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101 巻, 4 号
選択された号の論文の15件中1～15を表示しています
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岡本 美孝2008 年 101 巻 4 号 p. 247-253
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーTo improve the prognosis and QOL of patients with head and neck cancer, the development of new treatment strategies is of critical importance. We found that nasal submucosal administration of antigen presenting cells (APCs) is an effective and useful route for modalities affecting the immune system. Human Vα24 natural killer T (NKT) cells have a strong antitumor activity and are activated by a specific glycolipid antigen α-Galactosylceramide (α-GalCer). We carried out Phase-1 and Phase-1/2a study of nasal submucosal injection of α-GalCer-pulsed APCs and the intra-arterial infusion of activated NKT cells in unresectable or recurrent head and neck squamous cell cancer and showed the induction of significant anti-tumor immunity and some beneficial effects. The use of such therapeutic modalities may be helpful in the management of head and neck squamous cell cancer and need to be explored further. We summarize the present status of anti-cancer immunotherapy in the management of head and neck squamous cell cancer.抄録全体を表示PDF形式でダウンロード (6093K) -
阪上 雅史, 村上 信五2008 年 101 巻 4 号 p. 254-255
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーPDF形式でダウンロード (2090K) -
戸嶋 一郎, 鈴木 幹男, 花満 雅一, 福井 潤, 桜井 弘徳, 清水 猛史2008 年 101 巻 4 号 p. 257-260
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーPotassium bromate intoxication shows acute renal failure, hearing loss and neuropathy. We report a 56-year-old woman who drank a solution of cold wave neutralizer in a suicide attempt.
The patient showed severe renal failure, neuropathy and sensory neural hearing loss, but there was no vertigo or vestibular disorder. Early continuous hemodiafiltration (CHDF) after potassium bromate ingestion was effective for these symptoms. Slight improvement of renal failure and hearing loss, and complete improvement of neuropathy were confirmed on long-term evaluation. At present, dialysis is not required, and the patient can converse smoothly using a hearing aid.
We investigated 81 cases of bromate intoxication including the present case, reported in Japan up to 2006. Renal failure occurred in all cases, hearing loss and neuropathy were described in 56/65 (86%) and 21/21 (100%), respectively. These symptoms should be caused by the direct toxic effect of bromate. The cause of hearing loss seems to be disorder of the stria vascularis. We hope that a new cold wave neutralizer that does not contain no potassium bromate will become more widely promoted by the cosmetic industry.抄録全体を表示PDF形式でダウンロード (571K) -
平松 隆, 森 芳郎, 宮田 英雄2008 年 101 巻 4 号 p. 261-265
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーThe etiology of bullous myringitis (BM) is unknown. We speculated that BM involves middle ear barotrauma because of frequent bleeding in the tympanic membrane, including a patient with BM who strongly blew the nose.
We investigated 186 patients with BM aged one to 80 years old (average age; 8.83), including 16 patients with recurrent BM.
In six patients, BM was associated with blowing their nose. Patient ages ranged from 6 to 58 years old (average age; 32.7). None of the patients showed recurrent BM. Two patients had multiple bulla formations and 5 patients showed bleeding in the tympanic membrane. Among all 186 patients examined, 36 patients had multiple bulla formations and 78 of 181 patients demonstrated bleeding in the tympanic membrane.
These findings suggest that a sudden reflex of secretions and air from the nasopharynx into the middle ear could cause bulla formation on tympanic membrane.抄録全体を表示PDF形式でダウンロード (2601K) -
マルチスライスCTと3D Accu-i-tomo®による評価今泉 光雅, 小川 洋, 大森 孝一2008 年 101 巻 4 号 p. 267-274
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーWe evaluated traumatic facial nerve paralysis using both Multi-slice computed tomography and 3D Accu-i-tomo®. We report features of each modality in the assessment of temporal bone fractures.
We found that it was possible to estimate the areas of facial nerve damage using either of these methods, though a comparison of surgical findings with image findings showed that 3D Accu-i-tomo® described the facial nerve canal in greater detail than MSCT. However, for extensive fractures such as those of the skull base, MSCT findings were more useful than those of 3D Accu-i-tomo®. It appears that 3D Accu-i-tomo® is a simple and useful tool for investigating three-dimensional relationships using it's image processing software.抄録全体を表示PDF形式でダウンロード (8308K) -
杉本 一郎, 宮脇 浩紀2008 年 101 巻 4 号 p. 275-279
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーWe report a case of primary nasopharyngeal tuberculosis in a 27-year-old woman who had immigrated to Japan from Vietnam. She initially complained of right cervical swelling. A red granular mass with ulcer was observed in the nasopharyx. A biopsy from the nasopharynx showed tuberculous changes. Tubercle bacilli were detected in a smear of pharyngeal discharge. Since there were no apparent pulmonary tuberculous lesions, we diagnosed the case as primary nasopharyngeal tuberculosis with tuberculous cervical lymphadenitis.
The nasopharyngeal lesion disappeared after three weeks anti-tuberculosis chemotherapy. Tuberculous cervical lymphadenitis increased despite chemotherapy, and required dissection and drainage.
Anti-tuberculosis chemotherapy was administered by a short course of carefully monitored treatment.抄録全体を表示PDF形式でダウンロード (4126K) -
湯田 厚司, 野本 由人, 有馬 忍, 大津 和弥, 石永 一, 中村 哲, 竹内 万彦, 山下 恭史, 伊井 憲子, 間島 雄一2008 年 101 巻 4 号 p. 281-286
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーTwenty-six patients with nasopharyngeal cancer treated at Mie University Hospital between 1996 and 2005 were reviewed. The subjects consisted of 18 males and 8 females. The average age was 53.9-years-old. The clinical stage was IIA in 1, IIB in 4, III in 9, IVA in 7, IVB in 2 and IVC in 3. Histological classification by WHO was type I in 5, type II in 17 and type III in 4. Scheduled courses of alternating chemoradiotherapy were planned. A total 30.6-36Gy (1.8-2.0Gy five times per week) was administered between the skull base and supraclavicular fossa. An additional total 26-30Gy was administered over a decreased irradiation field. A total of 3 courses of chemotherapy were also administered. Each course of radiotherapy or chemotherapy was administered alternatively. Alternating chemoradiotherapy were administered in 21 of 26 cases. Of these 21 cases, poor prognoses were predicted in 2 cases demonstrating distant multiple metastases, 2 cases demonstrating invasion of the clivus, and one case demonstrating intracranial invasion. The other 5 cases were treated by conservative radiotherapy or chemotherapy due to their general conditions. The survival rate in the 21 cases treated by alternative chemoradiotherapy was 86.6% at 2 years and 67.8% at 5 years on Kaplan-Meier analysis.抄録全体を表示PDF形式でダウンロード (822K) -
高橋 淳人, 庄司 和彦, 児嶋 剛, 伊木 健浩, 水田 匡信2008 年 101 巻 4 号 p. 287-292
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーEndoscopic sinus surgery (ESS) is a well-documented procedure that has been used worldwide. Patients can undergo surgery under either local or general anesthesia. Under local anesthesia, one of the important issues for patients is the degree of intra-operative pain. We should perform the procedure without causing unbearable pain. This study evaluated the degree of intra-operative pain during ESS under local anesthesia and the ability of patients to cope with unbearable pain. Twenty-one patients were entered into this study (10 men, 11 women) operated by one surgeon between March 2006 and June 2007. During the first 9 months, 11 patients underwent the procedure without the maxillary nerve block. During the next 7 months, 10 patients were managed with the maxillary nerve block. The severity of pain was scored by the patient on a numerical rating scale (NRS). Pain severity was indicated by the number (minimum 0 and maximum 5).
Eleven patients without the block reported pain during of the opening maxillary sinus (average of score 2.91). However 10 patients with the block reported that there was little pain (score average 0.95). The difference between the two groups was significant. We confirmed the degree of the intra-operative pain during ESS and that pain could be successfully managed by maxillary nerve block. NRS is a useful tool to evaluate intra-operative pain under local anesthesia, because we can hear a report of the pain score even without visually monitoring the tool (NRS).抄録全体を表示PDF形式でダウンロード (794K) -
望月 幸子, 望月 高行, 米田 律子, 廣瀬 肇, 佃 守2008 年 101 巻 4 号 p. 293-297
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーAntrochoanal polyps mostly arise from the maxillary sinus and show a relatively high incidence in children and young adults. The base of the antrochoanal polyp is often found on the lateral or posterior wall of the maxillary sinus and extends toward the choana through the nasal cavity. The most important point during surgery for antrochoanal polyp is to remove it completely from its base. For this purpose, endonasal sinus surgery (ESS), combining middle meatal and inferior meatal approaches, is considered the most suitable. In this paper, we report 2 pediatric cases demonstrating antrochoanal polyps successfully treated by combined ESS approaches.抄録全体を表示PDF形式でダウンロード (3960K) -
阿部 晃治, 押川 千恵, 田村 公一, 武田 憲昭2008 年 101 巻 4 号 p. 299-302
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーPositron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) is useful for the diagnosis of head and neck cancers. We report 5 cases of abnormal FDG uptake in the contralateral larynx of patients with unilateral laryngeal palsy due to lung cancer, lung metastasis of breast cancer, lung metastasis of mesopharyngeal cancer, idiopathic cause and laryngeal cancer after complete remission. We concluded that overactivity of the laryngeal muscles that compensated for the paralyzed vocal cord caused a false-positive PET finding with abnormal uptake of FDG in the contralateral larynx of patients with unilateral laryngeal palsy.抄録全体を表示PDF形式でダウンロード (2236K) -
進 武一郎, 千々和 秀記, 三保木 隆夫, 権藤 久次郎, 中島 格2008 年 101 巻 4 号 p. 303-309
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーWe encountered a case of rapidly growing angiosarcoma of the left neck. The patient was a 55-year-old male who consulted our clinic complaining of a left infraauricular mass with subcutaneous bleeding. Neck MRI demonstrated a large mass (49×37×23mm) with outapparent tumor capsule. The lesion was diagnosed as carcinoma of the left parotid gland. Based on the findings of fine needle aspiration biopsy, we performed surgical removal and postoperative diagnosis demonstrated angiosarcoma. However, there was a rapid regrowth of the tumor and the patient developed peritonitis due to metastasis to the liver and lung. He died of respiratory failure. As angiosarcoma is a severe disease with a poor prognosis, difinitive diagnosis followed by a multimodal regimen is required for adequate treatment.抄録全体を表示PDF形式でダウンロード (7087K) -
野々田 岳夫, 出原 啓一, 大橋 敏充, 大西 将美2008 年 101 巻 4 号 p. 311-316
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーA 16-year-old boy underwent total laryngectomy following neck injury. While riding a bike, he was chased by police officers. He sped into a gas station, where a metal chain was used to block the entrance. As he did not notice the chain, his neck was strongly pulled back by the chain when he entered the gas station. He demonstrated dyspnea, stridor and dysphonia as a result of the injury. Surgical findings showed that his larynx was attached only to the hypopharynx at the upper portion although the skin was intact. The larynx was completely separated from the trachea between the cricoid cartilage and the first ring of the trachea and was ripped from the esophagus. A full-thickness laceration of the anterior esophagus extending obliquely into both pyriform sinuses was identified. We also found a purulent discharge in saliva leaking from the lacerated mucosa. As the wound was thought to be infected and difficult to sutured between the larynx and esophagus without saliva leakage, total laryngectomy was performed in order to avoid severe deep infection causing mediatinal abscess.抄録全体を表示PDF形式でダウンロード (6138K) -
兵 行義, 山田 作夫, 石松 昌己, 原田 保2008 年 101 巻 4 号 p. 317-323
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーBurow's solution has long been used as a local otological preparation in the treatment of otitis externa and otitis media.
To ascertain the antibacterial effect of Burow's solution on antibiotic resistant bacteria, it was examined using the disk method to determine whether the solution has a bactericidal effect and/or a bacteriostatic effect on methicillin-resistant Staphylococcus aureus (MRSA) and antibiotic resistant Pseudomonas aeruginosa isolated from the patients. In addition, we examined the effectiveness of diluted Burow's solution on these isolates.
The results showed that Burow's solution had larger average zones of inhibition than the other two antibacterial agents, levofloxacin and povidone-iodine. There was a difference in the susceptibilities of the antibiotic-sensitive bacteria and antibiotic-resistant bacteria to Burow's solution. The effective bactericidal dilutions of Burow's solution were found to be a 1:2 dilution and a 1:4 dilution for MRSA and antibiotic-sresistant Pseudomonas aeruginosa, respectively.
This study suggests that Burow's solution is an effective antibacterial agent, not only for antibiotic resistant bacteria but also for antibiotic-sensitive bacteria. Therefore, Burow's solution is considered to be useful for the treatment of otitis. The antibacterial effective dilution of Burow's solution depends on the bacterial species. Further study is required to demonstrate whether diluted Burow's solution is effective in a clinical setting.抄録全体を表示PDF形式でダウンロード (2095K) -
洲崎 春海2008 年 101 巻 4 号 p. 324-325
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーPDF形式でダウンロード (379K) -
星野 知之2008 年 101 巻 4 号 p. 326-327
発行日: 2008/04/01
公開日: 2011/10/07
ジャーナル フリーPDF形式でダウンロード (2520K)
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