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Sachio Takeno, Takaharu Tatsukawa, Jin Hong Chen, Rika Osada, Hiroko K ...
1999 Volume 1999 Issue Supplement102 Pages
1-8
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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Histamine contributes to various physiologic and pathologic responses in the upper respiratory tract, including changes to epithelial permeability, afferent nerve stimulation and smooth muscle contraction. However, its physiological and pharmacological effects on paranasal sinus epithelium have not been fully elucidated. In this study, we have developed a primary culture technique using human ethmoidal epithelial cells, which demonstrated that nearly half of the outgrowthal epithelial cells were ciliated. We examined the effects of histamine and its receptor antagonists on the cultured cells by two different methods: 1) measurement of the ciliary beat frequency (CBF) by a photoelectrical method at specific predetermined ciliated sites,2) employment of a novel fluorescent water-soluble probe, FM 4-64, in order to investigate the mechanisms of activity-dependent cell membrane recycling. Histamine alone increased the CBF of the cultured cells at all concentrations tested (10
-4 M,10
-5M and 10
-6 M). The response was nearly abolished in the presence of 10
-4 M pyrilamine, whereas no significant inhibition was observed when cells were pretreated with 10
-4 M cimetidine. PronouncedF M 4-64 labelingt riggeredb y histaminea dministrationw, as observedi n the plasma membrane of the cultured cells. Pretreatment with 10
-4M pyrilamine completely inhibited these time-dependent changes in FM 4-64 labeling. We concluded that histamine stimulation acts to increase the CBF and alters membrane dynamics mediated via specific H1 receptors of the sinus epithelial cells.
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Hiroko Kawamoto, Hiroshi Watanabe, Koji Yajin, Osamu Kouro
1999 Volume 1999 Issue Supplement102 Pages
9-13
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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Recently, the relationship between nitric oxide (NO) and allergies has been reported. The majority of NO effects appear to be mediated by activation of guanylate cyclase (GC). Methylene blue (MB) inhibits the activity of GC when applied to the nasal mucosa of allergic rhinitis volunteers. MB inhibited the nasal provocation reaction to specific allergens. We also investigated the effect of MB on antigen induced release of histamine and leukotrienes (LTs) from human nasal polyps
in vitro. MB inhibited the release of LTB
4 while it did not inhibit the release of histamine and LTC
4/D
4/E
4. MB potentially inhibits not only the release of chemical mediators, but also non specific nasal hypersensitivity.
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Toru Tashiro, Sachio Takeno, Naoyuki Ueda, Masaya Takumida, Katsuhiro ...
1999 Volume 1999 Issue Supplement102 Pages
14-20
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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A number of recent reports have demonstrated that long-term low-dose macrolide therapy is effective on in the treatment of chronic sinusitis as well as diffuse panbronchiolitis. In this study, we focused on the in vitro effects of macrolides on the ciliary beat frequency (CBF) of cultured human sinus epithelial cells. Sinus mucosal explants were successfully cultured on poly-L-lysine coated dishes with abundant outgrowthal ciliated cells. CBF measurements were carried out by a photoelectric method at specific predetermined sites on the 7 to 14 day cultured specimens. Both erythromycin (EM) and roxithromycin (RXM) had no significant effects on CBF at a relatively high concentrations (10
-4M). However, EM and RXM, at a concentration of 10
-5M, significantly increased CBF by 20% and 19% respectively four hours after administration. The cilio-stimulatory effects continued to the same degree for 24 hours. We further subdivided the ciliated cells into two groups on the basis of their mucociliary activity, predetermined before drug administration. The faster group included cells with a CBF of more than 630 beat/min and the slower group included those with a CBF of less than 630 beat/min. Interestingly, both EM and RXM at concentrations of 10
-4 M and 10
-5M showed no effect in the faster group. On the other hand, these drugs significantly increased the CBF of the ciliated cells in the slower group at both concentrations tested by a maximum of 34% with EM and 55% with RXM. These results suggest that macrolide antibiotics augment the ciliary clearance of human parnasal sinuses, and that this effect might be more pronounced when the epithelial ciliated cells are in somewhat disturbed conditions.
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Masaya Takumida, Tohru Tanigawa, Koji Yajin
1999 Volume 1999 Issue Supplement102 Pages
21-24
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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The purpose of this study was to investigate the effects of sodium nitroprusside (SNP) on isolated type I vestibular hair cell morphology. Vestibular hair cells were superfused with artificial perilymph containing SNP. Application of 3 or 30
mM SNP resulted in a high rate (50 and 33%, respectively) of bleb formation in the neck region and decreased (3
mM,5.4%; 30
mM,8.0%)mean cell length. This bleb formation and neck shortening may alter the ability of mechanotransduction and was suggested to disrupt mechanotransduction in the vestibule.
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Tsutomu Ueda, Tomohito Date, Makoto Shirane, Tetsumi Yamane
1999 Volume 1999 Issue Supplement102 Pages
25-31
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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Previous studies have shown a relation between the p53 tumor suppressor gene protein and expression of proliferating cell nucleolar antigen (PCNA), nucleolar organizing region (NORs) and biological malignancy of tumors, in addition to prognosis.
We examined p53 protein, one of the tumor supressor gene products, expression of PCNA, AgNORs which are considered to be an indicator of tumor proliferation activity in addition to cell nucleus area, in tongue neoplasms. The relation between clinical prognosis and the degree of cell variation was studied. The subjects included 19 cases of tongue cancer,7 leukoplakiaes, and 4papillomas. Using paraffin embedded sections, immunohistochemical staining with p53 antibody and PCNA antibody, and AgNORs staining were done. p53 protein was shown to be effective for differentiating of cancer cells from non-cancer cells in tongue neoplasms. In cancerous tissues, the higher the number of p53 positive cells, the larger the size of the tumors. Moreover, a significant difference was found between T2 and T3,4 (p<0.05). As to the shape of the dot in the AgNORs stained cells, there was a difference between cancerous and non-cancerous cells. The inequality in size of the nuclear area tended to be large, and the degree of heteromorphism was higher. The faster the progress of the tumor at the primary site was, the larger the size of the nuclear area.
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Masaya Takumida, Koji Yajin, Junko Ikeda, Tatsuo Kohriyama, Shigenobu ...
1999 Volume 1999 Issue Supplement102 Pages
32-35
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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Glycosphingolipids are molecules present on the surface of normal nerve cells and are considered antigenic. Recent studies have isolated these antigens in vestibular neuroepithelia, cochleovestibular nerves and the endolymphatic sac. The purpose of this study was to determine the presence of antibodies against the glycosphingolipid antigen, sulfoglucuronyl paragloboside (SGPG), in the sera of patients suspected of autoimmune inner ear disease. The sera of a total 41 patients, including cases of progressive sensorineural hearing loss (PSNHL) (n= 19), sudden deafness (SD) (n = 8), Ménière's disease (n = 9), mumps hearing loss (n = 5), were tested for antibodies against the SGPG antigen. Antibody titers were determined by the microtiter ELISA method. Antibody titers were elevated in 36.8% of patients with PSNHL,25.0% of sudden deafness patients, while no elevation was observed in Mniere' s disease patients and mumps patients. Because SGPG antigens have been recently isolated in the inner ear, especially in the cochleovestibular nerve, these structures can potentially become targets for anti-SGPG antibodies.
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Makoto Shirane, Tsutomu Ueda, Tomohito Date, Tetsumi Yamane
1999 Volume 1999 Issue Supplement102 Pages
36-43
Published: March 30, 1999
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The immunohistochemical expression of p53 protein and proliferating cell nuclear antigen (PCNA) and the number of argyrophilic nucleolar organizer regions (AgNORs) as well as the mean size of the nucleus were evaluated in twenty-three formalin-fixed, paraffin-embedded specimens from untreated patients with Ti and T2 laryngeal cancer. All of these patients underwent radical radiation therapy. The same factors were assessed in nine cases of laryngeal polyp patients as control patients.
In comparisons between cancer and polyp patients, the expression of p53 protein, PCNA and AgNORs and the mean nuclear area were significantly increased in the cancer patients. This will indicate the possible advantage of these factors in the differentiation of benign and malignant regions.
When non-recurrent and recurrent groups in cancer patients were compared, the expression of PCNA was significantly increased in latter group. The same tendency was recognized in the number of AgNORs. From these results it will be assumed that the marker of the cell proliferative activity, PCNA and AgNORs, will be utilized as a genetic prognostic indicator of laryngeal cancer.
This work was supported in part by a Grant-in-Aid for Cancer Research (7) from the Ministry of Health and Welfare.
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Keiko Okano, Sachio Takeno, Takaharu Matsushima, Sitau Hirata, Koji Ya ...
1999 Volume 1999 Issue Supplement102 Pages
44-49
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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House dust is a major allergen in perennial allergic rhinitis especially in adolescents. In this study, we assessed the long-term efficacy of 113 patients who were prescribed immunotherapy with house dust mite for treatment of allergic rhinitis and reached the expected maximum dose in the university hospital. The average period of immunotherapy was 40 months. In most of the patients, immunotherapy with Torii allergen extract resulted in marked improvement in the nasal symptom score, rendering 14 patients (12.4%) free of symptoms,51 (45.1%) considerably improved,26 (23%)improved and 22 (19.5%) unchanged. The therapeutic effects with respect to changes in nasal stiffness were less compared to changes in nasal discharge or sneezing. Out of 91 patients who had obtained satisfactory results, improvement in nasal symptoms occurred within 2 months in 43 patients (47%) and within 6 months in 76 patients (83%). The therapeutic schedule was generally compliant and no severe adverse reactions were observed after treatment with the extract. We also surveyed changes in nasal symptoms after the termination of immunotherapy, using telephone questionnaires. Of the 34 patients surveyed,3 patients showed a partial relapse. Patient-self-evaluation was generally favourable with respect to treatment outcome in 26 patients (70.5%). We concluded that immunotherapy was well tolerated and clinically effective in cases of perennial allergic rhinitis.
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Hiroshi Watanabe, Kentaro Imon, Takashi Ishino, Ryouji Gobara, Toshiyu ...
1999 Volume 1999 Issue Supplement102 Pages
50-53
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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The pharyngeal smears of 83 patients with cough and/or pharyngeal discomfort were examined. They were classified into three groups (eosinophilic, neutrophilic, and non-inflammatory) according to the cellular infiltration.
The eosinophilic group consisted of 17 patients (20.5%), the neutrophilic group consisted of 41patients (49.4%), and the non-inflammatory group consisted of 25 patients (30.1%).
We administered Azelastine (2 mg/day) and Suplatast tosilate (300 mg/day) to the patients in the eosinophilic group, Clarithromycin (400 mg/day) and L-carbocystein (1000 mg/day) to the neutrophilic group patients, and Tofisopam (150 mg/day) to the non-inflammatory group for 1-2 weeks.
Of the 83 patients,19 dropped out of the study. Among the remaining 64 patients the medication was slightly effective or better in 75.0% of the eosinophilic patients,75.9% of the neutrophilic patients, and 68.4% of the non-inflammatory patients.
In conclusion, the results indicate that pharyngeal smear examination, may be effective for patients with cough and/or pharyngeal discomfort.
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Sachio Takeno, Noriyuki Fukushima, Katsuhiro Hirakawa, Koji Yajin, Kaz ...
1999 Volume 1999 Issue Supplement102 Pages
54-60
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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At the Department of Otolaryngology, Hiroshima University School of Medicine, we conducted a retrospective survey of 430 ears operated on over a ten-year period from 1987 to 1997. All of the surgical procedures were performed by one of three surgeons. Data included 247 ears (57.5%) with middle ear cholesteatoma,117 ears (27.2%) with chronic otitis media (22 ears were adhesive),29ears (6.7%) with middle ear anomaly and 10 ears (2.3%) with otosclerosis. Data were compiled by retrospectively reviewing the charts of the patients. The surgical procedures included 373 (86.7%)tympanoplasties; 127 (29.5%) type 0,124 (28.8%) modified type III,73 (17%) type I and 49(11.4%) modified type IV, and 21 (4.8%) myringoplasties. Comparison of the success rate in terms of hearing improvement with each procedure showed a difference. The success rates were 90.5%for myringoplasty,74.7% for type I,64.5% for modified type III and 61.2% for modified type IV tympanoplasties. We also examined whether the grafting materials used for ossicular reconstruction might influence hearing results. For this purpose, auricular cartilage, cortical bone and artificial ossicular replacement prostheses (PORP or TORP) were used in 117 (67.6%),40 (23.1%) and 8 (1.7%) ears, respectively. The success rates of hearing improvement were 66.4% for cartilage,56.8% for cortical bone and 68.4% for artificial prostheses.
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Jun-Ichi Hasegawa, Shitau Hirata, Takaharu Tatsukawa, Toru Tashiro, No ...
1999 Volume 1999 Issue Supplement102 Pages
61-69
Published: March 30, 1999
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The clinical results of tinnitus therapy administered in our clinic were investigated. One hundred and ten patients with tinnitus (138 ears) were treated between 1994 and 1998. The characteristics of tinnitus were evaluated by the pitch match test, loudness balance test, intravenous lidocain test etc. All patients were treated by either intravenous lidocain injection, transtympanic injection of steroid, or electrical cochlear stimulation etc. or oral medication in general. The tinnitus was reduced in 56.5% of patients and disappeared in 12.3%.
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Naoyuki Ueda, Noriyuki Fukushima, Jun-ichi Hasegawa, Noriaki Tanimitsu ...
1999 Volume 1999 Issue Supplement102 Pages
70-75
Published: March 30, 1999
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Nineteen juvenile patients younger than 20 years of age with malignant head and neck tumors were treated at the Hiroshima University Hospital between 1979 and 1998. Patient age ranged from 2 to 19 years, and there were 10 males and 9 females. The average age was 14.3 years. The most common initial symptoms were nasal symptoms (i. e. nasal bleeding and obstruction) and next most common was swelling of the cervical lymph-nodes. The paranasal sinus was the most common tumor site.
Histologically, squamous cell carcinoma and mucoepidermoid carcinoma were the most common epithelial tumors, and malignant lymphoma and rhabdomyosarcoma were the most common nonepithelial tumors. According to the UICC system (1987), St Jude system, IRS (group I 1\T)8, patients were stage I,3 were IC,4 were Ill,3 were IV. Prognosis of the non-epithelial tumors and advanced epithelial tumors was poor.
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Noriaki Tanimitsu, Naoki Mori, Katsuhiro Hirakawa, Koji Yajin
1999 Volume 1999 Issue Supplement102 Pages
76-82
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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Malignant melanomas of the skin are less common in Japanese than in Caucasians. Mucosal malignant melanomas of the head and neck region, on the other hand, are not a rare condition in Japan. Nineteen patients with malignant melanomas in the otorhinolaryngological field treated at the Hiroshima University Hospital from 1976 to 1996 were clinically reviewed. The patient population included nine men and ten women, aged 38 to 86 years. The average age of the patients was 67.8 years, and they were usually in the seventh decade of life.
In fourteen cases, the tumors were localized to the nasal cavity and the paranasal sinuses, in four cases to the oral cavity and in one case to the nasopharynx. The treatment consisted of surgery, chemotherapy, immunotherapy, radiotherapy, or a combination of these modalities. The five year survival rate was 11.1%. The major factor contributing to a failure of treatment was local recurrence, followed by distant matastasis. Primary radical surgery seemed to offer the best chance for local control, and was important in improving patient survival in this disease. Although ineffective for a complete cure, chemotherapy may play a role in the treatment and in helping to prolong survival.
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Shitau Hirata, Haruo Hirakawa, Noriyuki Fukushima, Toshiyuki Ueda, Ken ...
1999 Volume 1999 Issue Supplement102 Pages
83-88
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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Chondrosarcomas occur most frequently in the pelvis, femur and humerus, and rarely involve the bones of the head and neck region. The case of a chondrosarcoma arising from the infratemporal fossa is reported here. The patient was a 60 year-old female who had swelling on the right side of her face and a mild disturbance of mandiblar movement for 8 years. CT scanning revealed a mass,4.4×3.7×3.2 cm, with a defect in the mandiblar bone of the right infratemporal fossa. MRI showed an irregular enhanced mass in that region. The tumor was removed via a lateral superior and inferior approach. The patient has been followed-up for 7 months without any evidence of recurrence.
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Shin Masuda, Katsuhiro Hirakawa, Rika Osada, Kyousuke Furukido, Kouji ...
1999 Volume 1999 Issue Supplement102 Pages
89-94
Published: March 30, 1999
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We present here the case of a multi-channel cochlear implant in a postlingually deaf and blind patient. The problems experienced in the mapping and rehabilitation of this patient were as follows:
1) The ordinary communication tools consisted of Braille and finger-Braille in addition to the cochlear implant. We could learn Braille quite easily.
2) We noticed that visual information was necessary for many processes during mapping.
3) Visual information was used not only for lip-reading, but also in many situations such as in detecting the person whom is speaking, in discriminating voices from noise, etc.
4) The rehabilitation of the patient's family in communicating with the patient was very important.
5) A rehabilitation program with intensive auditory training is needed.
It is true that there are many more problems in applying cochlear implants to deaf-blind patients than to deaf only patients. However, it is important to give auditory information through a cochlear implant to the deaf-blind patient.
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Kentaro Imon, Hiroshi Watanabe, Takashi Ishino, Ryouji Gobara
1999 Volume 1999 Issue Supplement102 Pages
95-99
Published: March 30, 1999
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The case of an eosinophilic granuloma of the soft tissues involving the parotid gland is reported. A blood examination showed a remarkable increase in the eosinophil and serum IgE levels, and the allergic AlaSTAT test was found positive for Candida and others. Surgical treatment was not performed because the size of the granuloma was not large, and reduced spontaneously. The administration of suplast tosilate was not effective. However, the administration of an antifungal drug was effective, and there has been no recurrence observed after 16 months of therapy.
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Hironori Miyawaki, Yoshie Horibe, Takashi Ishihara, Nobuharu Tagashira ...
1999 Volume 1999 Issue Supplement102 Pages
100-104
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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We experiencedt he case of a 56 year-01dm ale with mutiplev enous aneurysms in the rightn eck, bilaterapla rotidr egion and head region. The right-sidende ck tumor was softb ut could not be enlarged by a Valsalva maneuver. Venography revealed venous aneurysms in the right external jugularv ein and the rightp arotidg land. Resectionw as carriedo ut for the rights ided neck tumor and the subcutaneoush ead tumor. The righte xternalj ugularv enous aneurysm communicated with the righti nternall ugularv ein. The tumor in bilaterapla rotidr egion was not resectedd ue to the possibilitoyf facialp alsy and a ruputure of the aneurysm.
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Nobuyuki Miyake, Hiroyuki Takahashi, Yumi Fujihara, Toru Tashiro, Kazu ...
1999 Volume 1999 Issue Supplement102 Pages
105-108
Published: March 30, 1999
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Synovial sarcomas of the head and neck are extremely rare. A review of the literature revealed only 8 cases of synovial sarcomas in the head and neck in Japan.
We experienced the case a patient with a synovial sarcoma of the tongue. The patient was a 47- year-old man whose chief complaint was pain of the tongue. MRI revealed a high intensity mass in the tongue measuring 6×5×4 cm in size. The initial histological diagnosis based on a biopsy specimen was an acinic cell carcinoma. Chemotherapy turned out to be ineffective, and surgical resection was then performed. A postoperative microscopic examination of the tumor showed both epithelioid cells and spindle cells. Immunohistochemically, the epithelioid cells were keratin immuno-positive, whereas the spindle cells were vimentin immunoreactive. On the basis of these findings, the tumor was diagnosed as the biphasic type of synovial sarcoma. The patient underwent postoperative radiotherapy, and has had no recurrence or metastasis at present.
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Yoshiki Mori, Hironori Miyawaki, Shinji Kimura, Nobuharu Tagashira, Wa ...
1999 Volume 1999 Issue Supplement102 Pages
109-112
Published: March 30, 1999
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A review of the literature indicated that peripheral facial palsy was not rare, but that bilateral facial palsy occurred very rarely. We report here a 74 year-old man was treated for bilateral facial palsy. In this case, right facial palsy began 46 days after the onset of a palsy. The left side palsy did not recover in spite of our treatment. Therefore, we decided to perfrom a decompression on the left side. The left facial palsy recovered to about 70% after the operation.
Therefore, facial nerve palsy showing denervation should be considered for a decompression.
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Toru Handa, Koji Yajin, Katsuhiro Hirakawa, Noriyuki Fukushima, Masaya ...
1999 Volume 1999 Issue Supplement102 Pages
113-116
Published: March 30, 1999
Released on J-STAGE: November 27, 2012
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An 88year-old female presented with bacterial meningo-encephalitis secondary to a postoperative pyocele in her left fronto-ethmoidal sinuses.
She was admitted to our hospital because of high fever and unconsciousness. Left exophthalmus and left eyelid swelling also occurred. On examination, her cerebrospinal fluid showed a high cell colunt and CT scanning revealed infections in the left frontal and anterior ethmoidal sinuses. Ten days after her admission, an operation was performed by a transnasal approach for her fronto-ethmoidal pyocele.
The conciousness level of this patient recovered 23 days after operation. But right hemiplegia due to the meningo-encephalitis was recognized. After the sugery, no meningitis has recurred at the time of this report. We also discuss the rhinogenic intracranial complications of this case.
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Tomohito Date, Tsutomu Ueda, Makoto Shirane, Tetsumi Yamane
1999 Volume 1999 Issue Supplement102 Pages
117-120
Published: March 30, 1999
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We experienced the rare case of a malignant oncocytoma which arose from a minor salivary gland of the buccal mucosa. The case was a 57 year-old male with a small mass in his buccal mucosa as the chief complaint. External irradiation to the local field was performed after surgical removal of the primary lesion. Due to the presence of cervical metastasis, however, a left neck dissection performed 5 months later. The tumor cells were large, and acidophilic granules filled their cytoplasm. The nuclei were large and had very clear nucleoli. A tendency towards invasion into the veins and lymph ducts was also seen observed. These findings satisfied the clinical and pathohistological criteria for a malignant oncocytoma.
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Kyosuke Furukido, Hiroko Kawamoto, Akira Nagasawa, Toshiyuki Iwamoto, ...
1999 Volume 1999 Issue Supplement102 Pages
121-126
Published: March 30, 1999
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We report here the rare case of extramedullary plasmacytoma of the larynx in a 74 year-old female which recurred 4 times. She first visited our clinic complaining of hoarseness on Jun 12,1997. The appearance of the tumor was like a polyp in left vocal cord. Initially, we had instituted treatment for a polyp, and it was resected by a direct laryngomicrosurgery. One month after the first surgery, a local recurrence was found and was resected by CO
2laser. However two other recurrences were found.
The histological examination by HE staining was of chronic inflammation and on extramedullary plasmacytoma. The plasmacytoma (IgG, λtype) was detected using by immunoperoxidase staining.
Our current strategy is local treatment for a polypoid lesion. However, further recurrences could require a laryngofissure operation for complete resection of the lesion.
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Shinji Kimura, Tomoko Kawamata, Hironori Miyawaki, Nobuharu Tagashira
1999 Volume 1999 Issue Supplement102 Pages
127-130
Published: March 30, 1999
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We present here two patients with basal cell adenomas of the parotid gland. The first case was a 58-year-old female with swelling in her right parotid region that had been present for 8 years. The second case was a 43 year-old female with painful swelling in the right parotid region that had been enlarging.
In each patient, the entire tumor was resected along with the surrounding tissues.
The histopathological features of these two cases showed that the tumors were composed of well-defined nests of small basaloid cells, and these cells were not present beyond the apparent capsule extending into the adjacent tissues. These tumors were therefore diagnosed as basal cell adenomas. Both patients showed uneventful postoperative courses.
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Shinji Kimura, Yoshiki Mori, Hironori Miyawaki, Nobuharu Tagashira
1999 Volume 1999 Issue Supplement102 Pages
131-135
Published: March 30, 1999
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Osteogenesis imperfecta is a connective tissue disorder caused by a genetic defect in the synthesis of type I collagen. The symptons of blue sclera, a tendency towards spontaneous fractures and conductive hearing loss due to osteogenesis imperfecta are often termed Van der Hoeve syndrome.
A 28 year-old female with van der Hoeve Syndrome is reported here. At 20 years of age, she complained of bilateral tinnitus and hearing loss. Pure tone audiometry showed mixed hearing loss of 49 dB in the right ear, and 38 dB in the left ear. Stapes mobilization was then performed on her right ear. Surgical observation revealed that the stapedial footplates were fixed to the oval window but were otherwise normal in shape. She obtained an improvement in her hearing level in her immediate postoperative period.
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Takaharu Tatsukawa, Katsuhiro Hirakawa, Takashi Moriya, Ken Hayashi, M ...
1999 Volume 1999 Issue Supplement102 Pages
136-140
Published: March 30, 1999
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Extraocular sebaceous carcinomas of the skin are uncommon neoplasms. We report here the case of a giant sebaceous carcinoma arising in the skin of the submandibular region. The patient was 64 year-old Japanese man, and the tumor measured 104×76×26 mm and involved the submandibular bone.
The tumor was resected with the normal skin, and reconstruction of the defect was performed with a deltopectoral myocutaneous flap.
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Takaharu Tatsukawa, Noriyuki Fukushima, Katsuhiro Hirakawa, Koji Yajin
1999 Volume 1999 Issue Supplement102 Pages
141-144
Published: March 30, 1999
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We report here the case of a thyroglossal duct cyst occurring in the oral floor. The cyst was located above the oral floor muscles, and did not extend beyond the hyoid bone. The cyst was resected from the oral side.
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Tomohisa Hirai, Shin Masuda, Noriyuki Fukushima, Tomoyuki Ogawa, Koji ...
1999 Volume 1999 Issue Supplement102 Pages
145-150
Published: March 30, 1999
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Carcinoid tumors are rare in the middle ear; only 25 cases have been reported in the literature. We report here the case of a 19-year-old female with a carcinoid tumor of the middle ear who complained of pain in her left ear. A tympanotomy was performed, and a whitish, avascular, non-invasive mass was found in the tympanic cavity, mastoid antrum and external auditory canal. Most of the tumor was removed, but the possibility that tumor might be left around the stapes, the facial recess and the tympanic sinus could not be denied. If the tumor still exits in the middle ear, the speed of its growth should be quite slow, and the second operation will not have to be performed for at least one year. In the mean time, any recurrence of the tumor is detectable through the eardrum findings, CT, or MRI, and we coule perform a second operation immediately.
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