In order to research for the role of γ-globulin, the experiment was attemped. After the last of series of Bovine γ-globulin (BGG) injected into the experimental aseptic abscess, the amount of
125I labeled BGG in organs of the sensitized rabbit was counted. The amount of
125I-extracted γ-globulin from the experimental abscess injected with streptococcus was mesuremented as the method of the sensitized rabbit with BGG. The research of the sensitized rabbit with BGG revealed that the amount of
125I-BGG taken up was the highest in the lung, followed by the spleen, the liver, the tonsil, the renal and the heart, in that order. This result showed that the spleen, the liver, the tonsil and the lung had the higher ability of antibody formation or antibody possession. The antibody lever in the above organs was lower following intravenous injection with extracted γ-globulin from the experimental abscess than BGG injection. However, from this observation, the close relationship between BGG and the extracted γ-globulin had the antigenic ability. By means of autoradiography, it was revealed that antigen in tonsil adhered to the surface of the lymphoid cell in the subepithelial area and in the circumference of lymphnodules. In lung, antigen was involved in the fibrinoid degeneration of the thrombosis. In renal, antigen was seen in the basement membrane and the epithelial cell of the renal tubules. In spleen, antigen adhered to the surface of the small lymphoid cells in the outerzone of the lymphnodules and in the red pulp. This autoradiographic studies showed the part of antibody existence and found the Place of the antigen antibody reaction in the tissue or the cell, specially in tonsil characteristic sight. These findings suggested that the role of γ-globulin had the most important significance for the focal infection.
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