巻号一覧
前身誌
91 巻, 8 号
選択された号の論文の20件中1～20を表示しています
- |<
- <
- 1
- >
- >|
-
古川 仭, 吉崎 智一1998 年 91 巻 8 号 p. 765-771
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーThe purpose of this study was to examine the role of angiogenesis and the expression of matrix metalloproteinase 9 (MMP9) on metastasis in primary nasopharyngeal carcinoma (NPC). Intratumoral microvessels were highlighted by immunohistochemical staining of endothelial cells for von Willebrand factor (vWF). The expression of angiogenetic factors, including basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and transforming growth factor-α (TGF-α) was also evaluated in NPC specimens, in addition to the expression of Epstein-Barr virus (EBV) encoded small RNAs. The expression of bFGF, VEGF, TGF-α and LMP-1 increased significantly with the grade of regional lymph node metastases. Multiple regression analysis showed that the expression of latent membrane protein-1 (LMP-1) was the most important factor that affects the microvessel counts in NP.
Matrix metalloproteinases (MMPs) are frequently expressed in malignant tumor cells and are thought to play crucial roles in tumor invasion and metastasis. In this study, the expression of MMP9 was found to be increased in EBV-infected type III latency lymphoma cell lines. Type III cell lines express abundant LMP-1, the principal EBV oncoprotein, as well as the other latency proteins including the transcriptional factor EBV nuclear antigen 2 (EBNA2) which is also required for cell immortalization. Transection of an LMP-1 expression plasmid in the C33A cell line increased MMP9 expression, whereas overexpression of EBNA2 did not. Deletional and mutational analysis of the MMP9 promoter region was also carried out with chloramphenicol acetyltransf erase (CAT) assays. We found that binding sites for NF-κB, SP-1 and AP-1 also contributed to induction of the MMP9 promoter by the viral protein, LMP-1, mainly through the NF-κB and, to a lasser extent, the SP-1 and AP-1 sites. These results indicate that expression of MMP9 is induced by LMP-1. In conclusion, these observations suggest that LMP-1 plays a key role in metastasis in NPC.抄録全体を表示PDF形式でダウンロード (3025K) -
竹中 洋, 山本 祐三, 大城 康司1998 年 91 巻 8 号 p. 772-773
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーPDF形式でダウンロード (1783K) -
神畠 俊子, 武田 憲昭, 森脇 計博, 坂田 義治, 荻野 仁, 久保 武, 肥塚 泉1998 年 91 巻 8 号 p. 775-779
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーA 32-year-old man with Wernicke encephalopathy due to malnutrition is reported. The patient showed primary position upbeating nystagmus (PPUN) with severe ataxia and lateral gaze nystagmus. Neurootological examinations showed bilateral canal paresis, saccadic pursuit and disturbance of optokinetic responses. ABR revealed a prolongation of the I-III interwave interval, although his pure-tone audiogram was normal. Brain MRI demonstrated symmetrical high intensity areas on T2-weighted images in the periventricular regions of the third ventricle. MRI is a useful tool for the diagnosis of Wernicke encephalopathy in the early stages. After thiamine therapy, PPUN and ataxia gradually, but incompletely recovered, although lateral gaze nystagmus and the high intensity areas on MRI disappeared. These observations suggest that brainstem-cerebellar lesions contributed to the clinical manifestations of this case.抄録全体を表示PDF形式でダウンロード (2076K) -
山田 弘之, 加藤 昭彦, 石永 一1998 年 91 巻 8 号 p. 781-784
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーIn the past 4 years, middle ear surgery has been performed on 166 ears. A total of 42 ears operated on by modified type III tympanoplasties, and 19 ears operated on by type IV tympanoplasties were reviewed. The type III tympanoplasty group included 12 ears with cholesteatoma and 20 with chronic otitis media. The type IV tympanoplasty group included 9 cases of cholesteatoma and 5 cases of chronic otitis media. Postoperative hearing results were evaluated, and success rates in hearing results were 81.6% of type III patients, and 66.7% of type IV tympanoplasty patients. Second surgeries were performed on 7 ears previously operated on at other hospitals, and success was observed in 6 ears. In 18 ears, artificial columella (hydroxyapatite) was used for reconstruction of the ossicular chain, and discharge of the columella was observed in only 1 ear. In 21 ears with cholesteatoma and reconstruction of the ossicular chain, residual recurrence of cholesteatoma was observed in 3, but true recurrence of cholesteatoma was not experienced.抄録全体を表示PDF形式でダウンロード (616K) -
片岡 健一, 花田 誠, 田中 寛, 北野 博也, 矢沢 代四郎1998 年 91 巻 8 号 p. 785-792
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーReports on facial nerve schwannoma have been gradually increasing, and it is no longer a rare disease. We have had 4 cases of facial nerve schwannoma in our clinic since October, 1978, when our clinic opened. The first case (a 34 year-old, female), a small schwannoma was found in the tympanic portion of the facial nerve when she underwent a tympanoplasty for cholesteatoma. The second case (a 45 year-old, female), suffered from slowly progressive facial nerve palsy and later from severe vertigo. The third case (a 73 year-old, male), experienced severe vertigo with long-term facial palsy, while the fourth case (a 60 year-old, male), suffered from sudden onset of slight facial palsy with a subauricular tumor. The patients with facial nerve schwannoma complained of various symptoms such as facial nerve palsy, hearing disturbance, vertigo or dizziness, tinnitus, otalgia or headache, depending on the site of occurrence and tumor size. A multitumor type of schwannoma originating from a single facial nerve such as case 4 is rare. We reviewed the literature covering 11 cases of the multitumor type of facial nerve schwannoma. When we encounter a facial palsy patient with fluctuating degrees of palsy, in addition to the variety of symptoms mentioned above, and who does not response to extensive treatment, a diagnosis of schwannoma is considered. Accordingly, the pathway of the facial nerve, from the CP-angle to the parotid gland is carefully examined. MRI is a suitable method for examination.抄録全体を表示PDF形式でダウンロード (9071K) -
布施 健生, 吉田 信, 蟻 眞弘1998 年 91 巻 8 号 p. 793-796
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーWe encountered a patient with bilateral persistent posterior nasal hemorrhage. Nasal packing was not effective and more active treatment was required. On the left side, maxillary artery ligation was performed 3 years ago. Subsequently, angiography and embolization was performed on the right side. Comparing these two techniques, angiography and embolization was more effective and less harmful to the patient. Angiography and embolization were considered the treatment of choice in cases of persistent nasal hemorrhage after failure of nasal packing.抄録全体を表示PDF形式でダウンロード (5630K) -
平松 隆, 渡邊 英彦, 曽賀野 悟史, 浅野 幸一郎, 小泉 光1998 年 91 巻 8 号 p. 797-804
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーTwo patients with malignant melanoma of the nasal cavity and paranasal sinus who were treated at our clinic are described. Both patients underwent the initial treatment of the original tumor; combination therapy consisting of DAV chemotherapy and local injection of interferon-β, in compliance with the method of Yamamoto, in addition to local excision of the tumor.
Case 1 was a 54-year-old female. She had a tumor of the left nasal cavity and paranasal sinus with subdigastric nodal and ovarian metastases; the pathological diagnosis at the time of surgery for treatment of the ovarian tumor was a poorly differentiated carcinoma. She underwent the above initial treatment and a submandibular triangular dissection. She was subsequently diagnosed with an inguinal metastatic tumor at 6 postoperative months. Combination therapy consisting of DAV and local injection of interferon-β into the metastatic tumor was not effective. A change in the chemotherapy to CDV, however, resulted in the disappearance of the metastatic tumor. She has lived for more than 39 months with no local recurrence.
Case 2 was a 67-year-old female. She had a tumor of left nasal septum and no metastasis. She had no local recurrence for 34 months after the above initial treatment. Subsequently, however, she had a suspicious recurrent tumor of the left inferior nasal concha, and underwent combination therapy consisting of DAV and local injection of interferon-β. She has lived for more than 37 months.
These findings suggest that combination therapy consisting of DAV and local injection of interferon-β is useful for the local control of malignant melanoma after surgical treatment and that chemotherapy with CDV may be useful for the treatment of metastatic melanoma.抄録全体を表示PDF形式でダウンロード (11307K) -
播摩谷 敦, 朝倉 光司, 伊藤 順一, 浜本 誠, 形浦 昭克1998 年 91 巻 8 号 p. 805-810
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーClinical studies of twenty-four patients with sinonasal papillomas were performed. The cases were classified into three histopathological types: 1) exophytic (fungiform), 2) inverted, and 3) cylindrical cell (columnar cell) papillomas. In this study, inverted papilloma was the most common type. All types of sinonasal papillomas had male predominance. The mean age of patients with inverted papillomas was higher than that of patients with exophytic papillomas. The most common major symptom of exophytic papillomas was a nasal mass and that of inverted papillomas was nasal obstruction. The exophytic papillomas occurred in the nasal septum or the nasal vestibules, whereas the inverted papillomas occurred primarily in the lateral nasal wall and/or in the paranasal sinuses. Exophytic papillomas had a lower recurrence rate than inverted papillomas even though only intranasal tumor resection was undertaken in the former, whereas medial maxillectomy was performed in the latter. The resection range of inverted papillomas should be decided on the basis of the location and the degree of invasion to avoid inadequate excision. This is especially important when the inverted papilloma is located in the ethmoid sinus or on the middle turbinate. In such cases wider excision is needed to prevent recurrences. In our cases, there was no association of malignancy with sinonasal papillomas.抄録全体を表示PDF形式でダウンロード (768K) -
東松 琢郎, 松井 玲子, 川堀 眞一1998 年 91 巻 8 号 p. 811-815
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーSome patients with pollen hypersensitivity have oral allergic reactions to fresh fruits and vegetables. This condition has been termed Oral Allergy Syndrome (OAS). It is a distinctive type of IgE-mediated allergy resulting from direct oral contact with food, and is proposed to be due to cross-reacting allergens in the foods and pollens.
We studied 97 patients (43 male and 54 female patients) with birch pollen allergy (BPA). The diagnosis was confirmed by the clinical symptoms of seasonal rhinitis and the presence of the specific anti-birch IgE antibody by CAP-RAST (a score equal to or greater than 2). The onset of BPA, atopic symptoms and a family history were examined in an interview with each patient. We also asked about oral hypersensitivity to eighteen kinds of fruits and vegetables such as apples, potatos, kiwis, nuts, celery and melon.
The results were as follows:
1) 35% of birch pollen allergic patients had oral symptoms after fruit and vegetable ingestion.
2) The causative foods in OAS, in order of frequency, were apples, peaches, cherries, plums and others. Most patients with OAS showed hypersensitivity to more than two foods (mean value; 3.4 foods).
3) OAS-positive patients had a longer duration of BPA than OAS-negative ones (mean years 9.0 vs 5.7; p<0.025). The OAS was significantly related to the duration of BPA and a previous history of asthma.
4) No difference was observed in mean age or sex between the two groups.
5) The score for specific anti-birch pollen IgE levels was significantly greater in OAS-positive patients than in OAS-negative ones (p<0.0025), whereas no difference was observed in total IgE levels between the two groups.抄録全体を表示PDF形式でダウンロード (779K) -
韓 相善, 北村 薄之, 高北 晋一, 前谷 俊樹, 岩橋 由佳, 山本 典生, 宮崎 眞和1998 年 91 巻 8 号 p. 817-820
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーParaganglioma is not a particularly rare type of tumor, but intravagal paraganglioma is very rare. We recently treated a case of intravagal paraganglioma arising in the parapharyngeal space. A 70 year-old male was examined following complaints of infra-auricular swelling. A preoperative carotid angiogram revealed that the tumor had high vascularity and that the carotid bifurcation was not widened. We were able to remove the tumor transcervically with a partial submandibulectomy. Postoperatively, the patient complained only of hoarseness.抄録全体を表示PDF形式でダウンロード (5201K) -
戸川 彰久, 寒川 高男, 國本 優, 田中 智之, 坂口 幸作, 横山 道明, 山中 昇1998 年 91 巻 8 号 p. 821-824
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーExtramedullary plasmacytoma is a rare tumor of plasma cell origin. The case presented here involved an extramedullary plasmacytoma in the parapharyngeal space, occurring in a 53-year-old woman who presented with an irritable feeling in the pharynx.
Immunohistologic studies revealed the tumor cells to be of the IgG-κ type. The patient was treated surgically and showed no evidence of tumor recurrence at one year after the operation.抄録全体を表示PDF形式でダウンロード (5106K) -
森中 節子, 林 祥剛1998 年 91 巻 8 号 p. 825-829
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーA 23 year-old male who complained of hoarseness was admitted to our hospital because of a laryngeal tumor. The tumor was removed by laryngomicrosurgery in February, 1996 and the histopathological diagnosis was laryngeal papilloma. One and a half months after removal, the tumor recurred at almost the same site and gradually increased to the size before removal in April, 1996. The laryngeal tumor was observed to have recurred in December, 1996, but then disappeared spontaneously and completely in January, 1997.
Although the patient was not previously employed as a painter, he was engaged in the job of spray painting after the Hanshin earthquake (January 17, 1995). The onset of the complaint and the disappearance of the laryngeal tumor occured in accordance with the commencement and completion of his job as a painter, respectively. The role of the chemicals and papilloma virus in the development of laryngeal papilloma is discussed.抄録全体を表示PDF形式でダウンロード (3911K) -
森田 武志, 田渕 圭作, 北尻 真一郎, 篠原 かおる1998 年 91 巻 8 号 p. 831-834
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーMetastatic malignant melanomas to the neck of an unknown primary origin are very rare in Japan. A 76 year-old woman presented to our hospital complaining of a neck tumor on the left side. Cervical CT scanning revealed three swollen lymph nodes. A biopsy was performed, and the histopathological findings demonstrated that metastatic malignant melanomas had developed in the three cervical lymph nodes as large as 35mm in diameter. Subsequent staging examinations which were carried out included inspection of the whole skin and adjacent mucosa, CT scanning of the brain, neck and chest, abdominal ultrasound and CT scanning, a bone scan and Ga scintigraphy. We performed a radical left neck dissection, and a total of 60 Gy of irradiation therapy was delivered after the surgery. No recurrence has been observed for 15 months after the patient's first visit. Our report reviews this rare case of metastatic malignant melanoma to the left cervical lymph nodes of an unknown primary origin.抄録全体を表示PDF形式でダウンロード (3135K) -
鈴木 伸, 遠藤 壮平, 酒井 文隆, 濱田 敬永, 佐藤 正美, 伊藤 勇, 野村 泰之, 野口 雄五, 木田 亮紀1998 年 91 巻 8 号 p. 835-843
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーA total of 100 patients with 101 malignant head and neck tumors who were seen at the tumor clinic in the Department of Otorhinolaryngology and Bronchoesophagology in Nihon University Itabashi Hospital, were reviewed. One patient had two primary malignant tumors in the head and neck area. A total of 86% of the patients were referred to our hospital. One third of the patients were referred from other clinics, one third from affiliated hospital, and the remainder from other department within the university hospital. Ninety out of the 101 cases were primary tumors, 6 were secondary tumors, and the remaining 4 cases were metastatic tumors from other parts of the body. In the 90 patients with primary head and neck malignancies, the origin of the tumors were the pharynx in 23 cases, oral cavity in 20 cases, larynx in 14 cases, sinonasal area in 11 cases, thyroid in 7 cases, salivary gland in 4 cases, and other regions in 11 cases. Eighty out of the 90 patients with primary tumors were treated in our department. Sixty-one of the 80 cases of primary malignant tumors were squamous cell carcinomas, 7 were adenocarcinomas, 3 were undifferentiated carcinomas, and the remaining 9 had other pathologies. As primary treatment, radiation was performed in 68 patients (85.0%), chemotherapy was performed in 51 (63.8%), and surgery was done in 30 (37.5%). The response rate to primary treatment was 85% (CR in 62/80 (77.5%), PR in 6/80 (7.5%)).抄録全体を表示PDF形式でダウンロード (7192K) -
北原 糺, 村田 潤子, 小畠 小畠, 奥村 新一, 江崎 光彦1998 年 91 巻 8 号 p. 845-849
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーIn this paper, a very rare case of vasculo (angio)-Behcet's disease initiated with hoarseness due to inflammatory aortic aneurysm, is presented. A 35 year-old male with persistent hoarseness for half a month was revealed to have left recurrent laryngeal nerve palsy. Chest X-ray films showed slight enlargement of the aortic arch. CT demonstrated direct evidence of a saccular type aortic aneurysm at the branched area of the left subclavian artery. Aortic angiography demonstrated two additional aortic aneurysms at the right subclavian artery and in the lower abdominal area. The patient subsequently underwent emergency surgery for treatment of these aneurysms. The histopathological characteristics of the representative aortic aneurysmal lesions suggested a diagnosis of “vasculo-Behcet's disease”. Behcet's disease is usually characterized by oral and genital ulceration, folliculitis and uveitis. This patient, however, displayed no previous evidence of these symptoms. We would like to emphasize that some cases of left recurrent laryngeal nerve palsy require urgent management.抄録全体を表示PDF形式でダウンロード (5737K) -
墨 一郎, 川端 五十鈴, 渡邊 一夫, 木下 正信1998 年 91 巻 8 号 p. 851-856
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーA case of prolif erative myositis of the bilateral sternocleidomastoid muscle in a 64-year old woman is reported. The patient visited our clinic, complaining of a sore throat and cervical pain, with strong limitation of neck movement, especially backward movement. Physical examination revealed hardness along the bilateral sternocleidomastoid muscles. CT, MRI and Echo imaging studies suggested the presence of pathological lesions in the muscles. Immunochemical examination showed a high level of muscle emzymes, suggesting myositis. The histopathological diagnosis of the excised tissue was proliferative myositis. This disease is a very rare condition, and no case of bilateral myositis has been previously reported in the Japanese literature. We discussed this disease from a clinicopathological viewpoint.抄録全体を表示PDF形式でダウンロード (6511K) -
―文献的考察―高桑 由紀子, 高橋 晴雄1998 年 91 巻 8 号 p. 857-862
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーThe significance of adenoids in the pathogenesis of otitis media was investigated by reviewing recent literature. Adenoids are not likely to cause otitis media by compressing the eustachian tube, but are important as a reservoir of chronic infection supplying bacteria to the middle ear. Chronic infection of the adenoids by Haemophilus influenzae (particularly the non-typable strain) or Branhamella catarrharis may result in alterations of colonization by normal flora and impairment of the local immunological defense system in the adenoids; these in turn, may cause recurrent otitis media. Although the short-term effect of adenoidectomy on otitis media has been confirmed in several randomized clinical trials, its long-term effects, particularly on intractable otitis media, are questionable. Indications for adenoidectomy should, therefore, be evaluated on an individual basis, and include consideration of patient age, the presence or absence of a history of recurrent otitis media, chronic rhinosinusitis, and the results of bacteriological examination in the nasopharynx.抄録全体を表示PDF形式でダウンロード (894K) -
室野 重之, 古川 仭1998 年 91 巻 8 号 p. 863-866
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーThe clinical efficacy of erythromycin, clarithromycin (CAM) and roxithromycin on chronic paranasal sinusitis has been reported in numerous studies. We investigated the clinical efficacy of low-dose and long-term CAM on sinusitis in children. Each child was given 5-7mg/kg of CAM as two doses daily. The clinical efficacy was assessed by the quality and quantity of nasal discharge, and by the findings on plain X-ray films of the maxillary sinuses after 8 weeks of administration. Twenty-one out of 28 (75%) patients treated with CAM demonstrated an improvement in the quality of nasal discharge. Twenty out of 28 (71%) patients treated with CAM demonstrated an improvement in the quantity of nasal discharge. Twenty-four out of 28 (86%) patients treated with CAM demonstrated an improvement in their findings on plain X-ray films of their maxillary sinuses. Patients who received CAM demonstrated significantly better quality and quantity of nasal discharge, and their findings on plain X-ray films of their maxillary sinuses were better than patients who didn't receive CAM. Clarithromycin was judged to be useful in the treatment of sinusitis in children.抄録全体を表示PDF形式でダウンロード (449K) -
新美 成二1998 年 91 巻 8 号 p. 868-869
発行日: 1998/08/01
公開日: 2011/11/04
ジャーナル フリーPDF形式でダウンロード (355K) -
1998 年 91 巻 8 号 p. e1
発行日: 1998年
公開日: 2011/11/04
ジャーナル フリーPDF形式でダウンロード (26K)
- |<
- <
- 1
- >
- >|