Nippon Jibiinkoka Gakkai Kaiho
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
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Volume 113, Issue 8
Displaying 1-6 of 6 articles from this issue
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Review article
Original article
  • Relationship between IgE Antibodies to Recombinant Allergens rBet v 1 and rBet v 2 and Food Causing Oral Allergy Syndrome in Cases of Birch-pollen Allergy
    Tetsuo Yamamoto, Kohji Asakura, Hideaki Shirasaki, Tetsuo Himi
    2010 Volume 113 Issue 8 Pages 661-669
    Published: 2010
    Released on J-STAGE: May 13, 2011
    DOIhttps://doi.org/10.3950/jibiinkoka.113.661
    JOURNAL FREE ACCESS
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    Background: Persons allergic to birch pollen often report oral and pharyngeal hypersensitivity to fruit and vegetables, such as apples and peaches due to immunological cross-reactivity, or oral allergy syndrome (OAS) sometimes accompanied by systemic reaction. Such cross-reactive antigen reactions involve Bet v 1, the main birch-pollen allergen, and Bet v 2, birch-pollen profilin. We evaluated the food/antigen relationship.
    Methods: Subjects interviewed numbered 60-40 women and 20 men aged 12 to 70 (mean age: 35 years)-suffering OAS episodes and having IgE birch-pollen antibodies. Using CAP scoring we examined IgE antibodies to recombinant Bet v 1 (rBet v 1), recombinant Bet v 2 (rBet v 2), and recombinant Pru p 3 (rPru p 3) a peach lipid transfer protein (LTP). A CAP score of 0.35 or more was considered positive. We evaluated the relationship between recombinant allergens and 9 fruit often involving OAS-apple, peach, cherry, kiwi, pear, melon, plum, strawberry, and watermelon-based on subjects` reports.
    Results: Of the 60, all (100%) were rBet v 1-positive, 9 (15%) rBet v 2-positive, and none (0%) rPru p 3-positive. Rose-family fruit-apples, peaches, cherries, pears, plums, and strawberries-often caused OAS regardless of positive or negative rBet v 2 CAP and were associated with rBet v 1. In contrast, more of those who were rBet v 2 CAP-positive had OAS to non-rose-family fruit-melon and watermelon-than those rBet v 2-negative. In rose-family and non-rose-family classification of the 9 fruit, cluster analysis and kappa statistics showed non-rose-family melon, watermelon, and kiwi to be associated with rBet v 2, as were grass and mugwort pollen allergies.
    Conclusion: Bet v 1 is associated with OAS due to rose-family fruit and Bet v 2 with OAS due to non-rose-family fruit.
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  • New Scoring Proposed for Endoscopic Swallowing Evaluation and Clinical Significance
    Masamitsu Hyodo, Kaori Nishikubo, Kahori Hirose
    2010 Volume 113 Issue 8 Pages 670-678
    Published: 2010
    Released on J-STAGE: May 13, 2011
    DOIhttps://doi.org/10.3950/jibiinkoka.113.670
    JOURNAL FREE ACCESS
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    Dysphagia is becoming a critical medical and social issue with aging population. Appropriate treatment requires that swallowing be assessed objectively. The simple, clinic-based scoring we developed for flexible endoscopic evaluation of swallowing (FEES) uses four parameters—(1) the salivary pooling degree at the vallecula and piriform sinuses, (2) the glottal closure reflex induced by touching the epiglottis or arytenoid with the endoscope, (3) swallowing reflex initiation assessed by “white-out” timing, and (4) pharyngeal clearance after blue-dyed water is swallowed-categorized as 0 for normal, 1 for mildly impaired, 2 for moderate, or 3 for severe. Scores given by experienced otolaryngologists expert in treating dysphagic subjects correlated significantly with those of nonexpert otolaryngologists and speech-language-hearing therapists. Pharyngeal clearance evaluated by videofluorography correlated with FEES clearance scores, as did aspiration severity with total scores statistically significantly. Feeding procedures related significantly to total scores for the four parameters, indicating its usefulness in deciding oral food intake. Our new scoring is thus simple and reliable in evaluating dysphagia severity and features, and potentially clinically advantageous.
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  • A Clinical Study of Traumatic Tympanic Membrane Perforation
    Kazuharu Yamazaki, Ken Ishijima, Hiroaki Sato
    2010 Volume 113 Issue 8 Pages 679-686
    Published: 2010
    Released on J-STAGE: May 13, 2011
    DOIhttps://doi.org/10.3950/jibiinkoka.113.679
    JOURNAL FREE ACCESS
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    We reviewed 165 cases of traumatic tympanic membrane perforation treated in the last 9 years (2000-2008). Of these, 103 sustained direct injury and 62 indirect injury. Ear picking accounted for 90.3% of direct injuries. Perforation size followed the classification of Yoshikawa, with Grade I perforation the most common, according for 129 (78.2%). The anteroinferior quadrant perforation site was the most common, with 98 (59.4%). Of the 165, 66 were lost during follow-up. Of the remaining 99, perforations closed spontaneously in 85 (85.9%), within a mean 25.9 days. Tympanoplasty was done in 14, in whom postoperative hearing improved in 12. The remaining 2 had ossicular fractures associated with perilymph fistula. In the 14 undergoing surgery, tympanic membrane perforation relapsed in 4 and 2 developed cholesteatoma as tympanoplasty sequelae.
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  • A New Scoring System for Assessing the Severity of Adult Acute Rhinosinusitis
    Noboru Yamanaka, Muneki Hotomi, Akihisa Togawa, Yorihiko Ikeda, Shinji ...
    2010 Volume 113 Issue 8 Pages 687-698
    Published: 2010
    Released on J-STAGE: May 13, 2011
    DOIhttps://doi.org/10.3950/jibiinkoka.113.687
    JOURNAL FREE ACCESS
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    Treating acute rhinosinusitis requires assessing severity and selecting appropriate antimicrobial agents. In 2006, we developed clinical scoring system for diagnosing and treating acute rhinosinusitis based on three clinical symptoms of rhinorrhea, fever, and facial pain and three nasal findings of characteristics and nasal discharge amount, nasal mucosal swelling and nasal mucosal redness. To verify and update scoring, we studied score-based diagnosis of adult acute rhinosinusitis severity. Prevalence of symptoms such as fever and serous nasal discharge in 95 subjects was low as 8.4% and 3% indicating less useful as evaluation items on the diagnosis. Mucopurulent nasal discharge (r=0.67), facial pain (r=0.51), rhinorrhea (r=0.47), and swelling (r=0.45) correlated significantly with severity evaluated by attending otolaryngological specialists. Nasal mucosal swelling caused discrepancy between clinical scoring and specialists' assessment. Evaluated by multivaliate analysis, factors affecting severity assessment were mucopurulent nasal discharge, facial pain, and rhinorrhea (p<0.0001), but not swelling (p=0.49). We concluded that mucopurulent nasal discharge scored 0, 2, or 4, facial pain scored 0, 1, or 2, and rhinorrhea scored 0, 1, or 2 should be used in evaluation in new clinical scoring, classified by severity as mild scored 1-3, moderate scored 4-6, and severe scored 7-8 by evaluating consistency with specialist assessment.
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Educational lecture
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