INTRODUCTION: There are only a few reports about the effect of the neutrophil elastase (NE) inhibitor, sivelestat, on the pulmonary vascular permeability in patients with sepsis induced acute lung injury and/or acute respiratory distress syndrome (ALI/ARDS). The objective of this study was to investigate whether or not the NE inhibitor could improve the pulmonary vascular permeability of patients with ALI/ARDS and sepsis.
METHODS: We examined survived 22 pts with sepsis induced ALI/ARDS. All patients were mechanically ventilated. They were divided into two groups (the sivelestat 11 pts and non-sivelestat group 11 pts). Upon admission, the pulse contour cardiac output (PiCCO) monitoring system (Pulsion Medical Systems, Munich, Germany) was set up to provide an estimate of extravascular lung water (EVLW) index and pulmonary vascular permeability index (PVPI). PVPI is the ratio of EVLW to pulmonary blood volume. These measurements were taken immediately and subsequently every 24 h for 2 days. At the same time the PaO
2/FiO
2 ratio, sequential organ failure assessment (SOFA) score, peak end-expiratory pressure (PEEP), fluid balance, lactate and base excess were recorded. Statistical analyses: χ
2 test, the Mann-Whitney U-test, analysis of variance (ANOVA) and liner regression analysis were used. P < 0.05 was regarded as statistically significant.
RESULTS: There was no statistically significant difference in age, gender, source of infection, SOFA score and PaO
2/FiO
2 ratio on the baseline between the sivelestat group and the non-sivelestat group. Fluid balance of the second 24 h was significantly lower in the sivelestat group than in the non-sivelestat group (-6.9 ± 18.0, 14.4 ± 28.7 ml/kg, p<0.05). PVPI, SOFA score, PaO
2/FiO
2 ratio, PEEP and base excess in the sivelestat group improved significantly (p<0.05 or 0.01) during 48 h, while those values in the non-sivelestat group did not change significantly. In the sivelestat group, the change of EVLWI and PVPI were related to the change of PaO
2/FiO
2 ratio during 48 h (r = -0.78, -0.6, p<0.005, 0.05).
CONCLUSIONS: 1) The NE inhibitor, sivelestat, seems to provide good efficacy for reducing the pulmonary vascular permeability that plays an important role in improving oxygenation in sepsis induced ALI/ARDS. 2) The analysis of the difference in the fluid balance between two groups shows that sivelestat seems to have the effect of reducing also the vascular permeability of other organs.
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