Nippon Jibiinkoka Gakkai Kaiho
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
Search
Advanced search
OR
Browse
Search
Volume 115, Issue 11
Displaying 1-12 of 12 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Review article
Original article
  • A Clinical Study on 10 Cases of Cervical Tuberculous Lymphadenitis
    Yusuke Mada, Yuji Ueki, Akiyoshi Konno
    2012 Volume 115 Issue 11 Pages 950-956
    Published: 2012
    Released on J-STAGE: December 15, 2012
    DOIhttps://doi.org/10.3950/jibiinkoka.115.950
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Cervical tuberculous lymphadenitis is sometimes difficult to differentiate from sarcoidosis. We treated 10 patients with cervical tuberculous lymphadenitis from April 2002 to December 2011. Their ages ranged from 42 to 78 years old (mean 63.2 years), and the male-to-female ratio was 4: 6. All patients presented to our hospital with the chief complaint of a cervical mass. All patients underwent open biopsy of the cervical lymph nodes, and 8 patients were diagnosed histopathologically as having cervical tuberculous lymphadenitis. In the remaining 2 patients, caseous necrosis could not be recognized histopathologically and they were diagnosed as having sarcoidosis. However 8 weeks later, the culture of the acid-fast bacilli turned positive, and the diagnosis was corrected to cervical tuberculous lymphadenitis. In our cases, the culture of acid-fast bacilli was positive in 6 out of 9 cases (66.7%), and TB-PCR was positive in 4 out of 9 cases (44.4%). These results show that sensitivity of individual tests is rather low. For the diagnosis of cervical tuberculous lymphadenitis, it is important to suspect this disease from the findings of the sedimentation rate, tuberculin test, and ultrasonography with fine needle aspiration cytology. On performing an open biopsy of the cervical lymph nodes in the suspected patients, it is essential to combine histopathological study, TB-PCR and the culture of the acid-fast bacilli simultaneously.
    View full abstract
    Download PDF (702K)
  • The Clinical Significance of Thymidylate Synthase Expression in Human Papillomavirus-related Oropharyngeal Squamous Carcinoma
    Hisayuki Kato, Takehiro Yui, Naoki Yamamoto, Tatsuyoshi Okada, Makoto ...
    2012 Volume 115 Issue 11 Pages 957-964
    Published: 2012
    Released on J-STAGE: December 15, 2012
    DOIhttps://doi.org/10.3950/jibiinkoka.115.957
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The focus of human papilloma virus (HPV), particulary HPV 16 is on the role of carcinogenic and prognostic factors on oropharyngeal squamous carcinoma (OSCC). However, it remains unclear why patients with HPV-positive tumors have better outcomes than those with HPV-negative tumors. Thymidylate synthase (TS) is one of the initial key enzymes in the 5-fluouracil (5-FU) metabolic pathway. Clinical studies showed that intratumoural TS level was related to the response to 5-FU-based chemotherapy in patients with several types of cancer such as gastroenterological and head and neck cancers.
    We investigated the prevalence of HPV infection and TS expression in the patients with OSCC and evaluated the prognostic implications according to the HPV status and TS expression. We evaluated for high-risk HPV types (HPV 16, 18, 31, 33, 51, 52, 58) using a real-time polymerase chain reaction (RT-PCR) assay on archival biopsies from 54 patients with OSCC. Immunohistochemical assessments for TS were also performed. HPV was positive in 22 (40.7%) of 54 samples. Of these positive cases, 21 (95%) carried HPV 16 and only 1 (5%) HPV58 sequences. TS was overexpressed in 25 (46.3%) of 54 samples. Of these, 19 (76.0%) had an HPV-negative status and 21 (84.0%) were heavy smokers. TS overexpression was associated with the patients with HPV-negative tumors (P=0.02) and heavy smokers (p=0.012). Univariate analysis revealed that HPV positive status (77.3% vs. 29.0%; p=0.006) significantly improved overall survival. Conversely, no remarkable prognostic difference was observed on immunohistochemical analysis of TS expression. A multivariate analysis using Cox's proportional hazard model showed that early T stage (T1-2), early N stage (N0-1), and positive HPV status were significantly independent predictors for superior overall survival.
    Our studies suggested that positive HPV status was most strongly associated with a favorable prognosis in the patients with OSCC. TS expression has an unusual aspect as a biomarker for OSCC, though it was not related to prognosis.
    View full abstract
    Download PDF (651K)
  • Juvenile Nasopharyngeal Angiofibroma-Evaluation of the Invasion of the Pterygoid Canal-
    Suetaka Nishiike, Takashi Shikina, Hidenori Maeda, Sachiko Hio, Hideno ...
    2012 Volume 115 Issue 11 Pages 965-970
    Published: 2012
    Released on J-STAGE: December 15, 2012
    DOIhttps://doi.org/10.3950/jibiinkoka.115.965
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We operated on three patients with juvenile nasopharyngeal angiofibroma in the past 3 years. The endoscopic transnasal approach was utilized in all the cases, and in one case it was accompanied with a Caldwell-Luc procedure. All the tumors were located around the sphenopalatine foramen, but also had involved and enlarged the pterygoid canal. All the cases underwent preoperative selective embolization, but it was difficult to embolize the branch of the internal carotid artery. A partial resection of the middle turbinate facilitated the manipulation of the sphenopalatine foramen and the pterygoid canal. Endoscopic management of juvenile nasopharyngeal angiofibroma should be considered as a first-choice option for tumors at the early stage.
    View full abstract
    Download PDF (1037K)
Skill up lecture
Lifelong learning for Board Certified Otorhinolaryngologist
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top