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Volume 94, Issue 1
Displaying 1-16 of 16 articles from this issue
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AN EVALUATION OF IPSILATERAL AND CONTRALATERAL MASKING FOR TINNITUSKAZUO MURAL, MAKOTO OGASAWARA, TAKESHI ISHIKAWA, SHIN MIZUTANI, TAKASH ...1991 Volume 94 Issue 1 Pages 1-8
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIn this study, the tinnitus masking curves measured by the ipsilateral and contralateral masking test were evaluated for the unilataral tinnitus cases of following 4 groups ; 40 cases without hearing loss, 22 cases with symmetrical sensorineural hearing loss, 12 cases with unilateral deafness, and 70 cases with unilateral sensorineural hearing loss. Then the characteristics of tinnitus masking curves and central masking phenomenon for tinnitus masking were investigated. Consequently, tinnitus was masked by a masking tone given from nontinnitus ear when it reached at some definite loudness level, in spite of the presence of hearing loss or the degree of hearing loss in tinnitus ear. Then it was suggested to be a influence of central masking phenomenon in the contralateral tinnitus masking.View full abstractDownload PDF (616K) -
[in Japanese]1991 Volume 94 Issue 1 Pages 8-9
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (585K) -
COMPARISON OF CLINICAL FINDINGS AND TEMPORAL BONE PATHOLOGICAL FINDINGSYASUYUKI OHIRA, IMITAKA KAGA, AKIRA KODAMA1991 Volume 94 Issue 1 Pages 9-15
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSWe report temporal bone pathology in a 25-year-old man with bilateral temporal bone adenocarcinoma which was caused by metastasis from a primary lesion in the pancreas.
The initial symptoms began with vertigo and headache and the patient noticed left hearing loss in the left ear on the following day. A few days later, he noticed hearing loss in the right ear, and bilateral hearing was totally lost within two weeks of the onset.
In addition to severe bilateral sensorineural hearing loss, left IInd, bilateral V th and VIII th cranial nerve paralysis occurred.
Brain CT showed multiple metastatic lesions in the brain. The patient's general condition rapidly deteriorated, and he died of acute pneumonia on the 42nd day after onset.
At autopsy it was revealed adenocarcinoma of the tail and body of the pancreas and its metastasis to the brain and meninges.
Pathological study of the temporal bone showed infiltration of carcinomatous cells along the VII th and VIII th nerves in the bilateral internal auditory canals.View full abstractDownload PDF (1751K) -
TAKESHI KUSUNOKI, YASUHIRO YOSHIOKA, YOSHIHIKO KAHDA, KIOTAKA MURATA, ...1991 Volume 94 Issue 1 Pages 16-21
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSHuman thyroid papillary carcinoma cells (surgical materials) were cultured in a monolayer or a collagen gel system. In the monolayer culture, degeneration and necrosis of cancer cells were observed after 10 days of culture. In the collagen gel culture, degenerative necrosis were observed 14 days culture.
In histopathological observation monolayer cells proliferated in pavement-like form without forming any colony. On the contrary, collagen gel culture cells formed branching-type colonies and spheroid-type colonies. Those results suggested that papillary carcinoma cells can be cultured more like in vivo in collagen gel culture than monolayer culture.View full abstractDownload PDF (2140K) -
YUKIO MURATSUKA, OSAMU NISHIHIRA, HIROAKI INOUE, SHIZUO KOMUNE1991 Volume 94 Issue 1 Pages 22-27
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSTwo siblings of Laurence-Moon-Biedl (L-M-B) syndrome with nystagmus and/or sensorineural hearing loss were reported. One sibling had a slight hearing impairment as well as gaze and rebound nystagmus. The auditory brainstem responses (ABR) showed increased latencies of wave V on both ears. The optokinetic nystagmus (OKN) was limited toward the both horizontal sides. Nystagmus was superimposed on the eye tracking movement. Ocular hypermetria was observed, with bilateral weakness of caloric responses and even a failure of visual fixation suppression. Another sibling had a left-beating spontaneous nystagmus. The latencies of wave V of ABR were prolonged in both ears. The leftward OKN was limited and bilateral saccadic pursuits observed on eye tracking test. These results suggest that cerebellar of brain-stem lesions may be involved in L-M-B syndrome.View full abstractDownload PDF (447K) -
AGAINST CHEMOTHERAPEUTIC AGENTS AND CYTOKINESMAMORU TSUKUDA, AKIRA KUBOTA, MADOKA KANEKO, TOYOKAZU YOSHIDA, SHUJI S ...1991 Volume 94 Issue 1 Pages 28-33
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe closed relationship between nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) has been pointed out. However, it still remains unclear whether the EBV becomes a true factor in initiation and promotion in NPC or not, because of difficulty to establish this cancer strain.
We succeeded to establish the EBV-genome positive cell line (NPC-TY861) in 1986, which had been derived from the tissues of nasopharyngeal carcinoma. In this study, the characteristics of this cell strain were investigated by tests for sensitivity against several kinds of anticancerous agents and immuno-activated cells.
The sensitivity tests revealed that NPC-TY861 cell line was extremely sensitive to PEP, ADR, VCR, LPA and CDDP with dose dependent manner. Fruthermore, this cell strain had similar sensitivity to CDDP derivatives, such as 254-S, NK121, DWA2114R and CBDCA as KB cell strain did, which had been derived from an oral base cancer. The oral base cancer was a poorly differenciated squamous cell carcinoma histopathologically as same as NPC-TY861 cell strain.
On the other hand, NPC-TY861 cell strain showed no sensitivity to cytckines, TNF and IFN, Which have direct anti-cancerous actions.
NPC-TY861 cell strain had resistant to NK cells and much more resistant to LAK cells derived from IL-2 than Daudi cell strain did.
In order to elucidate the oncogeneous mechanism in NPC, it is indispensable to study the character of this cell strain and it would promise to get a new effective therapeutic method for the patient with NPC, who has bad prognosis.View full abstractDownload PDF (480K) -
PRIMARY LESIONS OF LARYNGEAL CANCERYOSHIHIRO TSURUTA, TAKASHI MATSUNAGA, HIROSHI MIYAHARA, OSAMU TANAKA, ...1991 Volume 94 Issue 1 Pages 34-40
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSFlow cytometric analysis of DNA content using paraffin-embedded materials has become an important diagnostic, as well as prognostic, method for clinical pathology and investigative oncology. DNA content as measured in paraffin-embedded materials is closely related with that obtained from fresh specimens. This method also permits retrospective analysis on a lot of cases and studying different specimens of a tumor for intratumor heterogeneity.
Flow cytometry was used to investigation of the DNA distribution in biopsy specimens from 30 patients with squamous cell carcinoma of the larynx. These patients had initially treated in our institute in the period from 1986 to 1988 and followed for two to four years. A modification of Hedley's method was used to prepare paraffin-embedded materials. DNA histogram were assessed in terms of DNA index (DI). The coefficient of variation for determination of DI ranged 4.2 to 13.7% (mean 7.8±2.4%). Using infiltrated lymphocytes and mesenchymal cells as an internal standards, aneuploid DNA histogram were found in 13 of 30 specimens (43.3%). DI ranged from 1.05 to 1.22. There was no significant correlation between DNA content and sex, age, tumor size, staging or treatment. The aneuploidy was found in 2 of 17 cases with well differentiated tumor (11.8%), 10 of 12 with moderately differentiated tumor (83.3%), one with poorly differentiated tumor (100%). 11.8% of patients with diploid tumor cells had recurrence during the interval of observation, compared to 38.5% of those with aneuploid tumor cells (p<0.05). In Tl lesions of glottic cancer aneuploid group had a significantly lower local control rate than diploid group (p<0.01).
These results suggested that DNA content analysis by FCM using paraffin-embedded materials is a very meaningful indicator for determination of locoregional control and radiosensitivity for laryngeal cancer and provide useful biological information.View full abstractDownload PDF (521K) -
SHOJI TAKOODA, WATARU NISHIJIMA, HIROYUKI USUI, ATSUKO IKEDA, TATSUROO ...1991 Volume 94 Issue 1 Pages 41-45
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSForty-four patients with cancer in the hypopharynx and cervical esophagus underwent pharyngoesophageal reconstruction with a free jejunal graft after total removal of a tumor combined with resection of the cirumferential tissues. The graft survival rate was 93.2% (41 of 44).
Postoperative complications occurred in 16 patients (36.4%), which included postoperative death in one (2.3%), graft necrosis in 3 (6.8%), fistula formation in 4 (9.1%) and graft stricture in 3 (6.8%).
All 3 cases of graft necrosis underwent successfully reimplantation. The mean interval time was 20.9 days until oral intake was possible. Thirty-two of 42 patients (76.2%) were able to take usual food. Esophageal speech was limited in the selected cases by this procedure. A cumulative survial rate of 5 years was 40.6% in this series.
This method of reconstruction should be advocated as one of relatively safe and reliable procedures for patients with hypopharyngeal and cervical esophageal cancer.View full abstractDownload PDF (368K) -
KIYOFUMI GYOU, YASUSHI SASAKI, TAISUKE KOBAYASHI1991 Volume 94 Issue 1 Pages 46-50
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSA variety of solutions were tested in vitro to find a suitable solvent of cholesteatoma debris for use in clinical practice. The specimens were taken during surgery from the patients of otitis media with cholesteatoma. They were divided in pieces and put in test tubes. Each tube was then admixed with one of the test solutions and incubated at 3TC for 48 hours. Hydrochloric acid (1N) and sodium hydroxide (1N) had no substantial effect to solve the debris. Urea (ION), acetylcys.
teine (20%) and chymotrypsin (1%) had a weak such effect. Proteolytic agents such as diiodosalitylic acid (0.1N), sodium dodecyl sulfate (O.1N) and cholic acid (0.1N) showed a stronger effect but not enough for clinical use. In contrast, a detergent which contains interfacial active agents and a proteolytic enzyme (alkaline cellulase), such as Attack4' and Hi-Top*, proved to be more effective to solve the debris. However, biological effect of such detergent on the ear is not clear. Further study will be necessary before actual application in the patients.View full abstractDownload PDF (1464K) -
TOSHIO OGOSHI, NOBUO USUI1991 Volume 94 Issue 1 Pages 51-56
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIn this paper, we examined distribution and deposition of inhaled 99mTc aerosols in human respiratory truct, nebulization equipment and expired aerosols. Jet nebulizers were used and aerosols were inhaled through the nose. Results were as follows:
(1) On normal breathing, deposition rate of human respiratory tructs in normal subjects were 22% of total dossage and there was no difference from sinusitis group. But, deposition rate of nasal cabity was higher than in sinusitis group normal in group.
(2 )In normal subjects, there was no influence of breathing pattern to deposition rate of nasal cavity.
(3)Distribution of the lung was significantly increased on deep breathing in both groups.
(4)Residual volume of nebulizer bottle were about 50% of total dossage.View full abstractDownload PDF (397K) -
TATSUYA GOTOH1991 Volume 94 Issue 1 Pages 57-65
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIn order to elucidate the cell characteristics of head and neck squamous cell carcinomas, the cell kinetics and lectinbinding patterns were compared with the histological classification and staging of the tumors, using surgically resected materials (maxillary sinus 10, oral cavity 21, pharynx 8, larynx 11). Eight biotinylated lectins (WGA, 1-PHA, ConA, UEA1, RCA1, SBA, DBA, PNA) were applied to the paraffin-embedded sections, and were visualized histochemically by the streptavidin-alkaline phosphatase method. The DNA contents of the isolated carcinoma cells obtained from the adjacent thick sections were evaluated using an epi-illumination cytofluorometer after propidium iodide staining. On lectin histochemistry, the binding pattern of WGA lectin was similar between carcinoma tissues and normal tissues, but the binding was more intense in well differentiated than less differentiated carcinomas. Lymph node metastasis was found to be related to the presence of cells with poor WGA-binding. In the binding patterns of the other lectins, RCA1, SBA and ConA were related to the differentiation of carcinomas, but they were not related to the TNM-classification. DNA cytofluorometry exhibited marked polyploidization, which progressed with the advancement of the clinical and pathological staging of carcinomas. However, the DNA ploidy pattern was not associated with the cell characteristics such as the degree of histological differentiation and the lectin-binding pattern, except that the appearance of aneuploidy had some relationship with the binding-patterns of UEA1 and 1-PHA.View full abstractDownload PDF (1803K) -
BIOCHEMICAL AND CYTOLOGICAL ANALYSISKATSUROH USHIJIMA1991 Volume 94 Issue 1 Pages 66-78
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSBoth paranasal and middle ear cavities are surrounded by bony walls and are lined with upper respiratory mucosae. Thus it can be worthwhile to compare the biochemical and cytological characteristics of the fluids in these cavities, and this gives valuable information to help us to understand the pathogenesis of otitis media with effusion.
The fluids in the otitis media with serous effusion (OME-S), otitis media with mucoid effusion (OME-M) and acute otitis media (OMA) were sampled for the middle ear diseases, and those in postoperative maxillary cyst (POMC) and acutely aggravated chronic maxillary sinusitis (CMS) were chosen for maxillary sinus group. LDH (lactate dehydrogenase), ALP (alkaline phosphatase), CHO (total cholesterol), LDH isozymes and ALP isozymes of these effusions were assayed and the results of each group were compared. Coincidently, through smear samples of these effusions, infiltrating cell count, cell differential count and cholesterol crystals were observed microscopically.
LDH activity of the fluids was extremely higher than those of the serum in all diseases. The LDH activity ratios to serum were CMS_??_OMA_??_OME-M>POMC>OME-S in order of activity.
LDH isozyme analysis showed higher LDH 4 and 5 than LDH 1 and 2 in all diseases. ALP activity ratios to serum were OME-S_??_OMA>OME-M_??_POMC_??_CMS in order of activity. Middle ear diseases manifested higher ALP activities than maxillary diseases. CHO ratios to serum were POMS>OME-MzOME-S>CMS_??_OMA in order of quantity. This result agreed with the frequencies of cholesterol crystallization of these fluids. The fluids of OME-M showed mild infiltration of cells, and cell differentiations were polymorphonuclear leucocyte>lymphocyte_??_ macrophage_??_epithelial cell in order of cell numbers. There were few infiltrating cells in the fluids of OME-S and differentiations were lymphocyte _??_polymorphonuclear zmacrophage in order of numbers. There were a few cells but were many cell debris in the fluids of POMC, and cells were polymorphonuclear_??_macrophage>lymphocyte in order of cell count.View full abstractDownload PDF (1130K) -
HAYATO MISAWA, TEIJI TANAHASHI, KOICHI TSUZUKI1991 Volume 94 Issue 1 Pages 79-88
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSAlthough both posteroventral cochlear nucleus (PVCN) and dorsal cochlear nucleus (DCN) are innervated by the descending branch of auditory nerve fibers, their intrinsic morphological organizations are so different that their physiological roles are expected to be different in signal processing. Temporal information coding of acoustic signals in the cochlear nucleus was examined by using stimuli of "tone-burst-trains (TBT) Responses of cochlear nucleus neurons of anesthetized cats were recorded either intracellularly or extracellularly. Responses of the neurons to TBT stimuli were classified into "adaptive type" and "non-adaptive type" The "adaptive type" neurons were mainly recorded from PVCN. Responses of these neurons to TBT stimuli decayed exponentially, because of short-term adaptation, in the subsequent tone-bursts.
These neurons faithfully preserve the adaptative behavior of auditory nerve fibers. On the contrary, the "non-adaptive type" neurons were mainly found in DCN. They showed variety of responses to TBT stimuli including facilitation, disinhibition and inhibition depending on duration and/or interval of tone-bursts. Our results suggest that some "non-adaptive type" neurons, showing facilitative and/or inhibitory responses to TBT stimuli, act as temporal filters that extract temporal information from acoustic signals.View full abstractDownload PDF (1285K) -
[in Japanese]1991 Volume 94 Issue 1 Pages 144-145
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (128K) -
[in Japanese]1991 Volume 94 Issue 1 Pages 146-147
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (99K) -
[in Japanese]1991 Volume 94 Issue 1 Pages 148-150
Published: January 20, 1991
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (216K)
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