We devised an apparatus utilizing the principle of a gyroscope to record head rota-tions in the vertical plane without mechanical restraint. However, the electro-oculographic (EOG) recording of vertical eye movements has several sources of error such as the presence of overshoot artifacts and the nonlinearity of the records. Those problems were not necessarily solved by letting the subject hold his upper eyelid with his own finger and recording EOG from an infraorbital electrode only. Thus, considerable further thought on eye movement measurements would be needed for analyzing the eye-head coordination in the vertical plane.

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We have studied the associated abnormal movement of the stapedial muscle as a part of the synkinesis which appeared during the course of recovery from the peripheral facial nerve palsy. The stapedial muscle movement was recorded by the impedance audiometer. Among the 15 patients, who were examined on 1 to 12 months after the onset of facial palsy, 30% of them showed abnormal associated movement of the stapedial muscle. However, none of them complained the tinnitus which was described for the first time by Watanabe et al. From this result, it was considered that not only the associated abnormal movement of the stapedial muscle but also some other factors might take part in the occurence of the stapedial tinnitus.

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Functional and morphological changes of the cochlea induced by the white noise of 100 dB SPL were studied using auditory brain-stem response (ABR) and scanning electron microscopy (SEM) in guinea pigs. Twenty guinea pigs with normal Preyer's reflex, weighing about 300g were used for this investigation. They were exposed to white noise of 100 dB SPL for one hour in six (Group A), three hours in six (Group B) and five hours in eight (Group C) experimental animals. ABR and SEM were performed just after and one week after the noise exposure.
A slight and temporary prolongation of the latency of AP (N₁) was detected but no morphological changes were observed in Group A. A moderate prolongation of the latency and swelling of supporting cells were observed but these changes returned to the preexposure condition in Group B. Severe and irreversible prolongation of the latency or no response were detected and marked disturbances of surface ultrastructure of hair cells (especially outer hair cells) were observed in the lower half of the third turn in Group C.
The power spectrum analysis of the noise revealed many echos of various cycles and morphological changes of hair cells were most remarkable in the region corresponded to the peaks of these spectra.

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To examine the effects of labyrinthine disorders eye-head coordination, the lateral gaze tests and the alternate side-to-side gaze tests were performed on ll patients with acute unilateral labyrinthine lesions and five patients with bilateral labyrinthine lesions. The lateral gaze tests were also performed under the condition when a target disappeared during head movement (target flash mode). The patients were examined within 13 days after the onset of the disease in cases of unilateral lesions, and one to nine months in cases of bilateral lesions.
1. In the lateral gaze tests, 10 patients with unilateral lesions and all the patients with bilateral lesions showed abnormal gaze recordings in which the ratio of peak compensatory eye velocity to peak head velocity (VOR gain) was less than 1.0. Abnormal responses were divided into an overshoot type and a rounding type, whether the gaze overshot the target angle or not. The abnormalities were found on gazing toward the involved side in unilateral lesion cases and toward the right and left sides in bilateral lesion Cases.
2 The appearance rates of abnormal responses, especially in overshoot type, were remarkably higher in the target flash mode of the lateral gaze tests and the alternate side-to-side gaze tests than in the continuously illuminated target mode of the lateral gaze tests. However, in unilateral lesions, abnormal responses appeared markedly more frequently on gazing toward the involved side than the intact side.
3 The normal and abnormal responses at 40°-lateral gaze in a patient with unilateral lesion and a patient with bilateral lesions were analyzed for VOR gain, peak head velocities, amplitudes of initial saccades and gaze deviations at the ends of initial saccades. While normal responses were mostly found at relatively slow head velocities, abnormal responses appeared as the head velocity was large. The head velocity of the overshoot type tended to be larger than that of the rounding type. The amplitudes of initial saccades on gazing toward the involved side in unilateral lesions and on gazing toward the right and left sides in bilateral lesions were definitely smaller than those on gazing toward the intact side in unilateral lesions as well as normal subjects. This indicates that a recalibration of saccades to make the amplitude of initial saccades smaller than the target angle occurs as a compensatory process in labyrinthine lesions.
4. In most of the unilateral lesions, abnormal responses disappeared within six months in any test condition. However, abnormal responses were still frequently found in bilateral lesions even six months after the onset of the disease. Those results indicate the difficulty of compensation in bilateral lesions.

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Nobody can deny that lubrication is one of the factors which influence the phonetic function of the larynx. However, no notable studies on the mechanism of lubrication have ever been carried out. This study is an effort to clarify how the larynx is lubricated.
The first experiments have been carried out in order to observe the mode of the secretive flow the tracheal and subglottic spaces. As the results of the experiments, the secretive fluid on the trachea traveled toward the vocal folds without phonation. And then, at the instance of phonation, the secretive fluid left immediately the subglottic area and appeared in the slit of the vocal folds.
The second, the mode of secretive flow was experimentally examined on the vocal folds during phonation. The second experiments indicated that the secretive fluid on the surface of vocal folds was rotating perpendicularilly to the free edge of the folds.
The third experiments of the amount of secretive fluid and its quality were also performed. Phonodynamic examinations including subglottic pressure and sound intensity were carried out in addition to acoustical analysis of the sounds. Results obtained in these experiments were discussed and analyzed from the viewpoint of phonodynamics.

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This study has been carried out in order to clarify the mechanism of wound healing of the vocal folds which vibrates very frequently during phonation. The wound was artificially made in the superficial layer of lamina propria of the canine vocal fold. The wound was uniformly obtained by use of a specially designed device. The vocal fold injured was studied biochemically, phonodynamically and histologically.
The first, the author has succeeded in improvement of the method for estimation of hydroxyproline which is said to be one of healing indexes.
The second, by use of the method mentioned above, the author performed experimental studies and obtained the results as follows.
1) The value of hydroxyproline increased and was saturated in 2 weeks after the wound injury.
2) The epithelium was almost regenerated in two weeks and fibrosis in the submucous layer was found in 3 weeks.
3) The excellent vibratory pattern was obtained after two weeks. From the results obtained, the author concludes that for the wound mentioned above, the whole course of the wound healing in the vocal fold is established between two and three weeks.

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The optimal dose of Flunisolide Nasal Spray in terms of clinical efficacy and safety in allergic rhinitis was determined at 16 institutions.
Flunisolide Nasal Spray was administered in doses of 50μg/day, 100μg/day and 200μg/day. The patients on 50μg/day received the test drug once a day (one spray to each nostril) either in the morning or evening. The patients on 100μg/day and 200μg/day received the test drug twice a day (1 or 2 sprays to each nostril) in the morning and evening. The duration of treatmnt was 2 weeks. Prior to the treatment, a 1-week observation period was set.
As a result, no significant difference was observed in efficacy for the different times of administration in the 50μg/day group. The percent improvement (improved or better) in the 50μg/day group, 100μg/day group and 200μg/day group was 48.9%, 79.7% and 79.0% respectively, indicating no significant difference in efficacy between the 100μg/day group and 200μg/day group. There was no significant difference between the treatment groups in the incidence of side effects, changes in serum cortisol levels and general clinical laboratory values.
Based on these results, it was concluded that the optimal dose of Flunisolide Nasal Spray in allergic perennial rhinitis was 1-2 sprays to each nostril twice a day.

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