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87 巻, 8 号
選択された号の論文の7件中1～7を表示しています
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小腫瘍の診断を中心に草刈 潤, 小林 俊光, 六郷 正暁, 荒川 栄一, 橋本 省, 大山 健二, 花島 隆敏, 河本 和友1984 年 87 巻 8 号 p. 923-935
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリー過去6年間に経験した聴神経腫瘍71耳を検討し次のごとき結論を得た.
(i) 難聴を示したのは94,4%,CPは79.7%でこの傾向は腫瘍の大きさが小さくなるほど低下した.
(ii) 内耳道の拡大は71%にあり,腫瘍の大小とは関係がなかった.
(iii) ABRでは全例に異常所見が見られた.その内訳としては,聴神経腫瘍に特徴的なI-V波間隔延長,III波以降の消失はそれぞれ22.6%,46.8%で残りの30.6%は無反応であった.
(iv) ABRの普及とCT Scanの改良が小腫瘍の診断に大きく寄与したと思われる.
(v) 小腫瘍の発見は第一線の医師の協力が不可欠である.抄録全体を表示PDF形式でダウンロード (1901K) -
福田 勝則, 古田 茂, 島 哲也, 花田 武浩, 伊東 一則, 内薗 明裕, 松永 信也, 大山 勝1984 年 87 巻 8 号 p. 936-943
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリー慢性副鼻腔炎鼻汁,病的鼻副鼻腔粘膜組織抽出液およびアレルギー鼻汁中のproteaseとprotease inhibitor活性を3H-caseinを基質として測定した.その結果.
1) 慢性副鼻腔炎鼻汁中protease活性はかなり高く,組織抽出液では低値であり,鼻アレルギー鼻汁ではほとんど活性を認めなかった.
2) 慢性副鼻腔炎鼻汁中proteaseは各種薬剤による変化や至適pH等により,その大部分は顆粒球由来のelastaseである可能性が示唆された.
3) α1-antitrypsin, α2-macroglobulin量は,慢性副鼻腔炎鼻汁,組織抽出液である程度検出し得たが,鼻アレルギー鼻汁では測定限界以下の量であった.しかし,trypsin阻害活性は,鼻アレルギー鼻汁ではるかに高かった.
4) 鼻アレルギー鼻汁中のprotease inhibitorは,gel chromatographyにて部分精製され,SDS電気泳動にて分子量約10,000の蛋白であることが確認された.このprotease inhibitorは,ヒトplasminやpapainは抑制しないが,chymotrypsinと慢性副鼻腔炎鼻汁中のproteaseを抑制し,顆粒球,特に鼻アレルギー鼻汁中に多く含まれる好酸球との関連が示唆された.抄録全体を表示PDF形式でダウンロード (495K) -
安藤 真姿子, 村上 泰1984 年 87 巻 8 号 p. 944-949
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリーWe examined the parotid gland of patients with Sjögren's syndrome by means of fine needle aspiration biopsy (F. N. A.). Typical findings were a number of lymphocytes mingled with some neutrophils, histiocytes and duct epithelial cells. Immature lymphocytes were also observed in some cases.
Neutrophils were dominantly obtained in acute swelling of the parotid gland suggestive of suppurative infection of these glands.
We conclude that F.N.A. is safe and valuable for differential diagnosis of parotid swelling in patients with Sjogren's syndrome.抄録全体を表示PDF形式でダウンロード (474K) -
平野 実, 寺沢 るり子, 麻生 正美, 川崎 洋, 吉田 哲二, 大久 保洋1984 年 87 巻 8 号 p. 950-955
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリーThis paper describes the results of Arslan-Serafini technique in 11, Amatsu technique in 15 and Panje technique in 1 case. Post-operative vocal function was evaluated in 3 Arslan-Serafini, 5 Amatsu and 1 Panje case. Following Arslan-Serafini operation, 7 patients became able to speak, whereas in the other 4, the shunt was closed spontaneously or because of infection and/or necrosis. Of the former 7, 6 patients had no or only slight aspiration but the other patient suffered from severe aspiration and, therefore, we had to close the shunt surgically. Following Amatsu operation, 5 patients obtained phonatory and protective functions. In other 3 patients who became able to phonate, the shunt had to be closed because of severe aspiration. In the remaining 7, the shunt was closed spontaneously or because of infection and/or necrosis. The patient who underwent Panje method became able to speak. There was no difference in phonatory function among the 3 phonosurgical treatment modalities. Compared to normal subjects, the fundamental frequency of voice was low, the ranges of frequency and intensity of voice were narrow and the glottal resistance and subglottal pressure were high.抄録全体を表示PDF形式でダウンロード (413K) -
その発現頻度ならびに形態学的変化と機能との関連について峯田 周幸1984 年 87 巻 8 号 p. 956-968
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリーEndolymphatic hydrops were tried to produce in 33 guinea pigs by obliteration of the endolymphatic sac, and the following three points were investigated.
1) The incidence of the spontaneous nystagmus.
2) The relationship between the time course and the degree of endolymphatic hydrops.
3) The relationship between the caloric response to cold water stimuli and the degree of endolymphatic hydrops.
The results were as follows:
1) By this procedure, endolymphatic hydrops were produced in 24 out of 33 guinea pigs (72.7%). The spontaneous nystagmus was noticed in 3 cases. However these spontaneous nystagmus seemed to be originated from other pathological changes. Namely, two cases were accompanied with labyrinthitis and one was labyrinthine bleeding.
2) Endolymphatic hydrops were more remarkable in the postoperatively prolonged cases.
3) The cases which showed severe endolymphatic hydrops had tendency of decreased caloric response to cold water stimuli.
Although the spontaneous nystagmus was not noticed in these model animals, morphologically and functionally these results were very similar to the findings of the patients with Meniere's disease.抄録全体を表示PDF形式でダウンロード (1722K) -
相川 通1984 年 87 巻 8 号 p. 981-991
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリーThe ototoxicity of various aminoglycoside antibiotics was evaluated after a single injection into the facial nerve through the stylomastoid foramen and a mechanism of the inner ear damage was studied in rabbits. Tobramycin (TOB), gentamicin (GM), kanamycin (KM), amikacin (AMK) and dibekacin (DKB) were dissolved 100mg/ml respectively, and their 0.04ml were given. Histological findings of the hair cell in 24 hours and 10 days after the injection was observed by the surface preparation technique with a phase contrast microscope. The concentration of these drugs in perilymph and tympanic cavity was concurrently measured by the bioassay method.
No hair cell damage was observable in any rabbit decapitated 24 hours after the injection. In the animals decapitated 10 days after the injection, however, the outer hair cells were damaged. The damage of the outer hair cell caused by TOB and GM was more severe than that by KM, AMK, or DKB. These results coincide with the ototoxicic evaluation of these drugs by general administration. There were no differences in the perilymph concentration between these drugs. Therefore it is thought that the difference of the ototoxicity resulting from the aminoglycoside antibiotics is due to the difference of their own otoxicities to the hair cells and not to the difference of their accumulation in the perilymph.
In order to clarify a mechanism of inner ear damage after the injection into the facial nerve, the serial horizontal sections of the temporal bones after an injection of indian ink 0.04ml were observed histopathologically. The indian ink was transudated into the tympanic cavity from the dehiscence of the facial nerve and along the stapedius muscle and the auricular branch of the vagus nerve. The indian ink was also observed in the intracranial space and inner auditory canal. There was high concentration of the drugs in perilymph and tympanic cavity. It is concluded that the inner ear damage after the injection of aminoglycoside antibiotics into the facial nerve through the stylomastoid foramen is caused by the drugs, which arrived in the perilymph along the cochlear nerve and through the round and oval window from the tympanic cavity.抄録全体を表示PDF形式でダウンロード (3255K) -
細井 裕司1984 年 87 巻 8 号 p. 992-1006
発行日: 1984/08/20
公開日: 2008/03/19
ジャーナル フリー1) 聴覚障害者,特に感音難聴者の語音弁別能と障害部位の関係を明確にするために,聴覚障害者の持つ聴覚系の周波数特性の影響を可能な眼り除いて語音弁別能を評価する方法を示し,次いで本法の臨床応用を可能にするマイクロコンピュータシステムを作成した.
2) まず,聴覚障害者の聴覚系の周波数特性を近似するディジタルフィルタを作成し,このフィルタを通した語音を聴力正常者に聴取させ,その実験結果からその周波数特性の聴覚系の持つ語音弁別能の正常基準値を導き出した.
3) この正常基準値から算出される語音認知能係数(d)を用いて,実験Iの20の感音難聴例について,障害部位別に語音弁別能を評価すると,後迷路性難聴では内耳性難聴に比べ低いdを取る傾向があった.
4) そこで症例を増して検討することにした.実験IIとして別の59感音難聴例についてマイクロコンピュータシステムを用いて,語音弁別能の正常基準値を推定し,これから語言認知能係数(d)を算出した.実験I,IIの感音難聴例計79例について検討したところ,後迷路性難聴の66%が-2未満のdをとり0以上の値を示したものが8%と,低いdを持つのに対し,内耳性難聴では,61%でdが0以上の値を取り,-2未満であったのは15%と,高いdを取る傾向を示した.
5) この実験結果を感音難聴の細別診断に利用するためにX2検定を行うことにより,感音難聴者でdが-2未満であれば,後迷路障害の可能性が,0以上であれば内耳障害の可能性が有意に高いことがわかった。
6) 実験IIIで,異聴傾向の分析の新しい試みとして,聴覚系の周波数特性の影響を除去して解析する方法を行い,内耳性難聴者では聴覚系の周波数特性に関連した異聴を示す傾向が強いが,後迷路性難聴では必ずしも一定の傾向は示さなかった.
7) 実驗IVで,シャープカット型難聴の障害部位診断に本法を応用し,シャープカット型難聴の主病巣は内耳にある可能性が強いと結論した.抄録全体を表示PDF形式でダウンロード (1264K)
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