascular and renal disease group was bigger than that in malignant tumor and miscellaneous disease group. Then it is concluded that not only hypertrophy of muscle fibers but hyperplasia of heart muscle cells occur in cardiac hypertrophy.View full abstractDownload PDF (442K) -
Toshiyuki ATSUMI, Takeshi MOTOMIYA, Noriko ISOKANE, Takio SHIMAMOTO1971 Volume 12 Issue 4 Pages 335-346
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSOne hundred and eighty patients with atherosclerosis obliterans were treated with pyridinolcarbamate for 5 to 225 weeks (mean 44.9 weeks).
1) Clinical symptoms and signs were improved by this treatment: intermittent claudication was improved in 50.9% of the total number of cases. Cyanosis disappeared in 37.9%. Paresthesia disappeared in 83.5%. Ulcers were healed in 84.0%. Pulse wave reappeared in plethy-smogram in 44%. Crest time was shortened in 18% of the total number of cases.
2) During a treatment period of 3 years almost of the all cases with symptoms of intermittent claudication, cyanosis, paresthesia and finding of crest time that were improved had improved within 20 weeks.Pain, ulcer and appearance of pulse waves in plethysmograms were also improved in more than half of all patients within 30 weeks, however, in a few cases, it took more than 30 weeks to cure and to improve these symptoms.
3) From the above results, it was concluded that pyridinolcarbamate treatment should be tried for 20 to 30 weeks as the first stage of the treat-ment and subsequently continue for 1 year even though clinical symptoms may not improve. It should also be tried for longer periods to prevent other complications resulting from atherosclerosis.View full abstractDownload PDF (2301K) -
Hideo UEDA, Yasumi UCHIDA, Kazuaki KAMISAKA1971 Volume 12 Issue 4 Pages 347-353
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSResponses of the renal mechanoreceptors to vasopressor agents were examined in mongrel dogs anesthetized with pentobarbital sodium. On injecting the agents, intrarenal pressure fell at first, then returned gradually to control level and overshot thereafter. Renal venous pressure, however, was not always changed in parallel with intrarenal pressure. The frequency of the impulses of low voltage, spontaneously discharging and slowly adapting units increased transiently at the onset of the fall in the intrarenal pressure, then decreased or disappeared. Thereafter, the frequency increased markedly with the return or overshooting of the pressure. The impulses of higher voltage and threshold, not spontaneously discharging and rapidly adapting units appeared transiently at the fall or return of the pressure. These findings are similar to those obtained in the previous studies in which the intrarenal pressure was altered mechanically to different direction from either renal arterial or venous pressure.
It is concluded that the mechanoreceptors were excited by the vasopressor agents indirectly through the alterations in the intrarenal pressure.View full abstractDownload PDF (2501K) -
Seizo YAMASHITA1971 Volume 12 Issue 4 Pages 354-367
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSExperiments were carried out to study whether thiamine deficiency is connected with alcoholic heart disease or not.
Thiamine deficient rats were orally given shochu, whisky and 40% ethanol either until the last stage or for 10 weeks through a stomach tube.General symptoms, electrocardiographic abnormalities, and cardiac histological and electron microscopical changes in the alcohol administered groups were less severe than those in the non-administered group. That is the alcohol lessened thiamine deficient cardiac lesions.
From the above, it is assumed that alcoholic heart disease is of essentially different nature from thiamine deficient cardiac lesions. And discussions were given on the mechanism.View full abstractDownload PDF (3660K) -
Tsuneaki SUGIMOTO, Kiyoshi SATO, Jugoro TAKEUCHI1971 Volume 12 Issue 4 Pages 368-375
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSVentricular arrhythmias accompanied by vagal or sympathetic hyperactivity occur frequently in the acute stage of myocardial infarction. The experiments were designed to study the influence of vagal or sympathetic activity on the incidence of ventricular arrhythmias after coronary occlusion. A right vagus or a left sympathetic nerve was electrically stimulated in anesthetized dogs before and after coronary occlusion while the electrocardiogram was monitored continuously. Sympathetic stimulation was found to enhance the frequency of ventricular arrhythmias very slightly after coronary occlusion. Vagal stimulation, in 4 out of 7 dogs, consistently elicited runs of ventricular tachycardia, the rate of which was slower than the sinus rate. On the other hand, sporadic ventricular extrasystoles coupled to the sinus beat were prevented by the suppression of the sinus rate. Ventricular fibrillation was not produced by either sympathetic or vagal stimulation.View full abstractDownload PDF (1923K) -
Masatoshi FUJISHIMA1971 Volume 12 Issue 4 Pages 376-382
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe effects of lowered perfusion pressure on the cerebral circulation, and on the lactate and acid-base parameter in cerebrospinal fluid (CSF) were studied in the light-anesthetized dogs. The cerebral perfusion pressure was lowered by bleeding the animal at the controlled arterial PCO2. There was a progressive increase in cisternal CSF lactate with consequent decrease in CSF pH and bicarbonate when perfusion pressure was reduced even though cerebral blood flow was unchanged. It is concluded that cerebral autoregulation in response to reduced perfusion pressure appears to be a function of tissue lactic acidosis, signifying tissue hypoxia due to the lowering of local cortical blood flow.View full abstractDownload PDF (363K) -
Akira KAMIYA, Tatsuo TOGAWA1971 Volume 12 Issue 4 Pages 383-391
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe effects of left atrial pressure and myocardial contractility on left ventricular stroke volume (SV), end-diastolic volume (EDV) and end-systolic volume (ESV) were investigated. The left ventricular volumes of dogs were measured by means of thermo-dilution with a thermistor of which time constant was very short (<0.05sec.). Ejected fractions measured in the experiments were averaged 0.50. The recordings were repeated on the 2 experimental conditions of cotrol and elevated left atrial pressure with fixed stimulation of stellate ganglion and cotrol and increased sympathetic stimulation with fixed left atrial pressure, where heart rates and arterial pressure were held constant. The results showed the close correlations only between left atrial pressure and EDV and between sympathetic stimulation and ESV. For elevation of left atrial pressure, the ratio of changes of EDV and ESV (ΔEDV/ΔESV) was about 4.1 which means that increase of SV in this case is chiefly due to increase of EDV. For increased sympathetic stimulation, ΔEDV/ΔESV was about 0.03 which means that increase of SV in this case is chiefly due to decrease of ESV.View full abstractDownload PDF (907K) -
Jiro NAKANO1971 Volume 12 Issue 4 Pages 392-400
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe effects of acute A-V fistula of different magnitudes on the cardiovascular dynamics were studied in anesthetized, open-chest dogs. It was found that A-V fistula decreases mean systemic arterial pressure, effective systemic blood flow, total and pulmonary peripheral resistances. On the other hand, A-V fistula increases heart rate, myocardial contractility, total cardiac output, stroke volume, left and right atrial pressures, pulmonary arterial pressure and systemic peripheral resistance. The magnitude of the above hemodynamic changes was essentially in proportion to the size of the fistula. It was also found that A-V fistula decreases superior mesenteric and femoral arterial blood flows and increases the peripheral resistances.View full abstractDownload PDF (1579K) -
Edward K. CHUNG1971 Volume 12 Issue 4 Pages 401-404
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSDownload PDF (334K) -
The Second Kindred of Familial Pheochromocytoma in JapanTatsuo SATO, Masahide SEINO, Osamu KITAHARA, Iwao ONO, Yukio MIURA, Ke ...1971 Volume 12 Issue 4 Pages 405-413
Published: 1971
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe second kindred of familial pheochromocytoma in Japan was reported. Bilateral pheochromocytomas were found in the elder and the youngest sister. In the other members of this family, no pheochromocytoma and thyroid tumor was found. Medullary thyroid carcinoma was removed before adrenalectomy in both patients. Diagnostic and therapeutic problems in these cases were discussed. It was our conclusion that once pheochromocytoma, especially in bilateral, or thyroid tumor has been found in either normotensive or hypertensive patients, other members of the family as well as the patient should be examined carefully for similar tumors. Tyramine test was less valuable for screening of paroxysmal type of pheochromocytoma.View full abstractDownload PDF (2148K)
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