Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
17 巻, 2 号
選択された号の論文の5件中1~5を表示しています
Original
  • Ayaji Asami, Midori Nakamura, Mizuho Takeuchi, Akira Nakayama, Hiroshi ...
    2008 年 17 巻 2 号 p. 37-46
    発行日: 2008年
    公開日: 2008/10/08
    ジャーナル フリー
    To develop hydroxyapatite that promotes early cure of postoperative tissue, we heat-treated hydroxyapatite and evaluated its pH-increasing effect and Ca release. We also evaluated the effect of heat-treated hydroxyapatite on osteoblast differentiation. (1) No marked change was observed regarding the surface morphology or structure of heat-treated hydroxyapatite on SEM. (2) When hydroxyapatite was immersed in physiologic saline, the saline was made more alkaline by heat-treated than non-heat-treated hydroxyapatite. (3) When hydroxyapatite was immersed in physiologic saline, more Ca ions were released from heat-treated than non-heat-treated hydroxyapatite. (4) X-ray diffraction analysis showed a peak of CaO, which is considered to explain the Ca ion release, in heat-treated hydroxyapatite. (5) When osteoblasts were cultured with hydroxyapatite, heat-treated hydroxyapatite prevented the decrease in the number of alkaline phosphatase-positive osteoblasts in the presence of non-heat-treated hydroxyapatite. Thus, heat-treated hydroxyapatite was suggested to promote early cure of postoperative tissue. Detailed analysis of in vivo effects of heat-treated hydroxyapatite is anticipated to make its clinical application possible.
  • Noriyuki Nagai, Mika Okauchi, Andrea Rodriguez, Mehmet Gunduz, Hailong ...
    2008 年 17 巻 2 号 p. 47-54
    発行日: 2008年
    公開日: 2008/10/08
    ジャーナル フリー
    We developed a novel method for titanium coating material using modified thermal decomposition technique, specifically focusing on presence of CaTiO3 and carbon C. Two layers of thin film coating composed of CaTiO3-amorphous carbon compound (CaTiO3-aC) and hydroxyapatite (HA) were generated on titanium surface. In this method, ratios of Ca/P as well as Ca/Ti, sintering temperature and sintering velocity were carefully planned. Within crystal structure of CaTiO3 granules, 4 atomic % of carbon in amorphous state was included. By our method, inclusion of carbon in HA suggested formation of carbonate apatite. Regarding with attachment-detachment experiment at titanium surface, adhesion strength was 2.5 times stronger in CaTiO3-aC/HA coating substrate as compared to HA only coating material. Results of the novel developed modified thermal decomposition method suggested that the 2 layers biomaterial composed of CaTiO3-aC (0.6 μm) and carbonate apatite-included HA (2.4 μm) can be used as a coating material on titanium surface.
  • Qu Hong, Jun Tan, Rajani Koirala, Yi Lina, Takako Shimizu, Keisuke Nak ...
    2008 年 17 巻 2 号 p. 55-62
    発行日: 2008年
    公開日: 2008/10/08
    ジャーナル フリー
    The Bolton’s analysis and Pont’s analysis are very useful calculations for orthodontic diagnosis. In Nepal, there is no study about Bolton’s and Pont’s analysis. So here we examined 100 Nepalese subjects all subjects were with molar and canine class I relationship. We have measured the model to establish a normative standard of Bolton’s OR and AR for Nepalese population and to find the reliability of Pont’s index for Nepalese, and to comparing them between Caucasian and Chinese. The normative value on OR of Nepalese was found to be 91.22% with a standard deviation of 1.99 and AR was 78.04% with standard deviation of 2.72. The normative standard of OR for Nepalese is similar to that obtained by Bolton for Caucasian and that of Chinese, but the normative standard of AR obtained for Nepalese is significantly different than that obtained by Bolton for Caucasian and also that of Chinese. The correlation coefficient between the measured arch width values and the corresponding calculated values according to Pont’s indexes were low in all cases with r values ranging from 0.07 to 0.29. Pont’s Index is not reliable for predetermination of ideal arch width values for Nepalese.
  • Gul San Ara Sathi, Masae Fujii, Ryo Tamamura, Silvia Susana Borkosky, ...
    2008 年 17 巻 2 号 p. 63-68
    発行日: 2008年
    公開日: 2008/10/08
    ジャーナル フリー
    In histological examination of ameloblastoma, marked juxta-epithelial hyalinization of the connective tissue adjacent to the epithelium was observed in many cases. However, the physicochemical mechanism of these changes and its role in ameloblastoma is still not understood. To analyze the expression pattern of the different types of basement membrane related molecules, apoptosis-related factors and their possible role in juxta-epithelial hyalinization, six cases of ameloblastoma were examined. Immunohistochemical staining was done using cell surface type heparan sulfate (HS), 10E4, basement membrane type HS, JM403, Heparanase, Caspase-6, BCL-2 and CD34 antibodies. Hyalinized area in all sections, were strongly positive to 10E4, but negative to heparanase. There was no CD34 positive endothelial cells within the hyalinization area. Tumor cells adjacent to this area were positive to 10E4, heparanase and caspase-6. This result suggests that hyalinization have an effect on tumor growth and stop stromal-tumor cell interaction by the help of HSPGs, resulting in the inhibition of the function of heparanase and angiogenesis. Finally, tumor cells adjacent to the hyalinization undergoes program cell death.
  • Qu Hong, Tan Jun, Sambha Shrestha, Zhu Enxin, Tan bo, Takako Shimizu, ...
    2008 年 17 巻 2 号 p. 69-76
    発行日: 2008年
    公開日: 2008/10/08
    ジャーナル フリー
    Angle class III malocclusion are very hard to treat only by orthodontic method for most adults. So in this study we have measured The mesio-distal tooth size and arch length on the dental casts of total 39 pairs (17 Chinese, 22 Nepalese) of Angle class III malocclusion, Upper lateral incisor, upper canine and upper second premolar shows significant difference between Nepalese and Chinese (P=0.02, P=.01, P=.003). Lower teeth show no significant difference between Nepalese and Chinese. Among Nepalese male and female lower lateral incisors, second premolar molar show significant difference (P=0.035, P=0.032, P=0.049), second premolar shows significant difference between Nepalese male and female (P=0.020). Among Chinese male and female shows no significant difference between upper teeth while lower first molar shows significant difference (P=0.041, P=0.00). For Nepalese OR 90.42 and AR 78.76 while for Chinese OR 89.58 and AR 78.16. No significant difference between Chinese and Nepalese OR and AR. Upper arch length for Nepalese male and female having angle class III malocclusion are 79.5 and 77 respectively. Lower arch length for Nepalese male and female with Angle class III malocclusion are 73.8 and 69.25. Among Nepalese upper arch length between male and female (P<0.05) shows significant difference but no significant difference between male and female in lower arch length (P>0.05). For Nepalese male the space lack for upper jaw is 3.7mm and for lower jaw 6.6mm.
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