Practica Oto-Rhino-Laryngologica
Online ISSN : 1884-4545
Print ISSN : 0032-6313
ISSN-L : 0032-6313
Search
Advanced search
OR
Browse
Search
Volume 86, Issue 10
Displaying 1-21 of 21 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • Effect of Surgery on Sleep Apnea Syndrome
    Tadao Nishimura
    1993 Volume 86 Issue 10 Pages 1363-1370
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1363
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The statistical analysis of data obtained by monitoring pre-and post-operative condition of patients treated for sleep apnea syndorome is reported.
    Between October 1988 and October 1992, surgery was performed on 162 patients (66 children and 96 adults), who complained of snoring and symptoms related to sleep apnea syndrome at Fujita Health University The Second Affiliated Hospital. Treatment for children was adeno-tonsillectomy. Treatment for adults was uvulo-palato-pharyngoplasty (UPPP) and/or nasal surgery. Pathological apnea (sleep apnea syndrome) was defined as apnea index (AI)≥5. Apnea index was defined as frequency of apnea per hour. Marked improvement was defined as≥75% reduction in AT or a postoperative AI below 5. Improvement was defined as 50-74% reduction in AT. Slight improvement was defined as 25-49% reduction in AI. No improvement was defined as less than 25% reduction in AI.
    Pathological apnea was recognized in 33 (50%) of 66 children. Of these 33 patients, 27 (82%) showed marked improvement after treatment; 3 (9%) showed improvement; 1 (3%) showed slight improvement and 2 (6%) showed no improvement. Pathological apnea was recognized in 83 (87%) of the 96 adult patients. Of these 83 patients, 24 (29%) showed marked improvement after treatment; 18 (22%) showed improvement; 13 (15%) showed slight improvement and 28 (34%) showed no improvement.
    View full abstract
    Download PDF (2308K)
  • Cystic Lesions of the Maxilla
    [in Japanese]
    1993 Volume 86 Issue 10 Pages 1372-1373
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1372
    JOURNAL FREE ACCESS
    Download PDF (1345K)
  • Evoked Otoacoustic Emission and Electrocochleogram in a Patient with Multiple Sclerosis
    Hiroaki Nishida, Mayumi Okada, Tsuneo Inoue, Yasuo Tanaka
    1993 Volume 86 Issue 10 Pages 1375-1385
    Published: October 01, 1993
    Released on J-STAGE: December 12, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1375
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A 24-year-old female with multiple sclerosis had right-sided hearing impairment with tinnitus. She underwent electrocochleography (ECochG) and examination of evoked otoacoustic emission (EOAE) to assess cochlear function.
    An acoustic probe, type K-3, prepared to measure EOAEs was inserted into the external ear canal. ECochG-AP and CM were recorded by a transtympanic needle electrode technique. The CM and AP were recorded simultaneously and separated into their respective two channels in real time operation by the processor programmed for the isolation of the AP and CM. Short tone bursts were employed as acoustic stimulation to evoke both EOAEs and ECochG-CMs. Clicks and short tone bursts were used to measure ECochG-AP.
    Both fast and slow components of EOAEs appeared in either the period of deteriorated hearing acuity or when it was improved. They showed normal detection thresholds and input-output curves during both periods.
    ECochG-CMs with almost normal detection thresholds and input-output functions were obtained during the period of deteriorated hearing acuity. Delayed CMs with normal delay times and normal detection thresholds were observed during both periods.
    AP (N1) input-output curves during relapse with hearing loss were notably lower in amplitude and longer in latency than those obtained at the time hearing impairment showed improvement.
    The EOAE and ECochG findings suggested that this patient had almost normal cochlear function, and we assumed from the MRI and ABR findings as well as the ECochG that the hearing impairment was caused by dysfunction of auditory pathways . in the brainstem, including involvement of AP (N1) levels.
    View full abstract
    Download PDF (2091K)
  • Clinical Effect of Fludiazepam on Tinnitus
    -Comparison with the Result of Lidocaine Test-
    Ryuji Kiyota, Taijiro Imakiire, Soiku Watanabe, Yasuo Iwabuchi, Koji A ...
    1993 Volume 86 Issue 10 Pages 1387-1395
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1387
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The therapeutic effect of fludiazepam was studied in 72 patients with tinnitus. Subjects were given oral fludiazepam 0.75mg daily, and the severity of tinnitus was recorded before and two or four weeks after the start of administration.
    The medication was effective in 65.3% of the patients. The efficacy was 79.3% among 29 patients with tinnitus that disappeared after intravenous lidocaine injection, and 72.2% among 54 patients with tinnitus reduced to less than half by such injection. There was a significant difference between the efficacy in the patients with tinnitus reduced to less than half by the injection and that in other patients (p>0.05). However, the efficacy of fludiazepam did not correlate with findings of a psychological test (TMI test: Toho-medical index test).
    A side effect, sleepiness was detected in 15.3% of 72 patients. However, the side effect was not severe enough to require discontinuation of the trial.
    These results indicate that fludiazepam is useful in the treatment of patients with tinnitus, especially, that which can be reduced by intravenous lidocaine injection.
    View full abstract
    Download PDF (1030K)
  • L-V Therapy for Sensorineural Hearing Loss Following Acute Carbon Monoxide Intoxication
    A Case Report
    Tsuyoshi Yoshihiro, Hidekazu Yamamoto, Takeshi Akisada, Junshi Yamakaw ...
    1993 Volume 86 Issue 10 Pages 1397-1401
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1397
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    23-year-old female had sensorineural hearing loss due to acute carbon monoxide intoxication after exposure to cooking-gas for about 33 hours.
    The audiogram showed marked hearing loss, especially in the high frequency range.
    L-V therapy for sensorineural hearing impairment had been reported to be effective in several other cases.
    We used L-V therapy, and her hearing was restored.
    View full abstract
    Download PDF (622K)
  • Changes in Bacterial Flora in the Tympanic Cavity Following Tympanoplasty
    Kiyofumi Gyo, Yoshinari Hirata, Naoaki Yanagihara
    1993 Volume 86 Issue 10 Pages 1403-1407
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1403
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Changes in bacterial flora in the tympanic cavity following tympanomastoidectomy were studied in 98 ears of 94 patients suffering from chronic otitis media with continuous otorrhea. Materials were collected preoperatively from the tympanic cavity with a cotton swab through the external auditory canal and postoperatively from the cavity with a draining tube placed through the hypotympanotomied space during the operation. The draining tube was removed 4 to 12 days after surgery and subjected to bacteriological study. In spite of the intensive use of various antibiotics to which the isolated bacteria were sensitive, some of the bacteria remained in the tympanic cavity. The incidence of representative bacteria before and after surgery were as follows: Staphylococcus aureus in 41 and 5 ears, Pseudomonas aeruginosa in 24 and 10 ears, Staphylococcus epidermidis in 24 and 9 ears and Corynebacterium in 23 and 3 ears, respectively. These results suggest that the postoperative use of antibiotics for 4 to 12 days is not always sufficient to eliminate bacteria in the tympanic cavity, especially in cases of Pseudomonas aeruginosa infection.
    View full abstract
    Download PDF (2084K)
  • Atelectatic Ear and Predispositional Fragility of the Tympanic Membrane
    Akihiko Fujita, Kyosuke Kurata, Nobuhiko Kazama, Haruo Takahashi, Iwao ...
    1993 Volume 86 Issue 10 Pages 1409-1412
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1409
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Atelectasis or adhesive otitis media is a potential sequela of otitis media with effusion. We investigated the relationship between the abnormal pars tensa retraction and predispositional fragility of the tympanic membrane against extrinsic force.
    The subjects were 11 patients with unilateral atelectatic ear. An attempt was made to estimate the original sti ength of the affected eardrum by comparing peak values of tympanograms from the non-pathological side of unilateral atelectatic ear with those from 100 normal controls.
    The mean static compliance of the eardrum was 1.55ml (SD=0.66) for the nonpathological side of unilateral atelectatic ears and 0.63ml (SD=0.16) for the normal controls. The atelectatic ear group showed a significantly higher static compliance of the eardrum.
    This finding suggests that some cases of the adhesive otitis media had a fragile eardrum with high compliance as a predisposition.
    View full abstract
    Download PDF (427K)
  • Auricular Trauma
    A Report of Three Gases
    Masako Miura, Toru Sekitani, Yoichi Ogata, Yoshihiko Okinaka, Yuji Ima ...
    1993 Volume 86 Issue 10 Pages 1413-1417
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1413
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Auricular injuries may develop into serious auricular deformities if not treated appropriately. Adequate care is necessary to prevent perichondritis of the auricles.
    Three patients with auricular injuries were treated in our hospital and recovered without auricular deformity. Two of them had injuries which reached to the auricular cartilage.
    The good results suggested that gauze packing which was placed along the contour of the auricular cartilage and around the auricle, was effective in preventing auricular deformity following hematoma and perichondritis of the auricle, in addition to adequate irrigation of the wound, debridement and administration of antibiotics.
    View full abstract
    Download PDF (4380K)
  • Solitary Fibrous Tumor of the Nasopharynx
    A Case Report
    Yuki Minami, Yoshihiro Tsuruta, Katsuari Yane, Osamu Tanaka, Hiroshi M ...
    1993 Volume 86 Issue 10 Pages 1419-1423
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1419
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A 62-year-old male visited Nara Medical University Hospital complaining of nasal obstruction. A tumor arising from the nasal septum occupied the nasopharynx. The histological diagnosis was solitary fibrous tumor.
    This tumor was identical histologically to solitary fibrous mesothelioma of the pleura. Immunohistochemical examination showed a “patternless” arrangement of spindle cells, stained positively for vimentin only.
    Since solitary fibrous tumor of the upper respiratory tract is rare, it is difficult to diagnose correctly.
    View full abstract
    Download PDF (3600K)
  • Clinical Investigation of 85 Children with Acute Sinusitis
    Akihiro Matsuoka, Tetsuya Shitara, Kazuo Yao, Akihiro Higuchi
    1993 Volume 86 Issue 10 Pages 1425-1429
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1425
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We reviewed the clinical profiles of 85 children with acute sinusitis, 68 males and 17 females aged 0 to 15 years. The length of time from the onset of symptoms to hospitalization and diagnosis was 4 hours to 7 days (average 4.3 days). The presenting symptoms were headache, periorbital swelling, fever, purulent nasal discharge, etc. Nasal allergy was diagnosed in 30 patients whose IgE antibody titers were high, over 1000IU/ml in most cases.
    A review of the development of acute sinusitis and its anatomic relationship explains the frequency of orbital cellulitis secondary to acute sinusitis and suggests that knowledge of this important relationship may lead to earlier diagnosis and vigorous treatment of this dangerous infection.
    View full abstract
    Download PDF (694K)
  • Histological and Imaging Study of Submucous Cleft Palate (SMCP) and Congenital Velopharyngeal Insufficiency (CVPI)
    Kyosuke Kurata, Kazunori Mori, Michio Kawano, Iwao Honjo
    1993 Volume 86 Issue 10 Pages 1431-1435
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1431
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    It has been considered that the cause of velopharyngeal insufficiency (VPI) is inadequate mobility of the soft palate resulting from an interruption and/or atrophic changes of the levator veli palatini muscle (LVP).
    The patients were classified into three group: 89 SMCP patients with Calnan's trias, 90 patients without the trias, and 42 patients with one or two part of the trias. Comparisons were made with respect to the mobility of the soft palate and lateral pharyngeal wall, histological configuration of muscle fibers and the status of the LVP, as determined by MRI.
    There was no significant difference among the three groups with respect to the morphology of the nasopharynx or mobility of the soft palate and lateral wall. Histological examination showed obvious atrophy of the LVP in all CVPI cases especially those without Calnan's trias, while changes in those with SMCP were less pronounced.
    Surprisingly, the muscle atrophy in SMCP patients was slight, whereas it was more pronounced in patients with CVPI. Thus, SMCP is characterized by abnormal development of the LVP and negligible muscle atrophy. In contrast, CVPI is characterized by conspicuous muscular lesions. These results suggest the involvement of myogenic or neurogenic factors in the pathogenesis of their diseased states.
    View full abstract
    Download PDF (3166K)
  • Retropharyngeal Abscess in an Elderly Woman
    Akira Shibano, Tadahito Saitou
    1993 Volume 86 Issue 10 Pages 1437-1441
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1437
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    An 83-year-old woman complained of pain on the right side of the neck. Nasopharyngeal fiberscopy revealed swelling of the posterior wall from the upper to the lower pharynx. CT scans revealed an abscess on the right side of the retropharyngeal space with infiltration of the right atlas. The abscess was incised, the area was irrigated, and antibiotics were administrated. Retropharyngeal abscess is common in children. In adults, it is often caused by tuberculosis, upper respiratory infections or foreign bodies in the throat. It is necessary to culture for anaerobes and to select antibiotics.
    View full abstract
    Download PDF (4809K)
  • So-Called C arcinosarcoma in the Hypopharynx and Esophagus
    Koichiro Shimamura, Noritake Watanabe, Hideyuki Kawauchi, Goro Mogi
    1993 Volume 86 Issue 10 Pages 1443-1451
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1443
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    So-called carcinosarcoma in the hypopharynx and cervical esophagus is a rare malignant neoplasm consisting of a squamous cell carcinoma and a sarcomatous appearing stroma. In this paper we describe two patients with this tumor; one in the hypopharyngeal posterior wall and one in the hypopharyngeal-esophageal anterior wall. The patients were a 41-year-old male who complained of pharyngeal pain and a 70-year-old female who complained of dysphagia. Histopathological and immunohistochemical examinations revealed spindle cell carcinoma in both cases. In the first, radiation therapy with 24 Gy was not effective, so radical resection and modified bilateral neck dissection were performed. Four months after the operation, a metastasis appeared in the parapharyngeal space. Chemotherapy with carboplatin (CBDCA) and fluorouracil (5-FU) and radiation therapy with 60 Gy were performed, but without effect. The patient died one year after the operation. In the second case, surgical therapy as in the first case was performed initially, and two courses of chemotherapy with cisplatin (CDDP) and peplomycin (PEP) were administered. The patient has had no recurrent tumors and no metastases during the 8 months since treatment.
    There have been only 8 reports of so-called carcinosarcoma in the hypopharynx in Japan. These 8 cases, plus our 2 cases, are reviewed.
    View full abstract
    Download PDF (9369K)
  • A Case Report of a Thyroglossal Duct Cyst Extending into the Larynx
    Mikiko Ochi, Shigenobu Iwata, Kazuo Sakurai, Kenji Takeuchi
    1993 Volume 86 Issue 10 Pages 1453-1456
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1453
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A 52-year-old female with a thyroglossal duct cyst extending into the larynx is reported. She had complained of an abnormal sensation in the larynx and laryngeal findings showed a diffuse smooth moderate swelling in the left vocal cord with out disturbance of vocal cord movements. This cyst passed through the hyoid bone beneath the attachment of the thyrohyoid membrane and extended into the left false vocal cord through the aryepiglottic fold. Diagnosis was not established until the tract was followed in its passage through the hyoid bone and upward to the base of the tongue during surgery. Pathological fundings of the excised cyst showed thyroid tissue and small lymph follicles in the wall of the cyst.
    View full abstract
    Download PDF (3180K)
  • Tuberculosis of the Head and Neck
    Satoru Takebayashi, Akira Kodama, Michihiko Nozue, Mika Suganuma, Taka ...
    1993 Volume 86 Issue 10 Pages 1457-1466
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1457
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Eighteen cases of tuberculosis of the head and neck region are reported.
    1) Fourteen of the 18 patients had cervical lymphnode tuberculosis, 2 had tuberculous otitis media and 2 had tuberculosis of the larynx.
    2) Recently, cervical lymphnode tuberculosis has become uncommon, but it is important to differentiate it from malignancy by histopathological and bacteriological studies.
    3) Fine needle aspiration biopsy (FNA), performed in 9 cases, was positive in 7 cases (77.8%).
    We conclude that FNA is useful in the diagnosis of cervical lymphnode tuberculosis.
    View full abstract
    Download PDF (4567K)
  • Respiratory Activity during Sleep in Obstructive Sleep Apnea Syndrome
    Yoshiaki Itasaka, Koji Yamakawa, Soichiro Miyazaki, Hiroyuki Tada, Kiy ...
    1993 Volume 86 Issue 10 Pages 1467-1474
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1467
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Sixty-two subjects with obstructive sleep apnea syndrome were studied during sleep to characterize the pattern of respiration. Their mean age was 48.4 years (range 20 to 74 years). These patients were compared to a group of 16 age-matched adults who had no respiratory problems. All-night polygraphic recording was performed without the use of any drugs. We examined the intraesophageal pressure, apnea index, mean apnea duration and duty cycle (inspiratory duration divided by the duration of the total respiratory cycle). The severity of sleep dyspnea was classified into three groups depending on the amplitude of intraesophageal pressure; slight (15-19 cmH2O), moderate (20-39cmH2O) and severe (40 cmH2O and over).
    As the grade of intraesophageal pressure increased, the apnea index increased accordingly. Moreover, there was a prolongation of the average duration of obstructive and mixed apnea. When the patients had severe respiratory disturbance during sleep, the duty cycle of the inspiratory muscles decreased progressively before obstructive apnea started. These findings suggest that obstructive apnea is related to the degree of upper airway stenosis and that the decrease in the duty cycle may be responsible for upper airway occlusion in addition to anatomical abnormality of the soft palate, sinking of the soft palate and base of the tongue and relaxation of the pharyngeal muscles during sleep.
    View full abstract
    Download PDF (1062K)
  • Dissociation of the Submucosal Nasal Gland of the Nasal Septum in Guinea Pigs
    Motoaki Ishigaki, Katsuhisa Ikeda, Hiroshi Sunose, Yukio Katori, Masaa ...
    1993 Volume 86 Issue 10 Pages 1475-1480
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1475
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A dissociation procedure for acinar cells of the nasal gland in the guinea pig has been developed. Under a whole mount of the nasal septum, the majority of nasal glands was distributed in the infraanterior area of the olfactory region and in the posterior area of the respiratory region. This technique employs meticulous and selective dissection with minimal contamination of epithelial cells and enzymatic treatment with collagenase. The dissociated cells were confirmed to be serous gland acini by negative stain with alcian blue and a relatively high electron density of secretory granules. More than 90% of acini were viable as judged by trypan blue exclusion. Ultrastructual integrity of the cell was well maintained following the dissociation procedure.
    View full abstract
    Download PDF (6752K)
  • Bifemelane Hydrochloride Therapy for Sudden Deafness
    Noriyuki Yanagita, Tsutomu Nakashima, Hironobu Morisaki, Yoshiaki Naka ...
    1993 Volume 86 Issue 10 Pages 1481-1497
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1481
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Various therapeutic regimens have been used in the treatment of sudden deafness, one of the sensori-neural hearing losses in which recovery is generally considered to be possible in the early stage of the disease. Drugs which improve the blood flow of the inner ear, cerebral metabolism activators and anti-neuritis agents are widely used. We used bifemelane hydrochloride, a cerebral function improver, to treat 80 patients suffering from sudden deafness. The drug was found to be as effective as other medications. Since combination therapies are popular for the treatment of sudden deafness, bifemelane may be a positive drug in combination therapy.
    Animal experiments were also performed to clarify the mechanism of action of bifemelane. The results indicate that bifemelane dilates cochlear blood vessels and increases blood flow.
    View full abstract
    Download PDF (2767K)
  • Studies on the Clinical Feasibility of Keigai-Rengyo-To for Chronic Sinusitis
    Kazuo Makimoto, Itoji Shibata, Kunihiro Sugita, Isao Uno, Isao Inoue, ...
    1993 Volume 86 Issue 10 Pages 1499-1508
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1499
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A clinical study was conducted on the feasibility of herbal medicine TJ-50 (Tsumura Keigai-rengyo-to) in treating chronic sinusitis. Thirty-nine patients were enrolled in this study (male 16, female 23), ranging from 16 to 86 years old.
    In all patients, Keigai-rengyo-to was administered orally three times daily for four to eight weeks. A higher rate of improvement in subjective symptoms were observed for postnasal drip, rhinorrhea and nasal obstruction, as well as for postnasal drip and volume of nasal mucus on rhinoscopic findings. When evaluation was based on both subjective symptoms and objective findings, 28 of 38 (73.7%) cases were graded as “slightly effective” or higher. This improvement rate was higher in the patient group with less than 12 months duration of chronic sinusitis. On X-ray findings of the paranasal sinuses, seven of 23 (30.4%) cases were graded “slightly effective”. No patient attained the grade “effective” or “markedly effective”. As to the clinical feasibility of Keigai-rengyo-to, judged from the above evaluations and safety due to fewer potential side effects, the grad “useful” was obtained in ten of 39 cases (25.6%) and more than “slightly useful” in 22 of 39 cases (56.4%). Side effects were observed in one case of eruptions which disappeared after treatment was discontinued, and in two cases of gastric symptoms.
    Gastric symptoms were mild, and were alleviated as the treatment was continued.
    View full abstract
    Download PDF (1171K)
  • Distribution to Tonsil and Maxillary Sinus Mucosa and Clinical Evaluation of Ofloxacin
    Yasuyuki Kimura, Mitsuru Furukawa, Yasuko Akemoto, Hideo Sakashita, Ka ...
    1993 Volume 86 Issue 10 Pages 1509-1514
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1509
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The distribution of ofloxacin (OFLX) in the palatal tonsil and maxillary sinus mucosa was quantitatively analyzed. OFLX (100mg), lomefloxacin (100mg), and tosufloxacin (75mg) were administered orally 2 hours before surgery. The tissue concentration of OFLX was 1.61±0.46μg/ml on average and was higher than the serum concentration (0.72±0.21μg/ml), the tissue/serum ratio (2.24) was significant. The tissue concentration of OFLX was higher than that of lomefloxacin and tosufloxacin. In addition, clinical and bacteriological trials on patients with otorhinolaryngological infections was carried out. OFLX was administered orally at a dose 600mg for more than three days. The incidence of stains resistant to OFLX (MIC>3.13μg/ml) was 5.8%. The overall clinical efficacy rate was 86.7% and there were no safety problems. It was concluded that OFLX is a useful drug for treating otorhinolaryngological infections.
    View full abstract
    Download PDF (629K)
  • Piriform Sinus Fistula
    [in Japanese], [in Japanese]
    1993 Volume 86 Issue 10 Pages 1516-1517
    Published: October 01, 1993
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.86.1516
    JOURNAL FREE ACCESS
    Download PDF (2049K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top