耳鼻と臨床
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
34 巻, 5 号
選択された号の論文の14件中1~14を表示しています
  • 鈴木 正治, 中村 英生, 山岸 益夫, 中野 雄一
    1988 年 34 巻 5 号 p. 1159-1162
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    Neurilemmoma originating in the ethmoid sinus is rare. We had a patient with neurilemmoma arising from the left anterior ethmoid sinus. A 60-year-old woman, with a painless swelling in the nasal root for the last 2 years, was examined. A CT scan image showed a solitary mass in the bilateral anterior ethmoid sinus and frontal sinus. Under general anesthesia, the tumor was removed completely with bilateral lateral rhinotomy adding transverse incision. Histological examination revealed a typical picture of neurilemmoma demonstrating Antoni A type. This case showed good postoperative course.
  • 第1報: 正常モルモットにおける記録法
    田島 和幸, 竹田 泰三, 岸本 誠司, 齋藤 春雄
    1988 年 34 巻 5 号 p. 1163-1168
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    The purpose of this study is to evaluate waves of antidromically evoked facial nerve response on normal guinea pigs. The facial nerve was stimulated at the stylomastoid foramen, and the action potentials were lead from the geniculate ganglion (an active electrode) and scalp (a reference electrode). To reduce the artifact, the polarity of the stimulation was alternated. All of the waves 1.5 msec after the stimulation disappeared after using a musle relaxant or transecting the facial nerve just distal to the stimulating site. Thereafter only a triphasic wave remained. The latency of the triphasic wave changed by shifting the stimulating electrode to the peripheral branch. This study revealed that the waveforms consist of two components, an initial triphasic antidromically evoked facial nerve response, followed by EMG.
  • 第2報: 病巣部位診断への応用
    田島 和幸, 竹田 泰三, 岸本 誠司, 齋藤 春雄
    1988 年 34 巻 5 号 p. 1169-1172
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    The purpose of this study is to offer a basis for clinical application of the antidromically evoked facial nerve response to intratemporal facial nerve paralysis. Antidromically evoked responses were recorded from the facial nerves of thirty-nine healthy guinea pigs. Waveforms recorded from active electrodes placed on the geniculate ganglion or the horizontal segment were analyzed in regard to site of lesions. Lesions were modeled by applying 4% lidocaine solution on the facial nerve at various sites. The normally evoked triphasic wave became biphasic when the presumed lesion was closely central to the recording site. Monophasic waves were recorded when the lesions were at the recording site. The results of this study gives basis for clinical interpretation of antidromically evoked responses in cases of intratemporal facial paralysis.
  • 佐藤 公則, 大久保 洋, 栗田 茂二朗, 渡辺 滋之, 伊藤 裕司
    1988 年 34 巻 5 号 p. 1173-1177
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    A case of deep neck infection that took a turbulent course and resulted in death was reported. The patient was a 65-year old male. Initial symptoms were swelling and pain of the throat, and high fever. On admission, swelling of the inferior portion of the right mandibular angle was observed. Leukocytosis was present but general condition was good. On cervical and chest X-ray, abnormal shadow was not observed but the distance between vertebrae and trachea was markedly wide. A parapharyngeal abscess was suspected and antibiotics were given. The patient complained of dyspnea 20 hours after admission. Emergency tracheotomy was done but the condition did not improved. Emergency drainage operation revealed necrosis of the carotid seath and cervical esophagus. The patient died two days after admission because of renal failure probably caused by septic shock. At autopsy, inflammation spread into the posterior mediastinum via danger space. It was one of the reason that this case took a turbulent course. Emergency drainage operation should be done in cases of deep neck infection where the distance between vertebrae and trachea is markedly wide.
  • 猪川 勉, 草場 雅子, 増山 敬祐, 北尾 友幸, 石川 哮
    1988 年 34 巻 5 号 p. 1178-1181
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    A case report of non-Hodgkin's lymphoma in the bilateral nasal cavity is reported and literature is reviewed. The patient, a 48 year-old-man, complained of nasal obstruction on the left side and bloody rhinorrhea. The histopathological diagnosis was diffuse large-cell type non-Hodgkin's lymphoma. Complete remission was observed with radiation therapy and repeated combination chemotherapy (VEMP) of 6 series. Local recurrence on the right nasal cavity was found 6 years after the complete remission, hence, radiation therapy and combination chemotherapy (VEPA) were again initiated. Complete remission was observed once more and a nine-month follow up showed no recurrence. Radiation therapy has been the treatment of choice for most patients with non-Hodgkin's lymphoma of the nasal cavity and paranasal sinus present with stage I-II of the disease. Usually, relapse develops within 2 years and most patients with failures have distant spread of the disease with or without local recurrence. Local recurrence alone at the first relapse is rare. We emphasized, in this paper, that intensive combination chemotherapy should be employed even for stage I patients in the treatment of non-Hodgkin's lymphoma of the nasal cavity and paranasal sinus.
  • 馬場 俊吉, 八木 聰明, 青木 秀治, 山口 潤, 森園 徹志, 山野辺 滋晴
    1988 年 34 巻 5 号 p. 1182-1187
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    In 70 comatose patients, the auditory brain stem response (ABR) was recorded on a time-course basis to judge prognosis. The time taken to judge prognosis and which of the two recorded responses, namely one on the right and the other on the left, reflects prognosis were also studied. As a result, the latency of the III-V wave was prolonged with the lapse of time in the vegetable cases compared with the recovery cases. In the case of death, the I-III wave latency in addition to III-V wave latency was prolonged with time. This suggested that judging prognosis by only one measurement would be risky and that making observations of ABR on a time-course basis would be necessary in judging prognosis. Changes in the I-V wave latency on the right were not necessarily consistent with those on the left in the same case. However, there was no difference in changes between the right and left as observed by prognosis. Therefore, either right or left responses may be used in judging prognosis.
  • 田中 資介, 中島 格, 小宮山 荘太郎, 上村 卓也, 岡村 精一
    1988 年 34 巻 5 号 p. 1188-1194
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    Serum levels of immunological parameters (IAP, PHA-induced lymphocyte transformation, lymphocyte subpopulations, NK cell activity) and squamous cell carcinoma-related-antigen (SCC-antigen) were measured in 185 patients with head and neck cancers and 28 patients with nonmalignant diseases. The levels of IAP and SCC-antigen in head and neck cancer patients were significantly higher than levels in patients with non-malignant diseases (p<0.01), and correlated well with the progression of clinical stages. No significant differences were observed in the results of PHA-induced lymphocyte transformation, lymphocyte subpopulations and NK cell activity between the patients with head and neck cancer and the patients with non-malignant disease. In contrast, the results of all parameters tended to worsen when the cancer patients entered into poor condition. These results indicated the importance to evaluate immunocompetence of head and neck cancer patients using several immunoparameters.
  • 都築 達, 藤岡 正, 福田 宏之
    1988 年 34 巻 5 号 p. 1195-1199
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    In the Japanese literature, the triple carcinoma localized only in the head and neck has not been reported. We experienced a case which strongly suggested the tripple carcinoma localized only in the head and neck. The first carcinoma was observed in the right vocal fold, the second in the left false vocal fold and the third in the soft palate. Surgical displacement of the false vocal fold following cordectomy was performed for the first carcinoma, total laryngectomy for the second and chemoradiotherapy for the third. The interval between the first and third carcinomas was three and a half years. The second and the third were synchronous. This case was discussed pathologically and clinically. As this result, the probability that the second and third carcinoma was the metastasis of the first was not negated. The second and third were regarded as primary tumors.
  • 2. Azelastin hydrochloride (Azeptin®) による血小板からのヒスタミン放出の抑制
    小杉 忠誠, 垣花 脩, 中村 真理子, 野口 修二, 玉城 昇
    1988 年 34 巻 5 号 p. 1200-1205
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    It has been known that platelet activating factor(PAF) plays some important roles in the development of allergic reactions. On the other hand, a close relationship between allergic reaction and platelet function was clarified in asthma and related diseases from the aspect of clinical laboratory findings. However, an accurate and direct role of platelet in these diseases was not clear. In this study, platelet was activated by PAF, and the release of a chemical mediator from the activated platelet was studied in order to study the direct action of platelet in allergic reactions. Furthermore, the effect of Azelastin hydrochloride, one of antiallergic drugs, on histamine release from the platelet of rabbits was studied. The results obtained from this experiment were as follows; Azelastin hydrochloride (with a final concentration of 2.5×10-4M) inhibited PAF-induced aggregation of PRP of rabbits. In addition, Azelastin hydrochloride inhibited the release of histamine from washed platelet of rabbit activated by PAF in the same manner as inhibitory action of aggregation.
  • ダイナミックパラトグラフィによる研究
    渡辺 滋之
    1988 年 34 巻 5 号 p. 1206-1219
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    Articulatory functions following treatments for carcinoma of the tongue were studied in 4 patients (including 1 case of reconstruction) by use of dynamic palatography, sound spectrography, X-ray videoscopy, and speech intelligibility tests. The results were summarized as follows: 1. Palatolingual contact area tended to decrease and an abnormal contact pattern was observed as the volume of the resected region increased. 2. In the case of laser partial glossectomy, almost normal contact patterns were observed during both vowel and consonant articulation and the speech intelligibility was high. 3. In the cases of hemiglossectomy and subtotal glossectomy, abnormal contact patterns were observed during the articulation of vowels /i/ and /e/ which require the elevation of the dorsal part of the tongue. 4. In the case of hemiglossectomy, the remaining tongue tended to incline toward the operated side, which was considered to be a compensatory movement. 5. In the cases of subtotal glossectomy and reconstruction, where the mobility of the tongue was severely disturbed, censiderable compensatory movements of the lips and jaw were observed.
  • 犬山 征夫, 藤井 正人, 田中 寿一, 高岡 哲郎, 細田 兵之助, 川浦 光弘, 田路 正夫, 田中 一仁, 大築 淳一, 甲能 直幸
    1988 年 34 巻 5 号 p. 1220-1227
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    In our department, 109 patients with advanced or recurrent head and neck cancer received palliative chemotherapy for the purpose of prolonging life and improving quality of life throughout the past 11 years. Single or combind agents used include peplomycin (PEP), cisplatin (CDDP), UFT, bleomycin (BLM)+mitomycin C (MMC), vincristine (VCR)+methotrexate (MTX)+BLM, VCR+MTX+BLM+MMC, CDDP+PEP, VCR+MTX+PEP, adriamycin (ADR)+CDDP+PEP, etc. The five-year survival rate was 3.3% (3/92) in this series. Two patients have survived for more than 7 and 8 years without recurrence following chemotherapy. We also evaluated the quality of life of all patients receiving chemotherapy. An improvement of quality of life was observed in 39 of them. The lives of thirty patients, whose performance status improved after chemotherapy, were prolonged and they enjoyed their home lives while receiving treatment at the outpatient level. Eight out of 39 cases, which resulted in prologed life and improvement of quality of life were presented. The use of chemotherapy at the outpatient level will be increasingly important in the future.
  • 佐藤 喜一, 松平 登志正, 佐々木 周興, 荒木 伸彦, 安田 誠夫, 吉江 忠正
    1988 年 34 巻 5 号 p. 1228-1242
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    The number of elderly patients who have been suffering with presbycusis and tinnitus is gradually are increasing. It is well known that drugs such as vasodilators, metabolic stimulators, vitamin-B complexes and tranquilizers are used in the treatment of tinnitus. Kallikrein is one of these medicaments. It acts as a capillary vasodilator, and has been for the past 50 years and received high evaluations in clinical appilication. In this clinical study, the authors have clarified the efficacy of Depot-Kallikrein injection (40 KU) for the 25 elderly patients, who had previously been treated with six tablets of Kallikrein (10 KU) daily. Before clinical application, the complaints of tinnitus were divided to 5 classes and were separated into 5 graded points as determined by quality and tone-height of tinnitus. The patients received intramuscular injections once or twice a week. The efficacy of this injection was evaluated according to the alteration of the graded points. Tinnitus was decreased significantly to 70.0+21.0% in the second week after administration of Depot-Kallikrein, and 39.0+21.0% in the fourth week. The above results suggest that Depot-Kallikrein is useful for treatament of tinnitus in elderly patients.
  • Cefaclorを対照とする二重盲検群間比較試験
    河村 正三, 馬場 駿吉, 森 慶人, 鈴木 賢二, 島田 純一郎, 征矢野 薫, 稲垣 光昭, 笠島 哲也, 形浦 昭克, 志藤 文明, ...
    1988 年 34 巻 5 号 p. 1243-1273
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    To evaluate the effectiveness and safety of the new drug oral cephem CS-807 for suppurative otitis media, a double-blind comparative study was carried out in 229 adult patients, using cefaclor (CCL) as a control drug. CS-807 and CCL were administered in a daily dose of 100 mg b. i. d. and of 250 mg t. i. d., respectively. 1. Improvement rates in clinical efficacy judged by physicians in charge were 71.2% for CS-807 and 65.5% for CCL; there was no significant difference between the two groups. 2. As for bacteriological efficacy. the elmination rate in acute exacerbation of chronic suppurative otitis media was found to be significantly higher in the CS-807 group (80.8%) than in CCL (58.3%). 3. As for causative organisms, clinical efficacy for cases isolating S. aureus was found in 71.4% for CS-807 and in 70.6% for CCL, and the overall efficacy rate was 67.4% for CS-807 and 70.3% for CCL. 4. As for improvement of symptoms, otorrhea was significantly decreased in CS-807 at day 7 ; swelling of the tympanic membrane at day 7 tended to be more reduced in CS-807 than CCL. 5. Side effects were observed in 6 cases each in the CS-807 and CCL groups. Abnormal laboratory findings were noted in one case in the CS-807 group. These results indicate that CS-807 100 mg b. i. d. is useful oral antibiotic for the treatment of suppurative otitis media.
  • Cafaclorを対照とする二重盲検群間比較試験
    馬場 駿吉, 森 慶人, 鈴木 賢二, 島田 純一郎, 征矢野 薫, 稲垣 光昭, 笠島 哲也, 河村 正三, 形浦 昭克, 志藤 文明, ...
    1988 年 34 巻 5 号 p. 1274-1296
    発行日: 1988/09/20
    公開日: 2013/05/10
    ジャーナル フリー
    In order to compare the clinical efficacy and safety of CS-807 with Cefaclor (CCL) in acute tonsillitis, a double blind study was carried out using a daily dosage of 100mg×2 of CS-807 and 250mg×3 of CCL. The number of cases evaluated for clinical efficacy were 172 (82 treated with CS-807 and 90 treated with CCL). The effective ratings of CS-807 and CCL were 78.0% and 84.4% as judged by committee, and 89.0% and 86.7% as judged by doctor in charge, respectively. Bacteriological effects were satisfactory to yield the eradication rates of 98.4% in CS-807 and 98.6% in CCL. The number of cases evaluated for safety were 182 (87 treated with CS-807 and 95 treated with CCL). The incidence of side effects was 3.4% (3) in CS-807 and 3.2% (3) in CCL. Most of them were mild gastro-intestinal disorders. The number of cases evaluated for utility were 172 (82 treated with CS-807 and 90 treated with CCL). The usefulness rating were 89.0% in CS-807 and 86.7% in CCL. There was no significant difference between CS-807 and CCL in clinical effect, bacteriological effect, safety and utility. From these results, a daily 200mg dosage of CS-807 was found to be as useful as a daily 750mg dosage of CCL for the treatment of acture tonsillitis.
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