巻号一覧
3 巻, 1 号
選択された号の論文の9件中1～9を表示しています
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Victor A. McKUSICK1962 年 3 巻 1 号 p. 1-3
発行日: 1962年
公開日: 2008/12/09
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Mototaka MURAKAMI, Riyoyu TAKEDA, Susumu MIYABO, Shinpei MORIMOTO, Kat ...1962 年 3 巻 1 号 p. 5-12
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリー(1) The excretion of aldosterone in the patients with essential hypertension was compared with that of normotensive patients in various experimental conditions with simultaneous measurement of urinary electrolytes.
(2) Under basal condition sodium excretion was found to decrease with the elevation of blood pressure. Some of the hypertensive patients had a slightly increased excretion of aldosterone when compared with normotensive patients, but the urinary level of aldosterone had no correlation with respective sodium output in urine. No difference in potassium excretion was observed between the both groups.
(3) During the restriction of sodium intake of 25mEq. per day, hypertensive patients had enhanced sodium conservation capacity with more pronounced increase of aldosterone excretion.
(4) Following an infusion of 500ml. of 4 per cent saline solution, hypertensive patients responded with a marked water and sodium diuresis than did normotensive patients.
(5) NaCl-loading and mineralocorticoid administration in hypertensive patients did not cause so significant suppression of aldosterone excretion as normotensive patients.
(6) From the above results it can be concluded that there is some difference in the adaptive response of aldosterone excretion between normotensive and hypertensive patients.抄録全体を表示PDF形式でダウンロード (417K) -
Ryozo OKADA, Satoru MURAO, Mamoru SAITO, Hideo UEDA1962 年 3 巻 1 号 p. 13-23
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリー(1) A new graphic method for morphological evaluation of narrowing of the coronary arteries was presented and was designated as coronary profile method. Microscopically measured external diameters of the arteries were plotted along the horizontal axis in logarithmic scale against wall/diameter ratios plotted along the vertical axis in arithmetic scale. Arteries in various sizes totaling 75 to 100 were plotted from the larger ones to the smaller ones in each case. The intima/wall ratios were also plotted by the same procedure.
(2) The profile can show a longitudinal and lateral view of the coronary arterial system and is especially useful in the examination of the changes of small arteries in the myocardium.
(3) The coronary profile of 10 cases with hypertension showed a peak of the medial reaction in the arteries of about 100μ in diameter. The medial reaction showed a close relationship with the grade of hypertension existed.
(4) The coronary profile of 6 cases with severe coronary atherosclerosis showed a different pattern. Three cases showed luminal narrowing only in the larger arteries and 3 others showed narrowing both in the larger arteries and the smaller arteries of about 100μ in diameter.
(5) Some other patterns of the coronary profile in various diseases were presented.抄録全体を表示PDF形式でダウンロード (1953K) -
Hideo UEDA, Masahiro IIO, Atsuo NAKANISHI, Tadashi KOIDE1962 年 3 巻 1 号 p. 24-33
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリーElectronic digital computer was applied on the analysis of radioisotope dilution curve, and 6 parameters including exponent k, integrated area under the dilution curve (S), cardiac output, mean circulation time, central blood volume and pulmonary blood volume (Newman) were calculated automatically at high speed.
Using this method, detailed analysis was performed in 14 cases. To obtain well correlated values with the conventional ones, 3 different procedures of computer program were examined and relatively good results were obtained by procedure 3.
Advantages of this method, high speed of the automatical calculation and relatively good accuracy, were discussed.抄録全体を表示PDF形式でダウンロード (471K) -
Chandler McC. BROOKS, Manual K. ANG, Rudolf Th. van DAM1962 年 3 巻 1 号 p. 34-45
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリー(1) Hypoxia resulted in an initial (10 to 24%) decrease in diastolic threshold followed, after a period of one-half hour or more, by a progressive elevation of threshold. Reversal to a normal level of excitability occurred on readmission of oxygen.
The drive-response (D-R) interval initially shortened and then became prolonged in hypoxia but these effects were less reversable.
Refractoriness was only slightly prolonged by hypoxia.
(2) Respiratory acidosis prolonged the D-R interval and increased diastolic threshold initially. Despite continuation of CO2 excess these effects tended to diminish as though compensatory changes occurred. On restoration of normal respiration the decrease in threshold overshot the norm. Refractoriness changed but little in the entire procedure.
Rapid increase in CO2 tension produced greater changes than did gradually induced acidosis.
(3) Rapidly produced metabolic acidosis caused A-V block at about pH 7.30, but with slow infusion of ammonium chloride the pH fell lower before block occurred.
Changes in diastolic threshold were biphasic, an initial decrease was followed by a rise before block occurred. The refractory period was significantly prolonged.抄録全体を表示PDF形式でダウンロード (711K) -
Mitsuo MIYAHARA, Minoru YOKOYAMA, Yukio NAGASAKI, Kozen KINJO1962 年 3 巻 1 号 p. 46-56
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリーActomyosin (AM) was isolated from the heart muscles of normal dogs and dogs with right-sided congestive failure, and also from posoas muscles of rabbits. Action of ouabain on supcrprecipitation, AM-ATPase activity, and isometric tension of glycerinated fibers was observed under various conditions, and it was concluded that1) lower concentrations (therapeutic dose) of ouabain accelerated superprecipitation, and unaffected both ATPase activity and tension-development of glycerinated fibers (in Ca-free medium), 2) in higher concentrations (toxic dose), ouabain inhibited all of the physicochemical properties of AM examined, 3) ouabain had some correlation with Ca in regard to tension-development of glycerinated fibers, since in low concentrations it counteracted the inhibitory effect of Ca, and in high concentrations it augmented this inhibition, and that4) all of the properties of AM extracted from cardiac, both normal and failing, and skeletal muscles had the similar response to this drug. Thus the improvement of the impaired superprecipitation, ATPase activity and tension-development was not observed by the treatment with ouabain.抄録全体を表示PDF形式でダウンロード (1466K) -
Jugoro TAKEUCHI, Shigeru YAGI, Tadanao TAKEDA, Eiichi UCHIDA, Gosuke I ...1962 年 3 巻 1 号 p. 57-72
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリー(1) The stimulation of the medial and midline nuclei groups in the thalamus and most of the hypothalamic and subthalamic nuclei resulted in an increase in blood pressure and a decrease in renal blood flow which was attributed to renal vasoconstriction caused by both neural factors and humoral ones, especially adrenaline.
(2) The stimulation of a part of medial, midlinc, ventral and lateral nuclei groups in the thalamus, the preoptic area and a part of anterior and middle portions in the hypothalamus caused a fall in blood pressure associated with a decrease in renal blood flow. The latter might be due in part to a decrease in cardiac output.
(3) On stimulation of the geniculate bodies and the ventral and lateral nuclei groups, there often occurred little or no circulatory changes.
(4) In order to induce more pronounced parasympathetic reactions, the diencephalon was stimulated after the sympathetic blocking agents such as hydergine® or guanethidine were administered intravenously, but it was not successful. There were no evidences that suggested the presence of renal vasodilator nerve in the diencephalon.
(5) Type A response induced by the electrical stimulation of dog's diencephalon was modified by guanethidine; there was frequently marked inhibition of immediate responses consequent to the stimulation or a delay in the onset of responses. This response was not nearly affected by reserpine and 1-hydrazinophthalazine.抄録全体を表示PDF形式でダウンロード (2449K) -
Kazuzo KATO, Katsuro SHIMOMURA, Akio KUROIWA, Tsuneaki SUGIMOTO, Sator ...1962 年 3 巻 1 号 p. 73-82
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリー(1) In 11 cases of advanced A-V block, irregularity of RR distance was studied, by analysis of QP-PQ curves.
(2) The generating mechanism of decreased A-V conductivity may chiefly be due to abnormal prolongation of the refractory period of the A-V junctional tissues.
(3) From the presence of constancy of A-V conduction time of ventricular captures, 2 types of the mode of A-V conduction delay were recognized;
a) the one suggesting abnormal prolongation of the absolute refractory period,
b) the one suggesting abnormal prolongation of both the absolute and relative refractory periods of the A-V junctional tissues.
(4) By displaying the incidence of A-V block, it was shown that advanced A-V block is not rare, as compared with other types of A-V block.
(5) Three complex cases in which other additional factors participate were presented.抄録全体を表示PDF形式でダウンロード (2567K) -
Terumasa MIYAMOTO1962 年 3 巻 1 号 p. 83-95
発行日: 1962年
公開日: 2008/12/09
ジャーナル フリーPDF形式でダウンロード (905K)
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