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Comparison with the Results of Treadmill Exercise
Masanori ISHII, Takeshi OGAWA, Kazunori USHIYAMA, Takuji TOMIZAWA, Yui ...
1991 Volume 32 Issue 4 Pages
425-433
Published: 1991
Released on J-STAGE: December 09, 2008
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To compare cardiorespiratory responses to standing arm ergometry and treadmill exercise, two graded exercise stress tests were performed in 30 patients with ischemic heart disease (IHD). Cardiac catheterization and expired gas analyses were also done. Standing arm ergometry was discontinued because of arm fatigue in 15 (50%) patients, whereas treadmill exercise was stopped due to leg fatigue in 8 (27%) patients. Maximal increase in rate-pressure product and oxygen uptake, and magnitude of ST-segment depression during standing arm ergometry were significantly smaller (p<0.01, p<0.01 and p<0.05, respectively) than those during treadmill exercise. Furthermore correlations of maximal change in rate-pressure product, oxygen uptake and extent of ST-segment depression were not close between the two exercise tests (r=0.76, r=0.67 and r=0.54, respectively).
Our results indicate that the ability to detect IHD with standing arm ergometry is lower than that with treadmill exercise and that it is not possible to predict accurately one's capacity for arm exercise from the treadmill exercise test.
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A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients
Maria Luisa FASANO, Iole GAETA, Giuseppina DE SIMONE, Rita IANNUZZI, L ...
1991 Volume 32 Issue 4 Pages
435-444
Published: 1991
Released on J-STAGE: December 09, 2008
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The antihypertensive effects of tertatolol, a new non-cardioselective beta-blocking drug, were investigated in 20 patients with mild to moderate primary arterial hypertension, in a placebo controlled double blind randomized study, After tertatolol 5mg o.d. significant decreases in both systolic and diastolic blood pressure and in heart rate were observed at rest (BP from 155/103±3/1 to 139/91±4/3mmHg p<0.01; HR from 79±2 to 60±2bpm p<0.01). Peak blood pressure, heart rate and myocardial O
2 consumption, indirectly measured as cardiac workload, determined during adrenergic stimulation by 70° head-up tilt, cold pressor test, mental arithmetic stress, isometric exercise and bicycle exercise were also reduced by 4 weeks of tertatolol treatment in comparison to pretreatment levels. No significant changes in the same parameters were induced by placebo. No side effects were observed during treatment.
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Katsuaki ENOMOTO, Yoshikazu KAJI, Takehito MAYUMI, Yasuo TSUDA, Shozo ...
1991 Volume 32 Issue 4 Pages
445-453
Published: 1991
Released on J-STAGE: December 09, 2008
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Echocardiography was used to compare the left ventricular function of 43 female patients with stable systemic lupus erythematosus with 93 healthy females in 3 age groups. Left ventricular systolic function was evaluated by the left ventricular ejection fraction and left ventricular diastolic function was evaluated by the diastolic descent rate of the anterior mitral leaflet (DDR), the ratio of mean systolic velocity to mean diastolic velocity in the left ventricular posterior wall (D/S ratio) and the ratio of peak mitral inflow velocity during the atrial filling period to that in the early filling period (A/E ratio). The left ventricular ejection fraction was not significantly different between patients and normal subjects. However, left ventricular diastolic function evaluated by these indexes in patients was different from normal subjects. These data suggest that left ventricular diastolic function is lower in patients with stable systemic lupus erythematosus than in normal subjects. It appears to deteriorate progressively with age. However, left ventricular systolic function remains normal.
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Yasumi UCHIDA, Takanobu TOMARU, Fumitaka NAKAMURA, Tomomitsu OSHIMA, Y ...
1991 Volume 32 Issue 4 Pages
455-471
Published: 1991
Released on J-STAGE: December 09, 2008
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The feasibility of percutaneous transluminal cardioscopy of the left ventricle was examined in 35 patients with or without various heart diseases. A guiding balloon catheter (7 or 9 French) was introduced through the right femoral artery into the left ventricle. The balloon was inflated, and a fiberscope (1.6 or 4.3 French) was advanced to the distal tip of the catheter. The balloon was then manipulated against the portion of the ventricle targeted for examination, and heparinized saline (10U/ml) at body temperature was infused through the catheter at 5ml/sec for 3 to 6 sec. The images were recorded on videotape and 16mm cinefilm. In 4 patients without demonstrable heart disease, the endocardial surface of the left ventricle was brown and the trabeculae became prominent during systole. The chordae connected to the mitral leaflets were white. In 3 of 5 patients with dilated cardiomyopathy, the endocardium was light yellow with thin trabeculae which barely contracted during systole. The endocardium was red or reddish-brown in 3 patients with acute myocarditis. In patients with rheumatic mitral stenosis white patches were scattered on the endocardial surface. In 7 of 8 patients the akinetic or dyskinetic segments representing prior infarctions were white. No complications other than transient ventricular arrhythmias were noted. We conclude that percutaneous fiberscopic imaging with a guiding balloon catheter is feasible and safe, and yields highly detailed images of the endocardium.
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Hiroyuki SUGA
1991 Volume 32 Issue 4 Pages
473-480
Published: 1991
Released on J-STAGE: December 09, 2008
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The balance of force in a cylindrical tube (Oka-Azuma equation) indicates existence of a negative circumferential tension in the wall of blood vessels
in vivo. However, we conventionally consider only a positive wall tension due to a positive transmural pressure in blood vessels. In this paper, the nature of such a negative circumferential tension in the vascular wall was reconsidered. The same type of negative tension or compressive force was shown to exist in any hollow and solid biological tissues placed in the atmospheric pressure. In living tissues, which have abundant water and are incompressible to external pressure, the compressive force by atmospheric pressure is simply the internal fluid pressure. The fluid pressure is a scalar and does not produce any effective net force vector. For this reason, there is no need to consider the compressive force component produced by the environmental pressure in the balance of force in living tissues.
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Takashi NAKAMURA, Kazutoshi SHIMOO, Toshiro KURIBAYASHI, Kin-ya MATSUB ...
1991 Volume 32 Issue 4 Pages
481-491
Published: 1991
Released on J-STAGE: December 09, 2008
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A high-frequency transducer was used to determine the optimal parameters for visualizing the heart in 40 normal Wistar, 15 SHR, and 10 aorta-banded rats. The rats were 5 to 30 weeks old and weighed between 105 and 705 grams. Two-dimensional and M-mode views of the ventricles, atria, valves, and great arteries were obtained by placing the transducer beneath the rats through the left or right parasternal window in either the prone or the right decubitus positions, respectively. Left ventricular (LV) mass was determined on the basis of a spheroid model; these values correlated well with the LV weight for both the Wistar rats (r=0.94, p<0.001) and the rats with cardiac hypertrophy due to pressure load (r=0.87, p<0.001). These results were highly reproducible. This indicates that echocardiography is useful for obtaining quantitative measurements in rats.
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Taku MATSUBARA, Takaharu ISHIBASHI, Mikio NAKAZAWA, Masaru YAMAZOE, To ...
1991 Volume 32 Issue 4 Pages
493-504
Published: 1991
Released on J-STAGE: December 09, 2008
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Using an isolated perfused rat heart preparation, the protective effects of lidocaine and diltiazem on ischemic derangements of myocardial energy metabolism were studied with
31P-nuclear magnetic resonance spectroscopy. The hearts were perfused with a solution containing lidocaine (4.27×10
-5, 12.80×10
-5M) or diltiazem (2.22×10
-7, 2.22×10
-6M) for 15min prior to the induction of global ischemia. The decrease in myocardial oxygen consumption rate, assessed as the product of heart rate and left ventricular systolic pressure (HR×LVP), was greater in diltiazem-treated than in lidocaine-treated hearts. Diltiazem and lidocaine significantly retarded the fall in myocardial pH during ischemia and improved ATP recovery after reperfusion. There was a good correlation between suppression of HR×LVP observed before induction of ischemia and decreased drop in pH during the early phase of ischemia in the diltiazem-treated groups (r=-0.78, p<0.01), but not in the lidocaine-treated groups. These results indicate that the beneficial effects of diltiazem on the ischemic myocardium are due primarily to the cardiodepressant effects. The beneficial effects of lidocaine cannot, however, be explained solely on the basis of the depression of oxygen consumption.
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Kan TAKAYANAGI, Kazuhiro HOSHI, Sachiko KIMURA, Teruo INOUE, Shigenori ...
1991 Volume 32 Issue 4 Pages
505-509
Published: 1991
Released on J-STAGE: December 09, 2008
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Nitroglycerin induced a paradoxical disappearance of a stenosed coronary artery in a 57-year-old man with non-Q wave myocardial infarction. On the coronary angiogram, the left anterior descending coronary artery (with a 95% stenosis) became completely invisible 2min after 0.3mg sublingual nitroglycerin. Three minutes later, the artery was opacified again. This transient occlusion may have resulted from a passive collapse of the distal portion of the artery, due to insufficient access of nitroglycerin across the stenotic region.
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Masatoshi KUROKI, Uichi IKEDA, Toshitaka NODA, Saichi HOSODA, Toshio Y ...
1991 Volume 32 Issue 4 Pages
511-514
Published: 1991
Released on J-STAGE: December 09, 2008
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Complete atrioventricular block (CAVB) during cardiac catheterization is a rare complication. We describe a patient with preexisting complete right bundle branch block who developed CAVB during left-sided cardiac catheterization. CAVB was induced when a left-sided catheter was passed through the aortic valve. We speculate that the patient's His bundle was injured by mechanical compression. Physicians should always pay attention to the possibility of the development of CAVB during cardiac catheterization, particularly in patients with preexisting heart block.
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Toru KUBOTA, Tsutomu IMAIZUMI, Akiko CHISHAKI, Yasuo HAYASHI, Tetsuji ...
1991 Volume 32 Issue 4 Pages
515-520
Published: 1991
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A 49-year-old woman experienced acute myocardial infarction with a hemodynamic pattern resembling constrictive pericarditis. To clarify its mechanism, we performed right atrial pacing and volume challenge test during the chronic state. Although these two interventions elevated diastolic pressures of the both ventricles, the dip and plateau pattern was not reproduced. Factors other than ischemia may be important in producing a hemodynamic pattern resembling constrictive pericarditis in acute myocardial infarction.
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An Autopsy Case
Tohru KAKU, Yasuhide NAKASHIMA, Hirofumi ICHIYASU, Masasuke SOEJIMA, K ...
1991 Volume 32 Issue 4 Pages
521-527
Published: 1991
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A 57-year-old woman with acromegaly associated with mitral chordal rupture is reported. She was noted to have abnormal development in the size of her hands and feet in childhood. She occasionally suffered from shortness of breath on exertion and nocturnal dyspnea for several years, and was diagnosed and treated as having congestive heart failure due to valvular heart disease. On admission to our hospital, chordal rupture was suspected on the basis of M-mode and two-dimensional echocardiography. Seven years after discharge, she died of congestive heart failure. On autopsy, the heart weight and ventricular wall thickness were increased. Rupture of the posterior chordae was confirmed, but evidence of an old myocardial infarction was not found. There was severe interstitial fibrosis in the left ventricular wall. A possible etiology of the chordal rupture in this case was thought to be the excessive stretching caused by the disproportional visceromegaly of the heart.
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Noboru Saito, Teruhiko Okada, Shoji Nishiyama
1991 Volume 32 Issue 4 Pages
537-539
Published: 1991
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The bead-like lesion in rat mesenteric artery occurred more frequent in old stroke-prone spontaneously hypertensive rats(SHRSP), aged over 8 months, and especially in male SHRSP than in female SHRSP or in older SHRSP than in old SHRSP, while it was very rare in older stroke-resistant SHH(SHRSR) and was not found in older Wistar Kyoto rats(WKY). The bead-like lesion was periarteritis nodosa microscopically. Electronmicroscopically, various cells such as endothelial cells, fibroblast-like cells and leucocytes showed the activated states; the well-developed Golgi apparatus and the dilated lumens of rough endoplasmic reticulum. In SHRSP of both sexes, aged 12-19.5 months, systolic blood pressure was higher in the cases with bead-like lesion than in the cases without it, and this finding was confirmed by the increment of heart weight. Therefore, high blood pressure is one factor to induce bead-like lesion in mesenteric artery.
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Noritoshi Takeichi, Xiaobin Li, Hiroshi Kobayashi
1991 Volume 32 Issue 4 Pages
540
Published: 1991
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Mari Kondo, Tatsuhiko Miyazaki, Ryo Tabei
1991 Volume 32 Issue 4 Pages
541
Published: 1991
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Masamitsu Fujii, Ryoichi Horie, Toru Katsube, Tomoichi Setogawa, Yukio ...
1991 Volume 32 Issue 4 Pages
542
Published: 1991
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Osamu Atsumi, Tadashi Mikami, Hiroshi Yoshimoto, Shuichi Matsuyama
1991 Volume 32 Issue 4 Pages
543
Published: 1991
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Yoh Hamada, Takaaki Chikugo, Yoshio Ohta, Kozo Okamoto
1991 Volume 32 Issue 4 Pages
544
Published: 1991
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Jun Yamazaki, Naoya Fujita, Taku Nagao
1991 Volume 32 Issue 4 Pages
545
Published: 1991
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Comparison between WKY and SHRSP
Yuta Kobayashi, Katsumi Ikeda, Eiichi Kakizoe, Kazumasa Shinozuka, Yas ...
1991 Volume 32 Issue 4 Pages
546
Published: 1991
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Hiroshi Takeshita, Masaru Nishikibe, Mitsuo Yano, Fumihiko Ikemoto
1991 Volume 32 Issue 4 Pages
547
Published: 1991
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Naoya Yukioka, Hideo Kataoka, Eiji Yamada, Fumitada Hazama
1991 Volume 32 Issue 4 Pages
548
Published: 1991
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Hideki Okunishi, Tatsuhiko Kawamoto, Masuhisa Nakamura, Mizuo Miyazaki
1991 Volume 32 Issue 4 Pages
549
Published: 1991
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Kazuo Yamamoto, Keiichi Shimamura, Satoru Sunano
1991 Volume 32 Issue 4 Pages
550
Published: 1991
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Yoshitaka Nishimura, Aritomo Suzuki
1991 Volume 32 Issue 4 Pages
551
Published: 1991
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Hideaki Yanagisawa, Yukei Higashi, Takeshi Tsutsumi, Hirofumi Osada
1991 Volume 32 Issue 4 Pages
552
Published: 1991
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Akiyoshi Fukamizu, Motoya Katsuki, Kazuo Murakami
1991 Volume 32 Issue 4 Pages
553
Published: 1991
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Katsumi Ikeda, Akihiko Fujimoto, Yasuo Nara, Ryoichi Horie, Hiroshi Is ...
1991 Volume 32 Issue 4 Pages
554
Published: 1991
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Takeshi Onda, Takako Tomita, Masahiko Ikeda, Noriko Suzuki, Isao Tomit ...
1991 Volume 32 Issue 4 Pages
555
Published: 1991
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Kenzo Moriyama, Keiichi Shimamura, Satoru Sunano
1991 Volume 32 Issue 4 Pages
556
Published: 1991
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Kouichi Hasui, Hideyasu Kiyomoto, Yasuharu Aki, Tetsuo Shoji, Toshiaki ...
1991 Volume 32 Issue 4 Pages
557
Published: 1991
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Satoru Kuriyama, Koji Nakamura, Yoshihiko Kaguchi, Takao Hashimoto, Os ...
1991 Volume 32 Issue 4 Pages
558
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Akihiro Ohno, Sadaharu Kato, Kazuho Honda, Mariko Hosaka, Masae Tanaka ...
1991 Volume 32 Issue 4 Pages
559
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Susumu Imaoka, Kazuo Takaori, Tokihito Yukimura, Kenjiro Yamamoto, Yos ...
1991 Volume 32 Issue 4 Pages
560
Published: 1991
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Natsuki Nakayama, Goro Miyakoda, Mika Otsuka, Youichi Yabuuchi
1991 Volume 32 Issue 4 Pages
561
Published: 1991
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Hideaki Higashino, Kunio Abiko, Aritomo Suzuki
1991 Volume 32 Issue 4 Pages
562
Published: 1991
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General progress following treatment. (First report)
Yoshio Ohta, Taka-aki Chikugo, Kozo Okamoto
1991 Volume 32 Issue 4 Pages
563
Published: 1991
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Hikaru Nishimura, Jiro Kubota, Makoto Okabe, Toshiyuki Kimpara, Masaku ...
1991 Volume 32 Issue 4 Pages
564
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Koji Machii, Korekiyo Wakitani, Tadao Okegawa, Akiyoshi Kawasaki
1991 Volume 32 Issue 4 Pages
565
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Prevention and therapeutic effects when administered at different stages of life
Hiroki Shiokawa, Yoshio Ohta, Kozo Okamoto
1991 Volume 32 Issue 4 Pages
566
Published: 1991
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Tomohiro Mitsubori, Takako Tomita, Hisano Saito, Masanori Ezaki, Takes ...
1991 Volume 32 Issue 4 Pages
567
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Yukio YAMORI, Satoru TSUCHIKURA, Minoru ADACHI, Shunsaku MIZUSHIMA, Ma ...
1991 Volume 32 Issue 4 Pages
568
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Hisao Minato, Yoshinobu Masuda, Kanoo Hosoki
1991 Volume 32 Issue 4 Pages
569
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Takeshi Takami, Hiroyuki Ito, Tsuneyuki Suzuki
1991 Volume 32 Issue 4 Pages
570
Published: 1991
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Kazushi Tsuda, Seiko Tsuda, Ichiro Nishio, Yoshiaki Masuyama, Menek Go ...
1991 Volume 32 Issue 4 Pages
571
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Masahiro Hirata, Kazuo Takeda, Tadao Kuwahara, Tatsuo Yoshitomi, Yusuk ...
1991 Volume 32 Issue 4 Pages
572
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Hiroko Togashi, Machiko Matsumoto, Mitsuhiro Yoshioka, Ken Morii, Mits ...
1991 Volume 32 Issue 4 Pages
573
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Hiromi Abeta, Hitoshi Kurumatani, Toshio Kushiro, Jun Koike, Yasunori ...
1991 Volume 32 Issue 4 Pages
574
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Masami Niwa, Meiko Fujimoto, Yasufumi Kataoka, Kohtaro Taniyama
1991 Volume 32 Issue 4 Pages
575
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Satoshi Iida, Fumihiko Kashiwagi, Rinnosuke Obo, Kenji Inamura, Jun Sh ...
1991 Volume 32 Issue 4 Pages
576
Published: 1991
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Takato Kagawa, Ryoichi Horie, Kouzo Moritake, Yukio Yamori
1991 Volume 32 Issue 4 Pages
577
Published: 1991
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