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Volume 81, Issue 6
Displaying 1-8 of 8 articles from this issue
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PARKINSONISMHAJIME HIROSE, SHIGERU KIRITANI, HIROHIDE YOSHIOKA, TATSUJIRO USHIJIMA ...1978 Volume 81 Issue 6 Pages 547-553
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe pattern of articulatory movements during the repetition of monosyllables was investigated in Parkinsonian dysarthria by means of pellet tracking technique using an x-ray microbeam system. Separately from the x-ray study, electromyographic recordings were obtained from pertinent articulatory muscles of the same subjects during similar performances. The data were specifically examined with reference to the rate, range and velocity of the movements of the articulators as well as to the pattern of coordination of the different articulators involved.It was found that there was a tendency toward gradual decrease in all the factors of the interval, range and velocity of repetitive movements. The result seemed to be comparable to the so-called hastening phenomenon which was often observed in the tapping test on patients with Parkinsonism. It was suggested that analysis of dynamic aspects of the different types of dysarthric subjects should be a promising approarch for elucidating the nature of articulatory disturbances of central origin.View full abstractDownload PDF (523K) -
IWAO OHTANI, KOHSEI OHTSUKI, TAKEO OMATA, JIN OUCHI, TAKEO SAITO1978 Volume 81 Issue 6 Pages 554-561
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe absolute diuretic potency of bumetanide (BUN) is 40-60 times that of furosemide (FM). When dosage of two drugs clinically used are considered, the relative ototoxic potency of BUN is very low (about 1/10 of FM). The purpose of this study was to determine the combined ototoxic effect of BUN with kanamycin (KM), and to compare it with that of FM and KM. Doses of BUN were 1/40 and 1/60 of FM. The results obtained were as follows.
1. Severe damage of the outer hair cell occurred in rabbits following the combined administra-tion of BUN and KM. No damage of the outer hair cells was detectable when BUN or KM were used alone with the same dose. The damage of the outer hair cells in rabbits injected with both BUN and KM was approximately equal to that of rabbits receiving both FM and KM. And there was no significant difference in the pattern of the outer hair cell damage between these rabbits.
2. The kidney of rabbits received both BUN and KM also showed the severely damaged lesions of the proximal tubules. And their lesions resembled that found in rabbits received both FM and KM. All of rabbits injected with BUN or KM alone showed the normal renalhistological findings under a light microscope.
Therefore, the ototoxicity of BUN in its clinical use is less than that of FM, but the ototoxic effect of BUN used with KM is approximately equal to that of FM with KM. That is, the combined ototoxic effect of the loop diuretics (BUN and FM) and KM may by closely related to the diuresis of diuretics. Severe damage occurred not only in the inner ear but also in the kidney when both BUN and KM were administered to rabbits. It may be, therefore, concluded that the combined administration of BUN and KM (probably another aminoglycoside antibiotics too) would also be dangerous to patients.View full abstractDownload PDF (1346K) -
IN INTRAVENOUS OLFACTION TESTHIROYUKI ZUSHO, HIDEYO ASAKA, YOSHIKO FUKUSHIMA, SEIKO SANADA, TSUGUO ...1978 Volume 81 Issue 6 Pages 562-568
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe intravenous olfaction test with Alinamin is a simple procedure and currently in widespread use. However, fundamentals about this test procedure are still obscure in many respects. This study was performed to elucidate the relationship between the olfactory thre-shold and the fatigue in this test.
An olfactory stimulus provided by the intravenous injection of Alinamin (2 ml) in 20 seconds exceeds the olfactory threshold of normosic individual by approximately 2000-fold.
Most of cases resulted in a negative intravenous olfactory test could not estimated by a standard olfactory acuity test. The latent time varies with the olfactory threshold, while the duration time is varied depending upon both the olfactory threshold and the fatigue. Therefore, extraordinary short duration time with a pertineat latent time may indicate the marked olfactory fatigue.View full abstractDownload PDF (569K) -
SOUSUKE KIUCHI1978 Volume 81 Issue 6 Pages 569-577
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe purpose of present investigation was to clarify the contributory factors for dysphagia.
In a series of 331 patients, who were confirmed radiologically to be affected either functional or organic disturbances in the proxismal part of the alimentary tract, dysphagia was the present symptom in 116 patients. Etiologically, these disorders included two main groups, neurogenic diseases and local structual lesions. Twenty eight patients with pharyngeal paralysis associated with central and peripheral nervous diseases, had been investigated. Of these, all had complained of dysphagia, including 6 patients whose chief complaint was aspiration. Radiological examina-tions revealed cricopharyngeal dysfunction in 6 patients.
The local structual lesions were divided into intrinsic lesion and extrinsic one. In a group of 188 patients with intrinsic lesions, 78 complained of dysphagia. Forty seven of them had carcinoma of the hypopharynx and esophagus, being the most common causes of dysphagia in this series. Achalasia of the upper esophageal sphincter and of cardia, esophageal stricture, and hiatus hernia were observed in 18 patients. Esophageal diverticulum and esophagitis were rare.
In 115 patients with extrinsic lesions, only 16 had complained dysphagia. Of 10 patients in whom dysphagia were related to malignant thyroid tumor and mediastinal tumors, 4 showed direct invasion of tumor to the esophagus. Another 6 showed external compression of the esophagus.View full abstractDownload PDF (1786K) -
GEORGE KASHIWAGI, GINICHIRO ICHIKAWA, ICHIRO ANDO, MASATAKA KOH1978 Volume 81 Issue 6 Pages 578-586
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSAuditory brain stem responses were recorded in five patients with cerebello-pontine angle tumor (2 meningionas and 3 acoustic neurinomas). The data were compaired with the results of BSR in animal experiments, and the pssbility of the topographical differential diagnosis for the central lesions by BSR were studied.
The results were as follows.
1) Three cases out of five showed indistinguishable patterns of wave II to wave V.
2) These patterns were considered as the typical BSR in cerebello-pontine angle tumors.
3) In the case of disturbances of cerebello-pontine angle, the decrease of amplitudes and the increase of latencies could be observed in the conponents after wave I.
4) The pattern was coincident with that of destruction of cochlear nucleus in animal studies.View full abstractDownload PDF (493K) -
ESTABLISHED CELL LINE ORIGINATING FROM THE HUMAN PARANASAL SINUSMINORU ISHIDA1978 Volume 81 Issue 6 Pages 587-603
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThis paper deals with two-year successive culture of human cancerous cells derived from squamous cell carcinoma of the maxillary sinus. The culture of the cells described in this paper has continued since June 4, 1975, and this cell line is considered to be stable and established. With a view to identifying the cultured cells, the author has been analyzing the cytologic findings by the seven major research tools which are detailed later.
The patient was a 48-year-old man with well differentiated squamous cell carcinoma. In the maxillary sinus classified to T3N1M0. This patient underwent necrotomy twice, but died in October, 1976.
1) In photomicroscopic study, most cultured cells were of sheetlike epithelial type which grew in multilayers and the superficial layer was cornified.
2) Electron microscopic study showed that the cells possessed desmosomes and tonofilamentsand were of eqidermoid origin.
3) Chromosomal studies showed that the distribution of the number at the 5th and 25th generations fell in the hyperdiploid range. Karyotype analysis showed the presence of several chromosomes suffering constitutional aberration. These chromosomes served as the marker.
4) The plating efficiency was about 42% in a modification of Eagle's MEM, and about 20% even in 0.3% soft agar suspension.
5) The growth curve showed that a period of 6 days was required for the cells to attain a 4-to 5-fold count increase.
6) Five of six nude mice given the cultured cells successfully developed tumor. The tissue of this tumor was characterized by relatively clear cytoplasm and anisonucleotic nuclei, and proved to be identical with the cells that had been groan by the patient, on accountof the high nucleocytoplasmic ratio.
7) The dispersed cells of the successively cultured tumor were found to agglutinate even in low concanavalin A concentrations.
These findings convinced the author that the successively cultured cells are derived from the epidermoid cells of human malignant tumor.View full abstractDownload PDF (5798K) -
ANESTHESIA ON THE LARYNGOMICROSURGERYHARUMI SUZAKI, SOTARO FUNASAKA, ATSUO FUKUNAGA, YASUSHI HANAI, HIROSHI ...1978 Volume 81 Issue 6 Pages 604-611
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSArterial pH, PaCO2, PaO2 and base excess were analyzed in ten patients out of 94 patients, who were undergone laryngomicrosurgery under general anesthesia in order to study the reliability of endotracheal intubation with smallsized tubes. The measurements were performed at three different conditions, that is, before induction, in spontaneous respiration and in assisted rdspiration.
The analysis of the measured values revealed that use of small-sized tubes (22, 24 and 26 French size) produced no abnormal condition as long as the assisted respiration was carried out.
Thus, it is concluded that this procedure is useful, and can be used even in the aged patient without any cardio-pulmonary problems for the laryngomicrosurgery.View full abstractDownload PDF (676K) -
[in Japanese], [in Japanese]1978 Volume 81 Issue 6 Pages 642-645
Published: June 20, 1978
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (314K)
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