巻号一覧
34 巻 (1993)
- 6 号 p. 685-
- 5 号 p. 539-
- 4 号 p. 385-
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- 2 号 p. 121-
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34 巻, 5 号
選択された号の論文の15件中1～15を表示しています
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Shinichiro NISHIYAMA, Kenichi KATO, Shigeyuki NAICANISHI, Akira SEKI, ...1993 年 34 巻 5 号 p. 539-550
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーWe performed a retrospective analysis of the fate of 990 medically treated Japanese patients with coronary artery disease. Patients were enrolled in this study between September 1973 and February 1984. They were confirmed to have significant coronary artery disease by coronary angiography. There were 924 males and 66 females with a mean age of 54.4 years. The mean duration of follow-up was 9.4 years with a range of 6.5 to 17.0 years. The 5-year and 10-year survival rates for the entire population were 92.1% and 84.4%. The 5-year and 10-year survival rates in patients with single-(SVD), double-(DVD), and triple-vessel disease (TVD) and left main trunk (LMT) disease were as follows: 96.0% and 91.9% for SVD, 93.8% and 87.5% for DVD, 83.2% and 68.3% for TVD, and 89.3% and 84.6% for LMT disease.
This was the first large follow-up study of coronary artery disease in Japan. Its results suggest that the prognosis of Japanese patients with coronary artery disease is more favorable than that of patients in Western countries. In addition, the findings should provide a control data base for future studies in Japan and the West.抄録全体を表示PDF形式でダウンロード (677K) -
Ömer AKYOL, Orhan SENCAN, Süleyman BÜYÜKBERBER, Or ...1993 年 34 巻 5 号 p. 551-555
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーWe studied GSH-Px enzyme activity in serum after acute myocardial infarction (AMI) and unstable angina pectoris (UAP). The study included 15 patients with AMI and 9 patients with UAP. Serum GSH-Px activity in the AMI group (0.992±0.071) (IU/ml) was higher than that of the UAP group. Serum GSH-Px activity was established as 0.683±0.110 (IU/ml) in UAP and 1.012±0.121 (IU/ml) in 10 healthy subjects (p<0.0005). We suggest that measurement of serum GSH-Px activity together with other enzyme tests such as CK-MB, LDH, GOT, etc. can be helpful in the differentiation of AMI from UAP抄録全体を表示PDF形式でダウンロード (247K) -
A New Once-Daily Calcium Antagonist in Non-Hypertensive Patients with Coronary Artery DiseaseTakeshi OGAWA, Kazuhiko YASUI, Takuji TOMIZAWA, Yasuro SUGISHITA1993 年 34 巻 5 号 p. 557-565
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーTo analyze the effects of the treatment of 5mg amlodipine on blood pressure and heart rate with a 24-hour ambulatory blood pressure monitoring device and to evaluate its antiischemic efficacy using treadmill exercise testing, 7 non-hypertensive patients with coronary artery disease were studied.
The systolic and diastolic blood pressure and heart rate recorded over the entire day and during daytime did not change significantly after the treatment. On the other hand, the systolic blood pressure decreased significantly at night (122±19→113±17mmHg, p<0.05) after treatment, but the change can be considered to be within the physiological range. Exercise duration increased significantly after the administration of amlodipine (9.7±4.8→11.1±4.9min, p<0.05). Systolic blood pressure, heart rate and rate-pressure product decreased significantly and in addition, ST segment depression was significantly less marked (-0.25±0.09→-0.21±0.09mV, p<0.05) after treatment, when compared at the same level of work load.
Therefore, the new once-daily calcium antagonist amlodipine is safe and efficacious in non-hypertensive patients with coronary artery disease.抄録全体を表示PDF形式でダウンロード (496K) -
Sex-Related Differences in a Cardiovascular Study in the ElderlyEdoardo CASIGLIA, Paolo SPOLAORE, Giuliana GINOCCHIO, Massimo MARCHIOR ...1993 年 34 巻 5 号 p. 567-577
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーThe prognostic value of electrocardiographic abnormalities has not been widely studied in the elderly. We examined the Minnesota code ECG items in 2254 elderly subjects of the Cardiovascular Study in the Elderly (CASTEL), performed on an Italian general population. In our experience, codes for ischaemia, 1st-degree atrio-ventricular block, bundle branch blocks, myocardial infarction, atrial fibrillation or sinus tachycardia were predictors of overall mortality in females, while only the former three items were predictors in men. Although ischaemia, left bundle branch block and atrial fibrillation were pre-dictors of cardiovascular mortality in both sexes, right bundle branch block, supraventricular arrhythmias and left ventricular hypertrophy were predictors only in men, and 1st-degree atrio-ventricular block were predictors only in women. Surprisingly, left anterior haemiblock and bifascicular blocks were not predictive of mortality.抄録全体を表示PDF形式でダウンロード (643K) -
A New Algorithm for Doppler Echocardiographic StudyYu-cheng ZHU, Hong CHEN, Yong GU, Qing-yuang MIAO, Takashi OKI, Nobuo ...1993 年 34 巻 5 号 p. 579-590
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーTo evaluate left ventricular (LV) diastolic function and potential, LV filling curves for 18 patients with atrial fibrillation (Af) were constructed and their positions and appearance were evaluated quantitatively by analysis of 95% maximal filling volume points and maximal curvature alteration points. The LV filling curves of group A (Af only) lay left superiorly, while those of group B (impaired LV diastolic function) were situated right inferiorly, all bending steeply. The LV filling curves of group C (mitral stenosis) bent slightly. The lowest normal filling volume points and compensation areas were calculated to evaluate LV diastolic function and were demonstrated to be very different in groups A and B. The lowest normal filling volume points of group C were similar to those of group A, but compensation areas were smaller, indicating a lower LV diastolic potential. It is concluded that the 95% maximal filling volume point, maximal curvature alteration point, lowest normal filling volume point and compensation area are effective indices for evaluating not only LV diastolic function but also the diastolic potential.抄録全体を表示PDF形式でダウンロード (611K) -
Koichi NONODA, Tatsuaki MATSUBARA, Masaaki KANASHIRO, Osamu SUZUKI, Ma ...1993 年 34 巻 5 号 p. 591-599
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーThis study examined the effects of ischemia/reperfusion on cardiac func-tion and diabetes-associated lipid peroxidation and scavenger induction in isolated working hearts. Cardiac function in diabetic rats was depressed in proportion to the duration of diabetes. Plasma levels of malondialdehyde (MDA) were increased significantly after diabetes of 1-week duration (1wD). MDA levels in the myocardium were increased significantly after 4-weeks (4wD) and tissue superoxide dismutase (SOD) activity was also elevated significantly in 8-week diabetic rats (8wD) as compared to control values. In both controls and diabetics, tissue MDA concentrations increased significantly during the first 3min of reperfusion following 20min of ischemia, compared with preischemia levels. At the end of reperfusion, tissue MDA levels decreased in controls and 1wD hearts, but remained elevated in the 4wD and 8wD cases. The SOD activity in 8wD hearts decreased significantly after 20min of global ischemia followed by 30min reperfusion, compared with preischemia levels. By contrast, there were no significant differences between preischemic and after-reperfusion data for parameters of cardiac function in 8wD rats. Thus, lipid peroxidation appears to have little influence on cardiac function during ischemia/reperfusion in rats with chronic diabetes.抄録全体を表示PDF形式でダウンロード (545K) -
SimulationTaketoshi NAMBA, Miyako TAKAKI, Junichi ARAKI, Kazunari ISHIOKA, Takuj ...1993 年 34 巻 5 号 p. 601-616
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーMyocardial Ca2+ handling during excitation-contraction coupling has been modelled mathematically to gain a better insight into the expectation that Ca2+ sensitization of contractile machinery may save myocardial energy utiliza-tion for Ca2+ handling. The basic model of myocardial Ca2+ kinetics and mechanoenergetics involved the sarcoplasmic reticulum (SR), sarcoplasm, tro-ponin C (Tn) and crossbridges (CB). The relations among the released Ca2+ ions from the SR, peak concentrations of sarcoplasmic free Ca2+ ([Ca2+]i) and Ca2+-bound troponin ([TnCa]) and peak contractile force were computed, based upon the assumptions that the released Ca2+ ions diffuse as free Ca2+ in sarcoplasm, bind kinetically with Tn with an association rate constant of k1, dissociate from TnCa with a dissociation rate constant of k2, and are seques-tered into the SR with consumption of ATP. TnCa was associated with GB cycling to develop force with a set of given on and off rate constants. The association constant Ka (=k1/k2) of TnCa as an index of Ca2+ sensitivity of Tn was varied 32-fold from 0.25 to 8/μM. Results showed that Ca2+ sensitization from a lower Ka level could most sharply decrease the total Ca2+ release re-quired to develop the same contractile force. Thus, it would reduce the total Ca2+ handling energy that the SR uses to maintain the same contractility.抄録全体を表示PDF形式でダウンロード (962K) -
Effect of Diltiazem on the Diabetic HeartToshimi SHIMADA1993 年 34 巻 5 号 p. 617-626
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーSerial changes in myocardial parameters related to non-insulin-dependent diabetes mellitus were investigated in DDY mice (control), untreated KK mice, and KK mice treated with diltiazem (150μg/kg body weight, KKd1: or 300μg/kg body weight diltiazem, KKd2). The isozyme ratio of lactate dehy-drogenase (LDH) _??_(LDH1+LDH2)/(LDH4+LDH5)_??_ was used as an index of aerobic metabolism of myocardial tissue. Mean blood sugar levels did not vary between 5 weeks and 30 weeks of age, ranging from 108 (range 60-198)mg/dl in DDY mice to 170 (range 110-282)mg/dl in KK mice. The ratio of heart weight to body weight was larger in KK mice than in DDY mice at 20 weeks of age, but was unaffected by diltiazem treatment. The LDH isozyme ratio showed that DDY mice were in an aerobic state at 15 and 20 weeks of age, while KK mice were in an anaerobic state at 10 and 15 weeks of age. The KKd1 and KKd2 groups exhibited the same LDH isozyme ratios as untreated KK mice; diltiazem had no effect on the LDH isozyme ratio at 20 and 30 weeks of age. The mean diameter of myocytes was increased in KK mice but diltiazem had no effect on this parameter. Interstitial fibrotic changes appeared at 15 weeks in untreated KK mice and progressed with age. These changes were completely suppressed in KK mice treated with diltiazem. These results suggest that hyperglycemia induces an anaerobic state in heart muscle, leading to muscle hypertrophy, degeneration, and fibrosis and that calcium antagonists may suppress these pathological changes.抄録全体を表示PDF形式でダウンロード (1089K) -
Masashi HORIMOTO, Takashi TAKENAKA, Keiichi IGARASHI, Masafumi FUJIWAR ...1993 年 34 巻 5 号 p. 627-631
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーA 63-year-old man with an acute anterior myocardial infarction demon-strated an intracoronary nonocclusive thrombus distal to the organic stenosis of the left anterior descending coronary artery. One month after the infarction the thrombus was completely dissolved, and spontaneous and provoked spasm oc-curred overlying the organic stenosis of the coronary artery. Thus coronary spasm superimposed on the atherosclerotic stenosis was suggested as a cause of the thrombus formation that led to myocardial infarction.抄録全体を表示PDF形式でダウンロード (1247K) -
Makoto TAMURA, Hirotaka ODA, Tsutomu MIIDA, Hironori SATO, Norio HIGUM ...1993 年 34 巻 5 号 p. 633-637
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーWe describe a case in which the guide wire penetrated through the left anterior descending artery into the left ventricular cavity during percutaneous transluminal coronary angioplasty. This complication of coronary angioplasty which had not been previously reported was suspected because of the characteristic motion of the guide wire on the X-ray image and was confirmed by echocardiography.抄録全体を表示PDF形式でダウンロード (1160K) -
Case Report Presentation and Review of the Relevant LiteratureGeorge KOUVARAS, George TSAMIS, Antonios POLYDOROU1993 年 34 巻 5 号 p. 639-642
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーSpontaneous coronary artery dissection is a rare incident occurring usually in young patients, predominantly in females. It is usually fatal and found postmortem. We present the case of a middle aged man with spontaneous left anterior descending coronary artery dissection found angiographically which caused an anterior wall myocardial infarction. We also briefly review the relevant literature.抄録全体を表示PDF形式でダウンロード (657K) -
Suguru MATSUOKA, Yuri USHIROGUCHI, Masahiro KUBO, Katsunori TATARA, Te ...1993 年 34 巻 5 号 p. 643-651
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーBalloon pulmonary valvuloplasty was performed in 3 infants with severe tetralogy of Fallot at days 24, 54 and 86 because of progressive hypoxemia.
In two patients, the balloon catheter (4cm long, 5-8mm diameter) could not pass through the pulmonary valve. This necessitated a smaller balloon and required a two-step procedure. Initially, a coronary artery balloon (2cm long, 3.5mm diameter) was used. Following balloon valvuloplasty, arterial oxygen saturation increased from 63 to 83% in case 1, from 69 to 85% in case 2 and 63 to 86% in case 3. Immediate postvalvuloplasy right ventricular cineangiography revealed that the maximal opening diameter of the pulmonary valve leaflets increased from 1-2mm to 3-4mm in cases 1 and 3, and from 2-3mm to 4-5mm in case 2. No significant complications occurred. Echocardiographic follow-up data showed that the diameter of the right ventricular outflow tract and pulmonary arteries increased with age.
The present results show that the pulmonary valvuloplasty is an effective procedure for relief of pulmonary valve stenosis in tetralogy of Fallot and to improve oxygenation and growth of the pulmonary arteries and right ventricular outflow tract without the need of an immediate aortopulmonary shunt.抄録全体を表示PDF形式でダウンロード (1311K) -
A Middle-aged Case of Markedly Delayed DiagnosisAkiko MATSUMOTO, Masao NITTA, Akihiro NIWA, Hiroshi HOSODA, Toshizumi ...1993 年 34 巻 5 号 p. 653-659
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーA rare case of Williams syndrome diagnosed at the age of 41 is documented. The first subjective symptom was chest pain and the patient displayed many other features in addition to severe supravalvular aortic stenosis with a systolic gradient of 60mmHg. The stenotic lesion had an area of 0.5cm2, and was associated with dilated and tortuous coronary arteries. Extended aortoplasty was successfully performed and the postoperative course has been excellent without any cardiac symptoms. In spite of the severe cardiac lesions, this case had been largely asymptomatic and presented unusual features related to the diagnosis and management of this syndrome in an adult. The pattern of abnormalities found in this case suggested problems in relation to the calcitonin/calcitonin gene related peptide (CGRP) and the elastin gene occurring in embryonic organogenesis.抄録全体を表示PDF形式でダウンロード (1538K) -
Masataka SUMIYOSHI, Yasuro NAKATA, Teruhiko HISAOKA, Shunsuke OGURA, Y ...1993 年 34 巻 5 号 p. 661-666
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーWe report the case of a 42-year-old male who suffered from ventricular fibrillation (VF) without obvious QT prolongation. His electrocardiogram showed incomplete right bundle branch block (IRBBB) and persistent ST segment elevation in the right precordial leads during sinus rhythm. Cardiac catheterization revealed no overt heart disease except moderate endocardial and subendocardial fibrosis in the left ventricle. Mental stress seemed to trigger VF, and ST elevation became prominent just before VF. Propranolol and mexiletine have been effective in preventing VF for over 3 years.抄録全体を表示PDF形式でダウンロード (754K) -
Report of a Case and Review of the LiteratureKarin RETTMAR, Ulrich STIERLE, Abdolhamid SHEIKHZADEH, Karl Werner DIE ...1993 年 34 巻 5 号 p. 667-683
発行日: 1993年
公開日: 2008/12/09
ジャーナル フリーWe report on a 44-year-old male with primary cardiac angiosarcoma who died 11 months after onset of nonspecific symptoms (thoracic pain and general fatigue) of intracerebral metastases. A right atrial tumor mass and a pericardial effusion could be demonstrated by transthoracic and transesophageal echocardiography. Cardiac angiography showed a right atrial hemangioma, fed by the right coronary artery.
In a review of 108 cases of primary cardiac angiosarcoma we summarize clinical features, diagnostic means, therapeutic approaches and life expectancy of this rare disease.抄録全体を表示PDF形式でダウンロード (1837K)
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