Practica Oto-Rhino-Laryngologica

New Method for Drug Application into the Inner Ear

Biodegradable Drug Delivery System

Juichi Ito

2005 Volume 98 Issue 1 Pages 1-4
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.1

JOURNAL FREE ACCESS

Show abstractHide abstract

It has been believed that inner ear sensory cells are very weak and recovery of function after damage is very difficult. That is why sensory neural hearing loss is very difficult to treat. Recently, several drugs and chemicals have been reported to protect, or to recover, inner ear function. However, application of those drugs to the inner ear is difficult because of its specific anatomical and physiological system.
A new drug delivery system (DDS) is introduced.
In particular, the application of nerve growth factor via biodegradable hydrogel is thought to be effective for the protection and recovery of inner ear function.

View full abstract

Download PDF (481K)
Transnasal Laryngeal Surgery with Flexible Tube

S. Tanaka

2005 Volume 98 Issue 1 Pages 6-7
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.6

JOURNAL FREE ACCESS

Download PDF (2152K)
Differences in the Effects of Steroid and Isosorbide for Acute Low-tone Sensorineural Hearing Loss

Yasuhiro Manabe, Dai Suzuki, Takehisa Saito, Shigeharu Fujieda

2005 Volume 98 Issue 1 Pages 9-14
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.9

JOURNAL FREE ACCESS

Show abstractHide abstract

Differences in the effects of steroid and isosorbide for acute low-tone sensorineural hearing loss (ALHL) were examined. The steroid group showed significant improvement compared to hearing levels after the same length of treatment in the isosorbide group. Since endolymphatic hydrops was considered the etiology, some ALHL patients progress to Meniere disease. However, isosorbide improves endolymphatic hydrops in ALHL patients. Our findings showed that ALHL also has etiologies other than an endolymphatic hydrops and that these also respond to steroid administration.

View full abstract

Download PDF (704K)
Two Cases of Ocular Flutter

Toshitaka Tohtani, Takeshi Kanaya, Masayoshi Nagamine, Reiko Karasaki, ...

2005 Volume 98 Issue 1 Pages 15-19
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.15

JOURNAL FREE ACCESS

Show abstractHide abstract

Ocular flutter (OF) is a pathologic condition of the oculomotor system characterized by bursts of irregular eye movements during which the patient may experience oscillopia. In this study, we report two cases of OF. One patient was a 47-year-old male who has very long (over 10 years) history of oscillopia and we initially diagnosed him as having OF by precise neuro-otological investigation. The other patient was a 15-year-old female whose OF was highly typical and the diagnosis was not difficult to establish. We administered carbamazepine, bacrofen, and diazepam to both patients, but these medicines did not suppress the bursts of irregular eye movements and did not decreased oscillopia or dizziness in either patient. However, only choto-san was very effective especially in first case. We discuss the potential efficacy of choto-san for saccade abnormality in patients with OF.

View full abstract

Download PDF (551K)
Endolymphatic Sac-expanding Surgery for Intractable Meniere's Disease

Masaaki Kitahara, Eiichiro Goto, Hiroshi Matsuoka

2005 Volume 98 Issue 1 Pages 21-25
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.21

JOURNAL FREE ACCESS

Show abstractHide abstract

This study evaluated the efficacy of endolymphatic sac-expanding surgery in comparison with medical treatment for intractable Meniere's disease. The outcomes of 47 patients with intractable Meniere's disease who underwent endolymphatic sac-expanding surgery were retrospectively compared with those of 22 patients who were offered surgery but preferred to continue medical treatment instead. Age, gender, disease duration, frequency of attacks and stage of hearing before treatment were almost equally distributed in both the surgically and medically treated groups. The outcomes were analyzed according to the 1995 AAO-HNS reporting guidelines. Definitive spells were completely controlled in approximately 90% of cases every year and hearing was improved in approximately 30% of cases for 0.5 to 6 years after surgery. Statistical analysis demonstrated that endolymphatic sac-expanding surgery is superior to medical treatment, at least from the perspective of immediate improvement in the quality of life. However, the proportion of cases showing hearing deterioration increased from 4% to 26% over 6 years after surgery. We would like to emphasize that further effort to improve and avoid deterioration in hearing remains urgent.

View full abstract

Download PDF (760K)
A Case of Granulocytic Sarcoma (Chloroma) with Acute Mastoiditis

Eriko Kamiya, Eiji Takeuchi, Hiroya Kitano, Hironori Sakurai, Mikio Su ...

2005 Volume 98 Issue 1 Pages 27-32
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.27

JOURNAL FREE ACCESS

Show abstractHide abstract

We report a case of Granulocytic Sarcoma (chloroma) with acute mastoiditis in a 14-year-old male. The patient was brought to our clinic because of left facial nerve palsy and acute bilateral otitis media. He was diagnosed as having acute mastoiditis, and underwent left mastoidectomy. One week later, however, leukocyts increased and the wound did not heal. A mass lesion in the mastoid was detected on MRI. We biopsied the mastoid and found Granulocytic Sarcoma (chloroma). Thereafter, the patient underwent chemo- and radiation therapy, but died due to the general deterioration of his condition. In this case, pathological examination and MRI were useful for establishing the final diagnosis.

View full abstract

Download PDF (8947K)
The Treatment Strategy for Peripheral Facial Nerve Palsy in Children

Jun Shuto, Satoshi Suenaga, Tetsuo Watanabe, Masashi Suzuki

2005 Volume 98 Issue 1 Pages 33-38
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.33

JOURNAL FREE ACCESS

Show abstractHide abstract

Statistical analysis was undertaken for 30 cases of peripheral facial nerve palsy in patients under the age of 15 years-old treated in Oita University Hospital between January 1981 and December 2003. Diagnoses were: Bell's palsy (n=14), Hunt's syndrome (n=7), otitis-related palsy (n=8), and traumatic palsy (n=1). This paper reports the results of treatment with particular regard to Bell's palsy and Hunt's syndrome.
Successful management of facial palsy requires confident and accurate diagnosis, reliable estimation of prognosis, and effective treatment. In children, however, it is difficult to evaluate the degree of facial palsy and to select an adequate therapeutic protocol. In our department, most patients were treated with steroids after informed consent was obtained from the parents.
On follow-up after 180 days, the complete recovery rate for Bell's palsy was 11 of 11 cases (100%) while that for Hunt's syndrome was 3 of 7 cases (42.9%). The final recovery rate was thus significantly higher for Bell's palsy than for Hunt's syndrome. For Bell's palsy, the recovery rate was better in children than in adults (55/68, 80.9%); however, that for Hunt's syndrome was worse in children than in adults (22/29, 75.9%).
Electroneurography (ENoG) was performed in 17 patients with Bell's palsy or Hunt's syndrome and the results corresponded with clinical outcome. Vestibular function testing was performed in 19 patients, and demonstrated ipsilateral canal paralysis (CP) in 2 cases, both of which were diagnosed as having Hunt's syndrome with poor clinical outcome. From the above results, it was concluded that CP on vestibular function testing suggests a poor prognosis.

View full abstract

Download PDF (2601K)
Effectiveness of Tranilast and Argon Plasma Coagulation for the Inferior Turbinate During the Pollen Season

A Report of 3 Cases of Cedar Pollinosis

Nao Makino, Hisashi Tokano, Hirofumi Maehara, Hiromi Kanazawa, Ken Kit ...

2005 Volume 98 Issue 1 Pages 39-45
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.39

JOURNAL FREE ACCESS

Show abstractHide abstract

Tranilast and argon plasma coagulation of the inferior turbinate (APC+T) was performed in 3 cases of cedar pollinosis during the pollen season in 2002. In all 3 cases, patients had perennial rhinitis that was well controlled by medical treatment but their symptoms became severe during the pollen season. Case 1 was a 23-year-old man, annoyed by uncomfortable nasal symptoms during the cedar pollen season despite using antiallergic medications. Case 2 was a 21-year-old man who had previously undergone APC+T during the pollen season, and wanted to undergo APC+T again. Case 3 was a 15-year-old man who had previously undergone CO₂ laser surgery and wanted to undergo APC+T.
Their nasal symptoms were classified into 5 grades according to a consensus report in 2002 on the diagnosis and management of rhinitis. In all 3 cases, the grade of their subjective symptom improved.
Based on these results, we concluded that APC+T is effective for patients with cedar pollinosis even if performed in the middle of pollen season.

View full abstract

Download PDF (2070K)
A Case Report: Blow-in Fracture of the Orbital Roof

Kazuhiko Yamamura, Kousei Takeda

2005 Volume 98 Issue 1 Pages 47-50
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.47

JOURNAL FREE ACCESS

Show abstractHide abstract

Blow-in fracture is a rare injury resulting from orbital trauma. Fragments of the orbital bone may increase orbital pressure, causing direct or indirect damage to the globe. Here, we report a case of impure type blow-in fracture of the orbital roof. A 28-year-old male presented with diplopia and frontal paresthesia caused by trauma. Coronal CT scan showed fracture of the orbital roof. We reduced the fracture via a frontal approach and achieved fixation with autologous septonasal mucosa to maintain mucociliary function of the frontal sinus. At 12 months' follow-up, he remains free of ophthalmologic symptoms and there is no clinical evidence of frontal disease.

View full abstract

Download PDF (4848K)
A Case of Repeated Acute Tonsillitis Caused by Actinomycosis

Masayuki Sakamoto, Ryuzaburo Higo, Yukiko Shinjo

2005 Volume 98 Issue 1 Pages 51-53
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.51

JOURNAL FREE ACCESS

Show abstractHide abstract

We describe a case of actinomycosis of the tonsils. A 25-year-old male underwent repeated acute tonsillitis. The condition was easily recovered by oral medication of antibiotics, but soon recurred. Tonsillectomy was performed for radical treatment. The lesion was diagnosed as actinomycosis of the tonsil based on typical histopathological findings. The infection might have been weakened during oral medication of antibiotics but still persisted, and reactivated after the cessation of treatment. Tonsillectomy plays an important role in the diagnosis and removal of this condition.

View full abstract

Download PDF (3024K)
Retrospective Study of Patients with Recurrent Papillary Carcinoma of the Thyroid Treated at Our Department

Kyoichi Terao, Yukio Tanaka, Hiroyuki Sunami, Takeshi Kusunoki, Kazuno ...

2005 Volume 98 Issue 1 Pages 55-60
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.55

JOURNAL FREE ACCESS

Show abstractHide abstract

Among patients who received primary treatment for papillary carcinoma of the thyroid at our department between 1975 and 2003, 29 patients developed recurrence. The interval until recurrence ranged from 6 months to 20.5 years, with a mean of 6.5 years. According to the T classification, 1 patient was T1, 6 were T2, and 22 were T4. The initial surgery included partial resection in 1 patient, lobectomy in 15, subtotal thyroidectomy in 5, and total thyroidectomy in 8. Unilateral paratracheal lymph nodes were resected in 15 patients treated by lobectomy and the bilateral paratracheal lymph nodes were resected in 13 patients who received subtotal or total thyroidectomy. Cervical lymph nodes were also resected in patients who were N+ clinically. The first recurrence involved the site of the primary lesion in 11 patients (at a site of infiltration in 6 and in the residual thyroid gland of 5), while lymph nodes were affected in 17 patients (cervical lymph nodes on the affected side in 13, ontralateral cervical nodes in 3, and paratracheal nodes in 1), and remote organs were involved in 3 patients (lung in 1, skin in 1, and brain in 1) (some patients experienced recurrence at 2 sites). The outcomes after repeat surgery was disease-free survival in 20 patients and re-recurrence in 9. Among the 9 patients who experienced re-recurrence, 6 are currently alive with disease and 3 have died. Among the 3 deaths, 2 were due to recurrence at the site of tracheal infiltration and 1 followed progression to undifferentiated carcinoma. In the present study, these cases were examined to discuss measures for improving the prognosis and salvage methods for patients with recurrent thyroid carcinoma.

View full abstract

Download PDF (916K)
A Case of Papillary Carcinoma Arising from Thyroglossal Duct Cyst

Akiko Sakabe, Tsuyoshi Udaka, Nobuaki Hiraki, Tetsuro Wakasugi, Takuro ...

2005 Volume 98 Issue 1 Pages 61-65
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.61

JOURNAL FREE ACCESS

Show abstractHide abstract

A case of papillary carcinoma arising from a thyroglossal duct cyst is reported. A 43-year-old man was referred to our clinic with an anterior cervical mass. CT scan and MRI imaging revealed a ring-enhanced cystic mass in his anterior neck, while ultrasonography showed an irregular echo in the mass. He was preoperatively diagnosed with thyroglossal duct cyst, and underwent resection of the mass by Sistrunk's procedure. Histopathological examination of the surgical specimen showed papillary carcinoma in the thyroglossal duct cyst. Because the histological findings indicated that the tumor had been completely resected, no additional treatment was given. His postoperative course was uneventful, and the patient is currently free from disease 3 years after surgery.
It is known that carcinoma, mostly papillary carcinoma, occurs more frequently in thyroglossal duct cysts than in the ordinary thyroid gland. Ultrasonography is a sensitive and useful method for detecting calcified lesions for the diagnosis of this disease. The epidemiology and clinical characteristics of papillary carcinoma associated with thyroglossal duct cyst were reviewed in the literature.

View full abstract

Download PDF (8218K)
A Case of Desmoid Tumor in the Posterior Neck

Shigetaka Moriai, Takashi Osaki, Yasuaki Harabuchi

2005 Volume 98 Issue 1 Pages 67-74
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.67

JOURNAL FREE ACCESS

Show abstractHide abstract

We report a desmoid tumor in a 75-year-old man, who presented with a tumor in the posterior neck in July 2003. The patient had a history of left lobectomy and neck dissection for thyroid carcinoma in September 2000.
CT findings indicated a large strongly enhanced tumor located in the posterior neck.
On T1-weighted MRI, the tumor was isointense to muscle and heterogeneously enhanced with gadolinium. The lesion also exhibited a high intensity on T2-weighted MRI.
PET showed FDG accumulation in the tumor, while 201mT1 scintigraphy showed T1 uptake in the tumor, suspected the recurrence of thyroid carcinoma. The tumor was excised under general anesthesia in November 2003. At surgery, the lesion was adherent to the surrounding tissue, but there were no post-operative neurological problems.
Pathological examination demonstrated multiplication of fibroblasts and abundant collagen but there were no remarkable features for example fission and necrosis, suggesting malignancy. However, the tumor showed a tendency to infiltrate by extension between individual muscle fibers.
From available information, desmoid tumors of the head and neck are rare, especially in the posterior neck lesions. These lesions are fibrous neoplasms with a good prognosis but significant morbidity with the potential for locally aggressive growth invading surrounding structures. The complicated anatomy of the head and neck seems to generate a tendency toward such lesions, but they do not display any metastatic potential clinically.
We have not detected any postoparative recurrence of the tumor for seven months to date.

View full abstract

Download PDF (13194K)
Docetaxel Combination Chemotherapy for Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck

Takema Sakoda, Aya Nosaka, Yuko Yamamoto, Takahiro Fukuhara, Kensaku H ...

2005 Volume 98 Issue 1 Pages 75-79
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.75

JOURNAL FREE ACCESS

Show abstractHide abstract

Systemic chemotherapy is generally acccepted as standard palliative treatment for patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) who are no longer amenable to surgery or radiotherapy. The standard treatment for patients with SCCHN is presently cisplatin-based combination therapy with 5-fluorouracil (5FU), which has achieved a high response rate. However, for patients with recurrent SCCHN who have already been treated with platinum and 5FU, second-line combination chemotherapy has not commonly been used. We treated 6 patients with recurrent SCCHN using docetaxel-based combination therapy. This therapy facilitated outpatient administration. The adverse effects were tolerable and 1 CR, 3 PR and 2 PD were achieved.

View full abstract

Download PDF (666K)
Endoscopy-assisted Middle Ear Surgery

S. Usami

2005 Volume 98 Issue 1 Pages 80-81
Published: January 01, 2005
Released on J-STAGE: October 07, 2011

DOIhttps://doi.org/10.5631/jibirin.98.80

JOURNAL FREE ACCESS

Download PDF (2100K)

Register with J-STAGE for free!