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Volume 103, Issue 7
Displaying 1-8 of 8 articles from this issue
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Shinichi Haruna, Nobuyoshi Otori, Hiroshi Moriyama, Masami Kamio2000 Volume 103 Issue 7 Pages 789-795
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSEndoscopic transethmoidal•transsphenoidal surgery was performed on 30 patients with pituitary tumors, and the usefulness of this procedure was evaluated. As with conventional endoscopic intranasal surgery, the ethmoidal sinuses were opened and a broad window was created in the ethmoidal sinus from the directions of the middle meacus and the olfactory cleft. Then an endoscopic washing device was attached to a 0° or 3° rigid endoscope and it was immobilized in the left nasal cavity with an endoscope immobilization apparatus. Removal of the tumor was then started from the right side by a bimanual technique. Based on the results, this surgical procedure was judged to be useful for the following reasons (1) it makes it easy to carry out the operative manipulations even in a narrowed nasal cavity, thereby reducing the overall time required for surgery, and (2) it is possible to prevent postoperative deformities of the nasal capity morphology caused by pressure on its lateral wall. In additional, (3) the surgical wound can be observed, and CSF leakage can be repaired immediately after completion of the operation. Corrective surgery can be performed on an outpatient basis early after the initial operation to correct postoperative deformities of the nasal paranasal cavities, which might later cause nasal obstruction or an olfactory disturbance. Finally, (4) employing the route of endoscopic transethmoidal•trapssphenoidal surgery facilitates the Performance of a second operation soon., or even several months, after the first operation. A second operation may be necessary in the event of recurrence of the pituitary tumor complication by chronic sinusitis.
On the basis of our experience in the this study, we conclude that our method of endoscopic transethmoidal• transsphenoidal surgery will be useful for reducing invasiveness in the nasal cavities and achieving maximum prevention of postoperative complications. In order to fulfill its potential, neurosurgeons will need to master forceps techniques in the visual field provided by the endoscope and to cooperate with oturhinologists who are skilled in endoscopic techniques.View full abstractDownload PDF (2089K) -
Transplantation of Human Tonsillar Lymphocytes and Human Skin into SCID MiceYoshikazu Yamamoto, Kiyonori Kuki, Yasuhiro Hayashi, Noboru Yamanaka2000 Volume 103 Issue 7 Pages 796-802
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSPustulosis palmaris et plantaris (PPP) has been considered as one of the typical tonsillar focal infections, based on the marked clinical improvement of the skin lesions after tonsillectomy. In early-stage of PPP, it has been reported that lymphocytes, predominantly CD4-positive cells, infiltrate the palmar and plantar skin. However, the origin and mechanism of infiltration by these lymphocytes is not clear and there are very few reports on whether tonsillar cells react directly with the skin, possibly due to the difficulty of establishing adequate animal models. In this study, we established an experimental animal model of mice with severe combined immunodeficiency (SCID) and observed the, reaction of the tonsillar lymphocytes (TL) or peripheral blood lymphocytes (PBL) of patients with PPP to their own plantar skin by transplanting the lymphocytes and skin of the patient into the mice. The results revealed that TL infiltrated the skin to a significantly greater extent than PBL, Most of these lymphocytes were T lymphcicytes, and no B lymphocytes were detected in the transplanted skin. Strong expression of LFA-1 and ICAM-1 was observed in the skin after the TL transplantation. These results suggest that TL have a strong affinity for the skin in PPP. and that the adhesion molecules may play an important role in the infiltration by lymtphocytes of the skin.View full abstractDownload PDF (2835K) -
Tomohiko Nigauri, Shinetsu Kamata, Kazuyoshi Kawabata, Katsuhumi Hoki, ...2000 Volume 103 Issue 7 Pages 803-811
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe purpose of this study is to ascertain the role of neck surgery and radiation therapy for cervical lymph node metastasis in oropharyngeal cancer patients. We reviewed 217 previously untreated patients with squamous cell carcinoma of the oropharynx who were treated at the Cancer Institute Hospital in Tokyo between 1971 and 1995. The N stage distribution was; N1: 83(38.2%), N1: 42(19.4%), N2a: 23(10.6%), N2b: 27(12.4%), N2c: 33 (15.2%), and N3: 9(4.2%). A predominance of cervical node metastases in level II and III was revealed and there were no skip metastases outside of level II and III. The control rate of cervical metastasis for each N stage was; N0: 96.9%. N1: 90.0%, N2a: 76.5%, N2b: 62.5%, N2c: 50.0%, and N3: 0%. Definitive irradiation provided sufficient treatment for small nodes, when the primary tumor growth was well controlled by radiation therapy. Neck dissection was necessary for more advanced neck metastases. Selective limited neck dissection (level II and III) is recommended for N0 and N1 patients, and modified or classical RND is considered to be better for most cases with N2 and N3.View full abstractDownload PDF (1069K) -
Yasukazu Mikami, Shinetsu Kamata, Kazuyoshi Kawabata, Tomohiko Nigauri ...2000 Volume 103 Issue 7 Pages 812-820
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThis study evaluates the use of ultrasonograpy (USG)to diagnose metastatic cervical lymph nodes.Threehundred and one lymph nodes were removed from 38 patients with squamous cell carcinomas of the head and neck. None of the patients had receive dany preoperative treatments for cancer. The lymph nodes were the histopathologically examined: 139 metastatic lymph nodes and 162non-metastatic nodes were found. USG was then usad to evaluate the size, internal echo, and margin of each lymph node.
Size was found to be the best criteria for distinguishing metastatic lymph nodes from non-metastatic lymph nods in all ccrvicalregions (78% accuracy). Superior internal jugular lymph nodes and submandibular lymph nodes larger than 7mm and mid and inferior internal jugular lymph nodes larger than 6mm were regarded as metastatic. Internal echos were chassified into five patterns; homogeneous hypoechoic, homogeneous hyperechoic, heterogeneous, eccentric hyperechoic, and centric hyperechoic. Homogeneous hyperechoic and heterogeneous patterns were characteristic of metastatic nodes, while eccentric hyperechoic patterns were characteristic of non-metastatic nodes. Homogeneous hypoechoic patterns were observed in both metastatic and non-metastatic nodes. Regular margins wer found in 81% of the metastatic nodes. Of the 22 lymph nodes with irregular margins, however, 91% were metastatic.
Evaluations using a Combination of USG and clinical fcature criteria were compared with evaluations using only thickness as a criterium, Although thickness is the single most important factor in diagnosing metastatic nodes, the combination of USG and clinical feature criteria improved the accuracy of diagnosis to 83%. Thus, diagnostic methods involving a combination of several criteria are more accurate than methods involving only a single criterium.View full abstractDownload PDF (2054K) -
Toshiro Kawano, Shigeru Furukawa, Hideki Matsuda, Masahiro Takahashi, ...2000 Volume 103 Issue 7 Pages 821-828
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe antitumor effect of the angiogenesis inhibitor TNP470, O-(chloro-acetyl-carbamoyl) fumagillol, a synthetic analogue of fumagillin, was studied in vitro and in vivo on, cell line KB which produced interleukin (IL)-8.
In vitro, TNP470 reduced the production of IL-8 from KB cells, the same as anti-IL-8 antibody (Ab.) The combination of anti-IL-8 Ab(10μg/ml) and TNP470 (10ng/ml) significantly inhibited the proliferation of KB cells, compared to no treatment (p<0.05). Proliferation of KB cells was also significantly more suppressed by simultaneous treatment of cisplatin and TNP470 (1mg/ml), than cisplatin alone.
The in vivo antitumor effect of TNP470 was studied using anti-IL-8 Ab, anti-vascular endothel growth factor (VEGF) Ab, and TNP470, in administered by different routes, i.e., intratumoral (i.t.), intraperitoneal (i.p.), and intravenous. TNP470 (10mg/ml) showed an antitumor effect, and intratumoral administration of TNP470 was the most effective route. Combined administration of anti-IL-8 Ab (i.p.) and TNP470 (i.t.) reduced tumor volume more than anti-IL-8 Ab alone did. These results suggest that the combination of TNP470, cisplatin, and anti-IL-8 Ab could be a beneficial treatment for solid tumors of the head and neck.View full abstractDownload PDF (872K) -
Shigeo Yamagishi, Masaki Ohnishi, Ruby Pawankar2000 Volume 103 Issue 7 Pages 829-835
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSgulate inflammatory cell infiltration and survival at sites of inflamation. IL-1, TNF-α, IL-6, IL-8 and GM-CSF have been reported to be released from cultured nasal epithelial cells (CNEC). Here, focusing on IL-1 and TNF-α as key cytokines, we examind whether these two cytokines could regulate the release of IL-6, IL-8 and GM-CSF from CNEC. CNEC were treated with antibodies to lL-lα and TNF-α at various doses for a period of 48 hrs. The levels of IL-6, IL-8 and GM-CSF in the culture supernatants were then estimated by ELISA. Treatment of CNEC with antibodies to IL-1α and TNF-α inhibited the release of IL-6, 1L-8 and GM-CSF from them in a dose-dependent manner. The inhibition of IL-6 and GM-CSF release was significantly greater after treatment of the CNEC with the antibodies to IL-1α. Furthermore CNEC expressed IL-1 receptors and TNF receptors. These results suggest that the epithelial cell-derived IL-1α and TNF-α can regulate the release of other cytokines like IL-6, IL-8 and GM-CSF in an autocrine manner.View full abstractDownload PDF (690K) -
Takema Sakoda, Akira Shibano, Yuko Saitoh, Yoshihiro Dake, Hideyo Sogo ...2000 Volume 103 Issue 7 Pages 836-839
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSA simple method for office closure of eardrum perforation using an atero-collagen graft used for dermal defects (TerdermisR) without fibrin glue was developed. Eardrum perforations were successfully closed in 71.4% of all cases (63 ears) after the initial treatment. Neither skin incision nor the use of temporal fascial grafts was necessary in this method. The merit of the method is that there is no possibility of blood infection because no blood materials are used.View full abstractDownload PDF (846K) -
Tetsuyoshi Umeno, Kazunori Mori, Tadashi Nakasima2000 Volume 103 Issue 7 Pages 840-843
Published: July 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSWe report a case of nasopharyngeal stenosis after uvulopalatopharyngoplasty (UPPP). A 42-year-old man underwent UPPP because of severe snoring. Two months later, a severe nasopharyngeal stenosis was observed upon examination. The stenosis was caused by the adhesion of the soft palate to the posteior pharyngeal scar.
X-ray examination of the patient's pharynx revealed that the postoperative nasopharngeal stenosis may have also been caused by the depth of the pharynx, in addition to the morphological anomaly. To avoid velopharyngeal insufficiency and nasopharyngeal stenosis, careful examination of the pharynx prior to surgery is highly recommended.View full abstractDownload PDF (736K)
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