Japanese Heart Journal
Online ISSN : 1348-673X
Print ISSN : 0021-4868
ISSN-L : 0021-4868
Volume 12, Issue 5
Displaying 1-10 of 10 articles from this issue
  • Takashi KINOUCHI
    1971 Volume 12 Issue 5 Pages 415-435
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    Compartmental analysis with Na24 has been carried out in 1) 16 subjects without edema, 2) 13 patients with edema, and 3) 5 uremic patients.
    Three compartment parallel model was chosen as the most suitable model for the simulation of sodium metabolism in the human beings by trial and error. The first diffusion space of Na24, which was named the functional extracellular space averaged 17.9% of body weight in the non-edematous group. The total exchangeable sodium might be divided into 1) the functional extracefular pool, 2) the rapidly exchangeable pool, and 3) the slowly exchangeable pool.
    The functional extracellular space remained almost constant in edematous states, unless the renal function is markedly impaired. It is revealed that the increase of the slowly exchangeable pool in edematous state is most remarkable, and is suggested that formation of edema and ascites would serve as a reservoir to maintain the homeostasis of the most active part of the body.
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  • Masahiko OKUNI
    1971 Volume 12 Issue 5 Pages 436-441
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    The revised Jones diagnostic criteria, 1965, for rheumatic fever were applied to the 143 cases which had been diagnosed as rheumatic fever by modified Jones criteria, 1956.
    Sixty-five per cent of the total cases were diagnosed as rheumatic fever by new as well as old criteria. In 10 per cent of the total cases diagnosis of rheumatic fever was established after the application of the exception rules.
    Twenty-five per cent of the total cases, 36 cases, were excluded by new criteria, in which 21 cases had rheumatic carditis. These excluded cardiac cases were divided into 2 groups; typical carditis with low ASO level and carditis with only one minor manifestation and elevated ASO level.
    The revised Jones criteria are considered to be insatisfactory in the definite diagnosis for the following types of rheumatic carditis; rheumatic carditis with an insidious onset, carditis seen after 2 months or more from the onset of the disease, carditis of a recurrent attack and typical carditis with a low ASO level.
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  • Norio MATSUO, Masahiro OSHIMA, Masuyoshi NAGANUMA
    1971 Volume 12 Issue 5 Pages 442-449
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    A report of 107 infants with serious congenital heart disease during the neonatal period is presented. Determination of the basic defects was made at autopsy and/or cardiac catheterization and selective cineangiocardiogram.
    The most frequent congenital cardiac anomalies were coarctation of the aorta syndrome, ventricular septal defect, complete transposition of the great vessels, and hypoplastic left heart syndrome, similar to previous reports in the Occident. The incidence of endocardial cushion defect and total anomalous pulmonary venous return was higher than previous Occidental reports. The incidence of associated noncardiac anomalies with serious cardiac signs was 26.2%.
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  • Keisuke HIRAOKA, Hiroyuki SHIMADA, Ryozo OKADA, Masaya SUGIURA
    1971 Volume 12 Issue 5 Pages 450-459
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    A total of 272 serial autopsy cases of the aged was examined for the histological studies of the adrenal cortex and measurement of the cortical volume. Focal hyperplasia of the adrenal cortex was classified into 4 groups; nodular hyperplasia, adenomatous hyperplasia, combined hyperplasia and adenoma. The findings were compared to blood pressure level (normotension, labile hypertension and steady hypertension), atherosclerosis of the aorta, medium to small-sized arteries and arterioles of 5 visceral organs (adrenal, kidney, heart, liver and brain). The results obtained were as follows:
    1) Focal hyperplasia in adrenal cortex was found in only 23.6% in cases with normotension and in 98.7% in cases with hypertension. Labile hypertension was closely related to nodular hyperplasia (p<0.001) and steady hypertension to adenomatous hyperplasia (p<0.001).
    2) Adrenocortical volume was enlarged in group of labile hypertension (3.8cm.3), and in cases with nodular hyperplasia (4.1cm.3), if compared to control group (2.8cm.3).
    3) Arterial lesions progressed in parallel with the degree of blood pressure level and its duration, and also became severer as progressing from nodular to adenomatous hyperplasia. Arterial lesions were more closely related with focal hyperplasia than with the blood pressure.
    4) Aortic lesions also showed the similar relations with blood pressure and adrenal changes.
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  • Kazuhiko MURATA, Fujio TERASAWA, Saichi HOSODA, Masao IKEDA, Masuji SE ...
    1971 Volume 12 Issue 5 Pages 460-466
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    Macroscopic examinations were made on the aorta, the coronary and cerebral arteries of 132 autopsy cases with long follow-up of blood pressure and total serum cholesterol for more than 10 years.
    The most outstanding finding in the present study was a significant positive correlation between the average of annual systolic pressure and the severity of atherosclerotic lesions in the aorta, the coronary and cerebral arteries. On the other hand, the average of annual diastolic pressure was related only to the severity of cerebral atherosclerosis.
    Although a linear correlation was demonstrated between the average of total serum cholesterol and the severity of stenosing atherosclerosis of the coronary arteries, the total serum cholesterol value was found to be unrelated to the severity of the atherosclerotic lesions of the aorta and the cerebral arteries.
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  • Masatoshi FUJISHIMA
    1971 Volume 12 Issue 5 Pages 467-473
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    Cerebral perfusion pressure was reduced by graded constricting of both carotid arteries in the anesthetized dogs, of which vertebral arteries were ligated bilaterally.
    Cerebral blood flow and cerebral metabolic rate of oxygen remained unchanged until cerebral perfusion pressure was lowered to about 50mm.Hg, indicating that cerebral autoregulation was preserved normally in these animals. Despite a slight decrease in arterial lactate levels, there was a progressive increase in lactate with a concomitant decrease in pH of cisternal cerebrospinal fluid (CSF) even during the autoregulatory range of cerebral perfusion pressure, suggesting that increase in CSF lactate resulted primarily from increase in brain tissue lactate. Increased CSF lactate/pyruvate ratio and decreased cerebral cortical blood flow suggest that brain tissue tends to be hypoxic, although cerebral blood flow remained unchanged.
    It could be concluded that the mechanism of regulating cerebral blood flow constant in response to lowered perfusion pressure is a function of CSF lactic acidosis resulting from brain tissue hypoxia.
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  • Seizo YAMASHITA
    1971 Volume 12 Issue 5 Pages 474-485
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    To study the correlation between thiamine deficient cardiac lesions and pyruvic acid contents, blood and organ pyruvic acid contents in normal, thiamine deficient and control pair fed rats were determined.
    1) Pyruvic acid increased generally in thiamine deficient groups but did not in control pair fed groups.
    2) In cases in which thiamine deficient symptoms were lacking, there were hardly any pyruvic acid increase.
    3) Myocardial and blood pyruvic acid contents were markedly high and pyruvic acid ratio between heart muscle and blood was lowest in cardiac lesion groups, the severer the bradycardia and cardiac hyper-tropy the higher the myocardial and blood pyruvic acid contents, and myocardial pyruvic acid contents were especially high in ST elevation cases.
    4) In thiamine deficient last stage cases, variations of pyruvic acid contents considered as agonal phenomena were observed.
    5) The above results indicate that pyruvic acid accumulation in heart muscle and blood, especially in heart muscle, is the strong factor of thiamine deficient cardiac lesions.
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  • Juro IRIUCHIJIMA, Akiyoshi KUMAZAWA, Kenji KAWAKAMI
    1971 Volume 12 Issue 5 Pages 486-493
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    Based on the lumped parameter Windkessel theory, compliance of the aorta of anesthetized dogs was calculated in vivo. The formula used was C=(SV-PSTS/R)/(P2-P1), where C=aortic compliance, SV=stroke volume, PS=mean systolic pressure, TS=duration of ejection period, R=total peripheral resistance, P1=aortic pressure at the onset of ejection and P2=aortic pressure at the end of ejection. Mean C with SD from 12 dogs weighing about 10 Kg. was 0.18±0.07 ml./mm.Hg. Aortic compliance was markedly increased on intravenous administration of a long active nitrite, N-ethoxy-carbonyl-3-morpholinosydnonimine (SIN-10), at a dose of 1 mg./Kg. (+237±90%, n=7, significant at P<0.001, 15 min. after injection), suggesting that this substance dilated smooth muscle in the wall of the aorta. Cardiac output and aortic pressure were both diminished upon SIN-10 administration. Though aortic compliance tended to increase as aortic pressure decreased, the increase in aortic compliance was much smaller (+41.2±45.3%, n=7, not significant at P=0.05), when a comparable decrease in aortic pressure was induced by electrical stimulation of the carotid sinus nerve.
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  • Dong-Kyu CHUNG, Edward K. CHUNG
    1971 Volume 12 Issue 5 Pages 494-499
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    A unique case of heretofore undescribed 2:1 ventricular electrical alternans in the presence of artificial pacemaker-induced ventricular rhythm is presented. Three instances of 2:1 ventricular pseudo-electrical alternans due to ventricular fusion bigeminy in patients with permanent demand pacemakers are also discussed.
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  • Shin-ichiro OHKAWA, Keisuke HIRAOKA, Hiroyuki SHIMADA, Masaya SUGIURA
    1971 Volume 12 Issue 5 Pages 500-506
    Published: 1971
    Released on J-STAGE: December 09, 2008
    JOURNAL FREE ACCESS
    A case of patent ductus arteriosus in a 74-year-old female was presented, who was the oldest case reported in Japan. The ductus was funnelshaped, 15mm. in lenght, 9×6mm. in size at the aortic opening between calcified and atheromatous plaques and had a membranous substance at the pulmonary opening.
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