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Volume 34, Issue 12
Displaying 1-4 of 4 articles from this issue
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Michio TSUKAMURA1959 Volume 34 Issue 12 Pages 387-391
Published: 1959
Released on J-STAGE: May 21, 2007
JOURNAL FREE ACCESSGenetic studies on the streptomycin resistance of Mycobacterium avium (strain Jucho) were conducted by the population analysis method assuming a hypothesis that one type of the population structure of first-step clones corresponds to one genotype. The resulting conclusions are as follows:
There are multiple genotypes producing different population structures of clones. Both intermediate and fully resistant population structures of clones are produced by a single gene mutation or by double or multiple mutations.View full abstractDownload PDF (534K) -
Toshiaki TAKAHASHI1959 Volume 34 Issue 12 Pages 392-400
Published: 1959
Released on J-STAGE: May 21, 2007
JOURNAL FREE ACCESSTetrads of triploid yeasts, H-981 and H-986, obtaining by the minimal plate mating technique between a homothallic diploid strain of Saccharomyces chevalieri and heterothallic haploid strains of S. cerevisiae were dissected with the aid of micomanipulator.
Ascospore germination rate of H-981 was very low (11.1%), and the germinating ascospores did not form more than 1-10 cells in complete medium. But the tetrad analysis of H-986 was possible (ascospore germination rate: 38.8%) (Table 1-3). Some tetrad of this hybrid showed the irregular segregational ratios (Table 1, 3). This fact is basing on the trisomic condition of the chromosome having every genetic marker in H-986. However the difference between theoretical segregational ratio and experimental ratio of AD/AD/ad, AR/AR/ar, and GA/GA/ga was significant (Table 5), as a result elimination of the univalent having dominant gene was assumed. From the segregation of MA/ma/ma, and ME/me/me (Table 6), trivalent pairing of the chromosome containing these genes was more likely. Concerning to the sexual behavior, unexpected segregants (Type III, VII?, VIII, IX) appeared (Table 4). To express the fact, elimination of the chromosome having D-locus and/or mating type locus was assumed. From these reasons, the appearance of aneuploid ascospores and the low viability of ascospore depeding on the abnormal chromosome number were discussed.View full abstractDownload PDF (816K) -
Akira TONOMURA1959 Volume 34 Issue 12 Pages 401-406
Published: 1959
Released on J-STAGE: May 21, 2007
JOURNAL FREE ACCESSThe present paper deals with a chromosome study of six human uterine cervix carcinomas with special regard to the number and morphology of the chromosomes in each tumor. The general clinical and pathological properties of tumors here studied are shown in Table 1. The results of the chromosome investigations have revealed that the most frequently occurring tumor cells having a characteristic number-mode (or-modes) along with particular idiogram (or idiograms) may represent the stemline cells in each tumor, and that they may serve as the primary progenitors of growing neoplasms.
No. 3 tumor contains at least two hyperdiploid stemline cells with 50 and 51 chromosomes. The 50-cells consist of 20 M-, 24 S- and 4 T-chromsomes. No. 21 and No. 45 tumors showed a hyperdiploid chromosome pattern (round 50 in number) in each. No. 49 tumor is represented by a hyperdiploid stem-cells with 52 chromosomes which include 28 M-, 20 S- and 4 T-chromosomes. No. 50 tumor is provided with two distinct stemlines: the one line is represented by the cells with 66 chromosomes, and the other by those with 75 chromosomes. The 66-cells contain in each 33 M-, 23 S- and 10 T-chromosomes, while the 75-cells are provided with 33 M-, 29 S- and 13 T-chromosomes in each. No. 53 tumor showed a hyperdiploid stemline cells having 55 chromosomes which consist of 26 M-, 22 S- and 7 T-chromosomes. The chromosome formulae of the stemline cells of the tumors here studied are given in Table 3.
It has been shown that the chromosomes of the stemline cells of six uterine tumors under study differ from one another in their number and morphology, as well as from those of the normal cell. Further, the evidence presented indicates that the stemline chromosome-numbers of the uterine tumors except No. 50 distribute in a hyperdiploid range form 50 to 55.View full abstractDownload PDF (1073K) -
Ichiro INOUYE1959 Volume 34 Issue 12 Pages 407-417
Published: 1959
Released on J-STAGE: May 21, 2007
JOURNAL FREE ACCESSTwenty five different stocks of wild-type Drosophila melanogaster were treated with nitromin (methyl bis-β-chloroethyl-amine N-oxide hydrochloride). The treatment was to immerse 70 hours old larvae in a 2% solution of nitromin for 3 hours in dark room. Such treatment proved to be effective in producing phenocopies in varied organs of the fly. Anomalies were found in such organs as the compound eye, wing, leg, abdomen, thorax, antenna, proboscis and ocellus. Of these, the compound eye was the organ most frequently and most severely affected. However, it was marked that different stocks of the flies behaved differently in response to the same treatment of nitromin. Differences of the responses were conspicuous in the rate of adult hatching, in the kind of the organs affected and the degrees of anomalies produced. In these respects there was a general tendency that responses of the individual stocks of the fly were definite though they were differed markedly between different stocks. Such differences of the response may be referred to differences of the genetical constitution possessed by different stocks of the wild-type flies examined.View full abstractDownload PDF (2756K)
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