We evaluated blood coagulation fibrinolysis and platelet function using Sonoclot
TM in hypothermia
in vitro. Methods: Whole blood samples were obtained from volunteers. Sonoclot analysis was conducted
in vitro at 37°C, 36°C, 35°C, 34°C, 33°C, and 32°C. Results: 1) son-ACT at 32°C was significantly higher than at 37°C. 2) Clotting at 37°C was significantly lower than at 32°C or 33°C. 3) The time to peak at 37°C did not differ significantly from other groups but was slower than at 32°C. 4) The peak signal at 37°C did not differ significantly from other groups. 5) The peak angle at 37°C was significantly higher than at 33°C, and tended to be higher than at 32°C. 6) The bottom signal at 37°C did not differ significantly from other groups. Conclusion: These results on enzyme activity and platelet function decreased, particularly below 34.0°C, suggesting that Sonoclot
TM is useful in trauma patients with demonstrated hypothermic coagulopathy and for brain trauma patients undergoing therapeutic hypothermia.
View full abstract