-
Motoyuki NAKAMURA, Naoshi ARAKAWA, Yasumi ABE, Hiroaki YOSHIDA, Shuets ...
1990 年 31 巻 4 号 p.
425-434
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
Several reports have demonstrated a close correlation between plasma atrial natriuretic peptide (ANP) concentration and atrial pressure in stable heart diseases. However, few studies have investigated whether plasma ANP concentration is a noninvasive indicator of hemodynamic parameters during the treatment of heart failure. Thus, we have studied the relationship between peripheral plasma ANP concentration and concurrent hemodynamic variables during the treatment of heart failure, and, in order to determine whether secretion of ANP is stimulated in this disease condition, we compared the plasma ANP concentration in the pulmonary artery with that in the peripheral veins.
Studies were performed in each of 9 patients with acute heart failure due to myocardial infarction (Group A) or chronic heart failure (Group B), who were matched as closely as possible for treatment, age, sex and cardiac output. In group A, no significant correlation was found between plasma ANP levels and any measured hemodynamic variables. In group B, peripheral plasma ANP concentrations were significantly correlated with left atrial pressure (r=0.82, p<0.01), but not with right atrial pressure (r=0.56, p>0.05). Furthermore, in group B ANP levels in pulmonary arterial plasma were consistently higher than those in peripheral venous plasma, whereas in group A the opposite was observed in expired cases.
These results suggest that measurement of peripheral plasma ANP is a useful noninvasive method for estimating left atrial pressure during the treatment of chronic heart failure. However, plasma ANP concentration may not be a valid means of estimating hemodynamic parameters in acute heart failure due to myocardial infarction. In such cases, the increased secretion of ANP was not obvious, and there may be other factors, in addition to atrial pressure, that regulate cardiac secretion of ANP.
抄録全体を表示
-
Ying-Shiung LEE, Ching-Ping LEE
1990 年 31 巻 4 号 p.
435-448
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
An electron microscopic study of left ventricular myocardium was carried out in 15 patients who had isolated rheumatic mitral stenosis, with particular reference to the relation among ultrastructural pathological findings, the severity of mitral stenosis and left ventricular function. They were divided into 2 groups based on left ventricular performance evaluated by 2-dimensional echocardiography and angiocardiography. The severity of mitral stenosis was determined by hemodynamic data and mitral valve areas measured by 2-dimensional echocardiography. Regardless of the level of left ventricular contractile function we consistently demonstrated varying degrees of ultrastructural pathological alterations of left ventricular muscle cells, involving the myofibrils, mitochondria, nuclei and other elements of the sarcoplasm and membranes surrounding the myocardial cells in all specimens examined. The ultrastructural pathological findings did not correlate with the severity of mitral stenosis reflected in the echocardiographic and hemodynamic data. However, those patients with abnormal left ventricular function always exhibited more extensive loss of myofibrils resulting from either disproportion of the mitochondria-to-myofibril ratio or myofibrillar degeneration. The present investigation provides the morphological data at the ultrastructural level to support the widely held concept of a myocardial factor i.e., the extent of myocardial involvement by the rheumatic process as the basic pathogenetic mechanism responsible for left ventricular dysfunction in patients with isolated rheumatic mitral stenosis. Furthermore, it is suggested that pathological alterations of myocardial ultrastructure were related to the extent of myocardial involvement by the rheumatic process rather than being structural adaptations in response to the hemodynamic derangement.
抄録全体を表示
-
Hiroshi KISHIDA, Tsutomu SAITO, Nagaharu FUKUMA, Noritake HATA, Takesh ...
1990 年 31 巻 4 号 p.
449-460
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
Antianginal and antiischemic effects and clinical pharmacologic actions of carvedilol, a novel β-blocking agent with a vasodilator action, were determined by Holter electrocardiographic monitoring in 13 patients with exertional angina. The patients were observed for 1 week prior to entry into the study, followed by 1 to 2 weeks of treatment with carvedilol. During the observation period the patients received one placebo tablet daily, and during the treatment period one 20mg tablet of carvedilol daily. Before and after the treatment 24-hour Holter electrocardiographic tracings were obtained. The mean interval of Holter monitoring was 11.2±4.5 days for the observation and treatment periods, and the mean time of drug administration was 8: 25 a.m. (±30min). The Holter electrocardiographic tracings which were obtained twice in 9 patients during the observation period showed a high degree of reproducibility with respect to the frequency, magnitude and duration of ST-segment depression. The total frequency of ST depression per patient was 4.5±3.4 events/day pre-drug and 2.1±2.1 events/day post-drug. There was a significant reduction in total frequency of ST depression post-drug (p<0.01). The frequency of asymptomatic ST depression was similarly decreased post-drug (p<0.01), and the total magnitude and duration of ST depression were significantly improved post-drug (p<0.01 and p<0.05, respectively). These effects of carvedilol lasted for 24 hours after administration. Considering that the heart rate was not excessively reduced during the night, and nocturnal myocardial ischemic episodes were not exacerbated, the mode of action of this drug seems to be based on not only a β-blocking action but also on a vasodilator action. Carvedilol benefits exertional angina when used in a 20mg s.i.d. regimen.
抄録全体を表示
-
Osamu TOCHIKUBO, Masao ISHII, Kohsuke MINAMISAWA, Eiji MIYAJIMA, Naomi ...
1990 年 31 巻 4 号 p.
461-476
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
A new device (called a hemodynamometer) employing the principle of the CO
2 rebreathing method has been developed for the noninvasive automatic measurement of pulmonary blood flow (cardiac output=CO). The device can also measure oxygen consumption (VO
2) and indirect blood pressure and record electrocardiographs (heart rate) at the same time and can automatically calculate total peripheral vascular resistance (TPR) by means of a computer. In this study, the hemodynamometer was used in 28 normotensive subjects and 42 patients with essential hypertension (27 with WHO stage I and 15 with WHO stage II) to evaluate hemodynamics during rest or ergometer exercise. To evaluate accuracy, the dye-dilution (cuvette) method was simultaneously employed in some subjects. The correlation coefficient (r) between CO measured by means of the hemodynamometer and CO measured by the cuvette method was 0.96 (n=39) with a differential of 0.08±0.53l/min and reproducibility was good (r=0.88, n=70). The average CO index for normotensive subjects at rest was 3.22±0.37l/min/m
2 (VO
2=210±30ml/min/m
2) and agreed with previously reported values. A significant difference was observed between the hemodynamics (CO and TPR indices) of the WHO-I group and those of the WHO-II group during rest or mild exercise (25-watt load).
Because it can measure CO and TPR easily and noninvasively, the hemodynamometer is considered useful for evaluating hemodynamic changes in hypertensive patients.
抄録全体を表示
-
Shaily SARIHYAN, Purshottam Lal WAHI, Nirmal Kumar GANGULY, Inderjit S ...
1990 年 31 巻 4 号 p.
477-482
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
The study comprised normal controls with 10 males and 10 females in each decade of age starting from birth till>70 years of age and also 20 cord blood samples (10 males and 10 females). In normal controls there was a progressive increase in the levels of total cholesterol and triglycerides in both men and women with age. Women had significantly lower levels of Tc and TG as compared to men until 40 years of age. Beyond this age levels of Tc were similar to those in men. HDL-c was lower in girls below 10 years of age compared to boys. Above 10 years of age women had significantly higher levels of HDL-c. Apo A-I and A-II levels were also significantly higher in women compared to men.
抄録全体を表示
-
Tsutomu IMAIZUMI, Marc D. THAMES
1990 年 31 巻 4 号 p.
483-492
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
Experiments were performed to investigate the physiologic significance of the crossover of baroreceptor afferent input to the contralateral nucleus tractus solitarius (NTS) in terms of reflex control of renal sympathetic nerve activity and to determine the physiologic significance of neuronal crossover which may occur beyond the NTS. Experiments were done in 14 alpha-chloralose anesthetized rabbits. Baroreflex control of left renal nerve activity was determined from responses to phenylephrine-induced increases and nitroglycerin-induced decreases in arterial pressure. Under control conditions, the mean regression slope for changes in renal nerve activity (imp/sec/mmHg change in arterial pressure) was -2.2±0.5. After unilateral NTS lesion (n=14) the gain of the reflex was -2.4±0.4imp/sec/mmHg. Denervation of baroreceptors ipsilateral to the NTS lesion (n=6) did not alter the regression slope (-2.7±0.5imp/sec/mmHg), but interruption of the contralateral carotid and aortic baroreceptor afferent fibers (n=8) markedly reduced the slope of the linear regression relationship from -2.4±0.3 to -1.1±0.3imp/sec/mmHg. We interpret these data to suggest that baroreceptor afferent input exerts its major reflex influence via the ipsilateral NTS and that there is modest influence exerted by fibers which cross over to the contralateral side. In addition, since we recorded from the left renal nerves and alternated the side of the NTS lesion, we interpret our findings regarding a lesion in only one NTS to suggest that there is crossover in the baroreflex pathway beyond the NTS which permits the NTS on one side to exert an influence on the renal nerves on the contralateral side similar to that seen when the NTSs on both sides are intact.
抄録全体を表示
-
Kazushi TSUDA, Hiroki SHIMA, Ichiro NISHIO, Yoshiaki MASUYAMA
1990 年 31 巻 4 号 p.
493-501
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
The purpose of the present study was to investigate the effects of a Ca
2+-antagonist on vascular sympathetic nerve activity in salt-dependent hypertension. Isolated mesenteric vasculature preparations from reduced renal mass-salt hypertensive and age-matched normotensive control rats were used to examine the effects of diltiazem on vascular responsiveness and norepinephrine release from sympathetic nerve endings. Pressor responses and endogenous norepinephrine release during electrical nerve stimulation were significantly greater in preparations from salt-dependent hypertensive rats than from normotensive control rats. Diltiazem inhibited both stimulation-evoked pressor responses and norepinephrine release in a dose-dependent manner. The attenuation of these responses was more pronounced in preparations from rats with salt-dependent hypertension than in those from control rats. These results indicate that norepinephrine release from vascular adrenergic neurons is enhanecd in the mesenteric vasculatures of rats with salt-dependent hypertension. The marked reduction of stimulation-evoked pressor responses and norepinephrine release by diltiazem suggests that enhanced Ca
2+-dependent adrenergic transmission may contribute to the exaggerated vascular sympathetic tone in salt-dependent hypertension.
抄録全体を表示
-
Kan TAKAYANAGI, Tsuneo FUJITO, Shigenori MOROOKA, Yutaka TAKABATAKE, Y ...
1990 年 31 巻 4 号 p.
503-507
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
We report 2 fatal cases of angina pectoris in patients who complained primarily of headache during the ischemic attack. The first patient, who was hospitalized because of headache and chest pain, demonstrated repeated ST-segment elevation and fatal ventricular fibrillation on ambulatory ECG monitoring. The second patient had post-infarction angina preceded by headache and by ST-segment elevation in the precordial leads. She eventually died of reinfarction. The mechanism of the headache in relation to the angina pectoris is discussed.
抄録全体を表示
-
Tomoh Masaki, Masashi Yanagisawa, Sadao Kimura, Yoh Takuwa, Katsutoshi ...
1990 年 31 巻 4 号 p.
517-518
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Ryoichi Horie, Toshihiko Shibukawa, Shunsaku Mizushima, Hiroyuki Yamas ...
1990 年 31 巻 4 号 p.
519
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Toshihiko Shibukawa, Ryoichi Horie, Manabu Kitao, Yukio Yamori
1990 年 31 巻 4 号 p.
520-521
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Hiromu Kawasaki, Shigeru Nakamura, Koichiro Takasaki
1990 年 31 巻 4 号 p.
522
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Koichiro Kishi, Tsutomu Inoue
1990 年 31 巻 4 号 p.
523
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Kenzo Moriyama, Keiichi Shimamura, Shoko Osugi, Satoru Sunano
1990 年 31 巻 4 号 p.
524
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Saiji Nakabayashi, Ryuzo Fukunaga, Satoshi Ogawa, Ryuji Hata, Kazuo Ki ...
1990 年 31 巻 4 号 p.
525
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Keiichi Shimamura, Kazuo Yamamoto, Shoko Osugi, Kenzo Moriyama, Satoru ...
1990 年 31 巻 4 号 p.
526
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Shoko Osugi, Keiich Shimamura, Kenzo Moriyama, Satoru Sunano
1990 年 31 巻 4 号 p.
527
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Takuzo Hano, Akira Baba, Masako Ura, Masahiko Shiotani, Akiyoshi Yoshi ...
1990 年 31 巻 4 号 p.
528
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Kumiko Yamamoto, Mitsuyo Saito, Kokichi Takeuchi, Nobuyuki Abe, Chikao ...
1990 年 31 巻 4 号 p.
529
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Mitsuyo Saito, Kumiko Yamamoto, Kokichi Takeuchi, Nobuyuki Abe, Chikao ...
1990 年 31 巻 4 号 p.
530
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Mari Kondo, Miho Terada, Ryo Tabei
1990 年 31 巻 4 号 p.
531
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Yoshitaro Matsumoto, Tomohiro Matsuyama, Osamu Uyama, Minoru Sugita, M ...
1990 年 31 巻 4 号 p.
532
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Naoya Yukioka, Eiji Yamada, Fumitada Hazama
1990 年 31 巻 4 号 p.
533
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Kazuhiko Suyama, Masaki Kurihara, Choichiro Miyazaki, Kenji Matsuyama, ...
1990 年 31 巻 4 号 p.
534
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Takato Kagawa, Ryoichi Horie, Kouzo Moritake, Yukio Yamori
1990 年 31 巻 4 号 p.
535
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Satoshi Iida, Fumihiko Kashiwagi, Rinnosuke Obo, Tatsushi Kamiya, Shun ...
1990 年 31 巻 4 号 p.
536
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Takao Kubo, Minoru Kihara, Yoshimi Misu
1990 年 31 巻 4 号 p.
537
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Shigeru Nakamura, Hiromu Kawasaki, Koichiro Takasaki
1990 年 31 巻 4 号 p.
538
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Takuya Matsuo, Takahide Kihara, Takashi Tanimura
1990 年 31 巻 4 号 p.
539
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Hiroshi Ogawa, Tomoyo Nishikawa, Sukenari Sasagawa
1990 年 31 巻 4 号 p.
540
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Masahiro Ito, Yosihisa Kawase, Kazuko Shichijo, Ichiro Sekine, Sinji U ...
1990 年 31 巻 4 号 p.
541
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Hamao Toda, Hisayo Oohata, Kazuko Fujimoto, Takeshi Suzuki, Koichiro K ...
1990 年 31 巻 4 号 p.
542
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Changes in Life Spans, Blood Pressures, Plasma Hormones, Fundus Oculi and Internal Organs. (Second report)
Yoshio Ohta, Hiroki Shiokawa, Taka-aki Chikugo, Nobuko Morita, Yoh Ham ...
1990 年 31 巻 4 号 p.
543
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Taka-aki Chikugo, Yoshio Ohta, Hiroki Shiokawa, Kozo Okamoto
1990 年 31 巻 4 号 p.
544
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
Captopril, SQ 29852, hydralazine or a combination therapy was administered to 11-week-old male M-SHRSP and 20- to 25-week-old male SHRSP all of which evidenced angionecrosis in verious organs. Blood pressures for captopril or SQ 29852 or hydralazine groups slightly lowered to about 220mmHg, and those of combination therapy groups decreased within normal range. In captopril, SQ 29852 and combination group, fibrinoid substances of blood vessels were absorbed and disappeared, and vacuoles were found in vessel wall, and smooth muscle cells proliferated and, then, blood vessels repaired. These latter effects were not seen in the rats given hydralazine.
抄録全体を表示
-
Noboru Saito, Teruhiko Okada, Toshiaki Moriki
1990 年 31 巻 4 号 p.
545
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Different Responses to Cytosolic Free Calcium Concentrations, ATP Releasing Potencies, and Aggregation Activities
Hideaki Higashino, Yukinori Yamanishi, Aritomo Suzuki
1990 年 31 巻 4 号 p.
546
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Takako Tomita, Masahiko Ikeda, Tomohiro Mitsubori, Takeshi Onda, Isao ...
1990 年 31 巻 4 号 p.
547
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Hiroko Togashi, Machiko Matsumoto, Mitsuhiro Yoshioka, Masaru Minami, ...
1990 年 31 巻 4 号 p.
548
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Young Sook Kang, Tetsuya Terasaki, Akira Tsuji
1990 年 31 巻 4 号 p.
549
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Jun Koike, Hitoshi Kurumatani, Toshio Kushiro, Hiromi Abeta, Hidenori ...
1990 年 31 巻 4 号 p.
550
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Masahiro Hirata, Kazuo Takeda, Toshiyuki Takesako, Ken Takenaka, Motoh ...
1990 年 31 巻 4 号 p.
551
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Yuji Naruse, Hiroshi Kawamura, Masahiro Maki, Hideaki Higashi, Kazuyos ...
1990 年 31 巻 4 号 p.
552
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Masahiro ITO, Kazuko Shichijo, Yosihisa Kawase, Saburou Shikuwa, Chao- ...
1990 年 31 巻 4 号 p.
553
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Kazuko Shichijo, Masahiro Ito, Yoshihisa Kawase, Saburo Shikuwa, Chiao ...
1990 年 31 巻 4 号 p.
554
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Masahiko Nomura
1990 年 31 巻 4 号 p.
555
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Katsumi Ikeda, Akihiko Fujimoto, Yasuo Nara, Ryoichi Horie, Hirohsi Is ...
1990 年 31 巻 4 号 p.
556
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Akihiko Fujimoto, Katumi Ikeda, Yasuo Nara, Ryoichi Horie, Hiroshi Ish ...
1990 年 31 巻 4 号 p.
557
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Takeshi Tsutsumi, Souichiro Sekiya, Yuukei Higashi, Hirofumi Osada, To ...
1990 年 31 巻 4 号 p.
558
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Sadayuki Sato, Tomoe Nakata, Souichiro Sekiya, Takeshi Tsutsumi, Hirof ...
1990 年 31 巻 4 号 p.
559
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー
-
Hikaru Nishimura, Jiro Kubota, Makoto Okabe, Toshiyuki Kimpara, Masaku ...
1990 年 31 巻 4 号 p.
560
発行日: 1990年
公開日: 2008/12/09
ジャーナル
フリー