Japanese Heart Journal
Online ISSN : 1348-673X
Print ISSN : 0021-4868
ISSN-L : 0021-4868
18 巻, 5 号
選択された号の論文の14件中1~14を表示しています
  • Keizo FURUKAWA, Tohru MATSUURA, Naoto ENDO, Masaru TOHARA, Jun ASAYAMA ...
    1977 年 18 巻 5 号 p. 611-620
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    The left ventricular filling and wall movement were investigated in subjects with a third heart sound or ventricular gallop by echocardiography. Nine patients with ventricular gallop, who had left ventricular volume overload diseases, and 6 normal subjects with a third heart sound had higher normalized peak rate of increase of the left ventricular dimension (peak dD/dT/D) than 10 normal subjects without a third heart sound (p<0.01). The normalized lengthening rate in the rapid filling phase was also higher in patients with ventricular gallop than in normal subjects without a third heart sound (p<0.05). The time from the second heart sound to peak dD/dT/D and rapid filling time did not show statistically significant values between subjects with ventricular gallop or a third heart sound and those without a third heart sound.These results suggest that higher peak filling, larger filling volume in the rapid filling phase and more abrupt cessation of the outward movement of the left ventricular wall may be a cause of the production of ventricular gallop in patients with left ventricular volume overlaod and of the physiological third heart sound.
  • Akira FURUSE, Akira MIZUNO, Goki SHINDO, Takaji YAMAGUCHI, Masahiro SA ...
    1977 年 18 巻 5 号 p. 621-628
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    A method is described for quantifying pulmonary regurgitation. This method is based on a comparison of the right and left ventricular stroke volumes which are determined from biplane angiocardiograms. These techniques were applied to study 18 postoperative patients with tetralogy of Fallot. In patients with an outflow patch, regurgitant fraction was well correlated with regurgitant area. The RVEDV/LVEDV ratio was also correlated well with regurgitant fraction. Although majority of patients maintained normal RV ejection fraction, there were small number of pa-tients with large regurgitant fraction and decreased RV ejection fraction.
  • Akira FURUSE, Akira MIZUNO, Goki SHINDO, Takaji YAMAGUCHI, Masahiro SA ...
    1977 年 18 巻 5 号 p. 629-637
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    Hemodynamic and angiocardiographic studies were performed in postoperative patients with tetralogy of Fallot. Pressure gradient between the right ventricle and pulmonary artery was correlated with the narrowest area in the pulmonary arterial pathway. Regurgitant fraction was also correlated with regurgitant area which was determined by preoperative area of the pulmonic annulus and width of the outflow patch. Follow-up study of postoperative patients with tetralogy indicated that those with pressure gradient less than 20mmHg and regurgitant fraction less than 15% could be considered ideally corrected. A table was constructed for determining the most appropriate width of the outflow patch for the ideal correction.
  • Mitsuo MATSUDA, Nobuharu AKATSUKA, Tetsu YAMAGUCHI, Tadanori SAITO, Hi ...
    1977 年 18 巻 5 号 p. 638-651
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    Systolic time intervals (STIs) were measured in 57 patients with progressive muscular dystrophy (PMD) of the Duchenne type, and were correlated with the stages of physical disability. The total electromechanical systole (Q-A2), pre-ejection period (PEP), and left ventricular ejection time (LVET) were corrected for heart rate using the linear regression equations calculated from 91 normal subjects. Each systolic time interval index (STII), i.e. corrected STI, was analyzed.
    In 15 ambulatory patients (Group P-1), the STIls did not differ significantly from those in normal controls. In 37 patients who were unable to walk (Group P-2) and 5 patients who were confined to bed (Group P-3), there was a significant increase (p<0.001) in the PEP index (PEPI), a decrease (p<0.001) in the LVET index (LVETI), and an increase (p<0.001) in the PEP/LVET compared with those in controls. The PEPI (p<.001), LVETI (p<0.025), and PEP/LVET (p<0.001) in Group P-2 differed significantly from those in Group P-1. In Group P-3, the PEPI (p<0.005), LVET (p<0.001), and PEP/LVET (p<0.001) were significantly changed in comparison with those in Group P-2.
    Remarkable myocardial histopathologic changes suggestive of dystrophy were revealed in autopsies of 3 patients who had been in the severely disabled stage and had shown impaired STIs.
    It is suggested that cardiac function in patients with moderate to ad-vanced PMD of the Duchenne type is deteriorated in proportion to the disability stages, i.e. the severity of changes in the skeletal muscles.
  • Yoshio TERASAWA, Motonao TANAKA, Kiyoshi KONNO, Keiko NIITA, Makoto KA ...
    1977 年 18 巻 5 号 p. 652-663
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    In order to examine the production mechanism of the midsystolic click in cases of a midsystolic click and a late systolic murmur, the relationship between the click and the motion of the mitral apparatus was studied by means of ultrasono-cardiotomography and the simultaneous recording of phonocardiograms and ultrasono-cardiograms (UCGs).
    It was found that the systolic click occurred in exact coincidence with the time at which the hump of the echo of the unusual early systolic anterior motion (early SAM) took its backmost position.
    This coincidence was found when the click was shifted either by postural changes or inhalation of amyl nitrite.
    The present ultrasono-cardiotomographic study demonstrated that the echo source of the early SAM could be attributed to the protrusion into the left ventricular outflow tract of the slackened elongated chordae tendineae in systole. The anterior leaflet moved suddenly to the position of maximal prolapse when the slackened chordae tendineae were stretched taut in midsystole. In other words, the midsystolic click occurred when the anterior leaflet prolapsed and the tension exerted on the chordae tendineae was at its maximum.
  • Yoshihiro FUTAMURA
    1977 年 18 巻 5 号 p. 664-678
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    The purposes of this study about the catheter-manometer systems are two-fold. One is to assess the effects of temperature change and saline flushing on the frequency response of the catheter-manometer systems. The second is to show the method of obtaining the maximum performance from conventional catheter-manometer systems by using the equalizing network. The temperature change from 25° C to 37°C affected little the frequency response of them. However, the saline flushing affected them considerably but they were stabilized after they were flushed frequently with saline or after vibrating pressure was applied to them for 2 or 3 min. These results suggest that it is possible to prevent the change of the frequency response of the catheter-manometer systems when used clinically.
    Then, the equalizing network was made in order to equalize the frequency response of the catheter-manometer systems. By using this network, up to 1.3 times the undamped natural frequency, the amplitude characteristics of the catheter-manometer systems became almost flat within about 10% of error and the phase shift became directly proportional to the frequency within 10% or less of error. In experiments with dogs, both the left ventricular pressure and their first derivative wave forms from this network were highly similar to those from standard systems. Seventy-three left ventricular tracings obtained with 10 catheter-manometer systems whose natural frequencies ranged from 28.9 to 69Hz were compensated by using this network. The correlation coefficient of the peak LVP was 0.995 and that of max dp/dt was 0.991. In clinical use, the distortion of LVP tracings obtained with the catheter-manometer system was reduced by this network. The compensated waves were similar to those obtained with the catheter-tip manometer and had few motion artefacts.
  • Keiichi HASHIMOTO, Masaru HIROSE, Soichi FURUKAWA, Hirokazu HAYAKAWA, ...
    1977 年 18 巻 5 号 p. 679-689
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    The following parameters were studied before and after acute occlusion of the anterior descending branch of the left coronary artery in 17 dogs: bradykinin (BK) in the coronary sinus blood, heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular max dp/dt (LV max dp/dt), and an index of myocardial contractility (LV max dp/dt/IP).
    BK levels increased, reaching a maximum of 30±13ng/ml 2 min after coronary ligation, accompanied by a significant elevation of LVEDP, and lowering of the myocardial contractility index. HR and LV max dp/dt showed no significant changes. A positive correlation obtained between the level of BK and LVEDP, as well as a negative correlation be-tween the level of BK and of both LVSP and myocardial contractility in-dex. Pretreatment with aprotinine (Trasylol), an inhibitor of kinin forming enzyme, prevented the increase in both BK and LVEDP after coronary artery ligation and caused an elevation of myocardial contractility index. These results suggest that BK formed within ischemic myocardium exerts a negative inotropic action on the heart.
  • Implications on the Developmental Hypotheses of the Transposition of the Great Arteries
    Jami G. SHAKIBI, F. REYHANI, Bijan SIASSI, Iraj ARYANPUR, M. PAYDAR, A ...
    1977 年 18 巻 5 号 p. 690-695
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    A comparative morphometric study was performed on the aortomitral valve apparatus of the embryonic and adult chicken hearts. It was found that the thickness of the aortic and mitral valve cusps diminishes dramatically as the embryo matures, however the relative length of the aortic valve, mitral valve and subaortic conus remains constant.
    A comparison of the aortomitral valve apparatus in chicken and man revealed that the subaortic conus is not completely resorbed in the fowl, whereas this process is well documented in the mammalian hearts. The implications of this observation on "the differential conal growth hypothesis" of transposition of the great arteries are discussed.
  • Homologous and Heterologous Anti-Heart Antibodies and Analysis of the Heart Specific Antigens
    Shinji FUKUTA, Toru YAMAMOTO, Yoshio KIMURA, Setsuko IWAMOTO, Junichi ...
    1977 年 18 巻 5 号 p. 696-704
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    The present study has indicated the presence of 3 heart specific antigens, using homologous and heterologous antibodies produced in immunized rabbits. Two of these antigenic proteins exhibit restricted organ specificity for heart and the other one shares by heart and kidney. One of these 2 heart specific antigens reacts to both homologous and hetero-logous anti-heart sera absorbed with kidney, while the other reacts to only heterologous anti-heart sera. The former has an electrophoretic mobility corresponding to that of serum β-globulin, and is found to have a molecular weight of about 175, 000. The latter has the same electrophoretic mobility as that of α2-globulin and is found to have a molecular weight of about 50, 000.
  • Takashi KATAGIRI
    1977 年 18 巻 5 号 p. 705-710
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    1. Gel electrophoretic analysis of structural proteins extracted from myocardial tissues in the presence of sodium dodecylsulfate (SDS) is applicable to study the relative amount of structural proteins from less than 1Gm of heart tissue.
    2. The compositions of structural proteins of the right and left atria and ventricles of the normal canine heart were identical and similar to those of skeletal muscle.
    3. The compositions of structural proteins of the atrium and ventricle of the normal human heart were also identical.
  • Takashi KATAGIRI
    1977 年 18 巻 5 号 p. 711-721
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    1. Changes of structural proteins in experimental and human myocardial infarction were studied by the determination of myosin- and acto-myosin-ATPase activities and gel electrophoretic analysis in the presence of sodium dodecyl sulfate (SDS).
    2. In animal experiments using dogs, the relative amounts of myosin and α-actinin decreased at 24 to 48 hours after coronary ligation, became lowest at 72 hours, and remained at this level for 2 weeks and returned to almost normal value at 28 days.
    3. Myosin-and actomyosin-ATPase activities decreased rapidly during 24 to 48 hours after ligation with temporary increase in their activities in the initial stage of ischemia and followed the similar time course as that of the amounts of myosin and α-actinin.
    4. SDS gel electrophoretic analysis of structural proteins of infarcted tissues of the human hearts obtained from 5 cadavers showed also marked decrease of the contents of myosin and α-actinin with relative preservation of actin, tropomyosin and troponin-T.
  • Jun FUJII, Akira SEKI, Toshiyuki TANAKA
    1977 年 18 巻 5 号 p. 722-728
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    The development of collaterals to an ischemic kidney was studied in rabbits with two-kidney Goldblatt hypertension. Hypertension was produced by applying a silver clip of 0.9mm in internal diameter on the left renal artery with the right kidney intact. Peri-ureteric collaterals were found at autopsy in 27 (32.9%) of 82 animals that were killed 7 days (early stage) and in 30 (40.5%) of 74 animals that were killed in more than 70 days (late stage) after clipping. The average blood pressure was 123.8±2.6(SE)mmHg in animals with collaterals vs. 125.3±2.1mmHg in animals without them in the early stage, and 142.5±4.4mmHg in animals with collaterals vs. 122.6±3.3mmHg in animals without them in the late stage. These results indicate that the collaterals to an ischemic kidney develop independently of the rises in blood pressure during the first week and the presence of collaterals is associated with moderate to severe hypertension in the late stage.
  • Yoshiro NAKAMURA, Masando TAKAHASHI, Shigehiko HATTORI
    1977 年 18 巻 5 号 p. 729-735
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    Effect of increased left atrial pressure and a positive inotropic agent upon asynergic left ventricle which was produced by acute occlusion of LAD were examined in 8 open-chest dogs. Systolic bulging in ischemic area was qualified by ESL/EDL in percentage. Left atrial pressure was controlled by the reservoir connected to left atrial appendage with a large bore tubing. Cardiac output and aortic pressure were decreased following coronary occlusion without change in isometric developed tension in nonischemic area of left ventricle. Increase of left atrial pressure from 5mmHg to 14mmHg produced rise in stroke volume to 191% and rise in aortic pressure to 156% in asynergic left ventricle respectively. These increases were not accompanied by change in ESL/EDL.
    Therefore, extracardiac factors were assumed to explain the prominent increase in left ventricular stroke work by elevation of left atrial pressure in asynergic left ventricle. Isoproterenol enhanced total cardiac performance by increasing the function of nonischemic area without deterious effect on the ischemic area.
  • Eiichi KIMURA, Keiji TANAKA, Kyoichi MIZUNO, Yuichiro HONDA, Hidehiro ...
    1977 年 18 巻 5 号 p. 736-742
    発行日: 1977年
    公開日: 2008/12/09
    ジャーナル フリー
    It is reported that nifedipine, a newly developed antianginal agent, was dramatically effective to suppress the repeatedly occurring ventricular fibrillation in 2 cases of variant form of angina pectoris.
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