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Tokuji Unno
1989 Volume 82 Issue 4 Pages
489-496
Published: April 01, 1989
Released on J-STAGE: November 04, 2011
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Non-salivary diseases that might be misdiagnosed as parotid lesions due to their localization are reviewed. These are classified into lymphadenopathies including inflammation and metastasis, masseteric muscle lesions including benign hypertrophy and tumors, odontogenic lesions, and dermal lesions including inflammations and cysts and parapharyngeal tumors. Imaging such as CT, echography and CT sialography are indispensable for differential diagnosis. Benign masseteric hypertrophy and odontogenic periostal abscess are misleading to otolaryngologists, whereas metastasis from the head and neck regions is often misdiagnosed by others. The earlier and more appropriate the examination and treatment plans are established, the better results are obtained.
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1989 Volume 82 Issue 4 Pages
498-499
Published: April 01, 1989
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Ryuichi Osanai, Ken Kitamura, Masahiro Mizuno, Teruo Simizu
1989 Volume 82 Issue 4 Pages
501-510
Published: April 01, 1989
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1. Three patients with multiple sclerosis presented with vertigo or dysequilibrium as an early symptom.
2. Neurootological examination showed abnormal findings in all three cases.
3. Gaze nystagmus, direction-changing positional nystagmus, rebound positional nystagmus and vertical positioning nystagmus were observed in these patients, indicating a disturbance of the central vestibular system.
4. MLF (medial longitudinal fasciculus) syndrome, indicating a brainstem lesion, was present in two patients.
5. Caloric testing was performed in two patients. The duration and the slow phase velocity of the caloric-induced nystagmus were within normal limits, while visual suppression of the caloric-induced nystagmus was impaired in both patients.
6. The optokinetic nystagmus pattern test was performed in two patients. The optokinetic nystagmus was markedly depressed when the patients first visited the vestibular clinic shortly after the onset of the vertiginous attack. It gradually improved towards normal during the course of the disease in close correlation with recovery from other neurological signs and symptoms.
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Tsutomu Yamazaki, Mitsuo Hayashi, Tatsuhiko Imoto, Namie Hayashi, Hide ...
1989 Volume 82 Issue 4 Pages
511-521
Published: April 01, 1989
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In 56 patients with senile sensorineural deafness, the degree of bone atrophy was assessed quantitatively by the MD method. Biochemical examinations were made to clarify the details of abnormal bone metabolism.
1) Abnormal bone matabolism is suspected in many patients with senile sensorineural deafness.
2) The serum calcium level is significantly lower and BUN significantly higher in patients with presbyacusis than in normal subjects.
3) A significant positive correlation is noted between hearing level and serum Al-P level in patients with presbyacusis.
After the treatment of 17 patients suspected of having abnormal bone matabolism on the basis of the results of the MD method with an active vitamin D preparation (1α(OH)D
3), 1μg/day for six months to three years and one month, hearing improvement was noted in 9 patients in a pure-tone hearing test and/or speach audiometric test. Hearing was decreased in 3 patients whose initial S-BUN level was significantly higher than that of the other patients.
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Hironobu Kurokawa, Shinsei Nisihara, Kiyofumi Gyo, Naoaki Yanagihara
1989 Volume 82 Issue 4 Pages
523-528
Published: April 01, 1989
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A 32-year-old housewife developed sudden bilateral hearing loss. Hearing of the right ear was improved by steroid administration but not that of the left ear. A 37-year-old male printer lost the hearing of his right ear after diving. Exploratory tympanotomy proved rupture of the round window, which was closed with perichondrium. However, no improvement of hearing had occurred four weeks after the operation. Steroid therapy was tried and his hearing improved. The hearing of these two patients was depended on the dose of steroid : an increase in the dose improved hearing and a decrease worsened it. The etiology of this disease is not clear, but may be related to autoimmunity.
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Keiichi Ichimura, Toshiaki Ikeda, Niro Tayama, [in Japanese], [in Japa ...
1989 Volume 82 Issue 4 Pages
529-535
Published: April 01, 1989
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The symptom of ear fullness or blocked ear has not been investigated so far, although it is commonly associated with a variety of ear diseases. A retrospective study of 41 patients in the last 3 years revealed that sudden sensorineural low tone hearing loss (SSLHL) was one of the most frequent causes of ear fullness. Clinically, this disease can be regarded to be nearly identical to cochlear hydrops or endolymphatic hydrops without vertigo, which has been described in the foreign literature. However, its etiology remains unclear. A review of the Japanese literature and a study of our 41 cases indicate that:
1) This disease is more common than expected.
2) It is likely that a considerable number of patients with SSLHL have been misdiagnosed as having Eustachian tube dysfunction, which has long been considered to be the primary cause of blocking sensation.
3) Although in most cases hearing was restored, 25% of the patients did not respond to treatment.
4) Recurrent attacks were noted in seven patients (17%). Such cases can be classified into two groups according to the outcome. In one group, the more numerous the attacks, the poorer was the response to treatment. In the other group, hearing recovered completely after each attack.
5) The treatment of choice is simply rest. Medical treatment with the calcium entry blocker flunarizine, isosorbide, or diuretics may be reserved for recalcitrant cases.
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Katsuhide Inagi, Tetsuya Shitara, Makito Okamoto, Kouji Tokumasu, Akit ...
1989 Volume 82 Issue 4 Pages
537-541
Published: April 01, 1989
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Aortitis syndrome is known to be an autoimmune disease, which has many symptoms of occulusive thromboaortopathy. It has recently been reported that the patients with systemic autoimmune diseases may have sensorineural hearing loss and that steroid therapy should be effective not only for the original disorder but also for the associated hearing disturbance.
Eleven patients (3 males and 8 females) with aortitis syndrome and sensorineural hearing loss have been treated in Kitasato University Hospital during the 16 years since the opening of the hospital.
The onset of hearing impairment was at 32 to 48 years of age, 10 years older than the mean age of onset of the aortitis syndrome reported in the literatures.
Various types of hearing impairment were noted : slight hearing loss, total deafness of sudden onset and fluctuating type. Tinnitus was associated with hearing loss in many cases.
Several patients also had vertigo and dysequilibrium, and in some of them the diagnosis was peripheral vestibular hearing loss, although in the cases of aortitis syndrome with hearing loss reported in the literature neither vertigo nor dizziness was mentioned.
The usual treatment for acute stage sudden deafness was not effective in most of our patients. However, one female patient treated with long-term steroid therapy for systemic arteritis showed marked improvement of both her hearing and her general condition.
We cannot conclude that the origin of sensorineural hearing loss is arteritis in the inner ear in all cases of aortitis syndrome with hearing loss. However, our cases of aortitis syndrome with steroid-dependant hearing loss indicate that the possibility remains of hearing loss due to arteritis of the labyrinthine artery in aortitis syndrome.
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Hiromitsu Saito, Tsunemasa Sato
1989 Volume 82 Issue 4 Pages
543-553
Published: April 01, 1989
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A patient who suddenly developed Primary Position Upbeat Nystagmus (PPUN) without any hearing disorder was tested with a series of examinations including ENG.
We describe this patient and review the literature on PPUN. He was a 57-year-old male who showed no nystagmus on the first medical examination, therefore, we ruled out congenital nystagmus. We suspected temporary micro obstruction of the infratentorial circulation, because PPUN occurred suddenly and disappeared gradually. We considered that the main focus was the cerebellar flocculus.
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Masaki Satoh, Katsuhiko Tanaka, Tadashi Yoshimura, Noboru Sakai, Hidey ...
1989 Volume 82 Issue 4 Pages
555-562
Published: April 01, 1989
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It is well known that the incidence of carcinoma in the external and middle ear is very low and that the prognosis is poor, especially for middle ear carcinomas.
During the past 15 years, 11 patients with carcinoma of the middle or external ear have been treated in the Department of Otolaryngology of Hokkaido University Hospital. Seven carcinomas were in the external auditory canal and four in the middle ear. The histopathologic diagnosis was squamous cell carcinoma in eight, and adenoid cystic carcinoma in three patients. Therapy was mainly a combination of irradiation and surgical resection. Three patients also received CDDP.
Our results revealed that the prognosis for external ear carcinoma is much better than for middle ear carcinoma. All four patients with middle ear carcinoma died, but five of the seven patients with external ear carcinoma are alive and free of the disease, at least one and a half year after surgery.
Carcinoma of the external ear canal tended to show radial extension, involving the soft tissues adjacent to the canal rather than extending longitudinally towards the middle ear.
The principal factor in the poor prognosis of middle ear carcinoma is ascribed to the destruction of the skull base, while that of the external auditory canal is deep invasion of the soft tissue around the canal.
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Akihiko Omura, Naoki Ohashi, Hiroshi Inaba, Kanemasa Mizukoshi, Takao ...
1989 Volume 82 Issue 4 Pages
563-566
Published: April 01, 1989
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Allergic rhinitis due to Chironomidae has been a problem in Northern Sudan since 1927, but there have been no reports of it in Japan. We performed a series of allergen tests with antigens extracted from various Chironomidae on patients with allergic rhinitis.
The scratch test was conducted on 85 patients diagnosed as having allergic rhinitis, and 16% of them had positive reactions. Provocative tests were given to 6 patients, and three of them had positive reactions implicating Chironomidae as the cause of their allergic rhinitis.
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Masato Yokoyama, Harumi Suzaki
1989 Volume 82 Issue 4 Pages
567-571
Published: April 01, 1989
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A 23-year-old male had a nasopalatine cyst, which caused 6×6×4cm defect in the maxillary bone and reached the oral vestibule and the floor of the nasal cavity. The cyst was completely removed, ` and 2-directional drainage routes for exudative fluid were made by mucosal resection in the floor of the nasal cavity and by opening of the left maxillary sinus. Postoperatively, the bone defect space filled up gradually with granulation tissue.
A review of the operative methods of treating nasopalatine cysts and our experience in this case lead us to stress the importance of multiple directional drainage, especially if there is a large bone defect space, after removal of the cyst. For that purpose transmaxillary-sinus drainage is useful.
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Takayoshi Itaya, Hiroya Kitano, Kazutomo Kitajima
1989 Volume 82 Issue 4 Pages
573-577
Published: April 01, 1989
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Twelve patients treated with maxillary artery ligation were compared with 15 patients treated only with medication. Elderly more numerous patients and patients with high blood pressure were in the ligation group.
The patients were followed for a long time after surgery. In the ligation group, the incidence of re-epistaxis was affected by the firmness of the ligation. For tight ligation clips were found to be better than silk thread.
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Keiko Nishikawa, Masutoshi Nishikawa, Akiko Okita
1989 Volume 82 Issue 4 Pages
579-583
Published: April 01, 1989
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Four patients with oral or pharyngeal hemangiomas were treated with the injection of a sclerosing agent, ethanolamine oleate, which has been used endoscopically in the treatment of esophageal varices. The hemangiomas of all four patients became smaller when this agent was injected directly into the tumor.
This treatment was effective and easier than surgery, so we recommend it as routine therapy for oral and pharyngeal hemangiomas.
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Masanori Sakaguchi, Eiko Tanaka, Kazuo Kawarada
1989 Volume 82 Issue 4 Pages
585-592
Published: April 01, 1989
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A case of gas gangrene of the oral cavity and the neck following pericoronitis is reported. A 47-year-old man who had suffered from pericoronitis of the right lower third molar underwent an incision by a dentist on March 9, 1987. Two days later, he had marked swelling of the oral floor and the left submandibular region with severe sore throat and trismus. He was admitted to the Nagano Red Cross Hospital on March 17. Computed tomography of the neck revealed abundant gas in the soft tissue. Hematological examination showed bleeding tendency. A diagnosis of gas gangrene with disseminated intravascular coagulation (DIC) was made and intravenous administration of antibiotics and gabexate mesilate (FOY) was started. Abscesses of the soft palate and the left lateral neck were successfully drained despite the presence of DIC. Peptococcus and a-streptococcus grew from the cultures of the pus. He recovered uneventfully after the drainage of the abscesses and was discharged on April 24.
Early complete surgical debridement with removal of necrotic tissue and administration of antibiotics are thought to be most important for the treatment of gas gangrene.
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Kazutomo Kitajima, Fumika Fujita, Hajime Fujishima, Makoto Hanada, Yos ...
1989 Volume 82 Issue 4 Pages
593-597
Published: April 01, 1989
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The leakage of saliva and/or food around Voice Prosthesis is not a rare problem. Patients who were forced to abandon the device were analyzed retrospectively to determine the possible causes of leakage.
The risk factors in the leakage were found to be:
1) Neck dissection followed by radiation therapy
2) Stiff neck due to re-operation
3) Poor handling of the prosthesis
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Mitsuru Furukawa, Michihiro Kamide, Takaki Miwa, Makoto Sakumoto, Ryoz ...
1989 Volume 82 Issue 4 Pages
599-603
Published: April 01, 1989
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Infectious mononucleosis due to Epstein-Barr virus (EBV) is an initial viral infection of B lymphocytes usually followed by extensive proliferation of T cells. Functional studies have shown that these T cells are cytotoxic to EBV-infected lymphoid cells and inhibit their proliferation. They also suppress autologous T-cell proliferation.
In an attempt to contribute to the understanding of the immunoregulation in infectious mononucleosis, we used monoclonal antibodies to characterize the peripheral lymphoid population in this disease.
We found an increase in the total number of T cells and OKT3, OKT8 and OK-Ial positive cells in patients with acute infectious mononucleosis, and concluded that EBV infection triggers the proliferation and activation of T suppressor and/or T cytotoxic cells.
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- Part-three; Intracellular Fine Structure of the Eustachian Tube -
Mariko Yamashita
1989 Volume 82 Issue 4 Pages
605-612
Published: April 01, 1989
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The fine structures of the epithelial cells of the guinea pig Eustachian tube were studied with a newly developed scanning electron microscopy technique. The intracellular organelles of the ciliated cells and the goblet cells could be observed threedimensionally, and the topographic relationships were analyzed. In both cells, the mitochondria were spherical or cask shaped and their cristae were tubular.
The rough endoplasmic reticulum was reticular, spreading out in the cytoplasm. The goblet cells contained a well-developed Golgi apparatus with stacks consisting of five to seven cisternae. The outermost part of the cisterna at the cis-face was fenestrated. This fenestrated cisterna was continuous with the neighboring Golgi stack. The Golgi apparatus of the ciliated cells was not so well developed, but a GERL-system was probably present.
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Akihiko Fujita
1989 Volume 82 Issue 4 Pages
613-624
Published: April 01, 1989
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To clarify the etiological role of adenoids in OME, the effects of adenoidectomy on hearing, Eustachian tube function and nasal sinusitis were examined. Adenoids were found to have no influence on tubal opening pressure or patency of the Eustachian tube in a static condition. Active function of the tube during swallowing, however, was improved significantly by adenoidectomy. In addition, adenoidectomy improved nasal sinusitis, and in these patients, hearing and active tubal function were satisfactory. These results suggest that adenoidectomy cures OME partly via improvement of pathological conditions of the nasopharynx represented by nasal sinusitis.
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Sawako Masuda, Yuichi Majima, Keisuke Hirata, Mikikazu Yamagiwa, Yasuo ...
1989 Volume 82 Issue 4 Pages
625-633
Published: April 01, 1989
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We evaluated the effectiveness of 1-cysteine ethyl ester, a sulf hydryl-type oral mucolytic, in 24 adults patients with chronic sinusitis. The patients received 300mg of 1-cysteine ethyl ester p. o per day for 4 weeks. Neither antiinflammatory agents nor mucolytic agents were given.
The effectiveness of 1-cysteine ethyl ester on subjective symptoms and rhinoscopic observations was 63%. X-ray opacity of the maxillary sinus was evaluated with a microdensitometer. The pre- and post- treatment data were compared in 10 patients (20 maxillary sinuses). The improvement of X-ray opacity following 1-cysteine ethyl ester treatment was noted in 45%. Nasal mucociliary clearance examined by the saccharin method (ST) was measured in 19 patients. Before the treatment, nasal ST was decelerates in 15 patients. After the treatment, their nasal ST had significantly improved. The general effectiveness of 1-cysteine ethyl ester on subjective symptoms, rhinoscopic observations and X-ray opacity was 60%.
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[in Japanese]
1989 Volume 82 Issue 4 Pages
634-635
Published: April 01, 1989
Released on J-STAGE: November 04, 2011
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