耳鼻と臨床
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
34 巻, 2Supplement2 号
選択された号の論文の29件中1~29を表示しています
  • レーザードップラー法による測定
    田中 克彦, 佐藤 信清, 寺倉 直明, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 565-568
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The cochlear blood flow was studied in guinea pigs with a laser Doppler flowmeter (Laserflo, TSI Co., U. S. A.). The present study revealed that the signals obtained by a probe applied on the bony wall of the cochlea were stable and sensitive enough to detect minute changes of the blood flow in the lateral wall of the cochlea. However, the signals were readily influenced by external vibrations or by oozing of blood around the tip of the probe, but neither ambient light nor respiratory movement of a respirator affected the measurement. Inhalation of CO2 gas caused simultaneous increase of both blood pressure and cochlear blood flow, the magnitude of which reaching 200%. Based on our pilot study, the laser Doppler flowmeter was deemed as a powerful tool for the study of the microcirculation in the cochlea.
  • 松島 純一, 高橋 国広, 伊福部 達, 熊谷 雅彦, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 569-574
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Three types of stimulating electrodes for the cochlear implant, e. g., tungsten, silver and platinum-iridium, were evaluated by means of neurophysiological methods. Of these, tungsten electrode was most rigid but was not suitable since this was less efficient in stimulating the cochlea. As regards the threshold of the compound AP recorded by glass micropipette in the cochlear nerve, there was no significant differences between silver and platinum-iridium electrodes. However, silver electrode was found easier in controling the stimulating current. Based on these results, the silver electrode was considered as the most suitable one for the cochlear implant.
  • 松浦 聖一, 福田 諭, 土田 伸子, 田中 克彦, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 575-579
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The anatomical relationship between superior cervical ganglion (SCG) and adrenergic nerve fibers in the inner ear has been well established. However, there are no available data which studied such relationship by means of tracer injection method. In this study, horseradish peroxidase (HRP) was injected into the scala tympani of guinea pig cochleas and superior cervical ganglia were examined by light microscopy. Seventy two hours after the injection, sporadic distribution of HRP-positive ganglion cells were found in the ipsilateral SCG but not in contralateral SCG, thereby confirming the fiber connection between SCG and ipsilateral cochlea.
  • 大橋 正實, 小成 祐子, 寺山 吉彦, 後藤 みずほ, 田中 克彦
    1988 年 34 巻 2Supplement2 号 p. 580-584
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Thirty three ears (29 cases) of conductive and mixed deafness without perforation of the ear drum were examined by impedance audiometry (tympanogram-TG, stapedial reflex-SR) and their results were compared with surgical findings and audiograms. These ears were classified into 4 groups according to surgical findings; Group 1 (N-9): complete disruption of the ossicular chain, Group 2 (N=8): ossicular chain maintained by fibrous strand, Groups 3 (N=14): fixation of the ossicular chain, and Group 4 (N=4): others. Then, the results of the audiological examinations were compared in respective groups and following conclusions were drawn; 1. Type of the ossicular chain abnormality cannot be assessed by the degree of A-B gap. 2.“Stiffness curve” is suggestive of stiffness of the chain. 3. TG cannot distinguish Group 1 and 2 but positive SR in whole frequency range indicates possibility of Group 2.4. Type A and Ad TG may be found in Group 3. However, these could be differentiated by appearance of the drum as well as by gradient coefficient ranging from 25 to 75mm H2O. 5. SR does not differentiate conductive and perceptive deafness but positive SR in both ipsilateral and contralateral ears suggests perceptive deafness.
  • 佐藤 信清, 大橋 正實, 土田 伸子, 古田 康, 依田 明治, 小成 祐子
    1988 年 34 巻 2Supplement2 号 p. 585-591
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Auditory evoked responses (ABR, MLR, SVR) were recorded in 6 children with severe brain damage. These patients showed abnormal responses in MLR and SVR, while normal responses in ABR. Some cases improved in responses during follow up period. Severe cortical lesions with atrophy and normal brain stem were documented by CT scan in patients except 1 case with normal CT. In 2 cases, the atrophy was very severe especially in unilateral hemisphere, but there was no significant differences between the sides on responses in MLR and SVR. In such a patient with brain damage, there are various patterns in auditory evoked responses, it is difficult to suppose the auditory origin of the wave in MLR and SVR only by CT scan and responses. We concluded that combinded auditory evoked responses were useful to diagnose auditory injuries of children with brain damage and accurate diagnosis gave benefits on the rehabilitation and development of such a children.
  • N1latency, -SP/AP比と予後との関連
    依田 明治, 大橋 正實, 佐藤 信清, 土田 伸子, 古田 康, 小成 祐子
    1988 年 34 巻 2Supplement2 号 p. 592-594
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    EcochG was recorded in 61 patients of sudden deafness in order to evaluate the prognosis of this disease. Our results showed that there was no significant difference in N1 latency and-SP/AP ratio between the patients with good recovery and those with poor prognosis. It is thus suggested that EcochG alone is insufficient to determine the prognosis of this disease. It appears that the prognosis of sudden deafness needs to be evaluated based on various factors such as period from onset to admission, mean hearing level at admission, hearing pattern, with or without vertigo.
  • 原田 千洋, 松島 純一, 熊谷 雅彦, 酒井 昇
    1988 年 34 巻 2Supplement2 号 p. 595-599
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The findings of MRI and CT were comparaed for acoustic tumors in 9 patients examined in our department from July 1985 to May 1986. In all of the 9 patients MRI showed the nerve bundle in the internal auditory meatus continuing into the tumor mass. In addition, the nerve bundle on the tumor free side could be viewed in 5 patients. MRI is superior to CT in the diagnosis of the intracanalicular tumors. MRI, as a safe and non-invasive method, should be the first diagnostic test in acoustic tumors suspected patients. In our opinion air CT, as a highly invasive method, should be the second choice in diagnosis.
  • 松島 純一, 熊谷 雅彦, 原田 千洋, 間口 四郎, 酒井 昇
    1988 年 34 巻 2Supplement2 号 p. 600-603
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The psychological factors influencing patients suffering from dizziness and vertigo for more than 3 months were tested by Cornell Medical Index and Self-Rating Questionnaire for Depression. In 33 patients, past histories of head and neck accidents were noted in 21%, peptic ulcers in 15% and hypotension in 15%. A depressive propensity was noted in 30% of the patients, while CMI type III and IV were noted in 58%. Patients with CMI type IV and an SRQ-D score higher than 16 accounted for 21% of the total. These results show that psychological factors may strongly influence patients suffering from dizziness and vertigo for more than 3 months.
  • 熊谷 雅彦, 松島 純一, 原田 千洋, 佐藤 公輝, 間口 四郎
    1988 年 34 巻 2Supplement2 号 p. 604-608
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The area, the length and the frequency analysis of the movement of the gravity center were examined during standing erect with eyes open, eyes closed and eyes open in the dark. In comparison with normal subjects, increases of the area and the length were observed in patients with peripheral vestibular disorders having nystagmus under the condition of eyes closed and eyes open in the dark, while no difference was obtained in patients with cerebello-pontine angle tumor. Characteristic changes in each frequency band were observed in patients with peripheral vestibular disorders having or not having nystagmus and in patients with cerebello-pontine angle tumor. These results are considered to be usable to establish a different diagnosis for each disease.
  • 予後に関する検討
    吉鶴 博生, 佐藤 信清, 土田 伸子, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 609-614
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The incidence of sensorineural hearing loss in the patients treated with hemodialysis is well known. Several cases of acute profound deafness in those patients have been reported in the literature. In this report, we added 2 cases of acute profound deafness in hemodialysis patients that were cured of the hearing loss. Both patients were males and were taken ipsilateral tinnitus and sudden severe hearing loss undergoing dialysis, but had no vestibular symptom. Although many factors have been suggested as causes of hearing loss those dialysis patients, in our cases that have been suggested transient circurating disorder of the inner ears. And the prognosis of the sudden severe hearing loss in the patient with dialysis is still not clear, but it was possible to predict the prognosis in accordance with the sudden deafness.
  • 福田 諭, 田中 克彦, 関口 四郎, 大橋 正實, 土田 伸子, 大沼 秀行, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 615-618
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Glial fibrillary acidic protein (GFAP), the specific protein of the astrocytes, was investigated in the two infant cases of the nasal glioma using immunohistochemical (ABC) technique for the further confirmation of the diagnosis. In both cases, the immunoperoxidase reaction for GFAP was positive in the many cells of the mass lesion. These positive reaction shows typical fibrillary process pattern and indicates the masses were of neuronal origin. In conclusion, immunohistochemical investigation of GFAP was very significant to confirm the diagnosis of the nasal glioma.
  • 当教室10年間の集計
    高橋 国広, 間口 四郎, 田中 克彦, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 619-624
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    One hundred and twenty patients with rhinogenic orbital complications visited Hokkaido University Hospital from January 1977 to December 1986. The retrospective study was done and following results were obtained: 1) Occurence was most frequent in the 3rd and 4th decade and rather more frequent in males. 2) Primary paranasal cysts with orbital complications were most often found in the frontal and ethmoidal sisuses. While postoperative paranasal cysts and paranasal sinusitis were most frequent in the maxillary and ethmoidal sinuses. 3) Exophthalmos and blepharal swelling were most numerous in the orbital complications. 4) Sphenoidal lesions had a tendency to cause visual disturbance easily. 5) Drainage operations were mainly performed and almost all orbital symptoms improved postoperatively except visual disturbance.
  • 間口 四郎, 高橋 国広, 松島 純一, 田中 克彦
    1988 年 34 巻 2Supplement2 号 p. 625-629
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Two cases of spheno-ethmoidal mucoceles with the bony destruction of the skull base are presented. It is sometimes difficult to differentiate paranasal tumors and cystic lesions only by radiological measures especially when these lesions are confined to posterior ethmoid or shpenoid, accompanying bone destruction. In such cases, past history of nasal or paranasal surgery is of help in suspecting mucocele and in addition, exploratory puncture often aids in establishing the correct diagnosis. However, one should be very careful in performing the puncture of the cysts adjacent to the skull base with bony erosion, since the needle may accidentally puncture the dura, causing intracranial hemorrhage.
  • 川浪 貢, 田中 克彦, 吉村 理, 佐藤 信清, 宮坂 和男, 阿部 悟, 多田 光宏, 井上 和秋, 野島 孝之
    1988 年 34 巻 2Supplement2 号 p. 630-636
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    During 11 year-period from 1976 to 1986, 6 patients with juvenile nasopharyngeal angiofibroma were operated in ENT department, Hokkaido University Hospital. Our experiences revealed that artificial embolization prior to the surgery was safe and effective measure for reducing the amount of bleeding. In this communication, we discussed about the methods of surgical approach and materials used for embolization.
  • 吉村 理, 田中 克彦, 寺倉 直明, 間口 四郎, 福田 諭, 酒井 昇, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 637-642
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The authors reviewed 26 cases of non-epithelial malignant tumors (NEMT) and 8 cases of malignant melanomas (MM) arising in the nasal cavity and paranasal sinus who were treated in ENT-clinic, Hokkaido University Hospital from 1977 to 1986. The clinical analysis of these patients are summarized as follows; 1. In NEMT-Group, malignant lymphoma were most numerous (58%) and was followed by rhabdomyosarcoma and malignant fibrous histiocytoma. 2. As regards the location of the tumor, NEMT were seen in both nasal cavity and in paranasal sinuses but all of MM originated from the nasal cavity only. 3. Age distribution of patients demonstrates that MM occured in older age-group. Male was predominant in both groups. 4. Nasal obstruction and nosebleeds were chief complaints in MM whereas those in NEMT was various. 5. Despite a variety of treatment modalities, prognosis was invariably poor in both groups of patients.
  • HD群, ダニ群の傾向について
    高木 摂夫, 福田 諭, 吉村 理, 間口 四郎, 村上 進
    1988 年 34 巻 2Supplement2 号 p. 643-648
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    A clinical review was made of 352 cases with nasal allergy in our allergy clinic from 1984 to 1986. The number of cases with nasal allergy occupied 2.2% out of all the patients visiting our hospital. Major allergen was house dust or mite in almost all of the cases. In the group of house dust and mite, the most of the cases has onset of symptom before 10 years old in male. On the other hand, females showed the variety in age of onset. In these group, the combination of other allergic diseases were more common in males. We consider that the sensitivity to allergic reaction is more active in the younger males.
  • 酒井 昇, 末永 通, 田中 克彦, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 649-653
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The differentiation of the ventricular mucosa of larynx in human fetuses has been studied only by light microscopy. So, we studied this mucosa in human fetuses (at gestational ages from 9th to 21st week) by transmission electron microscopy, and could disclose more detailed features of cytodifferentiation of this mucosa. These results and the review of the literatures lead to the following conclusions: 1. We could demonstrate for the first time that primary cilia appear in the ventricular mucosa of larynx at the 9th and 10th week of gestation. 2. Ciliated cells began to appear at the 9th week of gestation which was earlier than the previous reports by light microscopy, moreover we could get the details of ciliogenesis using electron micro-scope. 3. Goblet cells, although immature, appeared at the 16th week of gestation as the same time of previous reports. After the 18th week of gestation, secretory granules belonging to eccrine type could be found for the first time by ultrastructural level. 4. Glycogen granules in non-ciliated cells decreased in parallel with the cytodifferentiation, suggesting that they provide a source of energy necessary for the cell differentiation.
  • 酒井 昇, 末永 通, 田中 克彦, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 654-659
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The differentiation processes of the vocal cord mucosa in human fetuses have been studied only by light microscopy. So we studied the vocal cord mucosa in human fetuses (at gestational ages from 10th to 21st week) by scanning and transmission electron microscopies and could disclose more detailed features of cytodifferentiation of this mucosa. These results and the review of the literatures lead to the following conclusions: 1. We could demonstrate for the first time that primary cilia appear in the vocal cord mucosa of human fetuses. 2. Ciliated cells were observed on the vocal cord of the fetal life in human as well as animals. And the ciliogenesis was found to be same as the previous reports. 3. The formation of plicae on the surface of the vocal cord was due to the overgrown mucosa of the ventricle, and the mucosa caudal to these plicae possessed the features as the squamous epithelium which is proper to the vocal cord. 4. Glycogen granules in non-ciliated cells decreased in parallel with the differentiation of the cells, suggesting that they provide a source of energy necessary for the cell differentiation.
  • 本村 昌一, 田中 克彦, 福田 諭, 末永 通
    1988 年 34 巻 2Supplement2 号 p. 660-665
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Experimental respiratory tract infection was induced in mice by transnasal inoculation of Sendai virus and the infected respiratory mucosae were examined by scanning and transmission electron microscopy and immunofluorescent microsocpy. The scanning EM study delineated sequential changes of the tracheal and bronchial epithelial surfaces, where regeneration of the tracheal mucosa took place around 8 days postinoculation but that of the latter was somewhat delayed. It was conspicuous that multiplication of the virus by buddings was never encountered in the tracheal epithelial cells, despite the accumulation of the viral nucleocapsids in their cytoplasms.
  • 佐藤 公輝, 間口 四郎, 田中 克彦, 野島 孝之, 宝金 秀一, 堂坂 久美, 小倉 滋明
    1988 年 34 巻 2Supplement2 号 p. 666-672
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Amyloid tumor of the head and neck is uncommon condition which occurs more often in the larynx. We reported 4 cases of laryngeal amyloidosis. Of these, involvement of the pharynx was seen in 2 cases while that of trachea in 1. These patients were treated by surgical resection and our experience indicated that re-growth of the tumors did not occur despite incomplete resection of amyloid tumor. Review of 59 cases in the literatures indicated that amyloid deposits were found most frequently in the larynx (78%). In some instances, amyloid deposits were present in separate regions. It should be stressed that generalized amyloidosis invariably involved the tongue whereas localized type did not. It thus appeared that lingual involvement is of particular significance in deciding the type of amyloid lesion.
  • 林 光夫, 福田 諭, 滝沢 昌彦, 國分 武彦, 劉 沢周, 柏村 正明, 酒井 昇, 田中 克彦, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 673-676
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    From 1977 to 1986, 172 cases of esophageal foreign bodies were treated in the Department of Otolaryngology, Hokkaido University Hospital. The analysis of these patients are summarized as follows: 1. Age distribution of patients demonstrates that children under 5 years of age are most numerous, consisting 29% of all patients. 2. Coins were second most numerous (33 cases) and were found exclusively in children under 10 years of age. 3. Thirty six percent of the foreign bodies were fish bones, such as samon, sea scopion or cod-fish, which are the specialities of Hokkaido'area. 4. Seventy four percent of the foreign bodies were found lodging at the esophageal orifice. 5. Xerography was found quite effective in detecting fish bones or PTP in the esophagus.
  • 末永 通, 川浪 貢, 佐藤 公輝, 田中 克彦, 大橋 正實
    1988 年 34 巻 2Supplement2 号 p. 677-683
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Schwannoma arising in the cervical region is uncommon. It is usually difficult to obtain correct diagnosis of this tumor prior to the surgery, since many of the tumors lack neurological signs and symptomes. Therefore, the diagnosis has to depend on histopathological examination of the resected tumor and the origin of the tumor may inferred by postoperative neurological dysfunction. Since such postoperative sequelae are often unpredictable and may cause legal problems, one should be very careful in preoperative examination of the tumor. In this study, we evaluated the echograms of 4 cases of schwannomas recently experienced in our clinic and the diagnostic value of the echogram was stressed.
  • 間口 四郎, 高橋 国広, 田中 克彦
    1988 年 34 巻 2Supplement2 号 p. 684-688
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    We have developped a simple and specific enzyme-linked immunosorbent assay (ELISA) to determine serum cathepsin D level by using cathepsin D purified from human liver and polyclonal rabbit antibody for the cathepsin D. With respect to cathepsin D levels, they were significantly higher in head and neck cancer patients than in healthy subjects. A slight positive correlation between stage of cancer and serum cathepsin D level was observed. Serum cathepsin D levels in maxillary cancer and laryngeal cancer patients were higher than those of other head and neck cancer patients. There was no correlation between cervical lymph node metastasis and cathepsin D level.
  • 田中 克彦, 國分 武彦, 間口 四郎, 福田 諭, 吉村 理
    1988 年 34 巻 2Supplement2 号 p. 689-692
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    The patients with locoregional recurrence after total laryngectomy performed in our department was reviewed in order to determine curative potential of therapies for recurrent tumors. During the past 12 years, 101 patients with laryngeal cancer underwent total laryngectomy and later, 13 of them had local recurrence. In the majority of such cases (8/14), the recurrence was noticed within 18 months postoperatively but in 5, it occured later than 3 years after the surgery. The location of the recurrent tumors was various, including peristomal region, anterior or posterior wall of hypopharynx, base of tongue and esophageal orifice. Eight patients out of 14 died mainly of uncontroled recurrent tumor. On the other hand, 6 were alive, being free of the tumor. The follow-up period of these patients ranged from 5 months to 3 years and 10 months (2 years and one month on average). Poor prognosis of recurrence after total laryngectomy has been documented but this study disclosed that surgical salvage was possible in certain cases in which tumors were localized and did not involve the carotid artery.
  • 大沼 秀行, 寺山 吉彦, 酒井 昇, 菅沼 俊哉
    1988 年 34 巻 2Supplement2 号 p. 693-697
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    A case of proliferative myositis of the masseter muscle in a 49-year old man with complaints of left cheek swelling and trismus is presented. In Japanese literature, no case of proliferative myositis which ocurred in masseter muscle has been reported. Although proliferative myositis is benign, self-limited lesion, the condition might be initially confused with sarcomas, because of its rapid growth. Histological examination is inevitable to establish the diagnosis. CT scanning was very helpful to investigate the extent of the lesion. This patient is free of disease one and a half year after diagnosis by needle biopsy.
  • 当教室10年間の集計
    寺倉 直明, 田中 克彦, 吉村 理, 土田 伸子, 酒井 昇, 寺山 吉彦
    1988 年 34 巻 2Supplement2 号 p. 698-702
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    One hundred and seventeen cases of the parotid tumors operated in ENT department of Hokkaido University Hospital during 10 years period of 1977 through 1986 were reviewed. Ninety five cases (81.2%) were benign tumors while 22 cases (18.2%) were malignant. Age distribution was in wide range, most numerous in the fifth decade. However, malignant tumors were not uncommon in younger generation. Pain, facial nerve paresis and adhesion to surrounding tissue were important features indicating the malignant nature of the tumor. Nevertheless, it should be stressed that more than half of the malignant cases lacked such signs and symptoms. The general principle of the parotid tumor is surgical removal, but postoperative irradiation should be done for the malignant tumors. Except in the latter cases, it is essential to identify the facial nerve for avoiding unnecessary insults to the nerve. Since 39% of patients with malignant tumor died of distant metastasis, it appears imperative to prevent the metastasis for improving the survival rate.
  • 症例報告およびMRIの有用性について
    高木 摂夫, 吉村 理, 田中 克彦
    1988 年 34 巻 2Supplement2 号 p. 703-707
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Between 1977 and 1987, 8 cases of parapharyngeal space tumor (2 cases of pleomorphic adenoma, and schwannoma, respectively, a case of neurofibroma, neuroblastoma, retension cyst and branchial cleft cyst) were treated in our clinic. There were 4 males and 4 females. This papar reports these cases and discusses the availability of MRI diagnosis. We consider that the x-ray CT is presently most useful for the parapharyngeal space tumor. Howerer, MRI imaged tumor clearly without bone artifacts such as recognized in x-ray CT, and be able to take a information of tumor vascularity. So that MRI is very useful for diagnosis of parapharyngeal space tumor.
  • 古田 康, 田中 克彦, 土田 伸子, 坂本 毅
    1988 年 34 巻 2Supplement2 号 p. 708-711
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    A case of generalized xanthogranulomatosis initially manifested as unilateral submandibular tumor is reported. A 62-year-old female was first seen in our hospital in October 1984 complaining of a swelling of her right submandibular gland. Removal of the submandibular gland was performed in February 1985 and the histological diagnosis was reported as Xanthogranuloma. After the surgery, the disease progressed involving the left submandibular gland, subcutaneous tissue of the cheek skin and lung etc. Finally she died of pneumonia resulted from pulumonary mass which turned out as xanthogranuloma at autopsy. Xanthogranuloma is regarded as a benign disease but rarely reccurs and takes malignant course. The generalized form of xanthogranulomatosis has a very poor prognosis. Importance of complete surgical excision and long term follow-up are emphasized.
  • 吉村 理, 田中 克彦, 鎌田 正, 野島 孝之
    1988 年 34 巻 2Supplement2 号 p. 712-716
    発行日: 1988/03/20
    公開日: 2013/05/10
    ジャーナル フリー
    Multiple symmetrical lipomatosis (MSL) is the pathological condition characterized by diffuse symmetrical lipoid deposition which occurs primarily in the neck, thoracoabdominal and inguinal regions. So far only one case report of this disease is available in Japan. In this report, a 61 year-old male who complained bilateral neck mass mimicing malignant lymphoma is presented. The etiology of MSL remains unsettled but some postulate that the condition is the result of complex diseases or defect of lipid metabolism in which cyclic-AMP of lipoid cells is involved. Alcoholism and diabetes mellitus in this patient may suggest the possibility of the former. It is sometimes difficult to differentiate MSL from malignant lymphoma, but we found CT-scan is quite useful for the diagnosis of MSL, although histopathologicals study of biopsied specimen is necessary for establishing the diagnosis of this condition.
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