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82 巻, 3 号
選択された号の論文の21件中1～21を表示しています
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―咽喉頭異常感症を中心として―武藤 二郎1989 年 82 巻 3 号 p. 325-336
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーChinese Medicine helps to normalize and stabilize autonomic nervous system imbalances and endocrine and metabolic disorders.
In the field of oto-rhino-laryngology, Chinese Medicine is very effective when it is applied according to the traditional Chinese medical diagnoses for: 1) Abnormal sensation in the pharynx in patients with autonomic dysfunction. 2) Chronic inflammation. 3) Recurrent otitis media and pharyngitis. 4) Tinnitus, vertigo and dizziness with circulatory disturbances.抄録全体を表示PDF形式でダウンロード (1484K) -
佐藤 武男, 吉野 邦俊, 馬谷 克則, 路 波1989 年 82 巻 3 号 p. 338-339
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーPDF形式でダウンロード (1673K) -
―脊髄小脳変性症と多発性硬化症における検討―青柳 優, 鈴木 利久, 横山 寿一, 酒井 仁, 喜連 照夫, 小池 吉郎, 片桐 忠1989 年 82 巻 3 号 p. 341-351
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThe diagnostic usefulness of cross correlation function in the analysis of auditory brain stem responses (ABR) in Spinocerebellar degeneration (SCD) and multiple sclerosis (MS) was evaluated. ABR recordings from 30 normal males and females were averaged to produce normative ABR waveforms serving as templates for each gender. The cross correlation function between the individual ABR recording and the corresponding template was calculated, yielding an objective measure of the ABR waveform and gross latency. Cross correlation indexes were: RU (Correlation Coefficient at time O), RM (Maximal Correlation Coefficient) and DL (Latency Delay in msec).
In 22 patients with SCD with pontine atrophy diagnosed by CT scan, abnormalities of cross correlation function were detected more frequently (81.8%) than abnormalities of ABR peak latency (68.2% according to traditional criteria and 77.3% according to the criteria for each gender).
The evaluation of ABR waveform characteristics with cross correlation function using normative ABRs of the same gender were demonstrated to contribute to the diagnosis of slight lesions in the brain stem auditory pathway.抄録全体を表示PDF形式でダウンロード (4248K) -
―round window testの試み―辻 純, 森福 孝之, 中村 一, 伊藤 壽一, 本庄 巖1989 年 82 巻 3 号 p. 353-356
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThe electric stimulating threshold of the preoperative promontory test was compared with the postoperative threshold in the electrode of the cochlear implant and with the threshold of the warble-tone audiometry, vowel confusion test, consonant confusion test and the speech tracking test with the use of a speech processor postoperatively. In one patient in whom the reactivity of the promontory test was insufficient, tympanotomy was performed under local anesthesia before the cochlear implant operation, and the stimulating threshold was measured with the electrode placed directly on the round window membrane (round window test). There was no correlation between the result of the promontory test and the postoperative performance of the cochlear implant. The round window test is better than the promontory test for evaluating the performance of a cochlear implant.抄録全体を表示PDF形式でダウンロード (358K) -
―PrednisoloneとAzelastine―二木 隆1989 年 82 巻 3 号 p. 357-373
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThe first report concerning the effectiveness of a steroid in the treatment of Meniere's disease was written by Hauser in 1959. However, steroid therapy itself has been relegated to the treatment of “food allergy”, or atopic allergy or Type I reactions. On the other hand, since McCabe's report of “autoimmune sensorineural hearing loss”, several researchers have emphasized autoimmunity in the genesis of Meniere's disease and the effectiveness of steroids in its treatment.
Half of the active members of the Japan Society of Equilibrium Research actually use steroids in the treatment of Meniere's disease (Yazawa). Nevertheless, there are only a few reports describing steroid therapy of Meniere's disease. The first aim of this study is the demonstration of the effectiveness of a steroid, prednisolone, in the treatment of Meniere's disease.
In 16 patients (14- with Meniere's disease, two with delayed endolymphatic hydrops), the oral administration of prednisolone (average 15mg/day) caused significant (p <0.05) reduction of low-tone hearing loss, nystagmus, vertigo, dizziness and tinnitus.
The second aim of this study is seeking out and confirming an effective alternative to steroids to avoid side effects and dependency. A new anti-allergic agent, azelastine, which predominantly depresses the release of inflamatory chemical transmitters such as leukotriene C3, D4 and prostaglandin E2, was given in a dose of 2-3 mg/day immediately after steroid therapy to the same patients and resulted in significant (p <0.01) improvement of hearing with reduction of nystagmus, vertigo, dizziness and tinnitus. In a single dose given to 9 patients it caused significant (p <0.05) improvement in the same symptoms.
The importance of an alternative to steroids in the treatment of Meniere's disease is emphasized, and the contribution of autoimmunity in the etiology of Meniere's disease is discussed.抄録全体を表示PDF形式でダウンロード (2006K) -
浅野 公子, 小林 一女, 根岸 正之, 三辺 武幸, 岡本 途也1989 年 82 巻 3 号 p. 375-379
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーWe have already described the experimental and clinical uses of a new model AOR-501 Acoustic Otoscope developed for group and individual diagnosis of otitis media with effusion. This study assesses its effectiveness in children aged 0-3 years, whom we were not able to include in the earlier study because a tympanography was not possible.
Total of 162 ears in infants aged 0-3 years were tested with AOR-501. Examination was not possible in only 7 ears (4.3%), Of the 155 ears examined, 75 had middle ear effusion and 80 were normal.
Among the 75 ears with middle ear effusion, AOR-501 made a correct diagnosis in 45, a sensitivity of 60.0%. No statistically significant difference was noted between infants and the older patients assessed in the previous paper (x2 test). The sensitivity of AOR-501 does not differ with age, averaging 61.9%.
Among the 80 normal ears, AOR-501 judged 50 correctly (specificity 62.5%). The difference between infants and older patients was significant. That is, the specificity for those under 5 years of age was lower than in the older age groups.
If this recorder is used for the examination of young children in day care center, the probability {(+) predictivity} of a correct diagnosis of middle ear effusion is estimated to be only 51.4 %. Therefore, we conclude that this recorder is not very useful. It has been shown to be much less accurate than tympanography in older children and adults, and it appears to be of little use in younger children in whom tympanography is not possible.抄録全体を表示PDF形式でダウンロード (540K) -
石川 保之, 大森 孝一, 庄司 和彦, 網谷 良一1989 年 82 巻 3 号 p. 381-384
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーNasal ciliary beating frequency was determined by the photo-electric method and nasal mucociliary clearance by the Saccharin method in 16 laryngetomized patients. The control group consisted of 20 normal subjects. 1) The ciliary beating frequency of ciliated cells in the septal mucosa was 12.3+1.1 Hz in laryngectomized patients and 11.0+0.8 Hz in normal subjects (P<0.01). 2) The Saccharin time exceeded 11 minutes in 4 of the 16 laryngectomized patients and in 3 of the 20 normal subjects. The difference between the two groups was not significant.抄録全体を表示PDF形式でダウンロード (356K) -
青木 彰彦, 洲崎 春海, 周 明仁1989 年 82 巻 3 号 p. 385-389
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーTwo patients developed olfactory disturbance after the long-term oral administration of Tegafur as postoperative chemotherapy for cancer. A 53-year-old female received 600mg/day of Tegafur for two years until olfactory disturbance occurred. The second patient was a 54-year-old female who took 200mg/day of Tegafur for two and a half years.
A standard olfactory acuity test indicated anosmia in the first and severe hyposmia in the second patient. An intravenous olfaction test showed no response. Slight redness of the mucous membrane of the olfactory cleft was observed through a rigid type endoscope (outer diameter: 1.7 mm). The olfactory disturbance was not relieved by treatment with steroid hormones in the form of nasal drops or the oral administration of Vitamin B.
Tegafur, a metabolite of 5-FU compounds, is widely used in the treatment of cancer patients because of its low toxicity and good absorption. Olfactotoxicity of Tegafur should be kept in mind if it is administered for a long time.抄録全体を表示PDF形式でダウンロード (717K) -
―和歌山県, 大阪府南部における昭和63年のスギ花粉飛散数―中西 弘, 榎本 雅夫, 横山 道明, 寒川 高男1989 年 82 巻 3 号 p. 391-398
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThe increase of Japanese cedar pollinosis is becoming a social problem. The pathogenetic mechanism of this disease has been considered to be type I allergy, and therefore the amount of pollen in the air is closely related with the incidence of the disease.
We have been measuring the amount of Japanese cedar pollen at various sites since 1985. Here we report the result of measurements in 1988 and discuss . forecasts of the amount of pollen in the air. We have put Duhrum type pollen-traps on the rooftops of several hospitals to measure the amount of pollen in the air.
The results show that the pollen this year began to appear earlier and stayed later than in previous years. Accordingly we had more pollen this year than in an average year. The weather condisions which raise airborne pollen (in Wakayama City) appear to be an increase of the highest temperature of the day, an increase of maximum wind velocity, and a decrease of average humidity. We tried to forecast the amount of airborne pollen in Wakayama City but were unable to accumulate enough data. For forecasting the date of the first appearance of the pollen, the integrated figure of daily temperature since September 29 of the previous year (2026.75±47.67°C) seems to be most useful. It also seems that the weather condisions in the pollen generating period in addition to those in the pollen spreading period are important. Further accumulation of data is needed for precise forecasting.抄録全体を表示PDF形式でダウンロード (913K) -
古川 仭, 加藤 千維子, 上出 文博, 梅田 良三, 梅田 千弘1989 年 82 巻 3 号 p. 399-403
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーLesions of secondary syphilis were found in the right tonsil and on the palatoglossal arch. The pharyngeal mucous membrane and tonsil exhibited severe erosion with white-gray coating. Several Treponema pallida were seen in smears of the tonsillar exudate. Serological tests revealed high VDRL and TPHA titers. Histological examination showed severe inflammation with many lymphocytes and plasma cells, and thickened vascular endothelium. We also describe the present program of surveillance of sexually transmitted diseases in Japan and emphasize that ENT-physicians should be more aware of them in patients with otorhinolaryngological symptoms and signs.抄録全体を表示PDF形式でダウンロード (5301K) -
―術中迅速細胞診による試み―山本 茄三, 川上 理郎, 牧本 牧本, 高橋 宏明1989 年 82 巻 3 号 p. 405-413
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーCarcinomas of the mandibular gingiva, oral floor, tongue and buccal mucosa occasionally involve the mandibular bone. In those cases which have developed mandibular invasion, the extent of the invasion or the margin of surgical resection is usually determined by the roentgenologic findings in the mandible. However, we have recently treated some patients with recurrence of carcinoma in the mandible in spite of careful surgical resection based on preoperative roentgenologic assessment. To eliminate such recurrences, we performed rapid cytological examinations during surgery to demonstrate the presence or absence of carcinoma cells near the resection surface. The diagnostic efficacy of this method and its clinical feasibility are discussed.抄録全体を表示PDF形式でダウンロード (8163K) -
渋沢 三伸, 矢野 一彦, 西嶌 渡1989 年 82 巻 3 号 p. 415-420
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーMany factors influence the acquisition of functional esophageal speech after total laryngectomy or pharyngolaryngoesophagectomy. The type and extent of surgery are also important. It is usually difficult for the patients who have had pharyngolaryngoesophagectomy, especially those with free jejunal transplants, to acquire functional esophageal speech.
One patient with a free jejunal transplant fortunately acquired fluent esophageal speech. Examination of the pharyngoesophageal junction of this patient strongly suggested that the presence of a “functional” pharyngoesophageal junction is important for the acquisition of functional esophageal speech.抄録全体を表示PDF形式でダウンロード (7192K) -
飯塚 桂司, 古田 康, 川浪 貢1989 年 82 巻 3 号 p. 421-428
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーTwenty-five patients with cancer of the head and neck were treated with high dose 5-FU infusion alone or as part of multimodal cancer treatment program. The infusion dose was 1500mg/24 hours for 120 hours via a peripheral vein. The courses were repeated at 2-3 week intervals. The tumor response and clinical effect of 5-FU high dose chemotherapy were evaluated in 12 patients who received 5-FU infusion alone. In the 10 patients with previously untreated epidermoid cancer, tumor response was apparent in 6 (1 had complete response and 5 partial response). In 9 of the 10 epidermoid cancer patients 5-FU was clinically effective and proved to be useful in further treatment as a part of multimodal therapy. Mild leukopenia, stomatitis, diarrhea and vasculitis/pigmentation were prominent side effects, but they could be tolerated by all 25 patients, even those with far-advanced cancer. This chemotherapy could be combined with radiotherapy. The results demonstrate that 5-FU alone in high dose infusions can play a role in preoperative induction chemotherapy and in multimodal cancer therapy.抄録全体を表示PDF形式でダウンロード (2270K) -
古田 康, 川浪 貢, 飯塚 桂司1989 年 82 巻 3 号 p. 429-436
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーSeventy one patients with thyroid tumors received surgical treatment in our hospital from April 1985 to March 1988. 1) The pathological diagnosis in 39 patients (55%) was benign tumor (22 adenomatous goiters, 15 follicular adenomas, 2 cysts) and in 32 patients (45%) it was malignant tumor (27 papillary carcinomas, 3 follicular carcinomas, 1 malignant lymphoma, 1 squamous cell carcinoma). 2) For the preoperative diagnosis, delayed scintigraphy with 2a1T 1 C 1 and fine needle aspiration biopsy were quite useful in differentiating malignant thyroid tumors from benign ones. 3) Intraoperative frozen sections were helpful when the preoperative diagnosis was incorrect. 4) Cervical lymph node metastases were found in 75% of the patients with papillary or follicular carcinomas. 5) When cervical lymph node metastasis was obvious clinically, radical or modified neck dissections were performed. In patients without clinically apparent metastases, local neck dissection and sampling of the internal jugular chain were performed. When microscopic metastases were found in frozen sections, appropriate neck dissections were added.抄録全体を表示PDF形式でダウンロード (1099K) -
庄司 和彦, 北村 博之, 西川 益子, 高北 晋一, 田渕 圭作1989 年 82 巻 3 号 p. 437-440
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーFrom 1978 to 1987 141 patients with Graves' disease were treated surgically. Their clinical records were reviewed to evaluate the results of surgical treatment and the incidence of surgical complications. Complications of the surgery were rare, we experienced only two cases of postoperative bleeding and two cases of transient recurrent laryngeal nerve palsy. A high incidence (33%) of recurrent hyperthyroidism was found in the patients who were operated on from 1978 to 1982. The incidence of recurrence has decreased since 1983 when we decided to preserve about 6 grams of the thyroid gland; 80% of the patients operated from 1983 have been cured.抄録全体を表示PDF形式でダウンロード (427K) -
―鼓室階空気置換時の蝸牛機能―小林 俊光, 伊東 善哉, 桜田 桜田, 志賀 伸之, 草刈 潤, 高坂 知節1989 年 82 巻 3 号 p. 441-448
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThe hypothesis that acute, profound and reversible sensorineural hearing loss occuring in some cases of window rupture is caused by air-intrusion into the perilymphatic space at the time of rupture of the inner ear membrane (s) was tested by the introduction of air into the perilymphatic space of the guinea pig cochlea and the recording of cochlear potentials.
Perfusion of the scala tympani with air at a rate of 200 or 400 μl/mmn initially caused a slight decrease of EP (10-15mV), probably due to the pressure effect, but the EP (although recordings were notchy) remained at this level throughout the perfusion lasting for 20-30 minutes and returned quickly to the original level when perfusion was stopped. In contrast, the CM and AP showed a marked (but reversible) decrease during the air perfusion.
This study shows that the replacement of the scala tympani with air causes hearing impairment probably due to a reversible interference with the CM and AP production mechanisms rather than to strial dysfunction.抄録全体を表示PDF形式でダウンロード (2640K) -
渡辺 建介, 原田 宏美1989 年 82 巻 3 号 p. 449-455
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーWhen anesthetized guinea pigs which have been injected with horseradish peroxidase (HRP) are killed by decapitation, blood sludging and tracer leakage from the capillaries of the stria vascularis are observed.
When 400 mg/kg of hydrocortisone was injected, blood sludging occurred in 54% of the capillaries of the stria vascularis. With 150mg/kg of hydrocortisone, blood sludging occurred in 65%, and with 100mg/kg it occurred in 77% of the capillaries of the stria vascularis. When less than 50mg/kg hydrocortisone was administered, blood sludging occurred in 100% of the capillaries of the stria vascularis, as in the control animals. When a large dose of hydrocortisone was administered, HRP leakage also decreased.
We conclude that hydrocortisone prevents blood sludging of the strial capillaries after decapitation, and suggest that it may be useful in improving the blood circulation of the strial capillaries.抄録全体を表示PDF形式でダウンロード (6867K) -
村井 須美子1989 年 82 巻 3 号 p. 457-470
発行日: 1989/03/01
公開日: 2011/12/12
ジャーナル フリーNasal mucociliary function was evaluated by nasal scintigraphy in normal subjects. A microdrop of HSA or saline labelled with 99mTc was dripped into the middle part of each middle meatus in the nasal cavity and its clearance was observed by scinticamera. The accumulated concentration of ICI was determined every 30 seconds for 10 minutes. The changes of accumulated concentration were studied, and a curve of decreasing ICI-counts was obtained, with the “clearance rate” defined as 100% for the count at the initial 30 seconds and “half time” as the time when radioactivity was reduced to one half the initial count. Nasal resistance was measured by rhinomanometry with the oscillation method.
In nonsmokers, 10μl of saline was cleared (78.0±10.4%) significantly faster than 10μl of HSA (59.9 ±24.6%), and there was no significant difference in the clearance between 10μl and 5μl of HSA (55.9±27.7%). In smokers, the mucociliary clearance of lO1d of HSA and saline was significantly lower than in nonsmokers. The clearance of 10μl of HSA reflects a pathological state much better than that of 5μl.
In nonsmokers, there is a significant negative correlation between nasal resistance and clearance rate, suggesting that the more patent the nose, the faster the mucociliary clearance. When both nostrils were closed, the clearance rate was significantly depressed. When one nostril was closed, there was no significant effect on clearance. Nasal resistance was decreased by exercise with a bicycle ergometer. Nasal mucociliary clearance was slightly decreased after exercise but not significantly so.
Nasal patency may be one of the most important factors in mucociliary clearance, since it is slowed by nasal obstruction which would prolong inflammatory changes in the nose and paranasal sinuses.抄録全体を表示PDF形式でダウンロード (2811K) -
増田 佐和子, 間島 雄一, 稲垣 政志, 斎田 哲, 坂倉 康夫1989 年 82 巻 3 号 p. 471-478
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThis study was designed to determine the effectiveness of norfloxacin (NFLX), a new quinolonecarboxylic acid analogue, on the symptoms and signs of chronic sinusitis. The subjects of this study were 14 patients aged 13 to 71 years, who received NFLX 600mg per day p. o. for 2 weeks. Neither antiinflammatory nor mucolytic agents were given.
The effectiveness of NFLX on the subjective symptoms and rhinoscopic observations was 64.3%. X-ray opacity of the maxillary sinus was evaluated with a microdensitometer. The pre- and post- treatment data were compared in 13 patients (26 maxillary sinuses). Improvement of X-ray opacities by NFLX treatment was noted in 23.1 %. The general effectiveness of NFLX on the subjective symptoms, rhinoscopic observations and X-ray opacity was 65.4%. No side effects were noted.抄録全体を表示PDF形式でダウンロード (973K) -
一條 宏明, 朴沢 二郎, 永井 政男, 福岡 敬二, 太田 修司, 北山 裕隆, 西村 哲也1989 年 82 巻 3 号 p. 479-484
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーThe effect of the anti-depressant: Sulpiride on pharyngolaryngeal abnormal sensation was evaluated in 50 patients treated for 4 weeks. The depressive state of the patients was evaluated by the Self-Rating Questionnaire for Depression (SRQ D). 1) Depression was noted in 12 of the patients (24%). 2) Sulpiride improved the SRQ D scores of 70% of the depressed patients and of 36.8% of the non-depressed patients. 3) However, subjective symptoms were reduced in 84.2 % of the non-depressed patients and in 60% of the depressed patients. 4) Mild side-effects were noted in 4 patients (8%) during administration of this drug.抄録全体を表示PDF形式でダウンロード (742K) -
小野 克己1989 年 82 巻 3 号 p. 486-487
発行日: 1989/03/01
公開日: 2011/11/04
ジャーナル フリーPDF形式でダウンロード (311K)
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