The present paper reports some genetical data on transplantability of the MY-mouse sarcoma. This is a kind of the spindle cell sarcomas, which developed in a So-strain mouse. The mice have not yet been established as a pure inbred strain. It has been shown that the transplantability of this tumor shows a considerable difference according to the strain of the host tried (Table 1). In the transplantation experiments, it was found that the mice of D- and S-strains showed a high transplantability. Through selection these mice were separated into two strains; D-103 from D strain and S-4 from S strain. They showed a very high transplantability, giving 92.15% and 100% transplantability for D-103 and S-4, respectively, whilst C3H, A, DBA/2, SWR, Swiss albino and CBA strain mice were all negative in transplantability of this tumor. The transplantability Was observed in F
1 hybrids between two starins, D-103 C3H, and a successful results were obtained in every test. From this result, it is presumed that the transplantability of this tumor was controlled by some dominant genes (H-genes). In order to observe the number of these genes, the transplantability was examined in F
2 hybrids and back crosses, C3H×F
1: 57.3 percent of F
2 and 30.7 percent of RF
1 hybrids showed a positive transplantability. Based on the above results, it is most probable that about two dominant H-genes are concerned with the transplantability of this sarcoma.
In order to learn whether the re-transplantation of the MY-mouse is possible or not, further experiments were carried out. First, this tumor was successfully re-implanted into mice from which the tumor was removed by ligation. The results were summmarized in Table 3. It is interesting that the re-transplantation into D-103 mice showed entirely negative in result, while in S-4 mice 33.3 percent showed a positive re-transplantation. In F
1 (D-103×C3H) hybrids, all experimental individuals were positive in result, while the F
2- and RF
1-hybrids were wholly negative. The sarcoma was re-transplanted into the host bearing the MY-mouse sarcoma. In the latter case, D-103 mice showed a positive re-transplantation in 26.6 percent (Table 4). From the results of the above experiments, it is highly apparent that the transplantability of the tumor which developed in the mice of non-pure strain is to be controlled by some genetical factors in addition to histocompatibility genes.
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