Objective: In the previous study, the CYP database was constructed in order to relate drug-drug interactions to the CYP metabolic information of the package inserts.  In this study, we evaluated the clinical usefulness of the CYP database by using the Pharmaceutical and Medical Devices Agency (PMDA) Drug Monitoring Information.
Methods: We examined the drugs in CYP isoform responsible for drug metabolism.  The age, sex, suspect drugs and co-administered drugs were extracted from 6,236 cases of the PMDA database of drug monitoring from January till November of 2008.
Results: Twenty-three percent of all cases had co-administered drugs.  Forty-five percent of these cases were metabolized both suspect and co-administered drugs by the same CYP isoform, and three fourths of these cases were able to be detected only by the CYP database.  In addition, the administration of substrate medicines in combination with substrate medicines was the largest (57%), followed by cases of substrate medicines in combination with inhibitor medicines (28%).  Seventy-seven percent of the suspect drugs that had a large number of reported cases of side effects were substrate medicines, and the frequency of co-administration with substrate medicines was very high.
Conclusion: These data suggest that the CYP database, being used together with package inserts, might be a clinically useful tool to avoid adverse events caused by drug-drug interactions.

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Objectives: To optimize the treatment of patients on tube feeding, it is important to ascertain whether medicines are appropriate for administration by gastrostomy and nasogastric tubes.  In this study, we evaluated the drug information services provided to medical staff by clinical pharmacists related to 109 patients administered medication via a feeding tube in a neurological ward.
Design and Methods: We analyzed the records of drug information services provided to medical staff from January 2006 to December 2007 at the Higashi Nagoya Hospital.  We classified drug information services for avoiding obstruction of the feeding tube and chemical changes into four categories: ‘formulation changes’, ‘medication changes’, ‘incompatibilities’ and ‘administration method’, and evaluated the acceptance rate of the pharmacists’ recommendations for drug therapy via feeding tube.
Results: Drug information related to formulation and medication changes accounted for 130 and 88 cases, respectively.  Information related to incompatibilities accounted for 19 cases, involving anticipated chemical changes related to concurrent administration of drugs.  Information related to administration methods accounted for 24 cases.  The acceptance rate for information by medical staff was 92.0%.
Conclusions: Drug information to medical staff by pharmacists contributes to improved safety for patients administered medication via feeding tubes.  The acceptance rate for drug information was high, and the provision of drug information by pharmacists in the neurological ward was considered useful.

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