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87 巻, 2 号
選択された号の論文の8件中1～8を表示しています
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第6報 好塩基球と肥胖細胞の関係大塚 博邦, 奥田 稔, 坂口 喜清1984 年 87 巻 2 号 p. 141-148
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリー1. スギ花粉症を対象にスギ花粉末を鼻内に散布して誘発し,その前後の血中,鼻汁中,下鼻甲介粘膜表面擦過片中の好塩基球,肥胖細胞の変動をみることにより,好塩基球と肥胖細胞の関係を検討した.
2. 血中好塩基球は誘発1時間で減少し,2時間で再び増加した.
3. 鼻汁中の好塩基球は誘発2時間後に増多した.肥胖細胞の出現はわずかであり,誘発前後における一定の傾向はなかった.
3. 擦過片中の肥胖細胞数は誘発前,後2時間では著変なかったが好塩基球は著明に増多した.以上のことから好塩基球は脱顆粒を起こした肥胖細胞の代償的役割として血中から局所に遊走するものと考えられた.
5. また,血中,鼻汁中,擦過片中の好塩基球,肥胖細胞,好酸球のそれぞれの増多は各症例間で互いに相関性があり,感作程度の違いによってともに増減した.抄録全体を表示PDF形式でダウンロード (1121K) -
アルゴンレーザー照射による宮崎 充1984 年 87 巻 2 号 p. 149-157
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリーInvestigation of both striae and cochlear nerve lesion in guinea pigs were performed indirectly through the cochlear wall by means of argon laser irradiation. The changes of AP, CM and SP measured by the round window recording were investigated both after one hour and also after one month in the same animals. The following results were obtained.
1. There was no electrocochleographic correlation at the power 80 to 100mw irradiation between the apical and basal turn. However, in the cases of a high power irradiation such as 600mw at the apical turn, the irradiated region showed disappearance of the outer hair cells, and AP threshold was extremely increased and AP out-put potential was reduced. The CM responses below 0.5kHz were almost disappeared.
2. An one hour after the stria vascularis irradiation the out-put potentials of AP, CM and SP were reduced with the increase of irradiation power. However, after one month a well developed AP out-put potential was observed with intensive sound stimulus, even though the AP threshold was increased. Some animals of a low power irradiation showed a higher out-put potential than that of the control value.
3. In the cases of irradiation of the cochlear nerve, even a full month later the AP showed a lower out-put potential at intensive sound stimulus, but the threshold was relatively stable as compared with the out-put potential.
The above results indicate an interesting finding in view of the difference between cochlear and retro-cochlear lesion.抄録全体を表示PDF形式でダウンロード (2238K) -
臼井 信郎, 岩田 章男, 内山 真理, 司 明理1984 年 87 巻 2 号 p. 160-168
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリー1. 鼻粘膜誘発反応の状態をグラフで表わすことができた.
2. これらの鼻粘膜誘発反応曲線をパターン別に分類し,正常型,漸増型,遅発漸増型,山型,山谷型,急増急減型の6型に分けた.
3. ハウスダスト症例でも花粉症症例でも,抗原の相違による差はみられず,6型のいずれかに分類された.
4. 従来,偽陽性と判定されたもののうちで,急増急減型に属するものは誘発反応陰性であった.
5. 鼻粘膜誘発反応曲線の解析を行い,誘発直前の鼻呼吸抵抗Rrs•N,鼻粘膜の反応性を反映するΔRrs•Nおよび鼻粘膜の感受性を表わすTaの3つのパラメーターを抽出した.
6. 急増急減型,山谷型の一部,およびRrs•Nが初めから高い症例では解析できなかった.
7. 初めから鼻呼吸抵抗の高いものほど鼻粘膜誘発反応による鼻呼吸抵抗の上昇程度が強く現われた.抄録全体を表示PDF形式でダウンロード (1071K) -
特に年齢変化について古川 浩三1984 年 87 巻 2 号 p. 169-181
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリーLaryngeal movement during deglutition was analyzed by means of cineradiography on fortyeight males of different age groups who had no pathology. The film was analysed using a film motion analyzer and the laryngeal movement was measured in two directions, horizontal and vertical.
As a result, the vertical movement associated with swallowing was divided into 5 phases: 1) the slowly ascending phase, 2) the rapidly ascending phase, 3) the pause at the position of maximum rise, 4) the rapidly descending phase, and 5) the slowly descending phase.
The slowly ascending phase was observed during the period of voluntary stage (the first stage) of deglutition, whereas the rapidly ascending phase was observed during the period of reflexive stage (the second stage). The average duration at the maximum position of rise was 0. 24 seconds. The descending phase appeared during the third stage of deglutition. Throughout these phases, the greatest time difference as related to aging, was noted in the slowly ascending phase. There were no notable time differences among the different age groups in the rapidly ascending phase and in the pause at the maximum position of rise. There were some differences among the different age groups in the extent of vertical laryngeal movement and in the time required for it. However, there were no notable differences in the extent of horizontal movement and in the time for the second stage among the different age groups.抄録全体を表示PDF形式でダウンロード (1449K) -
広川 剛夫1984 年 87 巻 2 号 p. 182-194
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリーSuccess rate of transplantation of head and neck cancer to BALB/C athymic mice was 42.2% (19/45). Based of the technical procedures, human squamous cell carcinomas with three different kinds of differentiations were transplanted to the mice and were used as chemotherapy models. These three kinds consisted of a well differentiated squamous cell carcinoma (ES-4), a moderately differentiated squamous cell carcinoma (OKK-2) and a poorly differentiated squamous cell carcinoma (PNC-1-JCK). Bleomycin (BLM) and Mitomycin C (MMC) were selected as chemotherapeutic agents and were given intraperitoneally either alone or in combination. Administration of BLM on day 1 and 4 in combination with MMC on day 1 was more effective. A schedule of administration of BLM for seven consective days followed by administration of MMC on day 8 enhanced chemotherapy effect more effectively.抄録全体を表示PDF形式でダウンロード (1972K) -
その1臨床的研究中村 清純1984 年 87 巻 2 号 p. 195-201
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリーSeventy six patients, that locus of lesions were detected by computed tomography, were investigated by various audiometry to know the mechanism of auditory disturbance by cerebral apoplexy.
The following results were obtained;
1) The pattern of pure tone audiogram peculiar to cerebral apoplectic patients could not be found.
2) There was not significant difference in incidence of hearing impairment between the case of right hemispheric lesion and the left.
3) When the cerebral lesion was close to the brainstem, abnormality shown in ABR as well as distorted speech audiometry was detected by the test-tone through not only contralateral but also ipsilateral ear.
4) When the lesion was far from the brainstem, the abnormality was found more frequently by the test-tone through the contralateral ear than by it of the ipsilateral ear.
From results of ABR and distorted speech audiometry, it was suggested that hearing inpairment in apoplectic patients would be originated from not only the direct lesion of the corticogeniculate pathway but also the indirect influence induced by compressing the brainstem.抄録全体を表示PDF形式でダウンロード (566K) -
箕輪 靖弘1984 年 87 巻 2 号 p. 202-212
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリーIt has been reported that even the administration of a single dose of kanamycin (KM), when used concurrently with furosemide (FM), could produce a severe permanent hearing loss after recovery of the temporary hearing loss due to FM. In order to investigate the hearing impairment caused by the combined administration of KM and FM, the effects of KM and FM on hearing impairment were examined various time intervals.
The ototoxicity of cisplatin (CP) has been reported and the hearing loss caused by a single administration of CP and the effects of the combined administration of CP and FM were also studied.
Using Hartley guinea pigs, the auditory brainstem response (ABR) was recorded to study the physiological changes and the morphological changes were observed by scanning and transmission electron microscopy. The KM concentrations in serum and perilymph were measured, and the following results were obtained.
Subsequent to an intramuscular injection of KM (400rng/kg), FM (80mg/kg) was administered intravenously at various intervals of administration. The ABR study revealed that the most severe bearing loss at the administration intervals ranging from 30 minutes to 2 hours, whereas almost no combined effects were observed in ABR when the intervals were more than 3-4 hours.
When an intravenous injection of KM (200mg/kg) was followed by intravenous injection of FM (80rng/kg), ABR disappeared in two days in the cases within intervals of 1 hour, and permanent hearing loss occurred.
In cases administered CP 2mg/kg/day eight times or 4mg/kg/day four times, the ABR disappeared or the amplitude of ABR decreased obviously, as well as a severe degeneration of hair cells. The ABR began to return in some animals after withdrawal of the drug.
When FM (80mg/kg) was intravenously administered 30-90 minutes after intramuscular injection of CP (4mg/kg or 6mg/kg), disappearance of ABR or decrease of amplitude was observed in two days, however ABR tended to recover thereafter in many cases. Morphologically significant destruction of hair cells was observed, but the changes of stria vascularis were slight.
Hearing impairment caused by a combined medication of KM or CP with FM was found to be largely dependent on the intervals. It is suggested that the administration of FM during the high concentration of KM or CP in the blood may cause a temporary functional disturbance of the blood-cochlear barrier, which in turn causes KM or CP to be transferred in large quantities into the inner ear.抄録全体を表示PDF形式でダウンロード (2258K) -
稲垣 政志, 坂倉 康夫, 間島 雄一, 三吉 康郎1984 年 87 巻 2 号 p. 213-217
発行日: 1984/02/20
公開日: 2008/03/19
ジャーナル フリーThe absorption of aminodeoxykanamycin and human IgG from rabbit nasal mucosa was studied in vivo. Rabbit was tracheotomized and upper end of the esophagus was ligated. Drug was administered into rabbit nasal cavity with jet nebulizer and continuously sucked from the tube which inserted through th cephalad end of the tracheo-stoma. The pressure of jet nebulizer and suction was equal. The serum concentration was measured chronologically. Nine rabbits were given about 800mg of aminodeoxykanamycin and five were given about 168mg of human IgG. These micromolecular and marcomolecular substances were absorbed from rabbit nasal mucosa. The maximum peak of the serum concentration of aminodeoxykanamycin was attained much earlier than that of human IgG. Histologically, enzyme-labeled antibody method demonstrated human IgG in epithelial cytoplasma of rabbit nasal mucosa. These results suggest that there might be a different mechanism in absorption between aminodexykanamycin and human IgG.抄録全体を表示PDF形式でダウンロード (743K)
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