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Volume 13 (1972)
- Issue 6 Pages 471-
- Issue 5 Pages 379-
- Issue 4 Pages 281-
- Issue 3 Pages 187-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 13, Issue 3
Displaying 1-11 of 11 articles from this issue
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Masahito NAGASAKA, Hiroshi YOKOSUKA, Takeshi YAMANAKA, Tomohide SATO, ...1972 Volume 13 Issue 3 Pages 187-194
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSOn 79 ECG tracings obtained from 31 uremic patients, the influence of serum Ca, Na, and K concentrations on the QT duration in ECG was analyzed by multiple regression technique. It was found that Ca and K had negative and Na had a positive effect on QT duration, although only the effect of Ca was reaching the statistically significant level. Since serum electrolytes had correlations with each other, they were orthogonalized and tested for significance once again. Still Na and K did not reveal significant influences by this procedure. However, the effects of Na and K on QT duration were as the same direction and magnitude as reported in older literatures.
In the course of orthogonalization it was found that Ca and Na had negative influences on K. It seems that this fact presents a sound basis for the therapeutic use of Ca and Na salts in hyperpotassemia.View full abstractDownload PDF (478K) -
A. Yüksel BOZER, Gürler ILIÇIN, Ali APIKOGLU, Ayd&iac ...1972 Volume 13 Issue 3 Pages 195-200
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSSerum Na, K, Ca and P levels were determined in 23 cases under-going open heart surgery during preoperative, early and late postoperative periods. Serum Mg values were detected in the same manner, also during extracorporeal circulation. Serum K, Na, Cl and Ca levels decreased during postoperative period. No change in serum P was observed. Serum Mg values fell during early postoperative period in 13 cases containing no Mg in the circuit, but were close to normal in 10 cases where Mg was added into the priming volume in amount of 2mEq. per 1, 000 ml. Ringer's lactate. In both groups serum Mg values were low during cardiopulmonary bypass. It has been discussed that hemodilution, hyperaldosteronism, hyperparathyroidism and diuretics might be effective in hypomagnesemia in open heart surgery. Hypomagnesemia was thought to participate in the production of postoperative arrhythmias like hypopotassemia, and thromboembolic phenomenon. importance Hence, of addition of Mg into the circuit was emphasized.View full abstractDownload PDF (344K) -
Shigenori MOROOKA, Iwao ITO, Hisomu YAMAGUCHI, Tadanao TAKEDA, Yoshimi ...1972 Volume 13 Issue 3 Pages 201-213
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSFollow-up observations have been made on 64 cases of aortitis syndrome for an average period of 6.6 years (3 months to 15 years). Thirteen cases died during the observation period. The survival rate at the end of the 10th observation year was estimated to be 62%. Main causes of death were congestive heart failure and cerebrovascular accident. The prognosis depended mainly upon the grade of hypertension. The daily life of patients was more or less limited in 49% but improved slightly in the course. Symptoms and signs of active inflammatory process have been improved by steroid hormones. In some cases, long-term treatment with a small dose of steroid hormone was required for several years.View full abstractDownload PDF (622K) -
Kazuki KAWABE, John P. MERRILL, Donald E. OKEN1972 Volume 13 Issue 3 Pages 214-221
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSHypertension, produced in rats by unilateral nephrectomy and partial infarction of the remaining kidney, was transferred to recipient isogeneic rats so long as the kidney was transplanted within 12 days after infarction. After a week, the renin content of the transplanted infarcted kidneys was approximately one-third of that in control animals, indicating that the hypertension probably was not renin-related. Removal of the infarcted kidney and transplantation of an isogeneic normal kidney uniformly rendered previously hypertensive rats normotensive, while rats receiving a normal kidney without removal of the infarcted kidney remained hypertensive. Since the transplanted kidney is totally denervated and has a grossly reduced renin content, the hypertension of renal infarction is presumed to be the result of a humoral agent or agents other than renin. The low renin titer found by others in chemically or surgically denervated kidneys was found also in normal isografted and rejecting allografted kidneys, confirming the previously described contribution of the renal sympathetic nerve supply to renin production. The failure of infarcted kidneys to induce hypertension in isogeneic recipients when transplanted 2 weeks or more after infarction is unexplained.View full abstractDownload PDF (507K) -
Tan WATANABE, Fujio SHINTANI, Longtai FU, Junichi FUJII, Hiroshi WATAN ...1972 Volume 13 Issue 3 Pages 222-231
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-ST) in 12 to 20 left ventricular (LV) epicardial sites. The mappings were obtained 15min. after repetitive occlusions of a main branch of the left anterior descending coronary artery. In 5 dogs propranolol decreased E-ST from 4.0±0.8 during simple control occlusion to 1.5±0.3mV. (SEM) (p<0.01) and N-ST from 9.2±1.0 to 4.2±0.5 (p<0.01). At this time, LV myocardial contractility expressed by dP/dt/IIT decreased from 2, 320±280 to 1, 460±230 (p<0.01) along with significant reduction of cardiac output (CO). LV developed tension assessed from LV TTI/min. fell slightly and insignificantly. In contrast, in 5 dogs the infusion of isoproterenol increased E-ST from 1.5±0.2 to 3.1±0.7mV. and N-ST from 6.6±0.6 to 9.4±1.1 (both, p<0.01). The value of dP/dt/IIT increased from 1, 980±440 to 4, 610±920 (p<0.01) with concomitant increment in CO. LV TTI/min. elevated slightly and again insignificantly. It was concluded that, in beating in situ heart the severity and extent of acute myocardial ischemic injury can be altered by the changes in LV contractile state, even in the absence of changes in LV wall tension.View full abstractDownload PDF (486K) -
Akira KAMIYA, Tatsuo TOGAWA1972 Volume 13 Issue 3 Pages 232-240
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe relations of the left ventricular volumes of intact canine heart, such as stroke volume (SV), end-diastolic volume (EDV) and end-systolic volume (ESV), to the heart rates were studied. After atrio-ventricular block, varying ventricular pacing rates, the ventricular volumes were measured by means of thermal dilution using a thermistor with a very short time constant. The results showed that under left atrial pressure clamp, increases in pacing rates ranging from 50 to 160 beats/min. caused decreases in EDV in a considerable extent but no consistent and marked changes in ESV. Measurements of the left ventricular end-diastolic pressure (LVEDP) varying the pacing rates demonstrated that reductions in EDV at higher pacing rates were caused by lowering of LVEDP. From these results, some mathematical expressions on the control of SV were presented.View full abstractDownload PDF (368K) -
Yasumi UCHIDA, Hideo UEDA1972 Volume 13 Issue 3 Pages 241-249
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSUsing anesthetized dogs, the flow through the left ventricular wall has been continuously monitored by heated cross-thermocouples.
On occluding the anterior descending branch of the left coronary artery, an abrupt reduction in the flow through both the outer half and the inner half of the anterior wall occurred. In about 46sec., however, a gradual recovery of the flow was observed in these halves. This increased inflow into the ischemic outer half was eliminated, whereas the increased inflow into the ischemic inner half was little influenced, by ligation of the left circumflex branch and the right coronary artery.
It is considered that an immediate development of the intercoronary collateral circulation played a role in the recovery of the blood flow through the outer half, during which the blood inflow through the direct communications between the coronary arteries and the ventricular chamber contributed to the recovery of the flow through the inner half of the occluded zones.View full abstractDownload PDF (443K) -
Masayoshi YOKOYAMA, Michio NOGI, Kazuko YOKOYAMA, Shigeru SAKAKIBARA1972 Volume 13 Issue 3 Pages 250-257
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA lesion similar to the anomalous origin of the left coronary artery from the pulmonary artery was created in experimental dogs. When the pulmonary artery and the coronary artery were connected with a cannulating probe, 6 months after the ligation of the left circumflex artery, a marked blood flow was directed from the coronary side to the pulmonary side. During the 6 months, the peripheral coronary artery pressure rose to a level significantly higher than that of the pulmonary artery pressure; therefore, connecting the left circumflex coronary artery with the ascending aorta failed to induce a significant blood flow. Because of the approximately equal pressure levels in the aorta and the coronary artery, the establishment of a 2-coronary artery system using a vein bypass graft cannot supply a significant blood volume to the cardiac tissue through the new graft.View full abstractDownload PDF (484K) -
Tsunetaka MATOBA, Shoichi MINOTA, Kyozo KOKETSU1972 Volume 13 Issue 3 Pages 258-265
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSBullfrog's ventricular muscle fibers were able to generate the action potentials in the sodium-free hydrazine solution. The shape of these action potentials was quite different from that of the action potentials recorded in the Ringer's solution. In the sodium-free hydrazine solution, the absolute value of the resting membrane potential was smaller and the action potentials showed a slower maximum rate of rise, a markedly enhanced overshoot and a shorter duration of the plateau phase. Tetrodotoxin (TTX) or procaine added to the sodium-free hydrazine solution decreased the maximum rate of rise of the action potentials, whereas manganese suppressed the overshoot and the plateau phase without affecting the maximum rate of rise. These results indicated that the ionic mechanism underlying the production of the action potentials of bullfrog's heart muscles in the sodium-free hydrazine solution is essentially identical to that in the Ringer's solution. In other words, hydrazinium ion is able to perfectly substitute for sodium ion during the generation of the action potentials.View full abstractDownload PDF (382K) -
Richard J. KONES1972 Volume 13 Issue 3 Pages 266-271
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSDownload PDF (358K) -
Fablo MAGRINI, Cesare FIORENTINI, Alvise POLESE, Luisa GREGORINI, Maur ...1972 Volume 13 Issue 3 Pages 272-279
Published: 1972
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSDiagnosis of Ehlers-Danlos syndrome was made in a 37-year-old man on the basis of hyperextensibility of the fingers joints, hyperelasticity and fragility of the skin, molluscoid pseudotumor, calcified subcutaneous spheroids, microscopic alterations of the dermis, megacolon, intestinal bleeding and bilateral inguinal hernia.
A history of anginal pains, a loud ejection type systolic murmur over the aortic area and electro- and vectorcardiographic signs of unusually severe left ventricular hypertrophy simulated aortic valve stenosis. Cineangiograms of the left ventricle confirmed the existence of high degree concentric hypertrophy. Pressure, oxygen saturation, flow measurements, and cineangiography, however, excluded aortic stenosis and other hemo dynamic factors as causes of the hypertrophy. Finding of sudden narrowing of the aorta at the level of the arch reasonably accounted for the systolic murmur.
Cardiac anomaly is interpreted as dependent upon a primary myocardial disease, possibly related to the tissue disorders of the Ehlers-Danlos syndrome.View full abstractDownload PDF (1596K)
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