Nippon Jibiinkoka Gakkai Kaiho
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
Volume 92, Issue 3
Displaying 1-13 of 13 articles from this issue
  • TERUHIRO OGAWA
    1989 Volume 92 Issue 3 Pages 317-333
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    A adenocarcinoma arises rarely in the nasal cavity and paranasal sinus, 19 patients with this disease hospitalized in Shikoku Cancer Center Hospital were investigated.
    They were five with colonic-type, three with adenosquamous cell-type, and twelve with adenocarcinomas derived from mucous duct. Three cases of benign adenomas, i.e. one mucous duct-type adenomas and two pleomorphic type were also studied as references.
    In order to investigate the histological oncogenesis of adenocarcinomas, the histochemical studies were performed on the tissues in a comparison with those of squamous cell carcinomas.
    The methods employed were routine H-E stain, PAS stain, Alcian blue stain as well as special stains of immunohistological method using ABC (avidin biotin peroxidase complex) method, to identify a localization of CEA and cytokeratin.
    CEA was found to be localized at the apical surface with papillary or tubular shapes in colonic-type adenocarcinomas and adenosquamous carcinomas.
    On the other hand the mucous epithelium of the ductal portion was positive for CEA on the ductal-type adenocarcinomas.
    The positive localization of cytokeratin was found only in adenosquamous carcinoma and mucoepidermoid carcinoma, where squamous metaplasia of ductal epithelium was seen as the same pattern.
    This study concluded that the nature of the apical membrane surface and squamous metaplasias, which were often seen in the nasal and paranasal mucosa, might become one of the causes in the developing the squamous cell carcinoma predominantly rather than adenocarcinoma in the nasal and paranasal sinuses.
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  • TERUHIRO OGAWA
    1989 Volume 92 Issue 3 Pages 334-346
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    We report a clinicopathological study in 193 cases with squamous cell carcinoma (SCC) in the sino-nasal cavity.
    Squamous metaplasia were found in 62.6% and squamous dysplasia in 25.3% of the SCC cases.
    These lesions seem to be important factors related with cancer development.
    Etiologically, metaplasia was found too be related with age and sex (male-dominant), but not with smoking and history of sinusitis.
    Chronic inflammation, papillary or stratified proliferation and reserved cell hyperplasia were considered as factors inducing squamous metaplasia in review of pathological specimens.
    We infered from the distribution pattern of cytokeratin that it might occur serial changes from metaplasia, dysplasia, CIS to microinvasive carcinoma, whose phenomenon was commonly seen in cases of uterus squamous cell carcinoma.
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  • YOSHINORI NAKAJIMA, YASUO HATTORI
    1989 Volume 92 Issue 3 Pages 347-352
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    This report presents the results of the clinical observation of 96 children under ten years of age with acute otitis media (107ears) who visited our out-patient clinic from May 1986 to August 1987.
    The patients were classified into the following three groups according to clinical course: Group 1:25 cases (26.0%) in which acute inflammatory findings rapidly disappeared and otitis media was cured within two weeks with no evidence of effusion; Group 2:62 cases (64.6%) in which acute inflammatory findings rapidly disappeared but obvious accumulation of effusion which resolved gradually was observed and in which otitis media was cured from two weeks to three months after onset; Group 3:9 cases (9.4%) in which persistent accumulation of effusion for more than three months was observed and which required myringotomy and insertion of a ventilation tube and in which a diagnosis of otitis media with effusion was made.
    The presence or absence of allergic diseases, adenoid symptoms, and otorrhea, or history of tonsillitis had no affect on the prognosis of acute otitis media. However, patients with a history of acute otitis media were at a significantly higher risk of developing the disease chronically.
    At the time of the resolution of the tympanic redness, abnormal findings in the tympanic membrane and tympanogram (TG), suggestive of the presence of middle ear effusion, were observed in approximately 80% of the patients. Approximately 20% of the patients who showed Type Cs or B in TG at that time developed otitis media with effusion.
    Therefore, children with acute otitis media who are not cured promptly and who tend to take a chronic course are at risk of developing otitis media with effusion. We believe that myringotomy should be performed on such patients without delay.
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  • YURIKO SUGIUCHI, ISAMU WATANABE, TAKAHIRO FUTAMI
    1989 Volume 92 Issue 3 Pages 353-361
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    We have reported before that there are excitatory inputs to the cerebellar dentate nucleus (DN) from the cerebral cortex. This study was performed to examine whether the pontine nucleus (PN) and the nucleus reticularis tegmenti pontis (NRTP), which are among the precerebellar nuclei that relay inputs to the cerebellar cortex, also play a role as the relay nucleus of the excitatory input to the DN. In anesthetized cats, we stimulated the PN and the NRTP, and recorded intracellular potentials from DN neurons. Short-latency EPSPs were evoked from these nuclei and their latencies ranged from 1.1 to 3.6 msec, which are compatible with monosynaptic latencies. Systematic stimulation of the PN and the NRTP with weak stimulus intensities revealed that low-threshold foci for monosynaptic EPSPs in each cell were localized in the PN or the NRTP or both. We could not find monosynaptic inputs from the red nucleus and by recurrent collaterls of the dentate output neurons. Accordingly, the possibility was excluded that the monosynaptic EPSPs evoked from the PN and the NRTP were evoked by inadvertent current spread to the descending axons of DN neurons in the brain stem. The conditioning-testing stimuli of the cerebral peduncle and the PN or the NRTP yielded spatial facillitation. This result showed that the input from the cerebral cortex to the DN was relayed by way of the PN or the NRTP.
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  • I. SIALOGRAPHICAL AND HISTOPATHOLOGICAL FINDINGS OF THE MAJOR AND MINOR SALIVARY GLANDS
    OSAMU TANAKA
    1989 Volume 92 Issue 3 Pages 362-373
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    This work was an attempt to elucidate the diagnostic evaluation of sialogram and histopathological examination of the salivary gland in Sjögren's syndrome. The author investigated the correlation of the sialographical and histopathological features of the salivary gland in 89 confirmed cases of Sjögren's syndrome and 26 suspected cases, a total of 115 subjects and the following results were obtained.
    1) In determining the histopathological severity of the salivary gland lesions from sialogram, the parotid sialogram was more useful than the submaxillary sialogram.
    2) The severity of parotid sialogram correlated well that of labial gland histopathology.
    3) Biopsy of the labial gland was useful for histopathological diagnosis on Sjögren's syndrome but the histopathological change occured to a greater degree in the submaxillary gland than in the labial gland.
    4) From above results, in histopathological examination of severe case of Sjögren's syndrome, biopsy of the labial gland will be sufficient, but biopsy of the submaxillary gland must be employed for studying mild cases.
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  • II.ON THE RELATIONSHIP BETWEEN SJÖGREN'S SYNDROME AND CHRONIC THYROIDITIS
    OSAMU TANAKA
    1989 Volume 92 Issue 3 Pages 374-382
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    The histopathological findings of the salivary glands in Sjögren's syndrome and of the thyroid gland in chronic thyroiditis have similarity in lymphocytic infiltration of the stroma and decrease or disappearance of parenchyma.In order to investigate the pathogenesis of Sjögren's syndrome, the author performed serological and histopathological examination of the thyroid gland in 89 confirmed cases of SjSgren's syndrome and 26 suspected cases, a total of 115 subjects and the following results were obtained.
    1)Thyroidal microsomal and thyroglobulin antibodies were detected in 34.5% and 21.4% of 89 confirmed Sj&gren's syndroma.
    2)The positivity rate of the antithyroid antibodies increased in the more severe histopathological changes of the thyroid gland and thyroidal microsomal antibody, in particular, reflected the absence or presence of lymphocytic infiltration of the stroma.
    3)The correlation between histopathological findings of the thyroid gland and titers of antithyroid antibodies was insignificant.
    4)The correlation between histopathological grading of thyroid gland and of salivary glands was insignificant.
    5)Approximately 30% of confirmed cases of Sjögren's syndrome presented chronic thyroiditis as a complication, therefore, it was suggested that both Sjögren's syndrome and chronic thyroiditis might have a common etiology.
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  • YASUHARU HORIUCHI, HIROAKI HUNAI, KEIITI ICHIMURA, TOSHITAKA IINUMAM, ...
    1989 Volume 92 Issue 3 Pages 383-389
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    High-resolution Computed Tomography(HRCT)of nthe telnporal bone has now becolne a routine test for the diagnosis of various temporal bone lesions.Correct assessment of such minute structures as ossicles, especially stapes, is important in the pre-operative HRCT evaluation.On the other hand, analysis for the reliability of HRCT findings has not been done, including the superstructure of the stapes.
    A retrospectively study was done in oder to assess the availability of HRCT findings in axial overlapping scans in 226 ears, with respect to the superstructures of stapes.The study was concerned with the analysis of HRCTs of 148 normal ears, 71 ears of chronic otitis media and7ears of ossicular abnormalities.HRCT findings were compared to those of surgeries in pathological cases.
    The present study revealed that the superstructures of stapes are noted in 70% when the stapes surrounded by air.The major limitations in the proper analysis of stapes by HRCT are partial volume averaging and effects of soft tissue silhouetting, this is especially so when the stapes is surrounded by soft tissue density.
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  • YAYOI MIZUNO, YOSHIHARU HIROTA, TOSHITAKA IINUMA
    1989 Volume 92 Issue 3 Pages 390-394
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    Radiographic innominate line and TM line(Tuber maxillae line)which superimpose upon the maxillary sinus by Water's view were classified into four types.These are, no visualization, visualization of the whole length, upper half and lower half, respectively.324 sides of maxillary sinuses by Waters' were included in this study;of innominateline, no visualization 45%, whole length 17%, upper half 27%, and lower half 11%.
    Of TM line, no visualization 67%, whole length 9%, upper half 1.5%, and lower half 23%.
    Of diagnostic significance of the present study, the innominate line, especially the lower half with it's inferior extension, might be confused with bone tips of blow-out fractures, and the TM line, when destructed, will indicate posterior extension of the lesions.However, These lines only have limited application since about 30 to 50% of them are visualized by Waters' view.
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  • MORIHIRO IRIFUNE, SATOSHI OGINO, AMOTSU HARADA, TORU MATSUNAGA, KUNIO ...
    1989 Volume 92 Issue 3 Pages 395-401
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    A study about the desensitization therapy carried out on children with nassal allergy to house dust who were under 15 years old. The good effect was seemed in 35.7% of patients with the desensitization for 3 months, and 62.7% for 6 months, 90.0% for 12 months, 92.7% for 24 months.
    The patients with the dessensitization for over 6 months had a considerable effect, as if they dropped out. In the questionaire to patients who dropped out with no contact to us, the effect of this therapy was seemed on 83.3% in those who answered questions, as so we considered that the sensitization for children with nasal allergy was very important as the basic therapy. Reffering to the efficacy of this therapy, it was seemed to be recommended to childern who were about from 7 to 9 years old, or those who had allergic rhinitis for a long time.
    At the point of 6 months after starting HD desensitization, the patients who reacted intensivelyto the provocation test had not significantly the efficacy compared with those who reacted slightly, but other clinical data were not significantly concerned with the efficacy of this therapy.
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  • HIRO-OKI OKAMURA
    1989 Volume 92 Issue 3 Pages 402-413
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    The study was designed to examine the combined ototoxic effect of CDDP (Cisplatin, Cisdiammine dichloroplatinum) and electron beam irradiation, using guinea pigs.
    One group received physiological saline solution of 4m1/kg/day, and another group received CDDP of 2mg/kg/day for five days. And following the injection of saline or CDDP, the electron beam of 14Gy/day was applied to the both groups to the right ear for five days. Animals were sacrificed after 21 days, and temporal bones of these animals were removed for the inner ear histopathology. Temporal bones were classified into four groups (control, electron beam irradiation, CDDP administration, and combined administration group), and the inner ears were observed by the surface preparation technique with a phase contrast microscope, and by scanning and transmission electron microscopy, and by temporal bone study of serial sectioned slides.
    The main pathologic findings of the inner ear are as follows: Electron beam irradiation group showed no hair cell damage. CDDP group induced slight damage to the outer hair cells. Combined administration group (CDDP + electron beam irradiation) showed severe outer hair cell damage. Stria vascularis was degenerated moderately in the combined administration group and slightly in some animals of electron beam irradiation group. And Reissner's membrane and Hensen's cells, were damaged in the basal turn of cochlea of the combined administration group.
    All other cochlear structures (spiral ganglion, spiral lamina, basilar membrane, spiral prominance, tectorial membrane, blood vessels of the cochlea) and vestibular organs were lack of significant changes in all groups by a light microscopic observation.
    This study was clarified that combined administration of CDDP and electron beam irradiation showed severe ototoxic potentiation. Therefore, it is important that we must pay attention to the inner ear damage caused by combined therapy of CDDP and electron beam irradiation involving inner ear for the head and neck tumor.
    Electron beam irradiation, CDDP
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  • HIROSHI MIYAHARA, YOSHIHIRO TSURUTA, TAKEO SATO, KUNITOSHI YOSHINO, KA ...
    1989 Volume 92 Issue 3 Pages 414-419
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    From 1978 through 1984, we had 151 patients with T1NOM0 glottic carcinoma. They were treated by radiotherapy with 4MV x-ray in parallel opposing field of 5 x 5cm' or 6 x 6cm2. The total dose was 60 Gy/30 fractions/6 weeks.
    The local control rate was 88.1%, the local recurrence being noted in 18 cases (11.9%). Of these 18 cases, 6 underwent partial laryngectomy, and 10 total laryngectomy. The remaining two cases died : one refused further treatment for recurrence and the other died in spite of total laryngectomy due to recurrence after partial laryngectomy. The salvage rate was 94.1%. The cummurative survival rate was 82.6% in Tla, 71.5% in Tlb and 81.1% in 151 T1NO. The tumor response was poor in the presence of lesion occupying the whole length of the vocal cord. Also, in the cases with ulcer formation or thickened vocal cord as seen on laryngogram, local control rate was not good.
    Better results will be achieved by improving treatment techniques, specially by improving dosedistribution by wedge-filtered technique and method for immobilization in plastic shell during radiotherapy.
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  • YASUKO URAO
    1989 Volume 92 Issue 3 Pages 420-432
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
    Salivary gland tumors present diverse histopathological aspects and show various biological behavior. At present, the immunohistological method using anti-BrdU monoclonal antibodies, which was originated in the field neurosurgery, has been tried extensively in various fields of medicine. Using this method, the authors have attempted to detect biological characteristics of salivary gland tumor tissues, especially those of pleomorphic adenomas. The lab0elling index (L. I.) is defined as the percentage of the labelled cells (proliferating cells) in the tumor tissue. In order to confirm the usefulness of the L.I. for measuring the proliferating activity of tumor tissue, an investigation was conducted with respect to squamous cell carcinomas of the head and neck, excluding salivary gland tumors. The results indicate that the L.I. is highly correlated with the differentiation of these carcinomas. In salivary gland tumors, values of the L.I. are also higher for benign tumors than for normal or inflammating tissues and the values were even higher for malignant tumors. Values of the L.I. are low for pleomorphic adenomas, which are the majority of salivary gland tumors, as well as for other benign tumors. However considerable individual variabilities, are bound for pleom. ad. and the values of the L.I. are markedly high in some cases.
    These high values are particularly common in patients with whom strong positivity in Ga scintigraphy, or primary growth in the submandibular glands are found. The localization of proliferating cells shows a characteristic pattern in each type of tumor tissue. In pleomorphic adenomas, proliferating cells are sporadically distributed but the main growth is located at the site of the epithelioid proliferative region, excluding the duct-forming locus. However, the overall proliferating activity of myxochondromatous tumors is not generally low, and the proliferating activity is not particularly high in the region of infiltrating is the capsule.
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  • [in Japanese], [in Japanese], [in Japanese]
    1989 Volume 92 Issue 3 Pages 468-471
    Published: January 20, 1989
    Released on J-STAGE: March 19, 2008
    JOURNAL FREE ACCESS
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