The paper electrophoretic method to identify synthetic drugs difficult to separate by Stas-Otto method (antipyrine salicylate, theobromine and sodium salicylate, caffeine and sodium salicylate, caffeine and sodium benzoate, and pyrabital) and related compounds (barbital, phenobarbital, allobarbital, amobarbital, cyclobarbital, hexobarbital, antipyrine, aminopyrine, acetanilide, phenacetine, acetylsalicylic acid, caffeine, theophylline, and theobromine) was investigated by using M/30 Na
2HPO
4, 5N formic acid, 3% aqueous ammonia, 1% borax, and 10-fold diluted solution of Atkins-Pantin buffer (pH 10) as the electrolyte. The mobilities of the compounds were expressed relative to flavianic acid. It was found that synthetic drugs could be identified by using 3% aqueous ammonia and 5N formic acid as the electrolyte, and all related compounds, except acetanilide, phenacetine, and caffeine, could be separated and identified by selecting the above-mentioned electrolytes.
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