耳鼻と臨床
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
33 巻, 6 号
選択された号の論文の15件中1~15を表示しています
  • 佐藤 公輝, 末永 通, 田中 克彦
    1987 年 33 巻 6 号 p. 943-946
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    The head and neck region is a common location for schwannoma to occur. In the last 10 years, 18 cases of schwannoma of the head and neck were seen in Hokkaido University Hospital. The age of patients ranged from 14 to 70, 39.4 on average, and there was no sex predominance. In our study, the tumor was seen most often in the lateral neck. Painless mass was the chief complaint in more than half of patients. The nerve of origin could be detected in 8 cases, based on surgical findings and postoperative symptoms. Of these, 4 were found to have arisen from the vagal nerve. Cyst formation, which is often found in Antoni B type, is not an unusual feature of schwannoma. It was possible to detect these lesions in CT scan and echogram.
  • 1986年に行われたロックコンサートより
    戸田 行雄, 吉野 清美, 中島 博昭, 岡田 智幸, 佐藤 成樹, 岩武 博也, 佐久間 惇, 五島 久子, 渡来 潤次, 吉川 由絵, ...
    1987 年 33 巻 6 号 p. 947-952
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    18 young adults were divided into 3 groups of 6 subjects each and investigated as to their hearing level before and after exposure to loud sounds at a rock concert. The first group sat in a near front row, the second group sat in a middle front row and the third group sat in a middle row. A threshold shift in 4KHz was great and it ranged 60 dB at the maximum, while threshold shifts in 8 KHz and 1 KHz were rather moderate and ranged within 25 dB at the maximum. A threshold shift more than 10 dB in 4 KHz was observed in 35 out of 36 ears at the time of just after exposure to loud sounds, and in 18 out of 26 ears two hours after exposure. The shift was still observed in 6 ears the next day, but all recovered second day after the concert. The threshold shift in 8 KHz and 1 KHz was within the level of 15 dB 1 hour after exposure to loud sounds. For the second part of the investigation, the music was recorded 23 meters from bilateral speakers and sound level and octave band analysis was performed. Sound level was 95-110 dB (A). In octave band analysis, high energy was observed in middle frequencies, and Leq was 102 dB. Three dimensional display showed a chronologically same pattern in each octave band. Leq values at 14 different places of concert hall were all in high levels of more than 102 dB.
  • 戸田 行雄, 吉野 清美, 岩武 博也, 堤 康一朗, 渡来 潤次, 大竹 英夫, 竹山 勇
    1987 年 33 巻 6 号 p. 953-957
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    In a survey of about eight hundred junior high school students in Kawasaki, twenty one of them were found to listen to music through headphones at loud volumes for more than five hours a week. The preferred listening levels through headphones, and hearing acuity were compared for eighteen of these 21 students. The mean listening volumes for popular and rock music for these 18 students in an ordinary room were 83 dB (A) and 85dB (A), respectively. For many of these students, a significant portion of their listening hours was done while commuting on trains. To examine if the background noise had any effect on the listening volumes, the sound environment of a train was simulated by playback of noise recorded from inside a train. The mean levels at which the subjects listened to music with this background were 89 dB (A) and 90dB (A) for pop and rock music. Although the overall listening levels were significantly higher when in the noisier environment, the increase in listening volumes was lower for those subjects who preferred to listen to music at higher sound levels in the ordinary room. It was concluded that there were no significant abnormalities in hearing acuity in the eighteen junior high school students who have listened to music through headphones at mean sound levels of 85 dB (A) in an ordinary room, 90 dB (A) in a train sound environment for a period of one to five years.
  • 吉田 昭男, 佐藤 祐司, 川原 英之
    1987 年 33 巻 6 号 p. 958-962
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    Two cases of thyroid carcinoma infiltrating the tracheal lumen were reported. The first case, a 62 years old female, underwent right hemithyroidectomy and left subtotal thyroidectomy followed by tracheal resection from 2 nd. to 6 th. tracheal rings and tracheal reconstruction after performing laryngeal release. Histological examination revealed follicular carcinoma. She was discharged and showed no recurrence 18 months postoperatively. The second case, a 54 years old female, was operated on left hemithyroidectomy and right subtotal thyroidectomy combined with total laryngectomy due to an invasion to cricoid cartilge. Histological examination showed papillary carcinoma. She was discharged without any complication and has been doing well 14 months postoperatively.
  • 低悪性癌と高悪性癌の比較を中心として
    原口 茂徳, 村上 泰, 猪狩 武詔, 岡田 康司, 丸山 毅, 舘野 秀樹, 藤村 昭子, 浦尾 弥須子, 中山 尚樹
    1987 年 33 巻 6 号 p. 963-968
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    We studied clinical manifestations of 131 benign and 39 malignant parotid epithelial tumors; among 39 malignant tumors, 29 cases were histopatholigically high grade malignant cases and 10 cases were low grade malignant cases. Fixation, local pain, rapid growth of the tumor, cervical lymph node swelling, and facial palsy were more predominant in malignant tumors group (71%, 31%, 46%, 26%, 30%) than in benign tumors group (7%, 2%, 13%, 4%, 0%). High grade malignant group showed fixation, rapid growth of the tumor, and facial palsy more frequently (86%, 55%, 40%) than low grade malignancies (30%, 20%, 0%). The prognosis was poor in the malignant cases with fixation of the tumor and/or facial palsy.
  • ヒスタグロビン注射による
    小島 未知郎, 占部 成二, 宮崎 充
    1987 年 33 巻 6 号 p. 969-972
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    We evaluated the prophylactic efficacy of Histaglobin injection therapy for patients with Japanese Cedar pollinosis. The effective rates were 86.7% in the prophylactic treatment group (15 cases) and 78.6% in the post-symptomatic treatment group (42 cases). There was no statistically significant difference between two groups. Four cases in the prophylactic treatment group who had been injected since January showed no signs through the pollen season. The prophylactic method of Histaglobin injection was considered to be an available therapy for patients with Japanese Cedar pollinosis.
  • 山本 英一, 山本 久美子
    1987 年 33 巻 6 号 p. 973-976
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    A simple prosthetic palate made of dental materials was used to keep the functions swallowing and speech and to keep the wound clear in three radical maxillectomy and orbital removal patients. In spite of the poor prognosis of the disease, this method has merit because patients were able to communicate with family members when they were temporarily discharged from hospital.
  • 新里 祐一, 中島 格, 上村 卓也
    1987 年 33 巻 6 号 p. 977-982
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    Two cases of Küttner's disease are reported. Histologic examination of the submandibular gland tumors removed from a 67-year-old male and a 62-year-old male revealed the characteristic features of so-called Küttner's disease including periglandular lymphocyte infiltration and fibrinoid deposition. In this study, attention was paid to the secretory activity of glandular tissues using immunoenzymatic (PAP) technique. In the normal submandibular gland, lactoferrin (LF) and secretory component (SC) were actively produced in both glandular acini and ductules. In glandular tissues of Ktittner's disease, in which the acinal structures were damaged by lymphocyte infiltration, Lf and SC producing activity were decreased. Synthesis of Lf and SC was almost completely damaged in glandular ductules surrounded by fibrinoid structure deposits. Loss of secretory activity in glandular tissues suggests the decrease or absense of local immune system in the submandibular gland of Küittner's disease.
  • 今野 昭義, 花沢 秀, 岡本 美孝, 寺田 修久, 石川 和夫, 戸川 清
    1987 年 33 巻 6 号 p. 983-987
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    The results of planned combination therapy in 31 cases of stage II-IV mesopharyngeal cancer in the past 15 years were reviewed. The combination therapy consisted of intravenous chemotherapy using 5-fluorouracil (250mg×18), Linac Xray irradiation (2Gy×30) followed by sufficiently extensive resection and primary reconstruction. The 5 year survival rate (Kaplan -Meiner method) in stage II (N=2) was 100%, stage III (N=16) was 82% and stage IV (N=13) was 12%. The overall 5 year survival rate was 53%. Local recurrence was observed in only one case. The most frequent cause of treatment failure was distant metastasis, seen in 67% of those who died within 5 years. To improve the results of therapy in stage IV, furthur combination of chemotherapy consisting chiefly of CDDP and immunotherapy is assumed necessary.
  • 田中 寿一, 犬山 征夫, 藤井 正人, 高岡 哲郎, 細田 兵之助, 川浦 光弘
    1987 年 33 巻 6 号 p. 988-993
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    It has been reported that the combination therapy of 5-FU and radiation is more effective than radiation therapy alone in the treatment of head and neck cancer. This fact probably results from the increased sensitivity of cancer cells to radiation when given in conjunction with administration of 5-FU. UFT is an anticancer agent which is mixture of futraful and uracil in a molar ratio of 1: 4. UFT showed a higher response rate than 5-FU alone in the treatment of head and neck cancer. 5-FU concentration increases markedly in cancer tissue but remains at a low level in blood. Therefore, the combination of UFT and radiation is expected to show a higher response rate than the combination of 5-FU and radiation, because the efficacy of radiation against cancer tissue is thought to be further enhanced in tissues which contain high concentrations of 5-FU. In order to test the effectiveness of the combination of UFT and radiation, an experimental study was designed by using C57BL mice and YM12 fibrosarcoma. 5-FU and UFT were administered orally for twelve consecutive days and radiation was given for five consecutive days concomitantly. Results obtained are as follows: 1) the combination therapy of 5-FU and radiation was more effective than radiation therapy alone on YM12 fibrosarcoma but it did not reach statistical significance, 2) there was a statistically significant increase in efficacy of the combination therapy of UFT and radiation as opposed to radiation therapy alone or 5-FU plus radiation therapy, 3) no toxic effects were seen in the mice, and 4) the concentration of 5-FU in the tumor tissue was extremely higher in the UFT group than in 5-FU group. This result may explain the higher response to the tumor in the combination of UFT and radiation than in the 5-FU and radiation treatment.
  • 荻野 仁, 松永 亨, 玉置 弘光, 三好 敏之, 吉田 淳一, 川寄 良明, 古川 善英, 奥村 新一, 土井 勝美, 杉本 和彦, 大川 ...
    1987 年 33 巻 6 号 p. 994-1000
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
    Ofloxacin is a new oral antibacterial agent of pyridonecarboxylic acid, and has broad and strong antibacterial activity. Clinical trial on patients with otorhinolaryngological infections are reported below. Patients enrolled in this study were grouped in the following manner, Chronic otitis media: 36, chronic sinusitis: 14, acute lacunar tonisillitis: 11, and other: 11. Ofloxacin was administered three times a day for a daily dose of 600 mg. Concomitant administration of other antibacterial agents and antiiflammatories was prohibited. The doctors evaluated clinical effect on patients given ofloxacin for more than three days as either excellent, effective, slightly effective, or ineffective. Efficacy of ofloxacin was rated by patients as either effective or excellent. One patient with chronic otitis media was excluded from the efficacy analysis bacause sufficient dosing was impossible, due to side effects. Clinical effectiveness was excellent in 11, effective in 47, slightly effective in 11 and ineffective in 2. Clinical efficacy by disease was 77.1% for chronic otitis media, 85.7% for chronic sinusitis, 81.8% for acute lacunar tonsillitis. Overall clinical efficacy was 81.7%. Side effects of nausea and vomiting occurred in one patient, but these symptoms disappeared after ofloxacin dosing was discontinued. The occurence rate of side effects was 1.4%. Laboratory examinations, including a hepatic function test, were performed on 9 patients and no abnormalities were noted. Since the clinical efficacy rate of ofloxacin was as high as 81.7% and there were no problems in safety, it was concluded that ofloxacin is a useful drug for treating otorhinolaryngological infections.
  • 調 賢哉
    1987 年 33 巻 6 号 p. 1001-1003
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
  • 黒田 勲
    1987 年 33 巻 6 号 p. 1005-1009
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
  • -脳循環代謝改善薬, 抗血小板薬を中心として-
    飯野 耕三
    1987 年 33 巻 6 号 p. 1010-1016
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
  • 岡村 靖
    1987 年 33 巻 6 号 p. 1017-1028
    発行日: 1987/11/20
    公開日: 2013/05/10
    ジャーナル フリー
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