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Etsu HASHIDA, Takenobu TASAKI
1984 Volume 25 Issue 5 Pages
669-687
Published: 1984
Released on J-STAGE: December 09, 2008
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Using sinus arrhythmia as a control, we elucidated the random nature of RR intervals during atrial fibrillation in man and determined the function of the atrioventricular (AV) node from the variability of RR intervals. The major difference between the characteristics of sinus arrhythmia and those of atrial fibrillation is the presence of a significant correlation between successive intervals in the former. Since the pattern of distribution of RR intervals in atrial fibrillation is unimodal and skewed to the right and so can be fitted to an Erlang distribution, atrial inputs can be considered to be summated to a certain threshold for ventricular activation in the N region of the AV node, the number of cumulative atrial inputs corresponding to this threshold being the phase of this Erlang distribution. The function of the AV node during atrial fibrillation is to transform an exponentially distributed input into an Erlang-distributed output. Loss of inputs occurs between the atria and the N region and the greater the loss of inputs the slower the ventricular response. However, the greatest loss occurs in the N region for summation of atrial inputs required to elicit ventricular activation.
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Kozue IKEDA, Isao KUBOTA, Yoshihiko WATANABE, Keiji TAKAHASHI, Shoji Y ...
1984 Volume 25 Issue 5 Pages
689-700
Published: 1984
Released on J-STAGE: December 09, 2008
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In order to investigate the electrocardiographic changes in patients with chronic pulmonary emphysema (CPE), 87 unipolar electrocardiograms were simultaneously recorded in 20 normal subjects and 22 patients with CPE. The voltages and the sites of Max. R (most positive R) and Max. S (most negative S) in these 87 leads were investigated. Further, the voltages and the sites of the maximum and the minimum on isopotential maps during the QRS period were examined.
In patients with CPE, the sites of Max. R, Max. S, the maximum and the minimum were all positioned lower than in normal subjects. However, the voltages of Max. R and Max. S in CPE were not significantly different from those in normal subjects. It was considered that the most prominent change in the body surface maps in CPE was the downward shift of potential distribution. This change seems to be due mainly to the downward displacement of the diaphragm and the heart resulting from the overinflation of the lung.
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Yutaka NAKAYA, Masaki SUMI, Kyoko SAITO, Kazuya FUJINO, Masaru MURAKAM ...
1984 Volume 25 Issue 5 Pages
701-711
Published: 1984
Released on J-STAGE: December 09, 2008
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Vector arrow maps and isomagnetic maps were constructed with a second derivative SQUID (superconducting quantum interference device) gradiometer in normal subjects and in various pathological conditions to study the inverse problem of electromotive forces and to determine whether the magnetocardiogram (MCG) provides different information from the electrocardiogram (ECG). The current sources deduced from these maps corresponded well with the activation sequences in normal and pathologic conditions reported previously. As second derivative gradiometer measures of the spatial differentiation of the magnetic field, these maps reflected well the current sources close to the anterior chest, namely the right ventricle and right atrium. In addition, it was possible to better localize the sources with this detector than with the ECG or first order gradiometer, suggesting that the isomagnetic and vector arrow maps obtained with the second derivative gradiometer were useful for solving the inverse problem. The MCG also provided different information from the ECG, so use of the MCG in addition to the ECG might be helpful in determining current sources more accurately.
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Masuaki FUJIYAMA, Yoh-ichiro FURUTA, Akihiro TANABE, Jun MATSUMURA, Ju ...
1984 Volume 25 Issue 5 Pages
713-723
Published: 1984
Released on J-STAGE: December 09, 2008
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Different types of heart rate (HR)-cardiac output (COP) relationships were compared with their clinical features and hemodynamic findings in 56 patients with brady-arrhythmias (BA). HR was raised by increments of 10 beats per minute (bpm) at 3min intervals, from spontaneous rates to 100 or 110bpm by right ventricular pacing. Cardiac and left ventricular (LV) functions at BA were evaluated by intra-cardiac pressures, COP measured by the thermo-dilution method and echocardiographic data. HR-COP relationships were divided into the following 3 types: 24 patients of flat (F), 18 of peaked (P) and 14 of increased (I) type.
There were more patients with complete atrio-ventricular block, particularly His-ventricular block, and cardiomyopathic patients with the "P" type than with the other types. Cardiac index, stroke index, stroke work index and systemic vascular resistance were greater in "I", but these differences were not significant. LV peak systolic pressure (LVSP) and end-diastolic pressure (EDP) in "I" increased more than in "F". EDP, LV end-diastolic and end-systolic dimension (ESD) in "P" increased more than in "F". Systolic excursion and LVSP/ESD ratio in "I" increased more than in the other types. Heart failure prior to implantation of pacemaker (PM) and post-PM occurred more frequently in "P". "F" and "I" patients showed comparatively good clinical courses after PM.
Thus, cardiac and LV function during BA are maintained in "F" and are impaired in "P", as reported previously. On the other hand, cardiac functions are maintained in "I" as they are in "F", mainly due to contributions of the Frank-Starling mechanism and partly due to maintenance or slight augmentation of contractility.
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Kouji IMATAKA, Akira SEKI, Nobuo TAKAHASHI, Jun FUJII
1984 Volume 25 Issue 5 Pages
725-731
Published: 1984
Released on J-STAGE: December 09, 2008
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Vascular murmurs were routinely sought over the carotid arteries in 1, 777 outpatients of 40 years of age or older who attended the cardiovascular clinic of our institute, and carotid bruits were heard in 82 patients (4.6%). The prevalence of carotid bruits increased with age from 5/467 (1.1%) in patients aged 40 to 49 years to 26/150 (17.3%) in those aged 70 to 79 years. Calcification of the carotid arteries was examined by posteroanterior films of the cervical spine in 447 patients 60 years of age or older and carotid calcification was found in 20 (42.6%) of 47 patients with carotid bruits and in 50 (12.5%) of 400 patients without them. The incidence of carotid calcification in the former group was 3.4 times that in the latter (p<0.01), although the incidences of hypertension and glucose intolerance were not related to the presence or absence of carotid bruits. A history of cerebral bleeding or infarction was found in 19 (23.2%) of 82 patients with carotid bruits, as compared with 64 (3.8%) of 1, 695 patients without them (p<0.01). However, the location of the cerebrovascular lesions did not necessarily correlate with the laterality of the carotid bruits. These results indicate that patients with carotid bruits show an increased risk of stroke and that these bruits are a general and non-focal sign of severe atherosclerotic cerebrovascular disease.
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Takashi KATAGIRI, Youichi KOBAYASHI, Youichi TAKEYAMA, Hirokazu NIITAN ...
1984 Volume 25 Issue 5 Pages
733-743
Published: 1984
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1. An analytical procedure for the quantitative determination of the structural proteins from a biopsied human cardiac muscle weighing approximately 1mg was described to be applicable in clinical studies in 20 patients with various heart diseases. The principle of the method is glycerinization of heart muscle and analysis by SDS gel electrophoresis.
2. In 6 control heart muscles obtained from patients having almost normal hearts, the pattern of the structural proteins was similar to that of the normal canine heart. Myosin heavy chainactin ratio ranged 1.26±0.44.
3. In 5 cases with secondary cardiac hypertrophy, the pattern of the structural proteins was the same as that of the control heart.
4. In 4 cases with hypertrophic cardiomyopathy, an increase in myosin heavy chain was observed in 2 cases, while myosin heavy chain and α-actinin decreased in another 2 cases. Hypertrophy and severe disarray of myofibrils were noted in the former, and atrophy and degradation were done in the latter in electron microscopy. In 5 cases with dilated cardiomyopathies, the relative contents of myosin heavy chain and α-actinin was reduced in all cases together with atrophy and degradation of myofibrils.
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Vincent H. II GATTONE, Michael SHATTUCK, Friedrich C. LUFT, J. Marc OV ...
1984 Volume 25 Issue 5 Pages
745-753
Published: 1984
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To study the role the renal nerves may play in the hypertension of the SHR, we conducted a morphometric study of the afferent arteriole of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) which were subjected to renal denervation (or sham-operation). Methacrylate casts were made of the renal vasculature after perfusion fixation with glutaraldehyde. These vascular casts were then examined and measurements made with the scanning electron microscope (SEM). Afferent arterioles of the denervated SHR were dilated in comparison to the sham-operated SHR, but there was no difference between the afferent arteriolar diameters of the 2 groups of WKYs. However, the afferent arteriolar diameters of the SHR (either group) were smaller than those of the WKY. Renal denervation caused a reduction in systolic blood pressure compared to sham-operated in both strains of rat. We concluded that the dilation changes of afferent arterioles of denervated SHRs may be related to renal autoregulation resulting from the decreased blood pressure. However, the effect of the loss of sympathetic innervation of the arterioles cannot be ruled out.
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Miyoharu KOBAYASHI, Shigetoshi CHIBA
1984 Volume 25 Issue 5 Pages
755-763
Published: 1984
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Dopamine, administered at a constant infusion rate of 1-2μg/min into the cannulated sinus node artery of the isolated dog atrium, decreased sinus cycle length (SCL) from 630±19 to 501±22msec (mean±SEM, 38 trials in 12 atria). However, on sinoatrial conduction time (SACT) estimated by a constant atrial pacing method, dopamine produced 2 types of response (shortening and lengthening) with sinus tachycardia. In 24 trials in 11 atria, the drug decreased SACT from 86±8 to 56±4msec, and in 14 trials in 6 atria it increased SACT from 67±7 to 101±9msec. In general, the effects of dopamine on SACT were dependent on the control levels of SCL: dopamine caused a reduction of SACT at small levels of SCL and a prolongation at large levels. At a control sinus rate of 120 beats/min, dopamine usually shortened SACT. Dopamineinduced shortening of SACT was blocked by a beta-adrenoceptor blocker, propranolol, and an uptake blocker, imipramine, but not by a dopaminergic inhibitor, sulpiride. Furthermore, dopamineinduced lengthening of SACT tended to be suppressed by propranolol, but not by sulpiride. It is concluded that the dopamine-induced changes in SACT are mediated via beta-adrenergic mechanism and partially due to a tyramine-like action.
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Kazuto SAITO, Hideyo OHKURA, Tomoyoshi KASHIMA, Hiromitsu TANAKA
1984 Volume 25 Issue 5 Pages
765-772
Published: 1984
Released on J-STAGE: December 09, 2008
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We estimated the effect of digoxin on the myocardial potassium content and the action potentials of the left ventricular papillary muscles in dystrophic mice (C57BL/6JCL dy•dy). All of 10 dystrophic mice died following ip injection of digoxin at a dose of one quarter of the iv LD50 for normal mice. The myocardial digoxin concentration and the myocardial potassium content in dystrophic mice were similar to those in normal mice before and 60min after the ip injection of digoxin.
The action potential durations (APD) in dystrophic mice were significantly longer than those in normal mice. Perfusion of digoxin (2μg/ml) for 30min reduced the APD significantly and induced arrhythmias in dystrophic mice, but it did not bring about any significant change in normal mice.
These data suggest that dystrophic mice have increased sensitivity to digitalis. This hypersensitivity to digitalis is not due to increased myocardial digoxin uptake or decreased myocardial potassium content.
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Quantitation of the Safety Factor for Electrical Defibrillation
M.J. NIEBAUER, C.F. BABBS, L.A. GEDDES, J.E. CARTER, J.D. BOURLAND
1984 Volume 25 Issue 5 Pages
773-781
Published: 1984
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The overdose shock strengths required to depress ventricular contraction were determined for damped sinusoidal current in 7 metabolically supported, isolated contracting canine hearts. Each heart was suspended in an isoresistive and isotonic solution-through which the defibrillating shocks were delivered. Defibrillation thresholds were determined with standard damped sine wave shocks of 4.4-5.5msec duration. Then overdose shocks were delivered and the depressant effect on systolic left ventricular pressure was measured for shocks of 3-12 times threshold current. The minimum (threshold) current and energy densities required to defibrillate were 59.5±4.6mA/cm
2 (average) and 3.12±0.2mJ/cm
3. Increasing the shock strength above threshold produced a concomitant reduction of postshock left ventricular systolic pressure. The current and energy densities required to produce 50% depression (TD50) of left ventricular systolic pressure were 5.0 and 24.1 times the threshold current and energy densities respectively, indicating a wide safety margin using this criterion.
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Yoshiro NAKAMURA, Masayoshi NAGATA, Hidezo MORI, Kenji SAKURAI, Masand ...
1984 Volume 25 Issue 5 Pages
783-792
Published: 1984
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We investigated differences between ischemic and anoxic myocardium with respect to early mechanical and metabolic changes. Ischemia and anoxia were induced in the area perfused by the distal left anterior descending artery in 32 mongrel dogs. Since both the ischemia and the anoxia in this preparation resulted in very little change in global cardiac hemodynamics, indirect mechanical and metabolic effects on the involved myocardium were minimal. However, regional anoxia caused a later development of a myocardial systolic bulge than did regional ischemia (44.8±13.6vs 26.8±9.9sec). Myocardial ATP content was reduced to the same level 5min after the onset of ischemia and anoxia. Anoxia with high K
+ did not result in an earlier myocardial systolic bulge time, but myocardial ATP was maintained at a higher level than during ischemia. Anoxia with low pH also did not affect the time for development of a myocardial systolic bulge.
We concluded that neither acidosis nor hyperpotassemia are more causally related to the earlier development of a myocardial systolic bulge during regional ischemia than during regional anoxia. Also the absolute value of myocardial ATP content is unlikely to be causally related to the determination of myocardial contraction, as reflected by the development of a myocardial systolic bulge.
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Shigetoshi CHIBA, Miyoharu KOBAYASHI, Masahiro SHIMOTORI, Yasuyuki FUR ...
1984 Volume 25 Issue 5 Pages
793-803
Published: 1984
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When dilazep was administered intravenously to the anesthetized donor dog, mean systemic blood pressure was dose dependently decreased. At a dose of 0.1mg/Kg i.v., the mean blood pressure was not changed but a slight decrease in heart rate was usually observed in the donor dog. At the same time, a slight but significant decrease in atrial rate and developed tension of the isolated atrium was induced. Within a dose range of 0.3 to 1mg/Kg i.v., dilazep caused a dose related decrease in mean blood pressure, bradycardia in the donor dog, and negative chronotropic, dromotropic and inotropic effects in the isolated atrium. At larger doses of 3 and 10mg/Kg i.v., dilazep caused marked hypotension, frequently with severe sinus bradycardia or sinus arrest, especially in isolated atria.
When dilazep was infused intraarterially at a rate of 0.2-1μg/min into the cannulated sinus node artery of the isolated atrium, negative chrono- and inotropic effects were dose dependently induced. With respect to dromotropism, SA conduction time (SACT) was prolonged at infusion rates of 0.2 and 0.4μg/min. But at 1μg, dilazep caused an increase or decrease of SACT, indicating a shift of the SA nodal pacemaker.
It is concluded that dilazep has direct negative chrono-, dromo-and inotropic properties on the heart at doses which produced no significant hypotension.
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Mikiko FUNAKOSHI, Mitsuhide IMAMURA, Jun SASAKI, Masanori FUJINO, Tomo ...
1984 Volume 25 Issue 5 Pages
805-809
Published: 1984
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The progression of hypertrophic cardiomyopathy (HCM) to dilated cardiomyopathy (DCM) has been rarely reported. We report a patient with HCM who had been followed for 17 years and in whom DCM became evident.
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Analysis by In Vivo Voltammetry
Toshiharu Nagatsu, Masato Ikeda, Yoko Hirata, Keisuke Fujita, Hisahide ...
1984 Volume 25 Issue 5 Pages
820-822
Published: 1984
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The abnormality in catecholamine metabolism in the brain of SHR has been examined by use of in vivo voltammetry technique. In vivo release of dopamine and serotonin in the striatum under acute stress was more prominent in SHR at 4 weeks of age than in normotensive Wistar-Kyoto rats (WKY). Acute activation after stress of in vitro tyrosine hydroxylase activity was observed only in SHR, but tryptophan hydroxylase activity did not change significantly. It is concluded that central monoaminergic neurons are more susceptible to stress in SHR than those in WKY.
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Yukio Yamori, Takehiro Igawa, Toshimi Kanbe, Motoki Tagami, Masahiro K ...
1984 Volume 25 Issue 5 Pages
823-826
Published: 1984
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Major cellular abnormalities in the cardiovascular system of SHR detected up to the present "in vitro" under tissue culture condition were accelerated proliferation and deviated ionic transport of vascular smooth muscle cells (SMC). The experimental modification of these abnormalities 'in vitro' and 'in vivo' indicated that neural innervation and/or catecholamines as well as sodium and nutritional conditions might substantially affect the basic process of hypertension-induced vascular changes, hypertrophy and/or hyperplasia of medial SMC which further raised the peripheral vascular resistance in hypertension.
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Shoichi IMAI, Yoshito NAKAGAWA, Wan-Pao CHIN, Hajime NAKAHARA, Mikio N ...
1984 Volume 25 Issue 5 Pages
827-829
Published: 1984
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Effects of β-blockers on the peripheral sympatheic adrenergic nervous system were studied in atropinized pithed rats under curarized condition using the rise of the diastolic blood pressure produced by stimulation of the spinal nerves as a measure. All the three β
1-blockers used (practolol, atenolol and metoprolol) and oxprenolol produced an inhibition of the pressure rise, without producing a significant inhibition of the pressor response to close-arterial injection of noradrenaline. Propranolol failed to produce any inhibition. However, the pressor response to intraarterial noradrenaline was significantly potentiated by this compound.
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Comparison of Drug Response
Akio Ebihara
1984 Volume 25 Issue 5 Pages
830-832
Published: 1984
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Masaru Minami, Hiroko Togashi, Machiko Sano, Hideya Saito, Nishio Naka ...
1984 Volume 25 Issue 5 Pages
833-835
Published: 1984
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Previous study(1) has indicated that behavioral changes occur at the onset of cerebral accidents in stroke-prone spontaneously hypertensive rats (SHRSP). In the SHRSP stroke cases (SHRSP-stroke) in this study, the plasma norepinephrine concentration and blood pressure levels were higher than those in Wistar Kyoto rats (WKY) and stroke free SHRSP (SHRSP-control). These findings suggest that the increase in plasma norepinephrine level is at least in part associated with the blood pressure rise and behavioral changes in the SHRSP-stroke cases.
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Second Report
Tsuneyuki Suzuki, Masateru Minota
1984 Volume 25 Issue 5 Pages
836-838
Published: 1984
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1) Specific arterial runways such as right angular and recurrent branchings, sharp returnings, loopings, convolutions and long runways are a local factor in the incidence of hypertensive vascular changes in SHRSP. 2) The serial recurrence of the above factors in various combination in the arterial runways accelerates the incidence of vascular changes; e.g., in the kidneys, the testes and the adrenals. 3) In arterial runways which form arcades, vascular changes were found in the convexity of those terminal arcades which were composed of ar-teries of over 40μ in radius; e.g., in the mesentery and the uterus. 4) The lack of specific branchings in the shorter runways of the ovarian arteries results in a lower vascular change incidence rate in those organs.
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Difference from adrenal regeneration hypertension
Masanao Hirai, Yoshiko Masubuchi, Toshio Kumai, Taiichiro Ohno
1984 Volume 25 Issue 5 Pages
839-841
Published: 1984
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Male spontaneously hypertensive rat (SHR) originated from Kyoto-Wistar (WKY) were divided into 4 groups ; intact, castration (cast) performed at 4 weeks old (W) and adrenal enucleation (enucl) at 10W, cast at 4W and enucl at 22W, and enucl at 10W and cast at 22W. This would indicate 1) enucl-adrenal in the presence or absence of gonad increases significantly blood, pressure (BP) in both SHR and WKY, 2) gonadectomy significantly retards BP in both enuci-adrenal bearing and intact SHR, 3) gonadectomy did not alter the BP in WKY. These indicates that gonadal hormone(s) play of important role in the etiology of essential hypertension.
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Souichiro Sekiya, Takeshi Tsutsumi, Hirofumi Osada, Kenichi Harumi, To ...
1984 Volume 25 Issue 5 Pages
842
Published: 1984
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Sadayuki Sato, Tomoe Miyazawa
1984 Volume 25 Issue 5 Pages
843
Published: 1984
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Chie Kitagawa, Atsushi Chiba, Shiko Chichibu, Hiroyuki Ito, Kozo Okamo ...
1984 Volume 25 Issue 5 Pages
844
Published: 1984
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Koji Watanabe, Toshikazu Nishio, Chuzo Mori, Masahiro Kihara, Masayuki ...
1984 Volume 25 Issue 5 Pages
845
Published: 1984
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Hikaru Nishimura, Akinori Nishioka, Kikuko Imamura, Shinichiro Kubo, K ...
1984 Volume 25 Issue 5 Pages
846
Published: 1984
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Iwao Uchiyama, Eiji Yokoyama
1984 Volume 25 Issue 5 Pages
847
Published: 1984
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Masahiro Kihara, Yasuo Nara, Masayuki Mano, Keigo Fujiwara, Ryoichi Ho ...
1984 Volume 25 Issue 5 Pages
848
Published: 1984
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Relative left ventricle weight was significantly increased irrespective of blood pressure in normotensive Wistar-Kyoto rats given 1% NaCl in drinking water for two months. The present result first suggested that chronic excess salt intake might be one of possible factors inducing cardiac hypertrophy.
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Morphometric Assessment
Kikuko Imamura, Shoji Yamamoto, Yasushi Nakayama, Hikaru Nishimura, Ak ...
1984 Volume 25 Issue 5 Pages
849
Published: 1984
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Hiroyuki Ito, Yoshio Ohta
1984 Volume 25 Issue 5 Pages
850
Published: 1984
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Histochemical Determination of Smooth Muscle Cell
C Arai, Y Fukunaga, N Abe, K Takeuchi, M Saito, M Hasegawa, Y Takayama ...
1984 Volume 25 Issue 5 Pages
851
Published: 1984
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Histochemical Determination of Glycoprotein
K Takeuchi, Y Fukunaga, N Abe, M Saito, C Arai, M Hasegawa, Y Takayama ...
1984 Volume 25 Issue 5 Pages
852
Published: 1984
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Takao Kubo, Yoshio Goshima, Hiroshi Ueda, Yoshimi Misu
1984 Volume 25 Issue 5 Pages
853
Published: 1984
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M. Ohtsuji, M. Nomura
1984 Volume 25 Issue 5 Pages
854
Published: 1984
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We determined catecholamine (CA) content in brain of spontaneously hypertensive rat (SHR) and observed a decrease of noradrenarine (NA) content in the brain stem as previous report. Then we used Glutaraldehyde-formaldehyde fluorescence method for histochemical study. Fluorescence of ventral Al and dorsal A2 cell bodies in medulla oblongata was decreased. NA accumulation in caudal nervous ending of nucleus tractus solitarius (NTS) was reduced in SHR of pre-hypertensive stage aged 4 weeks. There were no changes in other regions, thalamus, hypothalamus, substantia nigra, locus ceruleus and periventricular nucleus.
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Katsuji Oguchi, Mayumi Tonooka, Hajime Yasuhara, Koji Sakamoto
1984 Volume 25 Issue 5 Pages
855
Published: 1984
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Takashi Sasaki, Nagao Kajiwara, Kazuaki Kuroda, Katsuichiro Sakai, Har ...
1984 Volume 25 Issue 5 Pages
856
Published: 1984
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Shizuo Yamada, Tsuyoshi Ishima, Machiko Hayashi, Takako Tomita, Eiichi ...
1984 Volume 25 Issue 5 Pages
857
Published: 1984
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Juro Iriuchijima
1984 Volume 25 Issue 5 Pages
858
Published: 1984
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Kazuo Nakamura, Akira Katoh, Keiji Nakamura
1984 Volume 25 Issue 5 Pages
859
Published: 1984
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Hirofumi Hayashi, Yoshiko Kobayashi, Akira Murakami, Jun Hashida, Tosh ...
1984 Volume 25 Issue 5 Pages
860
Published: 1984
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Masahiko NOMURA, Masataka OHTSUJI
1984 Volume 25 Issue 5 Pages
861
Published: 1984
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Takuya Matsuo, Takahide Kihara, Takashi Tanimura
1984 Volume 25 Issue 5 Pages
862
Published: 1984
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Kazushi Tsuda, Yoshio Kusuyama, Takuzo Hano, Masato Kuchii, Ichiro Nis ...
1984 Volume 25 Issue 5 Pages
863
Published: 1984
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Shunichi Maemura, Masami Niwa, Masayori Ozaki
1984 Volume 25 Issue 5 Pages
864
Published: 1984
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Tsukasa Takatsu, Tatsuo Shiigai, Jaw-Hwa Lin, Taichi Nakanishi, Yasuhi ...
1984 Volume 25 Issue 5 Pages
865
Published: 1984
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Yoshinari Nakamura, Kazuya Fukuda, Akira Baba, Takuzo Hano, Masato Kuc ...
1984 Volume 25 Issue 5 Pages
866
Published: 1984
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Noriko Murakami, Atsuko Niwa, Hideaki Higasaino, Aritomo Suzuki
1984 Volume 25 Issue 5 Pages
867
Published: 1984
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Atsuko Niwa, Noriko Murakami, Takashi Miyazato, Aritomo Suzuki
1984 Volume 25 Issue 5 Pages
868
Published: 1984
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M Kondo, T Ohmori, D Shimizu, M Terada, N Arita, I Ikeuchi, R Tabei
1984 Volume 25 Issue 5 Pages
869
Published: 1984
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For the purpose of comparing the number of enterochromaffin cell (EC cell) between the prehypertensive stage of SHR and normotensive WKY, the EC cell of the intestine was examined under the light and electron microscopy. The number of argyrophil cells of SHR were higher than that of WKY at each age of 3, 10, 30 days old. Moreover, the number of endocrine cell and the percentage of EC cells amang endocrine cells of the intestine increased gradually after birth in SHR.
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Hideo Ueda, Yoshio Suganuma, Teruji Koga, Naohiro Saito, Masaki Nakamu ...
1984 Volume 25 Issue 5 Pages
870
Published: 1984
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The salt loading on SHRSP aggravates the change of the arteriol and glomerulus in the kidney and enhances the blood pressure level. However, Beta-blocker (Nipradilol and Propranolol) alleviates the change of arteriol and glomerulus of kidney and the elevation of blood pressure in salt loaded SHRSP.
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Koichiro Kishi, Koichiro Kawashima, Hirofumi Sokabe
1984 Volume 25 Issue 5 Pages
871
Published: 1984
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