Journal of the Japan Epilepsy Society
Online ISSN : 1347-5509
Print ISSN : 0912-0890
ISSN-L : 0912-0890
Volume 11, Issue 1
Displaying 1-4 of 4 articles from this issue
  • Eiichi Katsumoto, Sakae Yamagami, Takahiro Ozaki, Noboru Yokotani, Koj ...
    1993 Volume 11 Issue 1 Pages 1-8
    Published: February 28, 1993
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    The c-fosmRNA expression of brain by means of Northern blot analysis after seizures induced by tossed-up stimulation of seizure-susceptible El [s] mice showed a peak 30 min, still remaining higher level of induction at 1 h and an attainment baseline by 2h. The mRNA expression by bemegride-induced seizures of El [s] and seizure-naive El [ns] mice was significantly elevated at 30 min and had rapidly reached baseline. Bemegride-induced c-fosmRNA expression of ddY mice attained a peak at 15 min and sharply declined thereafter. The particular prolongation of c-fosinduction observed in seizures of El mice seems to associate with abnormal plasticity by recurrent seizures. In Slot blot analysis, the induction of c-fosmRNA expression after seizures were gradually declined following order of tossed-up stimulated seizures of El [s], and bemegrideinduced seizures of El [s], El [ns] and ddY mice, suggesting that the different expression supposedely reflecting genetic seizure-susceptibility.
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  • Toshiyuki Naruto, Tsunekazu Yamano, Morimi Shimada
    1993 Volume 11 Issue 1 Pages 9-14
    Published: February 28, 1993
    Released on J-STAGE: June 07, 2011
    JOURNAL FREE ACCESS
    It is well-known that visual stimulation in terms of pattern reversal stimulation induces epileptic seizures in some patients. Cognitive function was tested in 5 patients with patternsensitive epilepsy during visual stimulation. Response time changed in relation to seizure discharges in EEG. If epileptogenic activity is the initial trigger of the functional change in the brain during visual stimulation, it will be accepted that all of the functional abnormalities of the brain have relationship to seizure discharges in EEG. However, the response errors increased in relation to the kind of stimulation rather than seizure discharges. It may be conjectured that the visual stimulation per segives rise to a functional change in the brain which does not depend on seizure discharges. It is conceivable that the functional change reduces the threshold of epileptogenic activity.
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  • Tadahiko Shibata, Hiroto Iwasa, Keijiro Koseki, Toshio Sato
    1993 Volume 11 Issue 1 Pages 23-30
    Published: February 28, 1993
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    Dipole Tracing (DT) method was applied to estimate the equivalent current dipoles (ECD) of the focal spike and slow wave complex (SWC).
    Scalp EEGs were recorded in five patients with localization-related epilepsies (four cases were temporal lobe and the other was frontal lobe epilpsy). The SWC was devided into three components for DT analysis; negative spike component, trough (positive component) and slow wave component. Estimated ECDs of the three components were closely located to each other at a districted regional brain area on the dominant side of the spikes. These results suggested that three components of the focal SWC might be originated from closely located electrical generators in the brain.
    Furthermore it was observed that the vectors of ECDs of the spike and the slow wave components indicated almost the same direction, but that of the positive component pointed a direction almost opposite to them. It was speculated that the spike component and the positive component in the scalp EEG might reflect the excitatory and inhibitory electrical activities, respectively.
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  • Sunao Kaneko, Akira Hayashimoto, Hidetoshi Niwayama, Yutaka Fukushima
    1993 Volume 11 Issue 1 Pages 31-35
    Published: February 28, 1993
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    In order to study the effects of zonisamide (ZNS) on serum levesl of phenytoin (PHT) and carbamazepine (CBZ). PHT and CBZ levels were determined in 17 cases before and after changes in ZNS dose. Drug compliance was good in all subjects. Diurnal variations of PHT and CBZ were determined in one case, and a clear increase in PHT levels and no change in CBZ levels, after ZNS dose increase, were obtained. Lassitude, sleepiness, ataxia, nystagmus and dysarthria observed in this case were ascribable to the increased level of PHT which was caused by an increase of ZNS dose.
    PHT levels increased significantly after comedication or increase of ZNS while increase of CBZ levels failed to reach statistically significant level.
    To eliminate the effect of one hour difference in sampling time changes in serum levels were recorded only when more than 25% of change in PHT or CBZ levels in comparison with those before ZNS dose change was observed. Based on this criteria, ZNS increased PHT levels in 40% of subjects and decreased in 10% of subjects. ZNS increased CBZ levels in 29. 4% of subjects.
    This study, therefore, indicates that the determinations of PHT and CBZ levels are needed when ZNS is to be coadiministered or ZNS dose to be changed.
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