巻号一覧
18 巻 (1972)
- 6 号 p. 371-
- 5 号 p. 293-
- 4 号 p. 221-
- 3 号 p. 151-
- 2 号 p. 75-
- 1 号 p. 1-
18 巻, 3 号
選択された号の論文の12件中1～12を表示しています
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その鼻悪性肉芽腫との接点について石井 善一郎, 佐藤 喜一, 山下 公一1972 年 18 巻 3 号 p. 151-154
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーNasal reticulum cell sarcoma, a pathological entity of so-called progressive gangrenous rhinopathy, has several pathologic characteristics as compared to usual reticulum cell sarcoma developed from the lymphatic system.
Four autopsy cases of the nasal reticum cell sarcoma generalized were characterized by less involvement of lymph nodes than the lymphatic reticulum cell sarcoma cases and were prone to the malignant histiocytosis. There are many biopsy cases of reticulum cell sarcoma of the nose associated with necrotizing angitis and/or necrophilic granuloma of unknown origin. These cases of amphoteric nature should be investigated more completely by various medical approaches.抄録全体を表示PDF形式でダウンロード (572K) -
特にWegener肉芽腫症について水越 鉄理1972 年 18 巻 3 号 p. 155-159
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーWegener's granulomatosis is an uncommon syndrome in which malignant granuloma-tosis in the upper respiratory tract occurs together with granulomatous and vascular lesions resembling those in polyarteritis nodosa. In this paper, clinical and pathological features based on clinico-pathological studies of our 2 autopsy cases and 54 autopsy cases selected from the Japanese literature were described and discussed. Considering from the clinico-pathological studies, the author agrees with Alarcon-Segovia and Brown's opinion (1964) that Wegener's granulomatosis may be pathologically considered in the middle entities in a continuous spectrum ranging from pure necrosis and granuloma formation (Loeffler's syndrome or eosinophilic granuloma) to pure angitis (PAN).抄録全体を表示PDF形式でダウンロード (645K) -
山口 宗彦, 北村 武, 石川 哮1972 年 18 巻 3 号 p. 160-164
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーSixty-eight cases of so-called necrotic rhinitis experienced in the Department of E. N. T. of the Chiba University were divided into 3 groups according Kitamura's classification, including typical Wegener's granulomatosis and reticulosarcoma of the nose. This classifi- cation was carried out according to history, clinical observations, microscopic findings of granuloma obtained by biopsy, immuno-pathological observation, autoptic findings and so on. Characteristic findings in each type were presented. It is speculated that the etiology of type I is immunopathological process provoked by wasting of local and systemic immune response. This pathological immune response is expressed by auto-antibody production. Besides, it is suspected that the etiology of type II may be a delayed allergic reaction by bacteria or pathological immune response provoked by auto-antigen, which may be a modified component in the infiltrated cells by prolonged unspecific inflammation.抄録全体を表示PDF形式でダウンロード (3380K) -
沢木 修二1972 年 18 巻 3 号 p. 165-169
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーFive cases of granululomatous lesions of the nose, observed at our clinic for past tweleve years, were examined autopsycally. Two of them had distant metastasis such as to the lung, kidney etc. One hundred and fourty-one cases, which chosen from the Japan Autopsy Records for the lastest thirteen years, were divided to the three groups, according to the autopsy diagnosis. Fifteen cases belong to reticulosarcoma type. Distant metastasis, such as to the lung, liver, kidney, were observed in 80% of them. Lymphnode metastasis to the cervical, paratracheal and retroperitoneal nodes were detected in 73%. Wegener's granuloma type, consists with 41 cases, had distant metastasis in 76%. However, it is the most prominent character that this group had no lymph node lesion except in two cases. Concerning malignant granuloma, the definition has been confused. Therefore it is con- sidered that the statistic observation of them has no reliable evidence. In general, both distant metastasis and lymph node metastasis are rare. As above mentioned, it is conclud- ed that so-called granulomatous lesions of the nose can be divided to three major groups from the standpoint of autopsy findings.抄録全体を表示PDF形式でダウンロード (633K) -
検査成績, 分類, 病原微生物について渡部 泰夫1972 年 18 巻 3 号 p. 170-175
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーLaboratory data of recently observed 6 cases at our clinic were reported. Of these patients, 2 patients were diagnosed as Wegener's granulomatosis, another 2 patients were suspected as Wegener's granulomatosis but the lesion was limited to the nose. Case 5 was treated as lethal midline granuloma. Eight years later, squamous cell carcinoma was proved in the lesion. Case 6 was diagnosed as Wegener's granulomatosis, but in the terminal stage, a biopsy of the necrotizing hard palate showed malignant tumor cells and diagnosed as reticulum cell sarcoma of the nose. The most remarkable data of examinations of these case 1 to 4 were decreased albumin-globulin ratio, increased serum fibrinogen, accelerated BSP, increased α 2-globulin and Ig and IgG, positive CRP and RA, and increased serum complement levels. Acid fast bacillus and EB-virus were not found remarkably in the nose. Some of reticulum cell sarcoma of the nose (Case 6) revealed the same laboratory results as shown in the patients of Wegener's granulomatosis. In using Walton's classification, following points should be remembered. Chemical studies of these diseases are important but they are not always diagnostic. Repeated biopsy of the lesions is imperative.抄録全体を表示PDF形式でダウンロード (821K) -
生検所見を中心として本多 芳男, 吉田 孝一1972 年 18 巻 3 号 p. 176-184
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーPathological studies of fifteen cases with necrotic granuloma of the nose revealed some unusual Endings in the visceral organs. In one case, Wegener's granuloma was suspected from a biopsy specimen, but pathological evidence of reticulosarcoma was shown from visceral organs with postmortem examinations. In another case, coexistence of reti- culosarcoma and periarteritis nodosa was shown in specimens both from the nose and the visceral organs.抄録全体を表示PDF形式でダウンロード (12230K) -
石井 哲夫1972 年 18 巻 3 号 p. 185-189
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーHistochemical studies were performed on the biopsied specimens from 5 patients with Wegener's granulomatosis and reticulum cell sarcoma. The activities of lactic dehydro-genase, acid phosphatase, and aminopeptidase were found to be more intense than the nasal mucosa without any significant disease. The activities of these enzymes in malignant granuloma were mainly located in the infiltrating cells and connective tissues. The little rise of activities of β-glucuronidase, N-acetyl-β-glucosaminidase was confirmed, whereas adenosine triphosphatase and alkaline phosphatase showed the similar activities to those of control specimen. Cholinesterase activity was not found in the tissue of granuloma. The serum level of these enzymes (lactic dehydrogenase, acid phosphatase and leucyl amino-peptidase) remained unchanged in malignant granuloma, though their activities were very intense in the tissues. The discrepancy of the enzyme activities between serum and tissues could be ascribed to the decreased permeability of blood vessels in granuloma. In this point, the malignant granuloma is different from the cancer and sarcoma.抄録全体を表示PDF形式でダウンロード (900K) -
佐々木 好久1972 年 18 巻 3 号 p. 190-196
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーAmong granulomatous gangrenous diseases arising in the nose there are Wegener's granulomatosis, reticulo-endothelial sarcoma and lethal midline granuloma (malignant granuloma, granuloma gangraenescens). But it is very difficult to differentiate each of these diseases though they are very different in their entities. Many efforts have been tried to elucidate and differentiate the entities of these diseases. We haven't gotten enough satisfactory success in this field yet. It is necessary to study not only the method of diagnosing each disease but also the reason for the complexity of these diseases. These diseases are very similar in nasal pathological and clinical aspects. In order to elucidate the reason of this complexity, an immunological research was carried out. Staphylococcus aureus was cultured after isolating it from the nose of patients and a precipitation reaction was observed between the solution of the bacteria and the patient's serum. Concentrated nasal discharge from the patient made the precipitation line for the patient's serum. And β -lipoprotein of serum from the patient or the normal human being formed the precipi-tation line for the nasal discharge from the patient.
Arthus phenomen between the bacterium and its antibody in the patient's serum and between β -lipoprotein of the serum and its antibody in the nasal discharge probably influences and modifies the patholgical and clinical feature of these diseases. Patients with lethal midline granuloma, reticulo-endothelial sarcoma in the nose had a high activity of plasmin in their serum. Patients with Wegener's granulomatosis had a slight increase of plasmin activity in their serum. These enzymological findings might be concerned with the localization of plasmin activator in the venules and the veins of the nasal mucosa. Cholinesterase activity in serum of all these patients decreased.抄録全体を表示PDF形式でダウンロード (1078K) -
血液レベルから見た病態とそのimmunologic profile形浦 昭克1972 年 18 巻 3 号 p. 197-204
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーThe author observed ten cases that involved five cases with Wegener's granuloma, two cases with midline granuloma and two cases with suspected Wegener's granuloma. Follow- ing points were discussed: 1) On serum protein observations, changes of serum hapto- globin as an acute phase reactant corresponded with various clinical stages. 2) On quantitative examination of plasma amino acids, it was an important factor that on these disease, tyrosine, phenylalanine and tryptophan which concerned with a collagen disease increased or decreased other than proline, crystine and arginine. 3) It was recognized that clinical stages were related to the increased fibrinolytic activity of blood. Especially the change of antiplasmin was important as a prodromal manifestation before the fibri- nolytic activity increased. The importance of the serological examination on clinical diagnosis of this disease was emphasized. The results of the immunologic response which the author was able to examine on these cases were also reported.抄録全体を表示PDF形式でダウンロード (956K) -
古内 一郎1972 年 18 巻 3 号 p. 205-210
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーWegener's type granulomatosis belongs to so-called “auto-immunity disease”. A special study of cellular immunity on the etiology of Wegener's type granulomatosis was performed.
The patient was administrated orally with Imuran 100-150 mg per day for six months. It was found that the condition of the patient improved objectively and subjectively after the administration of Imuran. Clinical findings after the treatment by Imuran revealed the disappearance of granulation tissue and crust in the nasal cavity. Laboratory exami- nation of the patient showed the following results; Tuberculin-, candida-, and mucor antigen test of the skin of the patient showed weaker reaction after the treatment. The number of leucocytes and small lymphocytes-ratio in the blood showed gradual decrease. Homo-skingraft to the patient after the treatment did not show rejective reaction. Par-centage of blastlike cell transformation of small lymphocytes after the incubation with phytohemoagulutinin showed gradual decrease.
Clinical and laboratory findings of the patient showed parallel improvement. Further study on cellular immunity will be necessary for the treatment of auto-immunity disease.抄録全体を表示PDF形式でダウンロード (10769K) -
陌間 啓芳1972 年 18 巻 3 号 p. 211-217
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーPDF形式でダウンロード (2311K) -
広戸 幾一郎, 白基 佑, 松村 祐二郎, 三橋 重信1972 年 18 巻 3 号 p. 218-220
発行日: 1972年
公開日: 2013/05/10
ジャーナル フリーPDF形式でダウンロード (347K)
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