Improvement of blood supply to the inner ear is essential to recover hearing impairment produced by vascular disorder that is seemed to be possible cause of sudden deafness.
Further we would like to stress two points: firstly, oxidative phosphorylation may be severely affected during interruption of blood supply. Secondly, both decrease in DPN-linked oxidations and leakage of intracellular potassium may occur as the results of decrease in ATP production.
Our experiments have shown that ATP may prevent the morphological changes in mitochondria of the cochlear tissues during anoxia and activate the biochemically damaged tissues, in good agreement with the previous investigators.
Therefore, we have presented the combined use of the measures for vascular dilatation (stellate ganglion block, microtinic acid injection), ATP injection and administration of both vitamine B complexes and vitamine B factors. This new therapeutic method seemed to be more effective to the cases of sudden deafness than the formers.
Considering that the inner ear is sensitive to anoxia as well as the brain, the treatment of sudden deafness should be began as early as possible, after its onset. And large dosage of drugs should be administered to patient, since the inner ear is less permeable to drugs than the other organs are.

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By using polyethylene tube prosthesis, the authors attempted to reconstruct a loss of continuity of the ossicular chain in eleven cases of chronic otitis media. The operations methods for treating otitis media mentioned above were as follows; i. e., malleo-stapediopexy, incudo-stapediopexy, extending of the stapes and artificial columella in case of missing stapes plate. Especially, the authors devised a new technique in the establishment of an incudostapediopexy. Performing malleo-stapediopexy, incudo-stapediopexy and extending of the stapes by means of polyethylene tube prosthesis, a loss of continuity of the ossicular chain was treated successfully and excellent results for improvement of hearing ability were obtained. Whereas in case of missing stapes plate, artificial columella did not present any demonstrable restoration of hearing ability. It should be stressed here in passing, that the restoration of hearing ability previously described continued more than at least one year, and that any demonstrable recurrence of middle ear inflammation was not observed excepting a case in whom after months of tympanoplasty inflammation recurred and patient's loss of hearing returned to the preoperative one.

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Two cases of abnormal maxillary sinus were reported.
In one case, maxillary sinus was completely divided into two cavities by bony wall, and its parasinus had no communication with nasal cavity. Histologically, there were some different findings between mucous membranes of two cavities.
In another case, bony ridge in maxillary sinus was observed radiographically and when operated, it was proved that maxillary sinus was divided into two cavities by bony ridge incompletly.

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Sato's method for local anesthesia in tonsillectomy was followed, in which had been reported some improvements in respect of side effects resulting from anesthesia.
Our clinical estimates on this method is the folloming.
strong points
1. lesser pains through injection
2. lesser pains and bleedings during operation
3. none anxious
4. lesser pharyngeal reflex
Weak points
1. necessity to add injection at the adhesive regions
2. long time to wait before operation

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The pathogenesis of several diseases has been ascribed in recent years to an interaction between autoantibodies and antigens present in the affected tissues. Hashimoto's thyroiditis, in which thyroid specific autoantibodies has been clearly demonstrated by M. Burnet and many other immunologists, is an outstanding example.
The author has experienced a case of this disease as followed: A seventy-three year old woman was admitted on September 1963 because of dysphagia and painless swelling of the soft palate. Microscopically this was a kind of malignant mixed tumor originated from the tissue of salivary gland and associated with Hashimoto's chronic thyroiditis and rheumatoid arthritis of the left knee joint. After the removal of the primary tumor, the struma was gradually reduced to the normal size and rheumatic pain on the knee joint and lumber region excervated on the contrary.
The author investigated on the medical literature the relationship between Hashimoto's thyroidits and malignant mixed tumor. This association could be explained on the basis that autoimmune mechanisms may play a part in the pathogenesis of both conditions.

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Cepharanthin was orally administered for the treatment of several nasal diseases which were consisted of 32 cases of acute rhinitis, 20 of acute maxillary sinusitis, 34 of allergic rhinitis, 80 of chronic maxillary sinusitis, 30 of postoperative chronic maxillary sinusitis and 4 atrophic rhinitis. Some nasal complaints such as nasal discharge, nasal obstruction, sneezing and postnasal drip, were markedly reduced in the cases of acute rhinitis and acute maxillary sinusitis, however, in the cases of chronic maxillary sinusitis and allergic rhinitis, little improvemnt was observed at the administration of this agent.
Authors assumed Cepharanthin was effective available agent for the treatment of these several nasal diseases, especially for these acute stadium.

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Thirty two cases, compalining of nasal occulsion, nasal discharge and sneezing, were treated with cor-tyzine (Tetrahydrozoline hydrochloride-predonisolone 0.05% nasal drops) which was said to have potent vasoconstrictive, decongestive, anti-inflammatory and anti-allergic actions when applied topically to the nasal mucosa.
This agent was effective in nasal disease, especially chronic vasomotor rhinitis and allergic rhinitis, and no side effects were observed.

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The oxygen consumption of the cochlea of guinea pig were measured by means of Warburg's manometer, using glucose, fructose, lactate, pyruvate, succinate, glutamate and aspartate as a substrate. In all cases marked oxygen consumption could be observed in vitro.
It was found that change in oxygen consumption on each substrate gave the same result as those of the brain. It was concluded that processes of aerobic metalism in the cochlea of guinea pig should be similar to those in the brain.

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Electrical activity of the esophageal muscle in dog was studied with a view in elucidating the nature of nervous innervation.
In resting phase esophageal muscle was kept quiescent and no muscle activity could be recorded. To obtain action potential by direct stimulation more intensive stimulus was required than the other skeretal muscles in the neck. The muscle responses induced by stimulation of the recurrent laryngeal nerve had variable time delay ranged from 2 to 10 msec. These results might be the consequence of either variable fiber size contained in the efferent nerve or mode of distribution of the endplate in the muscles.
A reflex response in the esophageal muscle was evoked by stimulation of the internal superior laryngeal nerve. A response was a asynchronous type with a latency of about 20 msec.
A relatively long latency and the repetitive nature of the discharge indicated that a response should be a polysynaptic reflex.
Sometimes stimulation of the recurrent laryngeal nerve evoked, besides a direct response from the muscle, a secondary response of considerably lower amplitude after an interval of about 20 msec.
The origin and nature of a secondary response were discussed.

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