Fifteen cases of nasopharyngeal fibroma occurring exclusively in adolescent males were examined histopathologically. The age of the patients on admission in this series ranged from eight to twenty-eight years, and all were males.
Histologically, the tumors consis ted of two elements -connective-tissue and vascular elements-as mentioned by many authors. Observation of large whole-tissue sections revealed that histological patterns of the tumor varied from one part to the other in size, shape and distrib ution of the vessels as well as in the behavior of the connective-tissue matrix, and it seemed possible to divide the whole tumor histologically into three parts, the base, the center and the peripheral or superficial portion. It was also noted that the histological element, especially the vascular one, of the tumor showed some definite differences depending on the age of the patients. Vascular elements in the tumors of older patients (19 years or more) mainly consisted of more mature vessels showing a muscular coat, and thin-walled vessels of the capillary type were seen in younger patients (14 years or less).
These tumors differed from a n ordinary fibroma in the respect that the vascular elements represented at least one important component of the tumor, and the term “juvenile nasopharyngeal angiofibroma” as used by Martin et al. seemed to be the most agreeable one.

View full abstract

Authors' experiments have been performed in view of pointing out relations between hearing impairment and electrolytes. The bloodplasma of normal young and adult guinea-pigs was diluted into one hundredth in density. The electrolytes therein were measured with flame r eaction and thevalue got was used for the contrast value. The animals were divided into the noise-exposure group and the streptomycin(DHSM)-injection group.
The potassium value of bloodplasma showed some decrease after 5 hours' noise-exposure. In animals exposed to 105-110 phon noise for 5 hours every day for ten days, the average potassium value was as small as 5.8 meq/l, a distinct decrease ! After about 2 weeks of exposure, however, there was some upward tendency to be seen. As to the injection group, similar decreases of less degrees were noticed both after a single injection or after 10 days' injection.
Sodium, on the other hand, showed no great change in value i n both experiment series, only a slight decrease of sodium value took place. The stress caused by noise concerns not only as a local impairment, but also as a general affection over the whole body.

View full abstract

In der folgenden Arbeit beschreiben wir 2 Fälle von Adenom der Nasen-und Kieferhöhle.
Beim 1. Fall handelt es sich urn einen 49 jährigen Bauern. Seit einem Jahr h atte er an der linken Wange eine schmerzlose Anschwellung und kam deshalb in die Universitätsklinik zur Untersuchung. Bei der Untersuchung erkannten wir, dass die Anschwellung durch einen Tumor hervorgerufen wurde. Der Tumor befand sich hauptsächlich in der linken Kieferhöhle und hatte bereits die laterale und faciale Wand teilweise zerstört. Der Tumor war nicht verwachsen und konnte deshalb durch die Denkersche Operation leicht entfernt werden. Der weiche, dünn rötlich und hühnereigrosse Tumor war an der Oberfläche uneben und wog 7.7g. Histologich war da s Tumorgewebe das typische Adenom. In einem Teil des Präparates sahen wir an die Schilddruse erinnernde Drusenschlauche.
Beim 2. Fall handelt es sich um einen 73 jährigen Bauern. Seit einem Jahr leidet dieser Patient an linksseitiger Nasenverstopfung und zeitweiliger Nasenblutung. Der Anlass dieser Krankheit war ein Tumor in der linken Nasenhöhle. Die Operation nach Denker ergab folgenden Befund: der Tumor war zu Beginn der Krankheit im mittleren Nasengang lokalisiert und breitete sich im Verlauf der Krankheit in die Nasen- und Kieferhöhle aus und griff die laterale und faciale Wand an. Der exstirpierte Tumor war gänseeigross und wog 20 g. Seine Oberflache war rotlich, weich und glatt. Die histologische Untersuchung ergab ein typisches Adenom.

View full abstract

With the advance in plastic surgery, tubed pedicle has extensively been used to make up defects of tissue, and in the field of otorhinolaryngology, it is also utilized in various plastic surgeries.
The present studies were undertaken to know whether it was possible to make a narrow and long tubed pedicle, which was necessary to build up the external ear of the microtia. For this purpose, circulation in the tubed pedicle was investigated clinically, and also experimentally by using tubed pedicle in the back of the rabbit.
1) A photoelectric blood flow met er was made to determine both the pulse wave which was principally arterial, and the absolute blood amount in the tubed pedicle.
2) Results obtained with the photoelectric blood flow meter and with skin thermometer were compared each other, and close correlation was observed between them.
3) Macroscopical changes, length-width ratio and the direct ion of blood flow by ligature of tubes were examined in clinical cases.
4) Establishment of circulation after making tubed pedicle in the back of the rabbit was investigated with the photoelectric blood flow meter and the following results was obtained At the next day after making the tubed pedicle, the pulse wave could be recorded from the majority of the cases, but the direction of blood flow was not discernible; thereafter the direction became gradually clear, and after 6 days, it was distinct.
5) The blood vessel and the surround ing tissue were observed in rabbits from immediately after making tubed pedicles, and it was found that there was no qualitative difference in cross section of the tube between the both ends and middle part, but there was quantitat ive difference, that is, healing process was retarded in the middle as compared with the both ends. Edema and cellular infiltration predominated from 3 to 5 days, capillary proliferation and increase in fibroblasts which came on from the 5th day, were visible as late as about 12 days, and on the 14th day, normal tissue was nearly restored except for degeneration in some parts. The time thereafter is considered optimal for transplantation.

View full abstract

It seems very rare that each of the multiple primary carcinomas has each metastases.
At clinical investigation and autopsy the authors recognized a case of multip le primary carcinomas from a woman of 69 years who had suffered from carcinoma of the cervical esophagus and stomach.
The cancer near the beginning of the esophagus was a squamous cell carcinoma with numerous epithelial pearls, that has metastases in the paratracheal lymph nodes and thyroid gland.
The cancer of the stomach was a common adenocarcinoma, that has metastases in the omentum and ileocecal region.

View full abstract

Ein 53jähriger Bauer, der sein künstliches Gebiss des Oberkiefers verschluckt hatte, besuchte am daruffolgenden Tag unser Ambulatoriurn. Durch die Röntgenaufnahme erwies sich, dass das Gebiss an der Grenzstelle zwischen den III. und IV. Brustwirbel eingekeilt war. Zuerst versuchte der Operateur den Fremdkörper endoskopisch zu entfernen. Dabei sah man den Fremdkörper an der 24 cm entfernten Stelle einkeilen. Das Gebiss war ziemlich gross und seine Spitze war in die Oesophaguswand eingestochen. Nachdem man die Spitze des Gebisses mit dem Spatel aus der Oesophaguswand abgelöst hatte, fasste man das Gebiss und zog es herauf. Trotz aller Bemühungen konnte man aber den Fremdkörper durch die erste Enge nicht extrahieren. Deshalb entschloss man den Fremdkorper durch die Oesophagotomia externa zu entfernen. Indem man durch die perorale Oesophagoskopie den Fremdkörper bis zur 17 cm entfernten Stelle heraufbrachte, schnitt man dort die Oesophaguswand von aussen und es gelang dem Operateur, den Fremdkörper sicher unter deutlicher Vision zu entfernen. Wenn man solchen Fremdkörper durch die perorale Endoskopie nicht extrahieren könnte, müsste man von aussen ohne Komplikation und Nebenverletzung entfernen.

View full abstract

The authors have discussed 6 cases of unresponsive Ulceration of the oral cavity with unknown etiology treated by themselves and 73 similar cases refered in literature.
The complications of diseases are eruptions, ulcerations and lesions of the eye in the order of frequency. Fever arising is not seldom.
There is no reliable treatment till now except the administration of “Tanderil”, steroid-hormone, antibiotics and some vitamines with certain satisfaction.
In view of the combination of the sympto ms and the effect of treatment, authers concluded that most of what has hitherto been regarded as unresponsive ulceration of the oral cavity with unknown etiology is the same in character as Behcet's disease.

View full abstract

Carbon dioxide has the strongest increasing effect on cochlear blood flow as well as cerebral blood flow, which is proved in living guinea pig's cochlea by impedance plethysmography (Morimitsu, 1961).
We a pplied the CO₂-gas mixing 7% in pure oxygen to inner ear disease such as Ménière's disease, post traumatic deafness, acoustic trauma, sudden deafness and unknown nerve deafness.
The results obtained is shown in table 1.
Hearing was improved in 13 (ears) of 41 ears.
Tinnitus, complained in 33 ears, was disappeared or alleviated in 11 ears.
Vertigo was relieved in 7 cases among 12 cases, but slight and temporary attack of vertigo or dizziness were provocated in 4 cases of 11 Ménière's patients.
Another point of interest about tinnitus is that tempo rary vanishment, alleviation, change of timbre and temporary provocation of tinnitus are seen during or direct after the carbondioxide inhalation.
These facts suggest the close relationship between the tinnitus and the cochlear blood flow. Noticeable side effects of this therapy were only transient headache and sweat.
This new method can be efficiently used for the treatment of inner ear diseases and has a possibility to become a new method to test the relationship between the responsibility of the cochlear blood flow and cochlear symptomes.

View full abstract