Pneumatosis intestinalis (PI) is a rare and severe disease characterized by the presence of gas within the gastrointestinal tract wall. There are numerous reports of the condition developing during treatment for head and neck carcinoma (HNC). Herein, we report cases of PI developing during treatment for HNC. Patients who were diagnosed as having PI while undergoing treatment for HNC at Nagoya City University Hospital between April 2014 and December 2023 were included in this study. We conducted a retrospective review of the patient background characteristics, symptoms, and treatment. During the study period, 9 cases who were undergoing treatment for HNC were diagnosed as having PI. The median age was 69 years old (range: 64-79 years). Six cases were male and 3 were female. The primary site of the cancer was the hypopharynx in 4 cases, oropharynx in 3 cases, and the oral cavity and maxillary sinus in 1 case, vespectively. As the treatment for HNC, 5 cases were receiving chemoradiotherapy (with cisplatin in 4 cases and cetuximab in 1 case), 2 cases were receiving treatment with paclitaxel and cetuximab, 1 case was receiving chemotherapy with 5-fluorouracil and cisplatin, and 1 case was receiving treatment with a cetuximab, 5-fluorouracil plus cisplatin regimen. A nasogastric tube was placed in 5 cases and gastrostomy had been performed in 1 case. As treatments for PI, 5 cases received antibiotic therapy while fasting and the remaining 2 cases were only fasting. None of the cases needed surgical treatment. There was no significant difference in the fasting or antibiotic treatment duration according to the presence or absence of portal venous gas. Although PI is a rare disease, special attention should be paid to cases undergoing treatment for HNC, including chemotherapy or molecular-targeted therapy, fasting for an extended period of time, and/or with implanted nasogastric tubes or gastrostomy devices. PI should be kept in mind as one of the adverse events that may have serious outcomes.
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