I experienced two complicated cases of ranula. The first case was a 9 years old girl. She had suffered from ranula for 3 years. At first, her ranulas were the bilateral oral type. After two surgeries via the oral approach, her ranulas changed into the plunging type. Thereafter, surgery was performed via the neck, but her ranula recurred immediately. After that, she got OK-432 intracystic injection therapy. However, following increased swelling after OK-432 therapy, dehiscence occurred at her operation wound and it became a salivary fistula.
The second case was an 8 years old girl. She had suffered from ranula for 2 years. At first, her ranula was the small oral type. She had a marsupialization operation but her ranula recurred as a very big plunging ranula. She then received three OK-432 therapy sessions, but they were not effective because of the dehiscence of the oral operation scar.
I treated theses cases with OK-432 after waiting for a long time till their wound became tight. The first case was cured with only one OK-432 injection. Case 2 needed 4 OK-432 injections to be cured because of the wound dehiscence.
The reason why these cases became complicated was the surgical procedure. We must be aware that marsupializaion and an excision operation for oral ranulas can sometimes cause a plunging ranula. A ranula is a mucocele through which saliva leaks from the sublingual gland. The strategy for treating ranulas must therefore be to stop leakage. The easiest method to stop saliva leakage is OK-432 and the most certain method is excision of the sublingual gland. Considering the fact that the efficacy of OK-432 therapy after surgery is low comparing to that of an unoperated case and OK-432 therapy does not increase the difficulty and risk of any subsequent operation, I believe that OK-432 therapy should be performed as a first choice. If the OK-432 regimen is not effective, transoral excision of the sublingual gland should be considered.
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