耳鼻と臨床
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
14 巻, 4 号
選択された号の論文の9件中1~9を表示しています
  • Gert Lange
    1968 年 14 巻 4 号 p. 217-227
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    末梢平衡器の感覚上皮における組織学的な変化は, 従来障害の記述と模写にもとついていたが, これでは今日も早充分とはいえない. 著者はこのたびOzothinが末梢平衡器に対しても, 蝸牛におけると同様にストレプトマイシンの毒性を減ずる作用があるかどうかを研究するにあたり, 光学顕微鏡下に変化した感覚細胞を算え上げて障害の率をパーセントで表わす方法をとった.
    モルモツト63匹について組織学的な検討を行なつた. 量的な決定は82個の上および外側半規管のクリスタを鏡検し, それぞれのクリスタについて100個の細胞を算出した.
    これらモルモツトの一部は対照群であり, 他は10~30日間の250mg/kgの水溶性硫酸ストレプトマイシンを筋注した. ストレプトマイシン処理した動物の半数は前もつて1.25ml/kg Ozothinを筋注した. また対照の一部はOzothinのみで処理された.
    末梢平衡器の機能を調べるために, モルモツトは温度検査を行なつた. 温度刺激によつて正常例では眼振が平均65打数となる. 眼振打数の減少を平衡機能低下の指標とした.
    温度検査は回転検査にくらべて眼振の解発がよくすぐれているが, 鼓膜が破れてしばしば中耳炎をおこすので系統的な経過観察はできず, ただ一回だけ断頭前に温度試験を行なつた.
    結果と考按
    1. ストレプトマイシン中毒後の前庭感覚細胞の障害の程度は, 障害された細胞を算出することにより組織学的標本の中に量的に確定することができた. この方法でストレプトマイシンの量の増加とともに, 段階的に中毒性変化の増加が認められた.
    2. 温度検査における興奮性は組織学的に認められる障害が増加するとそれに反して消失した. ストレプトマイシン注射30日後, モルモツトの半数は迷路反応が両側とも脱落した. しかしこの時点での毛細胞の変化は約50%で, 残余の毛細胞は何らの障害もみられなかつた. 前庭毛細胞においても, 蝸牛毛細胞の場合と同様に, 光学顕微鏡的にとらえうる変化がみられる前に正常の機能は失なわれるものと思われる.
    3. ストマイ中毒の場合まず第一にクリスタのI型感覚細胞が侵され, さらに大量の毒剤が与えられると基底細胞が部分的に破壊されるが, 支持組織の結合組織層は不変である.
    4. Ozothinは平衡器に対して蝸牛の場合と異なりストレプトマイシンに対する保護的な作用を示さなかった.
    5. このモルモツトの実験でも未公開の猿を用いた実験の結果からもメニエール病に対してストレプトマイシンとOzothinを一緒に与えれば平衡器だけ破壊することができるだろうという予想がたつ.
  • 河田 政一, 調 重昭, 豊田 弥八郎
    1968 年 14 巻 4 号 p. 228-236
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    These two years we have experienced 11 patients of Vogt-Koyanagi-Harada's syndrome in our clinic. The patients were examined neurotologically: tests of equilibrium, spontaneous and positional nystagmus, caloric test and so on.
    Vestibular functions of the patients suffering from this disease were as follows:
    1. In 10 of 11 patients we observed cochlear symptoms, such as tinnitus or sensorineural hearing impairment.
    2. In general subjective vestibular symptoms were rare among them. It may be due to good central compensation or to its smaller lesion.
    3. Objectively, in 8 patients we found some abnormalities of vestibular function in the course of the disease.
    4. We observed direction-fixed positional nystagmus in 6 patients ; directional preponderance in 3 and hypernystagmus by Hallpike's caloric test in 4.
    5. From the symptoms and the results of vestibular functional tests we came to the conclusion that the vestibular disfunction of the disease is more due to the disorder of otolithic organs than that of semicircular canals.
  • 中島 雅子, 調 重昭, 鳥居 浩, 安田 宏一, 磯矢 郁夫, 徳永 修
    1968 年 14 巻 4 号 p. 237-249
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    Discussion was made about 10 cases of paroxysmal postural vertigo and nystagmus. 7 of these cases were completely cured, while the others were restored from their subjective symptoms but not from their spontaneous and or positional nystagmus.
    Audiogram proved normal in 7 cases, but high-tone deafness in 2 cases and slight low-tone deafness in 1 case.
    Caloric test showed normal calorigram in 4 cases, canal paresis of one or both sides of the ear in 4 cases and directional preponderance in 2 cases. The 3 patients whose spontaneous and or positional nystagmus was not cured had organic diseases such as Raynaud's disease, Atlas-assimilation with cirvical rib and a whiplash injury. It was concluded that if the patient who had normal hearing was not suffering from an organic disease in central nervous system, neck or circulatory system, postural vertigo and nystagmus would be completely cured. Théraptique (N-N-Dibutyl-N-N-Dicarboxy -Morpholid-Ethylendiamin; stimulant of respiratory center) was the most effective agent in treatment.
  • 調 重昭, 安田 宏一
    1968 年 14 巻 4 号 p. 250-255
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    We reported the cases of migraine with cerebellar ataxia accompanied by vertical nystagmus to downward in a right lateral position. Usually we investigated the positional nystagmus by means of electronystagmography with the eye opened under Frenzel's glasses in the dark.
    Both cases are father and son aged 60 and 29, had an attack of a migraine and cerebellar ataxia in their middle ages. Similar symptoms and signs are proved in 5 persons among their family. We emphasized the clinical significance of vertical nystagmus in neurotological examinations, while the literature of such nystagmus findings is rare.
  • 沖縄ろう学校生徒208名の調査結果
    永渕 正昭
    1968 年 14 巻 4 号 p. 256-263
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    In 1967 the author investigated 208 children of Okinawa School for the Deaf with respect to the causes of deafness and audiometric aspects.
    Two hundred and eight children consisted of 107 boys and 101 girls aged from 6 to 18 years.
    Familiar deafness is an important pre-natal cause of deafness among them, and it was found in 41 families (22%). Consanguineous marriages of their parents amounted to 15 families (8%). There were three predominant diseases as post-natal causes of deafness, that is, febrile diseases suffered before the age of 2 years amounted to 38 children (18%), otitis media to 25 (12%) and measles to 24 (11.5%). One hundred and eighty-one children were subjected to hearing tests based on the standard audiometry. Hearing losses of the children were found to be more than 50 dB. Audiogram of the residual type was found in 90 children (50%) and total deafness Caudiogram of the scale-out type) in 19 (10.5%). In comparison with the hearing test results conducted in 1965, 46 children (25%) had progressive hearing impairments.
  • 本村 一彦, 末田 卓也, 松村 祐二郎
    1968 年 14 巻 4 号 p. 264-269
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    Two cases of antroepipharyngeal polyp and three cases of antromesopharyngeal polyp were reported. In each case, it was observed that the polyp originated in maxillary mucous membrane. As to treatment, it is suitable that the maxillary mucous membrane and ethmoid cells together with polyps should be removed. The X-ray examination making clear the contour of antroepipharyngeal polyp was helpful for diagnosis.
  • 荒川 雄司, 扇野 健一
    1968 年 14 巻 4 号 p. 270-274
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    Cases of primary multiple tumors are rare. A case of rare primary multiple cancers, in stomach and larynx was presented. The patient was 68 year old male who had been complaining of hoarseness in voice since August, 1964.
    Hyperkeratosis of both vocal cords was found on his first visit to our clinic in November, 1964. In May, 1965, he began to complain of distension feeling in the epigastrium, and the cardiac cancer (adenocarcinoma) was discovered in him by endoscopic examination.
    Gastrectomy was performed next month. The patient had not been conscious of anything wrong in the larynx ten months since the operation, until gradually his left vocal cord became ulcerated, but the movement of his vocal cords was fairly good.
    Squamous cell carcinoma was certified by the biopsy of the ulcerated tumor of his left vocal cord. Since the patient would not undergo an operation 60Co 4000 rads was irradiated to the laryngeal cancer twice, before and after the interval of three months. Unfortunately he died ten months after the radiation therapy.
  • 野村 和, 宮城 平, 川野 璋, 三橋 重信
    1968 年 14 巻 4 号 p. 275-278
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    The patient was male, aged 72. His cheif complaints were sore throat and swelling at the left submandibular region. The tumor was associated with metastasis and they were removed as one block. The tumor was approximately goose-egg in size, and was found to be cystic. No recurrence was noticed during two years after surgery.
  • 坂倉 光蔵, 犬山 征夫
    1968 年 14 巻 4 号 p. 279-283
    発行日: 1968/12/20
    公開日: 2013/05/10
    ジャーナル フリー
    40 patients were treated with Inteban (1-(p-Chlorobenzoil)-2- Methyl -5- Methoxy-Indole -3- Acetic Acid) and discussed the clinical effects of them. Most of the patients were cured in acute inflammatory diseases and have been asymptomatic, but not in chronic. Much better results were obtained in the subjects using together the another drugs, such as antibiotics, tranquilizer and protein resolving enzyme.
    Side effect was found in 2 patients, who complained the disturbance ofstomach.
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